id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21802,FGFR2,Fibroblast growth factor receptor 2,Tier 1,0.959,1,A_surface,62,73.94,0,0,,,1,5,"41786503,39759879,31357131,24242861,19212647",1,Crouzon syndrome,0.8637438969881663
P78504,JAG1,Protein jagged-1,Tier 1,0.958,1,A_surface,7,73.12,0,0,,,1,4,"37338014,37052638,23341879,18673242",1,Alagille syndrome due to a JAG1 point mutation,0.8586542923232751
P11166,SLC2A1,"Solute carrier family 2, facilitated glucose transporter member 1",Tier 1,0.956,1,A_surface,5,90.25,0,0,,,1,2,"39627234,33184583",1,encephalopathy due to GLUT1 deficiency,0.8521823225896756
P11362,FGFR1,Fibroblast growth factor receptor 1,Tier 1,0.954,1,A_surface,82,73.88,0,0,,,1,13,"41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904",1,hypogonadotropic hypogonadism 2 with or without anosmia,0.8472925100660907
P08581,MET,Hepatocyte growth factor receptor,Tier 1,0.953,1,A_surface,100,79.25,0,0,,,1,149,"42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766",1,papillary renal cell carcinoma,0.84195976263742
P06213,INSR,Insulin receptor,Tier 1,0.953,1,A_surface,87,77.62,0,0,,,1,14,"33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487",1,Leprechaunism,0.8448849372402896
Q8WZ42,TTN,Titin,Tier 1,0.953,1,A_surface,64,,0,0,,,1,1,29952259,1,dilated cardiomyopathy,0.8419847660466327
O00571,DDX3X,ATP-dependent RNA helicase DDX3X,Tier 1,0.951,1,A_surface,17,72.19,0,0,,,0,0,,1,X-linked non-syndromic intellectual disability,0.8362533125067105
P54760,EPHB4,Ephrin type-B receptor 4,Tier 1,0.95,1,A_surface,23,82.0,0,0,,,0,0,,1,Capillary malformation - arteriovenous malformation,0.8317426466005666
Q8WZA1,POMGNT1,"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1",Tier 1,0.948,1,A_surface,10,89.88,0,0,,,0,0,,1,"muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3",0.826104223872448
P36894,BMPR1A,Bone morphogenetic protein receptor type-1A,Tier 1,0.948,1,A_surface,11,82.62,0,0,,,1,1,30537181,1,juvenile polyposis syndrome,0.8278395086688584
O75844,ZMPSTE24,CAAX prenyl protease 1 homolog,Tier 1,0.942,1,A_surface,4,89.44,0,0,,,1,1,37565451,1,mandibuloacral dysplasia with type B lipodystrophy,0.8071967390737101
P25942,CD40,Tumor necrosis factor receptor superfamily member 5,Tier 1,0.941,1,A_surface,14,81.19,0,0,,,1,8,"41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856",1,hyper-IgM syndrome type 3,0.8038021669520221
O94766,B3GAT3,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3,Tier 1,0.94,1,A_surface,3,92.56,0,0,,,0,0,,1,"Larsen-like syndrome, B3GAT3 type",0.7995331164339264
Q14118,DAG1,Dystroglycan 1,Tier 1,0.938,1,A_surface,8,68.19,0,0,,,0,0,,1,autosomal recessive limb-girdle muscular dystrophy type 2P,0.7935290060634741
Q9UPN3,MACF1,"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5",Tier 1,0.938,1,A_surface,3,,0,0,,,0,0,,1,lissencephaly 9 with complex brainstem malformation,0.7945569032416216
P08473,MME,Neprilysin,Tier 1,0.937,1,A_surface,16,96.19,0,0,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
P35916,FLT4,Vascular endothelial growth factor receptor 3,Tier 1,0.937,1,A_surface,2,72.44,0,0,,,0,0,,1,lymphatic malformation 1,0.7904355931811005
Q16832,DDR2,Discoidin domain-containing receptor 2,Tier 1,0.936,1,A_surface,5,75.81,0,0,,,1,1,26067556,1,spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome,0.7854778386444168
O75880,SCO1,Cytochrome c oxidase assembly factor SCO1,Tier 1,0.935,1,A_surface,10,77.75,0,0,,,0,0,,1,"mitochondrial complex IV deficiency, nuclear type 4",0.7827872588103603
Q13554,CAMK2B,Calcium/calmodulin-dependent protein kinase type II subunit beta,Tier 1,0.932,1,A_surface,4,70.56,0,0,,,1,2,"29784938,26594036",1,"intellectual disability, autosomal dominant 54",0.7745713380655789
P29317,EPHA2,Ephrin type-A receptor 2,Tier 1,0.931,1,A_surface,100,82.25,0,0,,,1,16,"40563410,40408544,39259047,37251690,35700603,35397426,32169805,34541193,28235049,24586375,21902173,21793789",1,Total congenital cataract,0.7690993612962792
P12821,ACE,Angiotensin-converting enzyme,Tier 1,0.93,1,A_surface,97,90.94,0,0,,,1,108,"41505229,41326371,41315058,41027166,40975918,40578246,40549055,40494268,40394224,40157106,39796148,39643350,39638470,39368201,39326115,39277931,38989925,38783134,38559166,38454949,38189917,37692001,37526583,37422510,37385465,37231283,37191170,36924636,36327903,36128975,36069206,35985229,35831655,34248841,34227370,34213110,34109445,33362222,32981365,32969502,31542417,30707214,29367662,29244716,28507681,25035238,24861783,24125636,20373790,20119964,41716474,41274248,40642289,40333723,40321580,40227272,39964138,39923730,38553521,37932762,37808754,37375202,36822303,36714461,36581924,36288301,36170362,36073793,35972202,35910791,35748608,35542182,34953639,34876524,34855379,34798263,34696413,34619249,34458322,34282416,34230708,34230707,34166652,33684258,33683787,33629859,33561300,32838280,32551560,21147843,18209324,16607776",1,diabetic nephropathy,0.7656590329495216
O95714,HERC2,E3 ubiquitin-protein ligase HERC2,Tier 1,0.925,1,A_surface,15,,0,0,,,0,0,,1,developmental delay with autism spectrum disorder and gait instability,0.74952129063985
P01019,AGT,Angiotensinogen,Tier 1,0.921,1,A_surface,22,86.44,0,0,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P01730,CD4,T-cell surface glycoprotein CD4,Tier 1,0.921,1,A_surface,85,85.25,0,0,,,1,96,"41889731,41761629,41654945,41542672,41395530,41338305,41206244,40972397,40877519,40788329,40448637,39920212,39269432,38744189,38661725,37895096,37881079,37836456,37170724,37141264,37110712,36352911,36149728,34386332,33389440,32786336,32567629,32157125,31778957,31707227,31434881,31316164,30393236,29881374,29556342,29375127,29277631,29145483,28934318,28800954,28290464,27959341,27529508,28955932,26792955,25757623,25754473,25241192,25189099,24661998",1,HIV infection,0.7364522622142639
P21589,NT5E,5'-nucleotidase,Tier 1,0.916,1,A_surface,50,91.88,0,0,,,1,3,"38689291,30472954,25720604",1,hereditary arterial and articular multiple calcification syndrome,0.7199342086353593
P22455,FGFR4,Fibroblast growth factor receptor 4,Tier 1,0.915,1,A_surface,52,73.62,0,0,,,1,2,"39759879,30297602",1,cancer,0.7150377661800104
P09601,HMOX1,Heme oxygenase 1,Tier 1,0.905,1,A_surface,26,82.88,0,0,,,1,6,"37533140,40526855,40509588,39812275,37457170",1,heme oxygenase 1 deficiency,0.6838783130237968
P35968,KDR,Vascular endothelial growth factor receptor 2,Tier 1,0.904,1,A_surface,54,71.12,0,0,,,1,22,"29608400,27490795,26125598,10548435,9685413,41572478,41187655,39225423,33191671,32199927,30626772,21970900,21907194,20237249,19135441,18499900,17347807,16842232,16787141",1,neoplasm,0.681272749535704
Q9NZQ7,CD274,Programmed cell death 1 ligand 1,Tier 1,0.903,1,A_surface,74,88.25,0,0,,,1,67,"41855853,41830812,41781380,41770936,41629133,41479885,41205458,41195987,41173800,40972397,40811947,40789156,40758411,40682599,40581004,40516668,40209314,40188671,40119836,40016918,40012368,39929085,39916963,39824759,39805944,39532409,39454136,39440615,39417693,39352679,39344385,39332044,39222892,39003918,38940673,38859589,38763821,38636085,38621341,38446717,37944524,37923412,37531891,37364303,36484532,35972912,35624582,35268583,34523014,34156677",1,non-small cell lung carcinoma,0.6769230776549127
P17181,IFNAR1,Interferon alpha/beta receptor 1,Tier 1,0.901,1,A_surface,5,78.0,0,0,,,1,1,27068091,1,"immunodeficiency 106, susceptibility to viral infections",0.6703994774055272
Q07075,ENPEP,Glutamyl aminopeptidase,Tier 1,0.9,1,A_surface,7,93.5,0,0,,,1,2,38467937,1,hypertension,0.6677707312760746
Q9Y6N7,ROBO1,Roundabout homolog 1,Tier 1,0.897,1,A_surface,12,60.0,0,0,,,0,0,,1,neurooculorenal syndrome,0.6567040910170603
P27487,DPP4,Dipeptidyl peptidase 4,Tier 1,0.893,1,A_surface,100,96.25,0,0,,,1,4,"30056058,26605646",1,type 2 diabetes mellitus,0.6432827162361505
P27338,MAOB,Amine oxidase [flavin-containing] B,Tier 1,0.889,1,A_surface,56,95.62,0,0,,,1,1,26841904,1,Parkinson disease,0.6302940908016386
P22303,ACHE,Acetylcholinesterase,Tier 1,0.889,1,A_surface,78,92.94,0,0,,,1,135,"41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840",1,Alzheimer disease,0.628678841772617
Q13557,CAMK2D,Calcium/calmodulin-dependent protein kinase type II subunit delta,Tier 1,0.889,1,A_surface,9,83.38,0,0,,,1,1,29784938,1,Neurodevelopmental disorder,0.6312857608660509
P28907,CD38,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1,Tier 1,0.887,1,A_surface,55,90.88,0,0,,,1,5,"40931580,34364920,33742062,26242462",1,multiple myeloma,0.6233037747334318
Q07954,LRP1,Prolow-density lipoprotein receptor-related protein 1,Tier 1,0.886,1,A_surface,7,79.19,0,0,,,1,3,"41599761,38996211,25855589",1,developmental dysplasia of the hip,0.6197148309275711
P31431,SDC4,Syndecan-4,Tier 1,0.885,1,A_surface,5,63.28,0,0,,,0,0,,1,non-small cell lung carcinoma,0.6168120240815278
P27448,MARK3,MAP/microtubule affinity-regulating kinase 3,Tier 1,0.879,1,A_surface,14,68.25,0,0,,,1,2,"33328453,32637948",1,cancer,0.5979109389232433
P20701,ITGAL,Integrin alpha-L,Tier 1,0.877,1,A_surface,41,82.62,0,0,,,0,0,,1,psoriasis,0.5899795223699872
P0DOY3,IGLC3,Immunoglobulin lambda constant 3,Tier 1,0.876,1,A_surface,4,96.06,0,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P01859,IGHG2,Immunoglobulin heavy constant gamma 2,Tier 1,0.876,1,A_surface,5,87.38,0,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P01857,IGHG1,Immunoglobulin heavy constant gamma 1,Tier 1,0.876,1,A_surface,100,86.69,0,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P30530,AXL,Tyrosine-protein kinase receptor UFO,Tier 1,0.876,1,A_surface,4,75.06,0,0,,,1,22,"40751315,40566927,40479828,39788632,39440615,39347825,37961806,35116429,33988982,33251048,32486489,32174798,31684958,31276956,30340138,29246304,27448441,27111415,25998051,24881764,24441398,22910292",1,acute myeloid leukemia,0.5870034687571098
Q10588,BST1,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2,Tier 1,0.869,1,A_surface,6,89.62,0,0,,,0,0,,1,Parkinson disease,0.5634966060310903
Q16513,PKN2,Serine/threonine-protein kinase N2,Tier 1,0.868,1,A_surface,4,71.44,0,0,,,0,0,,1,neurodegenerative disease,0.5587297348479079
P13726,F3,Tissue factor,Tier 1,0.867,1,A_surface,54,84.81,0,0,,,1,36,"40611414,40001558,38811951,36291832,33892482,38776649,36203210,35036063,34386338,32224381,30302740,27563744,25953802,25521966,24998782,24880800,24319161,24263002,23876036,23528042,22951415,22658294,22632032,22116094,21696535,21389323,21144556,20139356,20135076,20004955,18826387,18235012,17272750,16676065,11127866,8578509",1,cervical cancer,0.5555433402271651