id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P33897,ABCD1,ATP-binding cassette sub-family D member 1,Tier 1,0.96,1,A_surface,14,80.62,1,0,,,0,0,,1,adrenoleukodystrophy,0.8656366512509434
P36021,SLC16A2,Monocarboxylate transporter 8,Tier 1.5,0.956,1,A_surface,7,79.56,1,0,,,0,0,,1,Allan-Herndon-Dudley syndrome,0.8533069932022032
Q9NQ11,ATP13A2,Polyamine-transporting ATPase 13A2,Tier 1,0.953,1,A_surface,25,79.62,1,0,,,0,0,,1,Kufor-Rakeb syndrome,0.8439049037191295
Q14524,SCN5A,Sodium channel protein type 5 subunit alpha,Tier 1.5,0.953,1,A_surface,16,67.25,1,0,,,0,0,,1,long QT syndrome 3,0.8448298602976083
Q969N2,PIGT,GPI-anchor transamidase component PIGT,Tier 1.5,0.953,1,A_surface,3,87.25,1,0,,,0,0,,1,multiple congenital anomalies-hypotonia-seizures syndrome 3,0.8439030764005646
P13637,ATP1A3,Sodium/potassium-transporting ATPase subunit alpha-3,Tier 1.5,0.953,1,A_surface,5,88.81,1,0,,,0,0,,1,alternating hemiplegia of childhood 2,0.842328126568451
P35499,SCN4A,Sodium channel protein type 4 subunit alpha,Tier 1,0.952,1,A_surface,3,72.44,1,0,,,0,0,,1,paramyotonia congenita of Von Eulenburg,0.8401628899371881
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,Tier 1.5,0.952,1,A_surface,5,68.81,1,0,,,0,0,,1,"developmental and epileptic encephalopathy, 11",0.8388748085806758
P07359,GP1BA,Platelet glycoprotein Ib alpha chain,Tier 1,0.95,1,A_surface,22,64.31,1,0,,,0,0,,1,Bernard-Soulier syndrome,0.8346884735388165
Q9HAB3,SLC52A2,"Solute carrier family 52, riboflavin transporter, member 2",Tier 1.5,0.95,1,A_surface,1,84.12,1,0,,,0,0,,1,riboflavin transporter deficiency,0.8333271825486935
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.95,1,A_surface,1,77.88,1,0,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
Q9NRA2,SLC17A5,Sialin,Tier 1,0.949,1,A_surface,7,84.12,1,0,,,0,0,,1,"free sialic acid storage disease, infantile form",0.8292382821211967
P63092,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Tier 1,0.948,1,A_surface,100,91.31,1,0,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
Q5JWF2,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas,Tier 1,0.948,1,A_surface,9,56.72,1,0,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
P16615,ATP2A2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,Tier 1,0.947,1,A_surface,15,85.44,1,0,,,0,0,,1,Darier disease,0.8223208039299769
Q13936,CACNA1C,Voltage-dependent L-type calcium channel subunit alpha-1C,Tier 1,0.947,1,A_surface,33,61.94,1,0,,,0,0,,1,Timothy syndrome,0.8227725490420764
P08514,ITGA2B,Integrin alpha-IIb,Positive Control,0.947,1,A_surface,78,88.12,1,1,8T2U,8T2V,0,0,,1,Glanzmann thrombasthenia 1,0.8224288672248264
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.947,1,A_surface,2,84.69,1,0,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P02730,SLC4A1,Band 3 anion transport protein,Tier 1,0.946,1,A_surface,54,82.12,1,0,,,0,0,,1,hereditary spherocytosis type 4,0.820137113225454
Q9H3H5,DPAGT1,UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase,Tier 1,0.943,1,A_surface,8,94.69,1,0,,,0,0,,1,DPAGT1-congenital disorder of glycosylation,0.8101246300555436
P51798,CLCN7,H(+)/Cl(-) exchange transporter 7,Tier 1.5,0.942,1,A_surface,9,80.94,1,0,,,0,0,,1,Autosomal recessive malignant osteopetrosis,0.8065499095904218
P49810,PSEN2,Presenilin-2,Tier 1,0.941,1,A_surface,2,71.81,1,0,,,0,0,,1,early-onset autosomal dominant Alzheimer disease,0.8047686386596943
Q9H2M9,RAB3GAP2,Rab3 GTPase-activating protein non-catalytic subunit,Tier 1,0.939,1,A_surface,1,79.62,1,0,,,0,0,,1,Cataract - intellectual disability - hypogonadism,0.7977527040203786
Q9Y5Y0,FLVCR1,Choline/ethanolamine transporter FLVCR1,Tier 1,0.938,1,A_surface,8,77.56,1,0,,,0,0,,1,Posterior column ataxia - retinitis pigmentosa,0.7932113640677738
Q9NW15,ANO10,Anoctamin-10,Tier 1,0.937,1,A_surface,5,86.12,1,0,,,0,0,,1,autosomal recessive spinocerebellar ataxia 10,0.7915327777093032
Q96JI7,SPG11,Spatacsin,Tier 1.5,0.937,1,A_surface,3,66.75,1,0,,,0,0,,1,Autosomal recessive spastic paraplegia type 11,0.7886006646085494
Q6PJF5,RHBDF2,Inactive rhomboid protein 2,Tier 1,0.936,1,A_surface,5,67.38,1,0,,,0,0,,1,palmoplantar keratoderma-esophageal carcinoma syndrome,0.7882817956366938
Q8TD43,TRPM4,Transient receptor potential cation channel subfamily M member 4,Tier 1.5,0.936,1,A_surface,25,77.44,1,0,,,0,0,,1,Familial progressive cardiac conduction defect,0.7868180621357534
P05023,ATP1A1,Sodium/potassium-transporting ATPase subunit alpha-1,Tier 1.5,0.936,1,A_surface,10,88.69,1,0,,,0,0,,1,"Charcot-Marie-tooth disease, axonal, type 2DD",0.7868851290226483
Q9NP58,ABCB6,ATP-binding cassette sub-family B member 6,Tier 1,0.934,1,A_surface,16,83.06,1,0,,,0,0,,1,dyschromatosis universalis hereditaria 3,0.7783407126197405
Q8N766,EMC1,ER membrane protein complex subunit 1,Tier 1,0.931,1,A_surface,10,87.44,1,0,,,0,0,,1,"cerebellar atrophy, visual impairment, and psychomotor retardation;",0.7687056132401411
P78536,ADAM17,Disintegrin and metalloproteinase domain-containing protein 17,Tier 1,0.929,1,A_surface,33,72.69,1,0,,,0,0,,1,neonatal inflammatory skin and bowel disease,0.7624558659108367
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.929,1,A_surface,8,95.62,1,0,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
Q9BVK8,TMEM147,BOS complex subunit TMEM147,Tier 1,0.928,1,A_surface,3,92.5,1,0,,,0,0,,1,"neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly",0.7615388401822349
P00846,MT-ATP6,ATP synthase F(0) complex subunit a,Tier 1.5,0.928,1,A_surface,10,88.94,1,0,,,0,0,,1,NARP syndrome,0.760749518172638
P20963,CD247,T-cell surface glycoprotein CD3 zeta chain,Tier 1,0.923,1,A_surface,38,62.41,1,0,,,0,0,,1,immunodeficiency 25,0.7436838111879828
P55011,SLC12A2,Solute carrier family 12 member 2,Tier 1,0.92,1,A_surface,14,73.12,1,0,,,0,0,,1,Delpire-McNeill syndrome,0.7337659829979022
O15554,KCNN4,Intermediate conductance calcium-activated potassium channel protein 4,Tier 1.5,0.914,1,A_surface,17,84.19,1,0,,,0,0,,1,dehydrated hereditary stomatocytosis,0.7145864899974032
O75110,ATP9A,Probable phospholipid-transporting ATPase IIA,Tier 1.5,0.914,1,A_surface,4,84.19,1,0,,,0,0,,1,neurodevelopmental disorder with poor growth and behavioral abnormalities,0.7120328673255018
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.913,1,A_surface,5,56.41,1,0,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
P03891,MT-ND2,NADH-ubiquinone oxidoreductase chain 2,Tier 1,0.91,1,A_surface,7,95.12,1,0,,,0,0,,1,Leber hereditary optic neuropathy,0.6993991624020442
Q8N1F7,NUP93,Nuclear pore complex protein Nup93,Tier 1,0.909,1,A_surface,9,79.88,1,0,,,0,0,,1,"nephrotic syndrome, type 12",0.6970966479548709
O75787,ATP6AP2,Renin receptor,Tier 1,0.909,1,A_surface,10,79.19,1,0,,,0,0,,1,syndromic X-linked intellectual disability Hedera type,0.6955327890748848
P54289,CACNA2D1,Voltage-dependent calcium channel subunit alpha-2/delta-1,Tier 1,0.908,1,A_surface,30,86.56,1,0,,,0,0,,1,Seizure,0.6942469435259896
Q9NZ42,PSENEN,Gamma-secretase subunit PEN-2,Tier 1,0.905,1,A_surface,27,92.62,1,0,,,0,0,,1,hidradenitis suppurativa,0.6825090820129278
P19634,SLC9A1,Sodium/hydrogen exchanger 1,Tier 1,0.901,1,A_surface,20,67.56,1,0,,,0,0,,1,Lichtenstein-Knorr syndrome,0.6714801793153262
P51797,CLCN6,H(+)/Cl(-) exchange transporter 6,Tier 1.5,0.897,1,A_surface,3,77.81,1,0,,,0,0,,1,"neurodegeneration, childhood-onset, with hypotonia, respiratory insufficiency, and brain imaging abnormalities",0.6554030932062199
P21731,TBXA2R,Thromboxane A2 receptor,Tier 1.5,0.892,1,A_surface,6,86.25,1,0,,,0,0,,1,bleeding diathesis due to thromboxane synthesis deficiency,0.639967145559869
P08172,CHRM2,Muscarinic acetylcholine receptor M2,Tier 1,0.889,1,A_surface,17,72.06,1,0,,,0,0,,1,asthma,0.6301982693270526
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.888,1,A_surface,22,80.12,1,0,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636