id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q05086,,,Tier 1,0.753,1,unknown,27,80.75,1,0,,,0,0,,1,Angelman syndrome,0.8429347259838658
P04275,,,Tier 1.5,0.749,1,unknown,48,75.5,1,0,,,0,0,,1,Von Willebrand disease,0.8296081124598669
Q15858,,,Tier 1,0.747,1,unknown,43,69.06,1,0,,,0,0,,1,primary erythermalgia,0.8237835765987434
Q92608,,,Tier 1,0.734,1,unknown,6,79.81,1,0,,,0,0,,1,DOCK2 deficiency,0.7814025939223274
Q5T5Y3,,,Tier 1,0.694,1,unknown,4,54.34,1,0,,,0,0,,1,"cortical dysplasia, complex, with other brain malformations 12",0.6471266259726068
P43487,,,Tier 1,0.651,1,unknown,4,83.38,1,0,,,0,0,,1,HIV infection,0.5030392466541774
Q14213,,,Tier 1,0.628,1,unknown,4,87.62,1,0,,,0,0,,1,neurodegenerative disease,0.42776938116451996
F8WCM5,,,Tier 1,0.624,1,unknown,4,48.81,1,0,,,0,0,,1,neurodegenerative disease,0.4145162522265602
Q13131,,,Tier 1,0.614,1,unknown,12,79.56,1,0,,,0,0,,1,cardiovascular disease,0.37913864498012223
P07360,,,Tier 1,0.611,1,unknown,15,89.75,1,0,,,0,0,,1,complement deficiency,0.3695798546847018
P20339,,,Tier 1,0.611,1,unknown,14,84.88,1,0,,,0,0,,1,tuberculosis,0.3708733841760982
P08034,,,Tier 1,0.604,1,unknown,15,80.25,1,0,,,0,0,,0,Charcot-Marie-Tooth disease X-linked dominant 1,0.8483281160610058
Q96HW7,,,Tier 1,0.599,1,unknown,11,83.19,1,0,,,0,0,,1,systemic lupus erythematosus,0.3316421846062003
Q8NBJ9,,,Tier 1,0.598,1,unknown,7,80.25,1,0,,,0,0,,1,hypothyroidism,0.32686531914177924
P23415,,,Tier 1,0.597,1,unknown,9,84.0,1,0,,,0,0,,0,hereditary hyperekplexia,0.822516157871453
Q96Q15,,,Tier 1,0.593,1,unknown,10,76.88,1,0,,,0,0,,1,contracture,0.30952829622581673
Q15061,,,Tier 1,0.593,1,unknown,3,69.62,1,0,,,0,0,,1,triple-negative breast cancer,0.31136131887350776
Q13422,,,Tier 1,0.591,1,unknown,10,47.75,1,0,,,0,0,,0,pancytopenia due to IKZF1 mutations,0.8043234687306351
P01185,,,Tier 1.5,0.585,1,unknown,5,79.44,1,0,,,0,0,,0,neurohypophyseal diabetes insipidus,0.7825664629740794
P48067,SLC6A9,Sodium- and chloride-dependent glycine transporter 1,Tier 1,0.582,1,unknown,9,81.12,1,0,,,0,0,,0,atypical glycine encephalopathy,0.7733051820377859
P29973,,,Tier 1,0.566,1,unknown,19,76.25,1,0,,,0,0,,0,retinitis pigmentosa,0.7206608041231198
P98073,,,Tier 1,0.563,1,unknown,14,81.5,1,0,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
P07305,,,Tier 1.5,0.562,1,unknown,16,68.75,1,0,,,0,0,,1,open-angle glaucoma,0.2081722206162343
Q8N9N8,,,Tier 1,0.554,1,unknown,4,75.69,1,0,,,0,0,,1,Nestor-Guillermo progeria syndrome,0.17918659722662342
Q5SWA1,,,Tier 1.5,0.54,1,unknown,5,49.03,1,0,,,0,0,,0,"microcephaly, short stature, and impaired glucose metabolism 2",0.6334721902580683
O15393,,,Tier 1,0.535,1,unknown,31,79.38,1,0,,,0,0,,0,COVID-19,0.6157541390484623
Q13639,,,Tier 1,0.532,1,unknown,3,80.88,1,0,,,0,0,,0,schizophrenia,0.6060830827022777
O43614,,,Tier 1,0.53,1,unknown,11,78.94,1,0,,,0,0,,0,insomnia,0.5988748728311054
O43543,,,Tier 1.5,0.529,1,unknown,16,87.12,1,0,,,0,0,,0,spermatogenic failure 50,0.5955217891975265
O75616,ERAL1,"GTPase Era, mitochondrial",Tier 1,0.504,1,unknown,2,77.94,1,0,,,0,0,,0,neurodegenerative disease,0.5128349940245936
Q15291,,,Tier 1,0.5,1,unknown,27,77.75,1,0,,,0,0,,0,neurodegenerative disease,0.500512770014237
P25025,,,Tier 1,0.499,1,unknown,18,79.56,1,0,,,0,0,,0,WHIM syndrome 2,0.4956521666475962
P06307,,,Tier 1,0.487,1,unknown,9,65.12,1,0,,,0,0,,0,Abnormality of the skeletal system,0.45523854320041374
Q6NW34,RMP64,Ribonuclease MRP subunit P64,Tier 1.5,0.485,1,unknown,3,64.0,1,0,,,0,0,,0,anauxetic dysplasia 3,0.44914218451265836
Q9UNN5,,,Tier 1,0.475,1,unknown,16,77.0,1,0,,,0,0,,0,atrial fibrillation,0.41761152415302133
Q9NVH2,,,Tier 1,0.465,1,unknown,8,88.06,1,0,,,0,0,,0,neurodegenerative disease,0.38183943401611947
Q86X95,CIRSR,Corepressor of RBPJ and splicing regulator,Tier 1,0.463,1,unknown,2,59.72,1,0,,,0,0,,0,major depressive disorder,0.3767349972483621
Q14416,,,Tier 1,0.461,1,unknown,31,85.69,1,0,,,0,0,,0,schizophrenia,0.36850365898315596
P13725,,,Tier 1,0.446,1,unknown,3,78.75,1,0,,,0,0,,0,coronary artery disease,0.3209548186332283
P32248,,,Tier 1,0.445,1,unknown,7,78.38,1,0,,,0,0,,0,neurodegenerative disease,0.31793347108990094
Q03188,,,Tier 1,0.437,1,unknown,14,48.03,1,0,,,0,0,,0,pernicious anemia,0.28985906769534225
Q32NC0,RMP24,Ribonuclease MRP protein subunit p24,Tier 1.5,0.43,1,unknown,3,74.06,1,0,,,0,0,,0,connective tissue disease,0.2652381012117321
Q9NY61,,,Tier 1.5,0.424,1,unknown,3,64.81,1,0,,,0,0,,0,skin neoplasm,0.24706398094697377
P02778,,,Tier 1,0.387,1,unknown,6,89.56,1,0,,,0,0,,0,rheumatoid arthritis,0.1225158134105281
A8MTA8,CIMIP2B,Ciliary microtubule inner protein 2B,Tier 1,0.383,1,unknown,2,68.75,1,0,,,0,0,,0,Meckel syndrome,0.11087395640541053
P49842,WHR1,Winged helix repair factor 1,Tier 1.5,0.361,1,unknown,5,87.44,1,0,,,0,0,,0,melanoma,0.036990092138582946
A0A5C2GQT9,,,Tier 1,0.35,1,unknown,5,96.38,1,0,,,0,0,,0,,
P0DOX7,,Immunoglobulin kappa light chain,Tier 1,0.35,1,unknown,14,96.19,1,0,,,0,0,,0,,
P23724,PRE7,Proteasome subunit beta type-6,Tier 1,0.35,1,unknown,30,94.62,1,0,,,0,0,,0,,
P25043,PUP1,Proteasome subunit beta type-2,Tier 1,0.35,1,unknown,30,93.62,1,0,,,0,0,,0,,