id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
Q9UJA9,ENPP5,Ectonucleotide pyrophosphatase/phosphodiesterase family member 5,Tier 1,0.87,1,88.12,0,0,,,,0,0,,0,neurodegenerative disease,0.33211724272317855
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q31135,H2-Ab1,,Tier 1,0.83,12,85.12,0,0,,,,0,0,,0,,
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
A6ND01,IZUMO1R,Sperm-egg fusion protein Juno,Tier 1,0.773,7,87.38,0,0,,,,0,0,,0,placental retention,0.23306495563589497
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
A0A5H2UYS3,HLA-A,,Tier 1,0.77,20,85.25,0,0,,,,0,0,,0,,
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P16471,PRLR,Prolactin receptor,Tier 1,0.747,12,61.03,0,0,,,,0,0,,0,familial hyperprolactinemia,0.5718636087471152
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
P01563,,,Tier 1,0.744,13,85.06,0,0,,,,0,0,,0,renal cell carcinoma,0.3938654263610389
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
P05187,ALPP,"Alkaline phosphatase, placental type",Tier 1,0.72,8,93.44,0,0,,,,1,7,"41329468,38238732,37425696,37047289,31687420,25919296,23467613",1,male reproductive organ cancer,0.16284411775950106
Q16878,CDO1,Cysteine dioxygenase type 1,Tier 1,0.72,17,93.62,0,0,,,,0,0,,0,adolescent idiopathic scoliosis,0.3105991982786747
Q12918,KLRB1,Killer cell lectin-like receptor subfamily B member 1,Tier 1,0.719,3,81.0,0,0,,,,0,0,,0,sensory perception of smell,0.287724180593876
P29622,SERPINA4,Kallistatin,Tier 1,0.719,3,86.69,0,0,,,,1,4,"38904251,30297859,37351609,28794177",1,optic atrophy,0.28896631154492924
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
Q99574,SERPINI1,Neuroserpin,Tier 1,0.712,3,88.12,0,0,,,,0,0,,0,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303
A0A583ZB34,,,Tier 1,0.71,9,84.38,0,0,,,,0,0,,0,,
Q96IY4,CPB2,Carboxypeptidase B2,Tier 1,0.709,10,94.12,0,0,,,,1,4,"37329944,36805075,35861072,30297859",1,type 2 diabetes mellitus,0.19338213943947646
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
P14207,FOLR2,Folate receptor beta,Tier 1,0.701,5,89.12,0,0,,,,1,2,28686804,0,neoplasm,0.11545394821329319
P25311,AZGP1,Zinc-alpha-2-glycoprotein,Tier 1,0.701,9,92.88,0,0,,,,1,1,41325160,1,neoplasm,0.10887540652591159
P01374,LTA,Lymphotoxin-alpha,Tier 1,0.7,3,83.44,0,0,,,,1,3,"41810142,30576605",0,,
P15248,IL9,Interleukin-9,Tier 1,0.7,5,84.06,0,0,,,,1,1,40972397,0,neurodegenerative disease,0.40148548290272756
Q5Y7D3,HLA-DQB1,,Tier 1,0.7,6,85.31,0,0,,,,0,0,,0,,
P14555,PLA2G2A,"Phospholipase A2, membrane associated",Tier 1,0.7,17,91.0,0,0,,,,0,0,,0,familial colorectal cancer,0.3326218692162316
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
O43570,CA12,Carbonic anhydrase 12,Tier 1,0.695,40,87.81,0,0,,,,0,0,,0,isolated hyperchlorhidrosis,0.6794515382695604
P00746,CFD,Complement factor D,Tier 1,0.695,40,91.0,0,0,,,,1,4,"38057414,38071633,28972568,25727321",1,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132
Q95460,MR1,Major histocompatibility complex class I-related protein 1,Tier 1,0.693,79,87.5,0,0,,,,1,2,"41134135,20000526",0,Immunodeficiency,0.3336382138166145
Q96QV1,HHIP,Hedgehog-interacting protein,Tier 1,0.692,11,79.75,0,0,,,,0,0,,0,Abnormality of the skeletal system,0.5195282784554633
P04435,TRBV7-9,T cell receptor beta variable 7-9,Tier 1,0.691,2,90.06,0,0,,,,0,0,,0,neoplasm,0.11454334012562349
A0A9P1NJI6,,,Tier 1,0.69,6,,0,0,,,,0,0,,0,,
Q15788,NCOA1,Nuclear receptor coactivator 1,Tier 1,0.69,100,46.72,0,0,,,,0,0,,0,neurodegenerative disease,0.48697450901885614
Q9NPF0,CD320,CD320 antigen,Tier 1,0.69,6,63.81,0,0,,,,1,1,39493449,0,Methylmalonic aciduria due to transcobalamin receptor defect,0.49918945650121177
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q02083,NAAA,N-acylethanolamine-hydrolyzing acid amidase,Tier 1,0.69,2,92.25,0,0,,,,0,0,,0,abscess,0.2726858643799341
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,Tier 1,0.687,3,92.44,0,0,,,,0,0,,0,"psoriasis 14, pustular",0.8155144873787125