id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P62873,GNB1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Tier 1,0.794,1,A2_pm_peripheral,100,97.06,1,0,,,0,0,,1,"intellectual disability, autosomal dominant 42",0.8462216225099116
P06737,PYGL,"Glycogen phosphorylase, liver form",Tier 1,0.787,1,A2_pm_peripheral,19,92.69,1,0,,,0,0,,1,glycogen storage disease VI,0.8220063508118274
P49770,EIF2B2,Translation initiation factor eIF2B subunit beta,Tier 1,0.787,1,A2_pm_peripheral,25,86.56,1,0,,,0,0,,1,CACH syndrome,0.824634396744653
P21333,FLNA,Filamin-A,Tier 1,0.786,1,A2_pm_peripheral,26,76.56,1,0,,,0,0,,1,Melnick-Needles syndrome,0.8200516896124751
P31040,SDHA,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",Tier 1.5,0.785,1,A2_pm_peripheral,4,93.94,1,0,,,0,0,,1,"mitochondrial complex II deficiency, nuclear type 1",0.815589203208636
Q01831,XPC,DNA repair protein complementing XP-C cells,Tier 1,0.782,1,A2_pm_peripheral,14,66.56,1,0,,,0,0,,1,Xeroderma pigmentosum complementation group C,0.8056391472748724
Q12840,KIF5A,Kinesin heavy chain isoform 5A,Tier 1.5,0.781,1,A2_pm_peripheral,4,75.31,1,0,,,0,0,,1,hereditary spastic paraplegia 10,0.8029405627392309
O00330,PDHX,"Pyruvate dehydrogenase protein X component, mitochondrial",Tier 1.5,0.779,1,A2_pm_peripheral,5,77.31,1,0,,,0,0,,1,pyruvate dehydrogenase E3-binding protein deficiency,0.7957753555992844
Q9NQG7,HPS4,BLOC-3 complex member HPS4,Tier 1.5,0.779,1,A2_pm_peripheral,1,61.66,1,0,,,0,0,,1,Hermansky-Pudlak syndrome with pulmonary fibrosis,0.7967575753847002
O00468,AGRN,Agrin,Tier 1.5,0.777,1,A2_pm_peripheral,1,68.81,1,0,,,0,0,,1,congenital myasthenic syndrome 8,0.7912009864338403
Q9BYI3,HYCC1,Hyccin,Tier 1,0.766,1,A2_pm_peripheral,5,67.75,1,0,,,0,0,,1,Hypomyelination - congenital cataract,0.7528702184568328
P13797,PLS3,Plastin-3,Tier 1,0.757,1,A2_pm_peripheral,6,88.75,1,0,,,0,0,,1,X-linked osteoporosis with fractures,0.721756781312783
P07357,C8A,Complement component C8 alpha chain,Tier 1,0.75,1,A2_pm_peripheral,11,78.69,1,0,,,0,0,,1,Immunodeficiency due to a late component of complements deficiency,0.700643416115894
P62987,UBA52,Ubiquitin-ribosomal protein eL40 fusion protein,Tier 1,0.712,1,A2_pm_peripheral,30,93.5,1,0,,,0,0,,1,HIV infection,0.5745684844613109
Q8NFH5,NUP35,Nucleoporin NUP35,Tier 1,0.702,1,A2_pm_peripheral,5,63.19,1,0,,,0,0,,1,influenza,0.5409211817593593
Q13033,STRN3,Striatin-3,Tier 1,0.701,1,A2_pm_peripheral,4,67.5,1,0,,,0,0,,1,neurodegenerative disease,0.5377902198332467
O75143,ATG13,Autophagy-related protein 13,Tier 1,0.701,1,A2_pm_peripheral,13,63.84,1,0,,,0,0,,1,neurodegenerative disease,0.5360512349298453
Q6IAA8,LAMTOR1,Ragulator complex protein LAMTOR1,Tier 1,0.7,1,A2_pm_peripheral,22,80.12,1,0,,,0,0,,1,neurodegenerative disease,0.5318107016634962
O15511,ARPC5,Actin-related protein 2/3 complex subunit 5,Tier 1.5,0.699,1,A2_pm_peripheral,2,92.19,1,0,,,0,0,,1,neurodegenerative disease,0.5305805352966168
P30154,PPP2R1B,Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform,Tier 1.5,0.699,1,A2_pm_peripheral,1,92.81,1,0,,,0,0,,1,cancer,0.5305484520119053
P49662,CASP4,Caspase-4,Tier 1,0.692,1,A2_pm_peripheral,9,78.38,1,0,,,0,0,,1,bacterial disease,0.5062783346658307
Q9UBL3,ASH2L,Set1/Ash2 histone methyltransferase complex subunit ASH2,Tier 1,0.691,1,A2_pm_peripheral,27,75.25,1,0,,,0,0,,1,neurodegenerative disease,0.5019091999413609
O00762,UBE2C,Ubiquitin-conjugating enzyme E2 C,Tier 1.5,0.689,1,A2_pm_peripheral,9,88.56,1,0,,,0,0,,1,neurodegenerative disease,0.49682303083942114
P83881,RPL36A,Large ribosomal subunit protein eL42,Tier 1,0.679,1,A2_pm_peripheral,30,94.31,1,0,,,0,0,,1,influenza,0.4619748183558772
Q5VZK9,CARMIL1,F-actin-uncapping protein LRRC16A,Tier 1,0.677,1,A2_pm_peripheral,3,67.38,1,0,,,0,0,,1,schizophrenia,0.45718735748281236
Q86TV6,TTC7B,Tetratricopeptide repeat protein 7B,Tier 1,0.673,1,A2_pm_peripheral,5,85.0,1,0,,,0,0,,1,neurodegenerative disease,0.4430588960838045
Q16763,UBE2S,Ubiquitin-conjugating enzyme E2 S,Tier 1,0.673,1,A2_pm_peripheral,9,80.69,1,0,,,0,0,,1,neurodegenerative disease,0.44489727765466
Q16555,DPYSL2,Dihydropyrimidinase-related protein 2,Tier 1,0.671,1,A2_pm_peripheral,15,90.25,1,0,,,0,0,,1,hypertension,0.4377422749119531
P61077,UBE2D3,Ubiquitin-conjugating enzyme E2 D3,Tier 1,0.667,1,A2_pm_peripheral,46,96.38,1,0,,,0,0,,1,hypertension,0.4222295115574527
P04899,GNAI2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Tier 1,0.665,1,A2_pm_peripheral,34,94.06,1,0,,,0,0,,1,ovarian granulosa cell tumor,0.4157773365202895
Q9H0A8,COMMD4,COMM domain-containing protein 4,Tier 1.5,0.663,1,A2_pm_peripheral,4,80.75,1,0,,,0,0,,1,neurodegenerative disease,0.4109063598016124
Q8N3R9,PALS1,Protein PALS1,Tier 1,0.652,1,A2_pm_peripheral,9,77.19,1,0,,,0,0,,1,COVID-19,0.3720065057444545
Q00536,CDK16,Cyclin-dependent kinase 16,Tier 1.5,0.652,1,A2_pm_peripheral,3,71.94,1,0,,,0,0,,1,Intellectual disability,0.3718454818549898
Q92797,SYMPK,Symplekin,Tier 1,0.651,1,A2_pm_peripheral,13,74.56,1,0,,,0,0,,1,dengue disease,0.3695798546847018
O60551,NMT2,Glycylpeptide N-tetradecanoyltransferase 2,Tier 1.5,0.651,1,A2_pm_peripheral,3,80.88,1,0,,,0,0,,1,HIV infection,0.37004182950305764
Q16658,FSCN1,Fascin,Tier 1,0.642,1,A2_pm_peripheral,28,94.19,1,0,,,0,0,,1,ankylosing spondylitis,0.3390409466148633
P50748,KNTC1,Kinetochore-associated protein 1,Tier 1.5,0.64,1,A2_pm_peripheral,1,71.5,1,0,,,0,0,,1,"osteoarthritis, knee",0.3323628521281481
Q9UNZ2,NSFL1C,NSFL1 cofactor p47,Tier 1.5,0.638,1,A2_pm_peripheral,3,74.06,1,0,,,0,0,,1,neurodegenerative disease,0.3262410536701536
Q4FZB7,KMT5B,Histone-lysine N-methyltransferase KMT5B,Tier 1,0.628,1,A2_pm_peripheral,10,54.91,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 51",0.7943209483524042
Q5JVL4,EFHC1,EF-hand domain-containing protein 1,Tier 1,0.626,1,A2_pm_peripheral,2,83.88,1,0,,,0,0,,0,juvenile myoclonic epilepsy,0.7858434985198706
P49459,UBE2A,Ubiquitin-conjugating enzyme E2 A,Tier 1.5,0.626,1,A2_pm_peripheral,5,94.12,1,0,,,0,0,,0,syndromic X-linked intellectual disability Nascimento type,0.7867796040270276
A7E2V4,ZSWIM8,Zinc finger SWIM domain-containing protein 8,Tier 1.5,0.625,1,A2_pm_peripheral,1,61.94,1,0,,,0,0,,1,aortic stenosis,0.28253434569668473
Q15019,SEPTIN2,Septin-2,Tier 1,0.621,1,A2_pm_peripheral,7,81.81,1,0,,,0,0,,1,"osteoarthritis, hip",0.2686294007302314
Q9NPP4,NLRC4,NLR family CARD domain-containing protein 4,Tier 1,0.619,1,A2_pm_peripheral,6,85.12,1,0,,,0,0,,0,periodic fever-infantile enterocolitis-autoinflammatory syndrome,0.7635956406357429
P35716,SOX11,Transcription factor SOX-11,Tier 1,0.614,1,A2_pm_peripheral,4,56.41,1,0,,,0,0,,0,intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism,0.7470288070793535
P50552,VASP,Vasodilator-stimulated phosphoprotein,Tier 1.5,0.604,1,A2_pm_peripheral,11,69.75,1,0,,,0,0,,1,neurodegenerative disease,0.21494427179372053
Q8IUC6,TICAM1,TIR domain-containing adapter molecule 1,Tier 1.5,0.581,1,A2_pm_peripheral,8,62.78,1,0,,,0,0,,0,Herpetic encephalitis,0.6364986386236531
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.577,1,A2_pm_peripheral,9,76.75,1,0,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
P55010,EIF5,Eukaryotic translation initiation factor 5,Tier 1.5,0.577,1,A2_pm_peripheral,6,73.19,1,0,,,0,0,,1,Abnormality of the skeletal system,0.12225325872435809
P56597,NME5,Nucleoside diphosphate kinase 5,Tier 1.5,0.563,1,A2_pm_peripheral,1,90.06,1,0,,,0,0,,0,"ciliary dyskinesia, primary, 48, without situs inversus",0.5766985649142533