id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P02462,COL4A1,Collagen alpha-1(IV) chain,Tier 1.5,0.854,1,A_assoc,4,48.47,0,0,,,0,0,,1,brain small vessel disease 1 with or without ocular anomalies,0.84655287380359
P22105,TNXB,Tenascin-X,Tier 1.5,0.837,1,A_assoc,3,87.81,0,0,,,0,0,,1,Ehlers-Danlos syndrome due to tenascin-X deficiency,0.7916412481554758
P35625,TIMP3,Metalloproteinase inhibitor 3,Tier 1.5,0.831,1,A_assoc,1,87.0,0,0,,,1,3,"42105605,36768220",1,Sorsby fundus dystrophy,0.7684253675298044
P08572,COL4A2,Collagen alpha-2(IV) chain,Tier 1.5,0.819,1,A_assoc,4,47.25,0,0,,,0,0,,1,porencephaly 2,0.7294975109351518
P36955,SERPINF1,Pigment epithelium-derived factor,Tier 1.5,0.811,1,A_assoc,3,90.12,0,0,,,1,17,"41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805",1,osteogenesis imperfecta,0.701995723393119
O00187,MASP2,Mannan-binding lectin serine protease 2,Tier 1.5,0.81,1,A_assoc,10,89.44,0,0,,,1,1,40371468,1,immunodeficiency due to MASP-2 deficiency,0.6996393077218865
Q9Y6C2,EMILIN1,EMILIN-1,Tier 1.5,0.786,1,A_assoc,2,62.91,0,0,,,0,0,,1,arterial tortuosity-bone fragility syndrome,0.6185329512431467
P49767,VEGFC,Vascular endothelial growth factor C,Tier 1.5,0.785,1,A_assoc,4,73.19,0,0,,,0,0,,1,Milroy disease,0.6170524106764851
Q16270,IGFBP7,Insulin-like growth factor-binding protein 7,Tier 1.5,0.785,1,A_assoc,1,84.44,0,0,,,1,4,"41192243,27679852,41280530",1,familial retinal arterial macroaneurysm,0.6182241349863704
P10451,SPP1,Osteopontin,Tier 1.5,0.772,1,A_assoc,3,53.41,0,0,,,1,62,"41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031",1,osteoporosis,0.5729473764531288
P10909,CLU,Clusterin,Tier 1.5,0.766,1,A_assoc,2,77.31,0,0,,,1,5,"42041411,37179603,36980195,35383192,26061649",1,Alzheimer disease,0.5545645077431476
P13497,BMP1,Bone morphogenetic protein 1,Tier 1.5,0.766,1,A_assoc,8,81.44,0,0,,,1,1,39939919,1,osteogenesis imperfecta,0.5547577676549571
O00622,CCN1,CCN family member 1,Tier 1.5,0.765,1,A_assoc,2,73.12,0,0,,,0,0,,1,Abnormality of the skeletal system,0.5505331194769112
Q68CZ2,TNS3,Tensin-3,Tier 1.5,0.762,1,A_assoc,1,56.81,0,0,,,0,0,,1,neurodegenerative disease,0.539772721274482
P55145,MANF,Mesencephalic astrocyte-derived neurotrophic factor,Tier 1.5,0.761,1,A_assoc,3,81.69,0,0,,,1,1,12698297,1,"diabetes, deafness, developmental delay, and short stature syndrome",0.5377386885662411
Q9Y3B8,REXO2,"Oligoribonuclease, mitochondrial",Tier 1.5,0.754,1,A_assoc,10,88.19,0,0,,,0,0,,1,neurodegenerative disease,0.5134178677464454
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.753,1,A_assoc,4,90.62,0,0,,,0,0,,1,age-related macular degeneration,0.5100732932209376
Q13177,PAK2,Serine/threonine-protein kinase PAK 2,Tier 1.5,0.736,1,A_assoc,5,74.62,0,0,,,0,0,,1,Knobloch syndrome,0.45371318009439854
Q13625,TP53BP2,Apoptosis-stimulating of p53 protein 2,Tier 1.5,0.735,1,A_assoc,6,58.97,0,0,,,0,0,,1,neurodegenerative disease,0.4484066399496438
Q9UKU9,ANGPTL2,Angiopoietin-related protein 2,Tier 1.5,0.727,1,A_assoc,1,78.19,0,0,,,0,0,,1,Abnormality of the skeletal system,0.4235882639081519
Q96SL4,GPX7,Glutathione peroxidase 7,Tier 1.5,0.721,1,A_assoc,1,92.69,0,0,,,0,0,,1,Abnormality of the skeletal system,0.40349356855524837
Q16627,CCL14,C-C motif chemokine 14,Tier 1.5,0.711,1,A_assoc,2,85.38,0,0,,,0,0,,1,neurodegenerative disease,0.37013422446672883
P22692,IGFBP4,Insulin-like growth factor-binding protein 4,Tier 1.5,0.706,1,A_assoc,4,77.25,0,0,,,1,6,"35323639,32515246,31930684",1,allergic rhinitis,0.35214760515440524
P12273,PIP,Prolactin-inducible protein,Tier 1.5,0.701,1,A_assoc,1,89.69,0,0,,,1,7,"41440247,36179084,35726753,35336001,28107930,26297462,21559755",1,neurodegenerative disease,0.3382059336442212
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.693,1,A_assoc,5,81.12,0,0,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
Q8WUP2,FBLIM1,Filamin-binding LIM protein 1,Tier 1.5,0.687,1,A_assoc,3,66.44,0,0,,,0,0,,1,COVID-19,0.28975781420803737
Q13253,NOG,Noggin,Tier 1.5,0.685,1,A_assoc,2,86.06,0,0,,,1,2,38397086,0,proximal symphalangism 1A,0.7844136456463046
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.684,1,A_assoc,8,73.25,0,0,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.682,1,A_assoc,5,87.06,0,0,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
P29120,PCSK1,Neuroendocrine convertase 1,Tier 1.5,0.682,1,A_assoc,3,82.5,0,0,,,0,0,,0,obesity due to prohormone convertase I deficiency,0.773875795833803
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.677,1,A_assoc,4,51.91,0,0,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
P55789,GFER,FAD-linked sulfhydryl oxidase ALR,Tier 1.5,0.677,1,A_assoc,7,76.88,0,0,,,0,0,,0,congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome,0.7556346526616893
Q12794,HYAL1,Hyaluronidase-1,Tier 1.5,0.672,1,A_assoc,1,94.0,0,0,,,0,0,,0,Hyaluronidase deficiency,0.7412407206736383
Q92752,TNR,Tenascin-R,Tier 1.5,0.672,1,A_assoc,2,78.5,0,0,,,0,0,,0,"neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus",0.7403484347367364
O15520,FGF10,Fibroblast growth factor 10,Tier 1.5,0.67,1,A_assoc,2,80.0,0,0,,,1,1,35415885,0,Lacrimoauriculodentodigital syndrome,0.7344198619465704
O00300,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,Tier 1.5,0.666,1,A_assoc,1,86.5,0,0,,,1,1,15562003,0,juvenile Paget disease,0.7184894548525037
P11686,SFTPC,Surfactant protein C,Tier 1.5,0.663,1,A_assoc,3,70.06,0,0,,,0,0,,0,Congenital pulmonary alveolar proteinosis,0.7110128683619542
O43897,TLL1,,Tier 1.5,0.662,1,A_assoc,1,80.31,0,0,,,0,0,,0,atrial heart septal defect,0.7050140477090344
P19835,CEL,Bile salt-activated lipase,Tier 1.5,0.658,1,A_assoc,7,82.56,0,0,,,1,2,"39653009,34940276",0,MODY,0.6940743944678538
P27352,CBLIF,Cobalamin binding intrinsic factor,Tier 1.5,0.655,1,A_assoc,2,90.5,0,0,,,0,0,,0,hereditary intrinsic factor deficiency,0.683930100359911
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.652,1,A_assoc,1,79.62,0,0,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
O75594,PGLYRP1,Peptidoglycan recognition protein 1,Tier 1.5,0.649,1,A_assoc,1,91.0,0,0,,,1,2,"35821507,33534888",1,dementia,0.16478389504231422
P02776,PF4,Platelet factor 4,Tier 1.5,0.635,1,A_assoc,10,75.06,0,0,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
O76093,FGF18,Fibroblast growth factor 18,Tier 1.5,0.631,1,A_assoc,1,87.56,0,0,,,1,1,35415885,0,cancer,0.6028027301556572
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.631,1,A_assoc,1,81.5,0,0,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
O95445,APOM,Apolipoprotein M,Tier 1.5,0.631,1,A_assoc,3,89.44,0,0,,,1,10,"38238732,36980195,35120890,32237898,30771967,37425696,37400771,34796696",1,type 2 diabetes mellitus,0.10169659060091507
Q15818,NPTX1,Neuronal pentraxin-1,Tier 1.5,0.628,1,A_assoc,1,75.75,0,0,,,0,0,,0,spinocerebellar ataxia 50,0.5937598292127286
P07098,LIPF,Gastric triacylglycerol lipase,Tier 1.5,0.626,1,A_assoc,1,89.75,0,0,,,0,0,,0,obesity,0.5864662753480862
Q9GZX6,IL22,Interleukin-22,Tier 1.5,0.619,1,A_assoc,6,88.12,0,0,,,1,7,"34208021,33869115,28942363,26792955,37041650",0,atopic eczema,0.5627493881195745
O00175,CCL24,C-C motif chemokine 24,Tier 1.5,0.613,1,A_assoc,2,82.12,0,0,,,0,0,,0,Iron deficiency anemia,0.5428194908352497