id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P10721,,,Tier 1,0.768,1,unknown,52,78.19,0,0,,,0,0,,1,gastrointestinal stromal tumor,0.8922566232622926
Q07889,,,Tier 1,0.761,1,unknown,91,76.38,0,0,,,0,0,,1,Noonan syndrome,0.8708318719184144
P06400,,,Tier 1,0.752,1,unknown,19,76.06,0,0,,,0,0,,1,retinoblastoma,0.8408754966665243
P52732,,,Tier 1,0.747,1,unknown,62,74.38,0,0,,,0,0,,1,"microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability",0.8220137873148912
Q9NP72,,,Tier 1,0.745,1,unknown,1,85.56,0,0,,,0,0,,1,Micro syndrome,0.816071079017092
Q04771,,,Tier 1,0.745,1,unknown,85,83.12,0,0,,,0,0,,1,fibrodysplasia ossificans progressiva,0.8164474171712364
P35222,,,Tier 1,0.743,1,unknown,50,81.06,0,0,,,0,0,,1,severe intellectual disability-progressive spastic diplegia syndrome,0.8101632011131414
P02751,,,Tier 1,0.74,1,unknown,69,69.62,0,0,,,0,0,,1,"spondylometaphyseal dysplasia, 'corner fracture' type",0.8013288836166759
O43318,,,Tier 1,0.73,1,unknown,25,69.0,0,0,,,0,0,,1,frontometaphyseal dysplasia 2,0.767839253516465
P84243,,,Tier 1,0.719,1,unknown,100,85.94,0,0,,,0,0,,1,Bryant-Li-Bhoj neurodevelopmental syndrome 2,0.7290694534626342
Q8TD19,,,Tier 1,0.714,1,unknown,2,73.94,0,0,,,0,0,,1,NEK9-related lethal skeletal dysplasia,0.7132294892240114
Q9H6S3,,,Tier 1,0.705,1,unknown,2,73.06,0,0,,,0,0,,1,"hearing loss, autosomal recessive",0.6818863306678549
P17948,,,Tier 1,0.685,1,unknown,12,72.62,0,0,,,0,0,,1,neoplasm,0.6169964471592176
P55210,,,Tier 1,0.684,1,unknown,47,81.69,0,0,,,0,0,,1,cataract,0.6121422420887519
P01861,,,Tier 1,0.676,1,unknown,15,86.75,0,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P27694,,,Tier 1,0.672,1,unknown,48,83.81,0,0,,,0,0,,1,"pulmonary fibrosis and/or bone marrow failure, telomere-related, 6",0.5720870296163543
Q96PU8,,,Tier 1,0.668,1,unknown,1,68.69,0,0,,,0,0,,1,cancer,0.5616375835401949
P45985,,,Tier 1,0.665,1,unknown,4,77.0,0,0,,,0,0,,1,neurodegenerative disease,0.5507437937196141
P17676,,,Tier 1,0.661,1,unknown,16,59.69,0,0,,,0,0,,1,neurodegenerative disease,0.5352429213193124
O14618,,,Tier 1,0.658,1,unknown,7,87.38,0,0,,,0,0,,1,neurodegenerative disease,0.5272415940824882
P54764,,,Tier 1,0.656,1,unknown,17,83.5,0,0,,,0,0,,1,medullary thyroid gland carcinoma,0.5195314334008982
P30419,,,Tier 1,0.655,1,unknown,52,83.25,0,0,,,0,0,,1,neurodegenerative disease,0.5174483590720084
Q8N1W1,,,Tier 1,0.654,1,unknown,2,61.56,0,0,,,0,0,,1,hearing loss,0.5135177841424435
Q16611,,,Tier 1,0.639,1,unknown,55,81.31,0,0,,,0,0,,1,chronic lymphocytic leukemia,0.46377569349166126
Q13432,,,Tier 1,0.634,1,unknown,9,77.88,0,0,,,0,0,,1,idiopathic CD4 lymphocytopenia,0.4456292509980772
Q9BXB4,,,Tier 1,0.633,1,unknown,1,74.06,0,0,,,0,0,,1,neurodegenerative disease,0.4435303946057042
P57735,,,Tier 1,0.621,1,unknown,2,86.62,0,0,,,0,0,,1,atrial fibrillation,0.40258191116027553
Q8IYB1,,,Tier 1,0.598,1,unknown,1,83.56,0,0,,,0,0,,1,Hashimoto's thyroiditis,0.32654837821466426
Q9UMX3,,,Tier 1,0.592,1,unknown,1,83.5,0,0,,,0,0,,1,"osteoarthritis, knee",0.3060308474018532
Q9Y4K1,,,Tier 1,0.592,1,unknown,3,48.94,0,0,,,0,0,,1,psoriasis,0.3053444558877832
Q5JTC6,,,Tier 1,0.59,1,unknown,3,48.31,0,0,,,0,0,,0,osteopathia striata with cranial sclerosis,0.8010289843367673
P16333,,,Tier 1,0.589,1,unknown,15,70.75,0,0,,,0,0,,1,Abnormality of the skeletal system,0.2961979178331516
P20338,,,Tier 1,0.587,1,unknown,4,87.5,0,0,,,0,0,,1,liver disease,0.28871835676838403
P43146,,,Tier 1,0.587,1,unknown,9,68.19,0,0,,,0,0,,0,mirror movements 1,0.7894844854575112
Q8WYB5,,,Tier 1,0.587,1,unknown,3,48.97,0,0,,,0,0,,0,genitopatellar syndrome,0.7887666805196595
Q92794,,,Tier 1,0.587,1,unknown,21,48.66,0,0,,,0,0,,0,autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome,0.7908994336990406
O60828,,,Tier 1,0.586,1,unknown,3,70.56,0,0,,,0,0,,0,Renpenning syndrome,0.7876227110842514
Q09013,,,Tier 1,0.574,1,unknown,2,77.62,0,0,,,0,0,,0,myotonic dystrophy type 1,0.7480475113698601
Q6IQ55,,,Tier 1,0.569,1,unknown,6,48.84,0,0,,,0,0,,0,spinocerebellar ataxia type 11,0.7308755447203157
Q15080,,,Tier 1,0.548,1,unknown,6,84.19,0,0,,,0,0,,0,chronic granulomatous disease,0.6592487859566178
Q9NUW8,,,Tier 1,0.538,1,unknown,48,80.62,0,0,,,0,0,,0,"spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1",0.6250066855961889
P39086,,,Tier 1,0.532,1,unknown,11,81.12,0,0,,,0,0,,0,epilepsy,0.6079292940174927
Q9NR31,,,Tier 1,0.529,1,unknown,6,86.0,0,0,,,0,0,,1,osteomyelitis,0.09576174303174592
Q6PCD5,,,Tier 1,0.525,1,unknown,1,70.12,0,0,,,0,0,,0,"Fanconi anemia, complementation group W",0.5849156442856244
P59666,,,Tier 1,0.524,1,unknown,6,73.5,0,0,,,0,0,,1,Sepsis,0.07982149765410096
Q496J9,,,Tier 1,0.521,1,unknown,6,78.0,0,0,,,0,0,,0,botulism,0.569067134332723
P35568,,,Tier 1,0.518,1,unknown,8,49.0,0,0,,,0,0,,0,Abnormality of the skeletal system,0.5600726776459989
P29074,,,Tier 1,0.511,1,unknown,8,77.19,0,0,,,0,0,,0,neurodegenerative disease,0.5366583695296713
Q9BZC1,,,Tier 1,0.509,1,unknown,2,61.47,0,0,,,0,0,,0,major depressive disorder,0.5312056211019677
P01903,,,Tier 1,0.5,1,unknown,100,89.19,0,0,,,0,0,,1,,