id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12263,,,Tier 1,0.9,7,63.59,1,0,,,,0,0,,0,,
Q12879,GRIN2A,"Glutamate receptor ionotropic, NMDA 2A",Tier 1,0.88,37,60.84,1,0,,,,0,0,,0,Landau-Kleffner syndrome,0.8407159711916629
P35346,SSTR5,Somatostatin receptor type 5,Tier 1.5,0.841,7,81.25,1,0,,,,0,0,,0,acromegaly,0.6094707180356006
Q5T848,GPR158,Metabotropic glycine receptor,Tier 1,0.839,6,58.03,1,0,,,,0,0,,0,diverticular disease,0.4384404783771627
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.835,4,83.25,1,0,,,,0,0,,0,progressive familial intrahepatic cholestasis type 3,0.851728159166962
P0DSE2,TRB,M1-specific T cell receptor beta chain,Tier 1,0.83,5,90.12,1,0,,,,0,0,,0,,
O75899,GABBR2,Gamma-aminobutyric acid type B receptor subunit 2,Tier 1.5,0.824,26,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 59",0.7356789732167734
Q9NS82,SLC7A10,Asc-type amino acid transporter 1,Tier 1,0.803,4,83.38,1,0,,,,0,0,,0,asthma,0.5295411410172121
O60895,RAMP2,Receptor activity-modifying protein 2,Tier 1,0.802,10,80.94,1,0,,,,0,0,,0,diabetes mellitus,0.4219370007650345
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.802,13,80.69,1,0,,,,0,0,,0,Congenital myasthenic syndromes,0.8223287249629152
P29275,ADORA2B,Adenosine receptor A2b,Tier 1.5,0.801,4,88.12,1,0,,,,0,0,,0,migraine disorder,0.6060142180667235
Q9H2X9,SLC12A5,Solute carrier family 12 member 5,Tier 1.5,0.8,2,78.44,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6993945840545625
P01909,HLA-DQA1,"HLA class II histocompatibility antigen, DQ alpha 1 chain",Tier 1,0.792,27,87.94,1,0,,,,0,0,,0,Pleural Mesothelioma,0.1228600330569846
Q13705,ACVR2B,Activin receptor type-2B,Tier 1.5,0.791,9,83.31,1,0,,,,0,0,,0,Heterotaxia,0.7109733260300651
Q96CS2,HAUS1,HAUS augmin-like complex subunit 1,Tier 1.5,0.79,1,88.62,1,0,,,,0,0,,0,device complication,0.27547205131467467
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,Tier 1.5,0.782,6,73.88,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 14",0.8165232785825526
Q13639,,,Tier 1,0.781,3,80.88,1,0,,,,0,0,,0,schizophrenia,0.6060830827022777
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.777,4,84.38,1,0,,,,0,0,,0,glucose-galactose malabsorption,0.8220991027793896
P30542,ADORA1,Adenosine receptor A1,Tier 1.5,0.777,5,92.44,1,0,,,,0,0,,0,asthma,0.7232344154541454
O15393,,,Tier 1,0.775,31,79.38,1,0,,,,0,0,,0,COVID-19,0.6157541390484623
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.769,20,91.12,1,0,,,,0,0,,0,psoriasis,0.7914863943708039
P43004,SLC1A2,Excitatory amino acid transporter 2,Tier 1.5,0.768,7,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 41",0.7772658651722512
O60931,CTNS,Cystinosin,Tier 1.5,0.764,6,89.44,1,0,,,,0,0,,0,nephropathic cystinosis,0.841818398377195
P98073,,,Tier 1,0.761,14,81.5,1,0,,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
Q9Y5Y9,SCN10A,Sodium channel protein type 10 subunit alpha,Tier 1.5,0.761,8,67.31,1,0,,,,0,0,,0,atrial fibrillation,0.7126293968222049
O75762,TRPA1,Transient receptor potential cation channel subfamily A member 1,Tier 1,0.76,17,81.94,1,0,,,,0,0,,0,familial episodic pain syndrome with predominantly upper body involvement,0.6615353934604322
O15552,FFAR2,Free fatty acid receptor 2,Tier 1.5,0.759,11,88.06,1,0,,,,0,0,,0,type 1 diabetes mellitus,0.09182737097469269
P35462,DRD3,D(3) dopamine receptor,Tier 1.5,0.757,6,75.38,1,0,,,,0,0,,0,schizophrenia,0.6687268941647396
O00591,GABRP,Gamma-aminobutyric acid receptor subunit pi,Tier 1.5,0.752,2,79.12,1,0,,,,0,0,,0,migraine disorder,0.6191855696357259
P0DMS8,ADORA3,Adenosine receptor A3,Tier 1.5,0.751,5,91.31,1,0,,,,0,0,,0,migraine disorder,0.6052134617149065
O43614,,,Tier 1,0.75,11,78.94,1,0,,,,0,0,,0,insomnia,0.5988748728311054
P46089,GPR3,G-protein coupled receptor 3,Tier 1.5,0.748,8,81.81,1,0,,,,0,0,,0,hypertension,0.18488148594282316
O15245,SLC22A1,Solute carrier family 22 member 1,Tier 1,0.744,16,84.25,1,0,,,,0,0,,0,coronary artery disease,0.5384890077265535
Q8N158,GPC2,Glypican-2,Tier 1,0.744,2,79.06,1,0,,,,0,0,,0,COVID-19,0.5409211817593593
O43526,KCNQ2,Potassium voltage-gated channel subfamily KQT member 2,Tier 1,0.744,24,58.19,1,0,,,,0,0,,0,Benign familial neonatal seizures,0.8423358217314708
P40879,SLC26A3,Chloride anion exchanger,Tier 1,0.742,13,85.06,1,0,,,,0,0,,0,congenital secretory chloride diarrhea 1,0.8189631913308207
D7RIG0,HLA-DRB1,,Tier 1,0.74,10,84.94,1,0,,,,0,0,,0,,
Q86YT5,SLC13A5,Na(+)/citrate cotransporter,Tier 1.5,0.739,4,86.06,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6853612674939716
A0A1B0GX56,TRDV1,T cell receptor delta variable 1,Tier 1,0.737,7,90.69,1,0,,,,0,0,,0,colorectal carcinoma,0.07391597093694036
Q14028,CNGB1,Cyclic nucleotide-gated channel beta-1,Tier 1,0.734,11,57.66,1,0,,,,0,0,,0,retinitis pigmentosa,0.7931901344765326
P41145,OPRK1,Kappa-type opioid receptor,Tier 1,0.725,28,79.5,1,0,,,,0,0,,0,alcohol dependence,0.6106562988740131
Q9H741,SPRING1,SREBP regulating gene protein,Tier 1.5,0.725,2,81.31,1,0,,,,0,0,,0,Anxiety,0.35244791107935663
P48764,SLC9A3,Sodium/hydrogen exchanger 3,Tier 1.5,0.725,1,65.94,1,0,,,,0,0,,0,congenital sodium diarrhea,0.6503153836708786
P23416,GLRA2,Glycine receptor subunit alpha-2,Tier 1,0.723,13,83.81,1,0,,,,0,0,,0,"intellectual developmental disorder, X-linked, syndromic, Pilorge type",0.7805605973560554
P41968,MC3R,Melanocortin receptor 3,Tier 1.5,0.723,6,83.88,1,0,,,,0,0,,0,alcohol drinking,0.3298167673588826
P29033,GJB2,Gap junction beta-2 protein,Tier 1,0.72,24,86.19,1,0,,,,0,0,,0,palmoplantar keratoderma-deafness syndrome,0.8149616697051898
B7Z8K6,TRDC,T cell receptor delta constant,Tier 1,0.72,12,81.38,1,0,,,,0,0,,0,,
Q9NZD1,GPRC5D,G-protein coupled receptor family C group 5 member D,Tier 1.5,0.716,2,76.06,1,0,,,,0,0,,0,multiple myeloma,0.5555243624684951
A0A0B4J271,TRAV12-3,T cell receptor alpha variable 12-3,Tier 1,0.715,12,92.56,1,0,,,,0,0,,0,ulcerative colitis,0.003139210371371825
Q695T7,SLC6A19,Sodium-dependent neutral amino acid transporter B(0)AT1,Tier 1,0.715,19,90.0,1,0,,,,0,0,,0,Hartnup disease,0.8464240093600148