id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12263,,,Tier 1,0.9,7,63.59,1,0,,,,0,0,,0,,
Q12879,GRIN2A,"Glutamate receptor ionotropic, NMDA 2A",Tier 1,0.88,37,60.84,1,0,,,,0,0,,0,Landau-Kleffner syndrome,0.8407159711916629
Q5T848,GPR158,Metabotropic glycine receptor,Tier 1,0.839,6,58.03,1,0,,,,0,0,,0,diverticular disease,0.4384404783771627
P0DSE2,TRB,M1-specific T cell receptor beta chain,Tier 1,0.83,5,90.12,1,0,,,,0,0,,0,,
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,80.12,1,0,,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
Q9NS82,SLC7A10,Asc-type amino acid transporter 1,Tier 1,0.803,4,83.38,1,0,,,,0,0,,0,asthma,0.5295411410172121
O60895,RAMP2,Receptor activity-modifying protein 2,Tier 1,0.802,10,80.94,1,0,,,,0,0,,0,diabetes mellitus,0.4219370007650345
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,90.88,1,0,,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,87.12,1,0,,,,0,0,,1,neurodegenerative disease,0.45156128674958135
P01909,HLA-DQA1,"HLA class II histocompatibility antigen, DQ alpha 1 chain",Tier 1,0.792,27,87.94,1,0,,,,0,0,,0,Pleural Mesothelioma,0.1228600330569846
Q13639,,,Tier 1,0.781,3,80.88,1,0,,,,0,0,,0,schizophrenia,0.6060830827022777
O15393,,,Tier 1,0.775,31,79.38,1,0,,,,0,0,,0,COVID-19,0.6157541390484623
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.769,20,91.12,1,0,,,,0,0,,0,psoriasis,0.7914863943708039
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,80.56,1,0,,,,0,0,,1,C1Q deficiency,0.6233532074390745
P98073,,,Tier 1,0.761,14,81.5,1,0,,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
O75762,TRPA1,Transient receptor potential cation channel subfamily A member 1,Tier 1,0.76,17,81.94,1,0,,,,0,0,,0,familial episodic pain syndrome with predominantly upper body involvement,0.6615353934604322
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,,1,0,,,,0,0,,1,,
P07360,,,Tier 1,0.755,15,89.75,1,0,,,,0,0,,1,complement deficiency,0.3695798546847018
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,85.0,1,0,,,,0,0,,1,Myasthenia gravis,0.5932721106551206
O43614,,,Tier 1,0.75,11,78.94,1,0,,,,0,0,,0,insomnia,0.5988748728311054
O15245,SLC22A1,Solute carrier family 22 member 1,Tier 1,0.744,16,84.25,1,0,,,,0,0,,0,coronary artery disease,0.5384890077265535
Q8N158,GPC2,Glypican-2,Tier 1,0.744,2,79.06,1,0,,,,0,0,,0,COVID-19,0.5409211817593593
O43526,KCNQ2,Potassium voltage-gated channel subfamily KQT member 2,Tier 1,0.744,24,58.19,1,0,,,,0,0,,0,Benign familial neonatal seizures,0.8423358217314708
P40879,SLC26A3,Chloride anion exchanger,Tier 1,0.742,13,85.06,1,0,,,,0,0,,0,congenital secretory chloride diarrhea 1,0.8189631913308207
D7RIG0,HLA-DRB1,,Tier 1,0.74,10,84.94,1,0,,,,0,0,,0,,
A0A1B0GX56,TRDV1,T cell receptor delta variable 1,Tier 1,0.737,7,90.69,1,0,,,,0,0,,0,colorectal carcinoma,0.07391597093694036
Q14028,CNGB1,Cyclic nucleotide-gated channel beta-1,Tier 1,0.734,11,57.66,1,0,,,,0,0,,0,retinitis pigmentosa,0.7931901344765326
P41145,OPRK1,Kappa-type opioid receptor,Tier 1,0.725,28,79.5,1,0,,,,0,0,,0,alcohol dependence,0.6106562988740131
P23416,GLRA2,Glycine receptor subunit alpha-2,Tier 1,0.723,13,83.81,1,0,,,,0,0,,0,"intellectual developmental disorder, X-linked, syndromic, Pilorge type",0.7805605973560554
P11215,ITGAM,Integrin alpha-M,Tier 1,0.72,30,86.25,1,0,,,,0,0,,1,systemic lupus erythematosus,0.30502849242596436
P29033,GJB2,Gap junction beta-2 protein,Tier 1,0.72,24,86.19,1,0,,,,0,0,,0,palmoplantar keratoderma-deafness syndrome,0.8149616697051898
B7Z8K6,TRDC,T cell receptor delta constant,Tier 1,0.72,12,81.38,1,0,,,,0,0,,0,,
A0A0B4J271,TRAV12-3,T cell receptor alpha variable 12-3,Tier 1,0.715,12,92.56,1,0,,,,0,0,,0,ulcerative colitis,0.003139210371371825
Q695T7,SLC6A19,Sodium-dependent neutral amino acid transporter B(0)AT1,Tier 1,0.715,19,90.0,1,0,,,,0,0,,0,Hartnup disease,0.8464240093600148
Q9NV96,TMEM30A,Cell cycle control protein 50A,Tier 1,0.71,33,89.5,1,0,,,,0,0,,1,atrial fibrillation,0.31177132249681394
P49019,HCAR3,Hydroxycarboxylic acid receptor 3,Tier 1,0.709,11,79.19,1,0,,,,0,0,,0,Oral ulcer,0.3943093179045574
O15342,ATP6V0E1,V-type proton ATPase subunit e 1,Tier 1,0.708,9,92.88,1,0,,,,0,0,,0,multiple myeloma,0.18220286553988743
Q9BXJ8,TMEM120A,Transmembrane protein 120A,Tier 1,0.706,5,89.25,1,0,,,,0,0,,0,congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency,0.1609725589293368
O60486,PLXNC1,Plexin-C1,Tier 1,0.703,4,79.06,1,0,,,,0,0,,1,asthma,0.532656225351722
P22888,LHCGR,Lutropin-choriogonadotropic hormone receptor,Tier 1,0.698,4,80.12,1,0,,,,0,0,,0,"Leydig cell hypoplasia, type 1",0.783461117057047
Q07699,SCN1B,Sodium channel regulatory subunit beta-1,Tier 1,0.695,36,87.06,1,0,,,,0,0,,0,Generalized epilepsy with febrile seizures-plus,0.7638796221342504
P30989,NTSR1,Neurotensin receptor type 1,Tier 1,0.695,24,79.62,1,0,,,,0,0,,0,Cough,0.31206841983343936
Q8NBJ9,,,Tier 1,0.688,7,80.25,1,0,,,,0,0,,1,hypothyroidism,0.32686531914177924
P63092,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Tier 1,0.683,100,91.31,1,0,,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
Q14213,,,Tier 1,0.683,4,87.62,1,0,,,,0,0,,1,neurodegenerative disease,0.42776938116451996
Q96RJ0,TAAR1,Trace amine-associated receptor 1,Tier 1,0.68,17,90.06,1,0,,,,0,0,,0,schizophrenia,0.41827765417829765
Q9UNN8,PROCR,Endothelial protein C receptor,Tier 1,0.68,13,86.44,1,0,,,,0,0,,1,venous thromboembolism,0.5497662282245215
Q14973,SLC10A1,Hepatic sodium/bile acid cotransporter,Tier 1,0.679,11,83.5,1,0,,,,0,0,,0,"hypercholanemia, familial, 2",0.6937781800382379
O15399,GRIN2D,"Glutamate receptor ionotropic, NMDA 2D",Tier 1,0.675,13,63.22,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 46",0.7529662497608808
Q8TDV5,GPR119,Glucose-dependent insulinotropic receptor,Tier 1,0.67,9,86.75,1,0,,,,0,0,,0,neurodegenerative disease,0.2992783744181862