id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P29400,COL4A5,Collagen alpha-5(IV) chain,Tier 1.5,0.794,1,A2_pm_peripheral,2,48.12,0,0,,,0,0,,1,X-linked Alport syndrome,0.8472963899466404
Q14315,FLNC,Filamin-C,Tier 1.5,0.791,1,A2_pm_peripheral,14,75.06,0,0,,,0,0,,1,hypertrophic cardiomyopathy 26,0.8363192336142512
O60315,ZEB2,Zinc finger E-box-binding homeobox 2,Tier 1.5,0.789,1,A2_pm_peripheral,1,48.16,0,0,,,1,3,"27719642,24146916,18698484",1,Mowat-Wilson syndrome,0.8313744323041312
P11274,BCR,Breakpoint cluster region protein,Tier 1.5,0.785,1,A2_pm_peripheral,5,64.81,0,0,,,1,20,"41951939,41535871,40882628,37937247,37103734,32929022,32507237,31825964,31650445,31295447,29299123,28686804,25809097,23836560,22411871,21810089,21653319,21030439,16990253,11713794",1,chronic myelogenous leukemia,0.8183048540102864
O95630,STAMBP,STAM-binding protein,Tier 1.5,0.782,1,A2_pm_peripheral,5,84.0,0,0,,,0,0,,1,microcephaly-capillary malformation syndrome,0.8060251236043802
P12814,ACTN1,Alpha-actinin-1,Tier 1.5,0.777,1,A2_pm_peripheral,4,85.25,0,0,,,0,0,,1,platelet-type bleeding disorder 15,0.7887662502912471
P55263,ADK,Adenosine kinase,Tier 1.5,0.769,1,A2_pm_peripheral,4,93.31,0,0,,,1,2,26051465,1,adenosine kinase deficiency,0.7617058236708037
Q9NZ09,UBAP1,Ubiquitin-associated protein 1,Tier 1.5,0.764,1,A2_pm_peripheral,3,62.5,0,0,,,0,0,,1,"spastic paraplegia 80, autosomal dominant",0.7464670113492812
Q6NZI2,CAVIN1,Caveolae-associated protein 1,Tier 1.5,0.76,1,A2_pm_peripheral,3,67.38,0,0,,,0,0,,1,congenital generalized lipodystrophy type 4,0.7317728549444928
Q92997,DVL3,Segment polarity protein dishevelled homolog DVL-3,Tier 1.5,0.759,1,A2_pm_peripheral,9,58.91,0,0,,,0,0,,1,autosomal dominant Robinow syndrome,0.7284158836126389
P22735,TGM1,Protein-glutamine gamma-glutamyltransferase K,Tier 1.5,0.754,1,A2_pm_peripheral,1,84.12,0,0,,,0,0,,1,autosomal recessive congenital ichthyosis,0.714755023666953
P31939,ATIC,Bifunctional purine biosynthesis protein ATIC,Tier 1.5,0.754,1,A2_pm_peripheral,5,97.38,0,0,,,0,0,,1,AICA-ribosiduria,0.7137167364484167
P35241,RDX,Radixin,Tier 1.5,0.749,1,A2_pm_peripheral,2,86.56,0,0,,,1,2,"33253235,30700648",1,"hearing loss, autosomal recessive",0.6973070672344621
Q8IXK2,GALNT12,Polypeptide N-acetylgalactosaminyltransferase 12,Tier 1.5,0.748,1,A2_pm_peripheral,1,93.5,0,0,,,0,0,,1,"colorectal cancer, susceptibility to, 1",0.6932727729787528
O43516,WIPF1,WAS/WASL-interacting protein family member 1,Tier 1.5,0.737,1,A2_pm_peripheral,4,58.5,0,0,,,0,0,,1,Wiskott-Aldrich syndrome,0.6561328889736038
Q12929,EPS8,Epidermal growth factor receptor kinase substrate 8,Tier 1.5,0.731,1,A2_pm_peripheral,2,70.31,0,0,,,0,0,,1,autosomal recessive nonsyndromic hearing loss 102,0.6354471967036509
Q9NZ56,FMN2,Formin-2,Tier 1.5,0.729,1,A2_pm_peripheral,2,49.97,0,0,,,0,0,,1,autosomal recessive non-syndromic intellectual disability,0.6298956049368037
O95425,SVIL,Supervillin,Tier 1.5,0.718,1,A2_pm_peripheral,2,53.44,0,0,,,0,0,,1,myofibrillar myopathy 10,0.5924877747412329
P09769,FGR,Tyrosine-protein kinase Fgr,Tier 1.5,0.716,1,A2_pm_peripheral,3,82.19,0,0,,,1,1,39564692,1,chronic myelogenous leukemia,0.5869168331059803
P10398,ARAF,Serine/threonine-protein kinase A-Raf,Tier 1.5,0.709,1,A2_pm_peripheral,6,70.06,0,0,,,0,0,,1,cancer,0.5616780822043126
Q01581,HMGCS1,"Hydroxymethylglutaryl-CoA synthase, cytoplasmic",Tier 1.5,0.707,1,A2_pm_peripheral,1,91.31,0,0,,,0,0,,1,neurodegenerative disease,0.55518193177393
Q9NT62,ATG3,Ubiquitin-like-conjugating enzyme ATG3,Tier 1.5,0.707,1,A2_pm_peripheral,4,73.38,0,0,,,0,0,,1,neurodegenerative disease,0.5571514462681344
Q02156,PRKCE,Protein kinase C epsilon type,Tier 1.5,0.706,1,A2_pm_peripheral,2,79.94,0,0,,,0,0,,1,acute myeloid leukemia,0.5549599198877609
P42680,TEC,Tyrosine-protein kinase Tec,Tier 1.5,0.705,1,A2_pm_peripheral,1,85.0,0,0,,,1,13,"39352470,39329798,36414190,36105684,35624657,35462326,35006795,30578658,30398689,27548775,26843427,25016253,24875764",1,alopecia areata,0.5491699656070116
P17252,PRKCA,Protein kinase C alpha type,Tier 1.5,0.704,1,A2_pm_peripheral,6,86.38,0,0,,,1,1,41505229,1,acute myeloid leukemia,0.547429504944985
P00326,ADH1C,Alcohol dehydrogenase 1C,Tier 1.5,0.704,1,A2_pm_peripheral,2,98.12,0,0,,,0,0,,1,alcohol drinking,0.5465864505308649
Q99828,CIB1,Calcium and integrin-binding protein 1,Tier 1.5,0.701,1,A2_pm_peripheral,9,75.75,0,0,,,0,0,,1,epidermodysplasia verruciformis,0.5381616248572979
Q16774,GUK1,Guanylate kinase,Tier 1.5,0.698,1,A2_pm_peripheral,14,93.94,0,0,,,0,0,,1,neurodegenerative disease,0.526507567426656
Q96PY5,FMNL2,Formin-like protein 2,Tier 1.5,0.695,1,A2_pm_peripheral,1,76.44,0,0,,,1,1,41149482,1,open-angle glaucoma,0.5157968177633478
O60861,GAS7,Growth arrest-specific protein 7,Tier 1.5,0.694,1,A2_pm_peripheral,2,83.75,0,0,,,0,0,,1,open-angle glaucoma,0.5145811266752988
Q53QZ3,ARHGAP15,Rho GTPase-activating protein 15,Tier 1.5,0.691,1,A2_pm_peripheral,1,76.06,0,0,,,0,0,,1,diverticular disease,0.5042377909782373
P09543,CNP,"2',3'-cyclic-nucleotide 3'-phosphodiesterase",Tier 1.5,0.689,1,A2_pm_peripheral,1,87.25,0,0,,,1,9,"40034273,38569854,37704353,35528922,31171207,30089209,27192549,19021295",1,"myopia 2, autosomal dominant",0.49606855995054094
Q86SR1,GALNT10,Polypeptide N-acetylgalactosaminyltransferase 10,Tier 1.5,0.688,1,A2_pm_peripheral,2,90.75,0,0,,,0,0,,1,obesity,0.49376752835968046
O75815,BCAR3,Breast cancer anti-estrogen resistance protein 3,Tier 1.5,0.687,1,A2_pm_peripheral,1,65.69,0,0,,,0,0,,1,neurodegenerative disease,0.4887088231206927
Q96FQ6,S100A16,Protein S100-A16,Tier 1.5,0.687,1,A2_pm_peripheral,3,81.12,0,0,,,0,0,,1,neurodegenerative disease,0.4899214982350221
Q8TBX8,PIP4K2C,Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma,Tier 1.5,0.684,1,A2_pm_peripheral,5,80.31,0,0,,,0,0,,1,neurodegenerative disease,0.47990990136472794
O00194,RAB27B,Ras-related protein Rab-27B,Tier 1.5,0.684,1,A2_pm_peripheral,1,84.56,0,0,,,0,0,,1,major depressive disorder,0.4805047942947544
O15247,CLIC2,Chloride intracellular channel protein 2,Tier 1.5,0.682,1,A2_pm_peripheral,3,92.94,0,0,,,0,0,,1,neurodegenerative disease,0.47298055353356755
P55290,CDH13,Cadherin-13,Tier 1.5,0.681,1,A2_pm_peripheral,1,85.06,0,0,,,0,0,,1,obesity,0.46894210628323796
P29966,MARCKS,Myristoylated alanine-rich C-kinase substrate,Tier 1.5,0.68,1,A2_pm_peripheral,1,49.56,0,0,,,0,0,,1,neurodegenerative disease,0.46643540997688115
Q2M2I8,AAK1,AP2-associated protein kinase 1,Tier 1.5,0.68,1,A2_pm_peripheral,8,58.38,0,0,,,0,0,,1,gout,0.46827769429345545
Q9Y6G9,DYNC1LI1,Cytoplasmic dynein 1 light intermediate chain 1,Tier 1.5,0.679,1,A2_pm_peripheral,3,59.34,0,0,,,0,0,,1,viral disease,0.4619748183558772
P50479,PDLIM4,PDZ and LIM domain protein 4,Tier 1.5,0.674,1,A2_pm_peripheral,3,70.19,0,0,,,0,0,,1,neurodegenerative disease,0.44613257652494276
Q15052,ARHGEF6,Rho guanine nucleotide exchange factor 6,Tier 1.5,0.664,1,A2_pm_peripheral,2,71.12,0,0,,,0,0,,1,X-linked non-syndromic intellectual disability,0.4120399602397905
Q9UDT6,CLIP2,CAP-Gly domain-containing linker protein 2,Tier 1.5,0.662,1,A2_pm_peripheral,2,73.81,0,0,,,0,0,,1,neurodegenerative disease,0.4062409434374931
P30838,ALDH3A1,"Aldehyde dehydrogenase, dimeric NADP-preferring",Tier 1.5,0.661,1,A2_pm_peripheral,7,97.94,0,0,,,0,0,,1,keratoconus,0.4038959168376703
P55196,AFDN,Afadin,Tier 1.5,0.66,1,A2_pm_peripheral,6,63.22,0,0,,,0,0,,1,colorectal adenocarcinoma,0.40056821502974077
O00159,MYO1C,Unconventional myosin-Ic,Tier 1.5,0.654,1,A2_pm_peripheral,1,84.31,0,0,,,0,0,,1,neurodegenerative disease,0.38105114285659336
P09496,CLTA,Clathrin light chain A,Tier 1.5,0.651,1,A2_pm_peripheral,1,70.12,0,0,,,0,0,,1,influenza,0.3695798546847018
Q8TBC4,UBA3,NEDD8-activating enzyme E1 catalytic subunit,Tier 1.5,0.651,1,A2_pm_peripheral,12,92.88,0,0,,,0,0,,1,dengue disease,0.3695798546847018