id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,95.62,1,0,,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,86.06,1,0,,,,0,0,,1,"cleft palate, proliferative retinopathy, and developmental delay",0.5770707112957068
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,89.31,1,0,,,,0,0,,1,neurodegenerative disease,0.5385822922582763
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,89.69,1,0,,,,0,0,,1,congestive heart failure,0.5999952111132625
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,80.12,1,0,,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,90.88,1,0,,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,87.12,1,0,,,,0,0,,1,neurodegenerative disease,0.45156128674958135
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,80.56,1,0,,,,0,0,,1,C1Q deficiency,0.6233532074390745
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,91.38,1,0,,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,,1,0,,,,0,0,,1,,
P07360,,,Tier 1,0.755,15,89.75,1,0,,,,0,0,,1,complement deficiency,0.3695798546847018
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.755,19,72.06,1,0,,,,0,0,,1,Knobloch syndrome,0.5526223217595396
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,85.0,1,0,,,,0,0,,1,Myasthenia gravis,0.5932721106551206
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.75,9,76.75,1,0,,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.743,1,77.88,1,0,,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
P11215,ITGAM,Integrin alpha-M,Tier 1,0.72,30,86.25,1,0,,,,0,0,,1,systemic lupus erythematosus,0.30502849242596436
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.72,3,76.69,1,0,,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.711,5,56.41,1,0,,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
Q9NV96,TMEM30A,Cell cycle control protein 50A,Tier 1,0.71,33,89.5,1,0,,,,0,0,,1,atrial fibrillation,0.31177132249681394
O60486,PLXNC1,Plexin-C1,Tier 1,0.703,4,79.06,1,0,,,,0,0,,1,asthma,0.532656225351722
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.702,2,84.69,1,0,,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P01825,IGHV4-59,Immunoglobulin heavy variable 4-59,Tier 1.5,0.69,3,91.56,1,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q8NBJ9,,,Tier 1,0.688,7,80.25,1,0,,,,0,0,,1,hypothyroidism,0.32686531914177924
Q6NT16,SLC18B1,MFS-type transporter SLC18B1,Tier 1.5,0.688,4,84.62,1,0,,,,0,0,,1,Parkinson disease,0.276931649354752
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,Tier 1.5,0.685,5,68.81,1,0,,,,0,0,,1,"developmental and epileptic encephalopathy, 11",0.8388748085806758
P63092,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Tier 1,0.683,100,91.31,1,0,,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
Q14213,,,Tier 1,0.683,4,87.62,1,0,,,,0,0,,1,neurodegenerative disease,0.42776938116451996
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.682,10,90.25,1,0,,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
Q9UNN8,PROCR,Endothelial protein C receptor,Tier 1,0.68,13,86.44,1,0,,,,0,0,,1,venous thromboembolism,0.5497662282245215
O75935,DCTN3,Dynactin subunit 3,Tier 1.5,0.68,1,88.38,1,0,,,,0,0,,1,viral disease,0.03700998752471888
Q8TD43,TRPM4,Transient receptor potential cation channel subfamily M member 4,Tier 1.5,0.68,25,77.44,1,0,,,,0,0,,1,Familial progressive cardiac conduction defect,0.7868180621357534
P05023,ATP1A1,Sodium/potassium-transporting ATPase subunit alpha-1,Tier 1.5,0.679,10,88.69,1,0,,,,0,0,,1,"Charcot-Marie-tooth disease, axonal, type 2DD",0.7868851290226483
Q92536,SLC7A6,Y+L amino acid transporter 2,Tier 1.5,0.678,2,83.19,1,0,,,,0,0,,1,Abnormality of the skeletal system,0.48544421359843914
P36021,SLC16A2,Monocarboxylate transporter 8,Tier 1.5,0.675,7,79.56,1,0,,,,0,0,,1,Allan-Herndon-Dudley syndrome,0.8533069932022032
P18564,ITGB6,Integrin beta-6,Tier 1.5,0.675,14,82.88,1,0,,,,0,0,,1,Hypoplastic amelogenesis imperfecta,0.6045342804405103
P32241,VIPR1,Vasoactive intestinal polypeptide receptor 1,Tier 1.5,0.667,17,76.0,1,0,,,,0,0,,1,diverticular disease,0.2747596866638145
O95563,MPC2,Mitochondrial pyruvate carrier 2,Tier 1.5,0.665,17,89.44,1,0,,,,0,0,,1,mitochondrial pyruvate carrier deficiency,0.18534429712437792
O15554,KCNN4,Intermediate conductance calcium-activated potassium channel protein 4,Tier 1.5,0.661,17,84.19,1,0,,,,0,0,,1,dehydrated hereditary stomatocytosis,0.7145864899974032
Q14344,GNA13,Guanine nucleotide-binding protein subunit alpha-13,Tier 1,0.66,17,91.44,1,0,,,,0,0,,1,lymphoma,0.37253457492562664
Q14524,SCN5A,Sodium channel protein type 5 subunit alpha,Tier 1.5,0.654,16,67.25,1,0,,,,0,0,,1,long QT syndrome 3,0.8448298602976083
P13637,ATP1A3,Sodium/potassium-transporting ATPase subunit alpha-3,Tier 1.5,0.654,5,88.81,1,0,,,,0,0,,1,alternating hemiplegia of childhood 2,0.842328126568451
Q5JWF2,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas,Tier 1,0.653,9,56.72,1,0,,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
Q13936,CACNA1C,Voltage-dependent L-type calcium channel subunit alpha-1C,Tier 1,0.65,33,61.94,1,0,,,,0,0,,1,Timothy syndrome,0.8227725490420764
O60449,LY75,Lymphocyte antigen 75,Tier 1.5,0.65,4,75.62,1,0,,,,0,0,,1,Abruptio Placentae,0.31953367678705413
Q15027,ACAP1,"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1",Tier 1.5,0.649,7,84.38,1,0,,,,0,0,,1,hypothyroidism,0.4891091360736571
O00468,AGRN,Agrin,Tier 1.5,0.649,1,68.81,1,0,,,,0,0,,1,congenital myasthenic syndrome 8,0.7912009864338403
O00478,BTN3A3,Butyrophilin subfamily 3 member A3,Tier 1.5,0.648,9,82.81,1,0,,,,0,0,,1,neoplasm,0.07870866954589865
Q8TEM1,NUP210,Nuclear pore membrane glycoprotein 210,Tier 1.5,0.644,2,79.56,1,0,,,,0,0,,1,HIV infection,0.5409211817593593
Q9Y4R8,TELO2,Telomere length regulation protein TEL2 homolog,Tier 1.5,0.64,3,83.88,1,0,,,,0,0,,1,TELO2-related intellectual disability-neurodevelopmental disorder,0.7971337980726797
O60443,GSDME,Gasdermin-E,Tier 1.5,0.638,2,77.44,1,0,,,,0,0,,1,autosomal dominant nonsyndromic hearing loss,0.6288670542083885