id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,95.62,1,0,,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
P35346,SSTR5,Somatostatin receptor type 5,Tier 1.5,0.841,7,81.25,1,0,,,,0,0,,0,acromegaly,0.6094707180356006
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,86.06,1,0,,,,0,0,,1,"cleft palate, proliferative retinopathy, and developmental delay",0.5770707112957068
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.835,4,83.25,1,0,,,,0,0,,0,progressive familial intrahepatic cholestasis type 3,0.851728159166962
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,89.31,1,0,,,,0,0,,1,neurodegenerative disease,0.5385822922582763
O75899,GABBR2,Gamma-aminobutyric acid type B receptor subunit 2,Tier 1.5,0.824,26,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 59",0.7356789732167734
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,89.69,1,0,,,,0,0,,1,congestive heart failure,0.5999952111132625
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.802,13,80.69,1,0,,,,0,0,,0,Congenital myasthenic syndromes,0.8223287249629152
P29275,ADORA2B,Adenosine receptor A2b,Tier 1.5,0.801,4,88.12,1,0,,,,0,0,,0,migraine disorder,0.6060142180667235
Q9H2X9,SLC12A5,Solute carrier family 12 member 5,Tier 1.5,0.8,2,78.44,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6993945840545625
Q13705,ACVR2B,Activin receptor type-2B,Tier 1.5,0.791,9,83.31,1,0,,,,0,0,,0,Heterotaxia,0.7109733260300651
Q96CS2,HAUS1,HAUS augmin-like complex subunit 1,Tier 1.5,0.79,1,88.62,1,0,,,,0,0,,0,device complication,0.27547205131467467
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,Tier 1.5,0.782,6,73.88,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 14",0.8165232785825526
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.777,4,84.38,1,0,,,,0,0,,0,glucose-galactose malabsorption,0.8220991027793896
P30542,ADORA1,Adenosine receptor A1,Tier 1.5,0.777,5,92.44,1,0,,,,0,0,,0,asthma,0.7232344154541454
P43004,SLC1A2,Excitatory amino acid transporter 2,Tier 1.5,0.768,7,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 41",0.7772658651722512
O60931,CTNS,Cystinosin,Tier 1.5,0.764,6,89.44,1,0,,,,0,0,,0,nephropathic cystinosis,0.841818398377195
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,91.38,1,0,,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
Q9Y5Y9,SCN10A,Sodium channel protein type 10 subunit alpha,Tier 1.5,0.761,8,67.31,1,0,,,,0,0,,0,atrial fibrillation,0.7126293968222049
O15552,FFAR2,Free fatty acid receptor 2,Tier 1.5,0.759,11,88.06,1,0,,,,0,0,,0,type 1 diabetes mellitus,0.09182737097469269
P35462,DRD3,D(3) dopamine receptor,Tier 1.5,0.757,6,75.38,1,0,,,,0,0,,0,schizophrenia,0.6687268941647396
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.755,19,72.06,1,0,,,,0,0,,1,Knobloch syndrome,0.5526223217595396
O00591,GABRP,Gamma-aminobutyric acid receptor subunit pi,Tier 1.5,0.752,2,79.12,1,0,,,,0,0,,0,migraine disorder,0.6191855696357259
P0DMS8,ADORA3,Adenosine receptor A3,Tier 1.5,0.751,5,91.31,1,0,,,,0,0,,0,migraine disorder,0.6052134617149065
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.75,9,76.75,1,0,,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
P46089,GPR3,G-protein coupled receptor 3,Tier 1.5,0.748,8,81.81,1,0,,,,0,0,,0,hypertension,0.18488148594282316
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.743,1,77.88,1,0,,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
Q86YT5,SLC13A5,Na(+)/citrate cotransporter,Tier 1.5,0.739,4,86.06,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6853612674939716
Q9H741,SPRING1,SREBP regulating gene protein,Tier 1.5,0.725,2,81.31,1,0,,,,0,0,,0,Anxiety,0.35244791107935663
P48764,SLC9A3,Sodium/hydrogen exchanger 3,Tier 1.5,0.725,1,65.94,1,0,,,,0,0,,0,congenital sodium diarrhea,0.6503153836708786
P41968,MC3R,Melanocortin receptor 3,Tier 1.5,0.723,6,83.88,1,0,,,,0,0,,0,alcohol drinking,0.3298167673588826
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.72,3,76.69,1,0,,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
Q9NZD1,GPRC5D,G-protein coupled receptor family C group 5 member D,Tier 1.5,0.716,2,76.06,1,0,,,,0,0,,0,multiple myeloma,0.5555243624684951
Q9BZV2,SLC19A3,Thiamine transporter 2,Tier 1.5,0.712,19,81.56,1,0,,,,0,0,,0,biotin-responsive basal ganglia disease,0.8189646480334981
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.711,5,56.41,1,0,,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
Q401N2,ZACN,Ligand-gated cation channel ZACN,Tier 1.5,0.711,9,77.56,1,0,,,,0,0,,0,atrial heart septal defect,0.20510272364083965
Q2M385,MPEG1,Macrophage-expressed gene 1 protein,Tier 1.5,0.71,5,82.75,1,0,,,,0,0,,0,immunodeficiency 77,0.7043238859467001
Q8N6U8,GPR161,G-protein coupled receptor 161,Tier 1.5,0.708,2,68.62,1,0,,,,0,0,,0,medulloblastoma,0.583267884969527
P34995,PTGER1,Prostaglandin E2 receptor EP1 subtype,Tier 1.5,0.707,1,74.81,1,0,,,,0,0,,0,erectile dysfunction,0.5684936888228123
Q8TDU6,GPBAR1,G-protein coupled bile acid receptor 1,Tier 1.5,0.703,5,80.44,1,0,,,,0,0,,0,cholelithiasis,0.13532265841527905
Q1HG43,DUOXA1,Dual oxidase maturation factor 1,Tier 1.5,0.703,2,82.44,1,0,,,,0,0,,0,familial thyroid dyshormonogenesis,0.33299144907091627
Q99705,MCHR1,Melanin-concentrating hormone receptor 1,Tier 1.5,0.702,10,84.44,1,0,,,,0,0,,0,carpal tunnel syndrome,0.3206604001931773
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.702,2,84.69,1,0,,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P33032,MC5R,Melanocortin receptor 5,Tier 1.5,0.693,3,82.62,1,0,,,,0,0,,0,color vision disorder,0.32934412559476917
P01825,IGHV4-59,Immunoglobulin heavy variable 4-59,Tier 1.5,0.69,3,91.56,1,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P25929,NPY1R,Neuropeptide Y receptor type 1,Tier 1.5,0.69,6,79.88,1,0,,,,0,0,,0,mathematical ability,0.4585181664868048
Q16280,CNGA2,Cyclic nucleotide-gated channel alpha-2,Tier 1.5,0.689,2,77.75,1,0,,,,0,0,,0,neurodegenerative disease,0.3406621245682051
Q6NT16,SLC18B1,MFS-type transporter SLC18B1,Tier 1.5,0.688,4,84.62,1,0,,,,0,0,,1,Parkinson disease,0.276931649354752
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,Tier 1.5,0.685,5,68.81,1,0,,,,0,0,,1,"developmental and epileptic encephalopathy, 11",0.8388748085806758
Q9UM01,SLC7A7,Y+L amino acid transporter 1,Tier 1.5,0.685,5,83.81,1,0,,,,0,0,,0,lysinuric protein intolerance,0.8450026270275782