id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P06865,,,Tier 1.5,0.759,1,unknown,2,93.44,0,0,,,0,0,,1,Tay-Sachs disease,0.8629597356732491
P56589,,,Tier 1.5,0.749,1,unknown,2,88.88,0,0,,,0,0,,1,Zellweger syndrome,0.8285793075049609
P09603,,,Tier 1.5,0.618,1,unknown,8,57.41,0,0,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
O75365,,,Tier 1.5,0.612,1,unknown,4,86.88,0,0,,,0,0,,1,hypertension,0.3732487322932303
Q5IJ48,,,Tier 1.5,0.593,1,unknown,1,76.44,0,0,,,0,0,,0,ventriculomegaly-cystic kidney disease,0.8112741813611002
O15297,,,Tier 1.5,0.583,1,unknown,1,67.88,0,0,,,0,0,,0,intellectual developmental disorder with gastrointestinal difficulties and high pain threshold,0.7779617805712467
O60930,,,Tier 1.5,0.574,1,unknown,7,79.56,0,0,,,0,0,,0,"progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",0.74733857283595
O60882,,,Tier 1.5,0.568,1,unknown,1,83.31,0,0,,,0,0,,0,Hypomaturation amelogenesis imperfecta,0.7281006394540224
O75838,,,Tier 1.5,0.564,1,unknown,1,88.62,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.7117048435819099
G2XKQ0,SUMO1P1,Small ubiquitin-related modifier 5,Tier 1.5,0.5,1,unknown,1,79.81,0,0,,,0,0,,1,,
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.5,1,unknown,2,88.38,0,0,,,0,0,,1,,
P01579,,,Tier 1.5,0.498,1,unknown,8,85.31,0,0,,,0,0,,0,Primary hemophagocytic lymphohistiocytosis,0.49197933519665166
O95352,,,Tier 1.5,0.484,0,unknown,0,87.62,0,0,,,0,0,,1,"spinocerebellar ataxia, autosomal recessive 31",0.7618016657355056
Q5TAT6,,,Tier 1.5,0.481,0,unknown,0,55.59,0,0,,,0,0,,1,Congenital myasthenic syndromes,0.7544056165993482
P48509,,,Tier 1.5,0.473,0,unknown,0,88.25,0,0,,,0,0,,1,"epidermolysis bullosa simplex 7, with nephropathy and deafness",0.7253740723597262
P34910,,,Tier 1.5,0.38,0,unknown,0,50.94,0,0,,,0,0,,1,neurofibromatosis type 1,0.4178305579352045
O60941,,,Tier 1.5,0.377,0,unknown,0,75.38,0,0,,,0,0,,1,cutaneous melanoma,0.4068656041128879
Q5I7T1,,,Tier 1.5,0.375,0,unknown,0,93.0,0,0,,,0,0,,1,Abnormality of the skeletal system,0.4010039380812394
Q5SR56,SLC71A2,Solute carrier family 71 member 2,Tier 1.5,0.372,0,unknown,0,76.75,0,0,,,0,0,,1,atrial fibrillation,0.3910715051744718
Q9H8H3,TMT1A,Thiol S-methyltransferase TMT1A,Tier 1.5,0.358,0,unknown,0,96.12,0,0,,,0,0,,1,heart failure,0.3434183182553741
O15232,,,Tier 1.5,0.354,0,unknown,0,79.38,0,0,,,0,0,,0,multiple epiphyseal dysplasia type 5,0.8302929519450023
O95343,,,Tier 1.5,0.35,0,unknown,0,67.88,0,0,,,0,0,,0,holoprosencephaly,0.8181248878625513
P49326,,,Tier 1.5,0.349,0,unknown,0,94.94,0,0,,,0,0,,1,type 2 diabetes mellitus,0.3139213554354413
O95741,,,Tier 1.5,0.267,0,unknown,0,86.38,0,0,,,0,0,,1,glioblastoma multiforme,0.03986072724380628
A3KN83,,,Tier 1.5,0.255,0,unknown,0,67.31,0,0,,,0,0,,0,neurodegenerative disease,0.49840530754835893
Q9BYX7,POTEKP,Putative beta-actin-like protein 3,Tier 1.5,0.255,0,unknown,0,94.81,0,0,,,0,0,,1,,
A6NMY6,ANXA2P2,Putative annexin A2-like protein,Tier 1.5,0.255,0,unknown,0,94.25,0,0,,,0,0,,1,,
Q3KR37,,,Tier 1.5,0.248,0,unknown,0,67.5,0,0,,,0,0,,0,chronic lymphocytic leukemia,0.47654335621881755
O43439,,,Tier 1.5,0.242,0,unknown,0,63.69,0,0,,,0,0,,0,Abnormality of the skeletal system,0.45637506575193026
Q14147,,,Tier 1.5,0.24,0,unknown,0,80.5,0,0,,,0,0,,0,Neurodevelopmental disorder,0.4499737391856989
Q96LM5,SPMIP2,Protein SPMIP2,Tier 1.5,0.232,0,unknown,0,62.75,0,0,,,0,0,,0,Abnormality of the skeletal system,0.4220350712092463
O94964,MTCL2,Microtubule cross-linking factor 2,Tier 1.5,0.221,0,unknown,0,54.25,0,0,,,0,0,,0,skin cancer,0.38790668759818864
Q53TS8,CATSPERT,Cation channel sperm-associated targeting subunit tau,Tier 1.5,0.22,0,unknown,0,39.66,0,0,,,0,0,,0,male infertility due to globozoospermia,0.3830436487908655
Q6P4F1,POFUT3,GDP-fucose protein O-fucosyltransferase 3,Tier 1.5,0.218,0,unknown,0,87.94,0,0,,,0,0,,0,Abnormality of the skeletal system,0.377894214690425
Q6UWJ1,SLC9D1,Solute carrier family 9 member D1,Tier 1.5,0.209,0,unknown,0,75.94,0,0,,,0,0,,0,Anxiety,0.3453798727200914
Q14802,,,Tier 1.5,0.206,0,unknown,0,68.25,0,0,,,0,0,,0,Hypomyelination neuropathy - arthrogryposis,0.3360486957577248
Q2TAC6,,,Tier 1.5,0.205,0,unknown,0,64.62,0,0,,,0,0,,0,Non-immune hydrops fetalis,0.3326218692162316
Q13491,,,Tier 1.5,0.199,0,unknown,0,82.31,0,0,,,0,0,,0,open-angle glaucoma,0.31489783643542385
Q9HAT0,,,Tier 1.5,0.191,0,unknown,0,85.25,0,0,,,0,0,,0,Vitiligo,0.28500489474800955
O95447,,,Tier 1.5,0.187,0,unknown,0,62.31,0,0,,,0,0,,0,neurodegenerative disease,0.27241083934376026
Q9BSJ5,MTNAP1,Mitochondrial nucleoid-associated protein 1,Tier 1.5,0.186,0,unknown,0,44.44,0,0,,,0,0,,0,exostosis,0.270767386991046
Q494R4,DRC12,Dynein regulatory complex protein 12,Tier 1.5,0.154,0,unknown,0,88.31,0,0,,,0,0,,0,familial lipoprotein lipase deficiency,0.16278033923544344
Q6P2E9,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6P3W7,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6P9H4,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PD62,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PI48,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PI78,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6PL24,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,
Q6Q788,,,Tier 1.5,0.15,0,unknown,0,,0,0,,,0,0,,1,,