id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12883,MYH7,Myosin-7,Tier 1,0.871,1,A_assoc,43,74.25,1,0,,,0,0,,1,hypertrophic cardiomyopathy,0.9029865147265421
P04180,LCAT,Phosphatidylcholine-sterol acyltransferase,Tier 1.5,0.848,1,A_assoc,7,86.75,1,0,,,0,0,,1,Fish-eye disease,0.8273460309828392
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.847,1,A_assoc,10,90.25,1,0,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.84,1,A_assoc,3,76.69,1,0,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.838,1,A_assoc,15,90.88,1,0,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P35858,IGFALS,Insulin-like growth factor-binding protein complex acid labile subunit,Tier 1.5,0.833,1,A_assoc,1,90.56,1,0,,,0,0,,1,Reduced insulin like growth factor binding protein acid labile subunit concentration,0.7760522769257892
O15230,LAMA5,Laminin subunit alpha-5,Tier 1.5,0.828,1,A_assoc,2,79.12,1,0,,,0,0,,1,"nephrotic syndrome, IIa 26",0.7594872666460903
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.815,1,A_assoc,18,91.38,1,0,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
P48200,IREB2,Iron-responsive element-binding protein 2,Tier 1,0.799,1,A_assoc,1,86.75,1,0,,,0,0,,1,"neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia",0.664403876125082
P02745,C1QA,Complement C1q subcomponent subunit A,Tier 1,0.79,1,A_assoc,11,82.62,1,0,,,0,0,,1,C1Q deficiency 1,0.6319053256658114
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.787,1,A_assoc,11,80.56,1,0,,,0,0,,1,C1Q deficiency,0.6233532074390745
A8K2U0,A2ML1,Alpha-2-macroglobulin-like protein 1,Tier 1,0.764,1,A_assoc,5,80.5,1,0,,,0,0,,1,Otitis media,0.5479914512784171
Q08043,ACTN3,Alpha-actinin-3,Tier 1,0.752,1,A_assoc,3,84.19,1,0,,,0,0,,1,Abnormality of the skeletal system,0.5080072819822437
P05161,ISG15,Ubiquitin-like protein ISG15,Tier 1,0.74,1,A_assoc,22,85.88,1,0,,,0,0,,1,COVID-19,0.4668295741563516
Q9BVC4,MLST8,Target of rapamycin complex subunit LST8,Tier 1,0.733,1,A_assoc,45,91.62,1,0,,,0,0,,1,neurodegenerative disease,0.4440338170862142
O95970,LGI1,Leucine-rich glioma-inactivated protein 1,Tier 1.5,0.697,1,A_assoc,9,92.56,1,0,,,0,0,,0,autosomal dominant epilepsy with auditory features,0.8225657483127345
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.687,1,A_assoc,20,91.12,1,0,,,0,0,,0,psoriasis,0.7914863943708039
P19876,CXCL3,C-X-C motif chemokine 3,Tier 1.5,0.679,1,A_assoc,2,81.88,1,0,,,0,0,,1,neurodegenerative disease,0.26311734927710556
P19875,CXCL2,C-X-C motif chemokine 2,Tier 1.5,0.674,1,A_assoc,4,81.62,1,0,,,0,0,,1,neurodegenerative disease,0.24624512698601778
Q2MKA7,RSPO1,R-spondin-1,Tier 1,0.669,1,A_assoc,12,74.69,1,0,,,0,0,,0,palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome,0.7285342885472184
P12272,PTHLH,Parathyroid hormone-related protein,Tier 1,0.666,1,A_assoc,11,62.88,1,0,,,0,0,,0,brachydactyly type E,0.7203484375635054
Q8N300,SVBP,Small vasohibin-binding protein,Tier 1,0.649,1,A_assoc,24,85.06,1,0,,,0,0,,0,"neurodevelopmental disorder with ataxia, hypotonia, and microcephaly",0.6640118055835142
O95631,NTN1,Netrin-1,Tier 1.5,0.648,1,A_assoc,5,88.5,1,0,,,0,0,,0,mirror movements 4,0.6611393488240481
Q9NWU2,GID8,Glucose-induced degradation protein 8 homolog,Tier 1.5,0.631,1,A_assoc,1,91.94,1,0,,,0,0,,1,Abnormality of the skeletal system,0.10187555420552867
Q9UHF0,TAC3,Tachykinin-3,Tier 1,0.63,1,A_assoc,2,64.88,1,0,,,0,0,,0,hypogonadotropic hypogonadism 10 with or without anosmia,0.5995324402695232
P13727,PRG2,Bone marrow proteoglycan,Tier 1,0.629,1,A_assoc,9,75.94,1,0,,,0,0,,1,prostate cancer,0.09730351635618993
Q6IBW4,NCAPH2,Condensin-2 complex subunit H2,Tier 1.5,0.62,1,A_assoc,1,62.41,1,0,,,0,0,,0,"cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1",0.5674645203025676
Q63HQ2,EGFLAM,Pikachurin,Tier 1.5,0.574,1,A_assoc,3,80.56,1,0,,,0,0,,0,mathematical ability,0.41387833248094535
P06850,CRH,Corticoliberin,Tier 1,0.562,1,A_assoc,5,61.97,1,0,,,0,0,,0,autosomal dominant nocturnal frontal lobe epilepsy,0.37224647599732263
Q7L8A9,VASH1,Tubulinyl-Tyr carboxypeptidase 1,Tier 1,0.559,1,A_assoc,14,78.25,1,0,,,0,0,,0,Abnormality of the skeletal system,0.36366533692746233
P18509,ADCYAP1,Pituitary adenylate cyclase-activating polypeptide,Tier 1,0.559,1,A_assoc,12,62.56,1,0,,,0,0,,0,alcohol drinking,0.36407172744864225
O15240,VGF,Neurosecretory protein VGF,Tier 1,0.545,1,A_assoc,5,60.44,1,0,,,0,0,,0,Abnormality of the skeletal system,0.3156209584671744
P0DMC3,APELA,Apelin receptor early endogenous ligand,Tier 1,0.544,1,A_assoc,3,72.56,1,0,,,0,0,,0,attention deficit hyperactivity disorder,0.3148526492327248
M5A8F1,ERVH48-1,Suppressyn,Tier 1.5,0.519,1,A_assoc,1,74.94,1,0,,,0,0,,0,hypertension,0.23115391486595976
Q5T4W7,ARTN,Artemin,Tier 1.5,0.512,1,A_assoc,5,75.0,1,0,,,0,0,,0,neurodegenerative disease,0.20507822956537197
Q99731,CCL19,C-C motif chemokine 19,Tier 1,0.485,1,A_assoc,5,83.19,1,0,,,0,0,,0,neoplasm,0.11672269610339286
Q9H293,IL25,Interleukin-25,Tier 1,0.485,1,A_assoc,3,79.0,1,0,,,0,0,,0,neoplasm,0.11536752730834607
Q7L2J0,MEPCE,7SK snRNA methylphosphate capping enzyme,Tier 1,0.485,1,A_assoc,5,62.66,1,0,,,0,0,,0,Neurodevelopmental delay,0.11826555349910459
Q8IZI9,IFNL3,Interferon lambda-3,Tier 1.5,0.484,1,A_assoc,3,84.81,1,0,,,0,0,,0,hepatocellular carcinoma,0.1145400757875244
O00230,CORT,Cortistatin,Tier 1.5,0.484,1,A_assoc,5,62.84,1,0,,,0,0,,0,neoplasm,0.11461560504839655
Q9Y5Q6,INSL5,Insulin-like peptide INSL5,Tier 1.5,0.477,1,A_assoc,3,64.06,1,0,,,0,0,,0,polycystic ovary syndrome,0.08868171274230166
Q7Z4H4,ADM2,Protein ADM2,Tier 1,0.469,1,A_assoc,2,58.38,1,0,,,0,0,,0,neoplasm,0.06251866797932627
P0DSE2,TRB,M1-specific T cell receptor beta chain,Tier 1,0.45,1,A_assoc,5,90.12,1,0,,,0,0,,0,,
P13848,7,Capsid assembly scaffolding protein,Tier 1,0.45,1,A_assoc,15,,1,0,,,0,0,,0,,