id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
P21730,C5AR1,C5a anaphylatoxin chemotactic receptor 1,Tier 1,0.741,19,85.75,1,0,,,,1,5,"33495506,29981048,29327939,28288993,25901944",0,anti-neutrophil cytoplasmic antibody-associated vasculitis,0.5076734733894334
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P46094,XCR1,Chemokine XC receptor 1,Tier 1.5,0.715,1,84.94,1,0,,,,1,1,35212764,0,COVID-19,0.459103766220463
P32239,CCKBR,Gastrin/cholecystokinin type B receptor,Tier 1.5,0.713,5,75.75,1,0,,,,1,2,"33776434,27754762",0,gastroesophageal reflux disease,0.4256110167566802
P20809,IL11,Interleukin-11,Tier 1,0.712,8,82.62,1,0,,,,1,8,"39408993,39263947,28791655,27878687,25696907,24629635",0,"osteoarthritis, hip",0.31754029889853136
P25106,ACKR3,Atypical chemokine receptor 3,Tier 1.5,0.71,14,82.44,1,0,,,,1,2,"40401615,28670693",0,oculomotor-abducens synkinesis,0.49893280382434735
P15309,ACP3,Prostatic acid phosphatase,Tier 1,0.695,17,92.25,1,0,,,,1,3,"41890985,25591398",0,prostate cancer,0.5521391557206573
P48061,CXCL12,Stromal cell-derived factor 1,Tier 1,0.685,34,83.25,1,0,,,,1,36,"41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275",0,HIV-1 infection,0.3675509850165065
Q6NW40,RGMB,Repulsive guidance molecule B,Tier 1,0.683,11,79.44,1,0,,,,1,1,39263947,0,Abnormality of the skeletal system,0.42535629367019584
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.681,8,63.03,1,0,,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
Q9UEF7,KL,Klotho,Tier 1,0.676,6,89.06,1,0,,,,1,19,"41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411",0,type 2 diabetes mellitus,0.5587488336100863
P51681,CCR5,C-C chemokine receptor type 5,Tier 1,0.674,25,85.38,1,0,,,,1,23,"36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773",0,HIV infection,0.7442590579227027
P56704,WNT3A,Protein Wnt-3a,Tier 1,0.665,4,88.31,1,0,,,,1,1,37231925,0,neurodegenerative disease,0.5271953966006525
P05113,IL5,Interleukin-5,Tier 1,0.664,5,86.69,1,0,,,,1,12,"40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585",0,asthma,0.6399821251487101
Q12809,KCNH2,Voltage-gated inwardly rectifying potassium channel KCNH2,Tier 1,0.655,23,62.75,1,0,,,,1,1,22617876,0,Romano-Ward syndrome,0.8549238933917284
P08100,RHO,Rhodopsin,Tier 1.5,0.645,4,88.75,1,0,,,,1,45,"41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760",0,retinitis pigmentosa,0.8481942240861982
P15391,CD19,B-lymphocyte antigen CD19,Tier 1.5,0.642,4,62.22,1,0,,,,1,13,"41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492",0,"immunodeficiency, common variable, 3",0.6821072538733047
Q13651,IL10RA,Interleukin-10 receptor subunit alpha,Tier 1,0.641,7,62.0,1,0,,,,1,2,"25870409,25558474",0,Autosomal recessive early-onset inflammatory bowel disease,0.8151052076044897
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.641,4,75.62,1,0,,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
P45844,ABCG1,ATP-binding cassette sub-family G member 1,Tier 1.5,0.639,5,81.12,1,0,,,,1,1,41854184,0,neurodegenerative disease,0.3915225348167794
P51654,GPC3,Glypican-3,Tier 1.5,0.636,4,75.06,1,0,,,,1,65,"42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753",0,Simpson-Golabi-Behmel syndrome type 1,0.762708583613362
P31785,IL2RG,Cytokine receptor common subunit gamma,Tier 1.5,0.635,14,75.5,1,0,,,,1,2,"30800133,33869115",0,gamma chain deficiency,0.8469997000418428
O95342,ABCB11,Bile salt export pump,Tier 1.5,0.624,8,83.12,1,0,,,,1,1,36313979,0,progressive familial intrahepatic cholestasis type 2,0.8372060401943777
O00206,TLR4,Toll-like receptor 4,Tier 1,0.621,15,89.19,1,0,,,,1,32,"41864915,41444487,40521190,39897575,38931862,38742374,38280803,37360693,36916435,36908619,35410404,35402075,35189346,34831332,32784904,29910175,29250957,25483705",0,major depressive disorder,0.5065500149392951
O14625,CXCL11,C-X-C motif chemokine 11,Tier 1,0.62,2,79.94,1,0,,,,1,4,"36649818,32784904,30578658,23935890",0,neoplasm,0.11537901464416651
P49238,CX3CR1,CX3C chemokine receptor 1,Tier 1.5,0.62,2,80.5,1,0,,,,1,2,28727998,0,age-related macular degeneration,0.4006854573775187
Q06141,REG3A,Regenerating islet-derived protein 3-alpha,Tier 1.5,0.62,4,89.0,1,0,,,,1,2,"39695715,24771595",0,alcohol drinking,0.29724052454892086
Q07325,CXCL9,C-X-C motif chemokine 9,Tier 1.5,0.617,1,87.44,1,0,,,,1,7,"42046114,37395276,35204399,35018777,33742062,27959341,27819142",0,neoplasm,0.1199067650750674
P41146,OPRL1,Nociceptin receptor,Tier 1.5,0.61,4,82.31,1,0,,,,1,1,14970396,0,neurodegenerative disease,0.4039002828932129
P15018,LIF,Leukemia inhibitory factor,Tier 1,0.605,5,87.12,1,0,,,,1,38,"41611413,38359901,37549567,37175248,36838669,33640806,32253765,31791592,31357280,30771937,30037541,29289340,28963578,28763192,27855943,26877178,26764106,26695234,26344338,26113415,25335821,25311485,25035238,24716781,22648816,22471443,27335672,20673578,20151395,19803140,18646283,17315151,16331583,16053313,11791582,9823713,39571081,31461490",0,alcohol drinking,0.24197086949132446
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.605,100,49.22,1,0,,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P04201,MAS1,Proto-oncogene Mas,Tier 1.5,0.605,3,83.5,1,0,,,,1,10,"40518278,34016094,30415442,27936442,23618401",0,Abnormality of the skeletal system,0.40450059258174326
P41231,P2RY2,P2Y purinoceptor 2,Tier 1.5,0.605,3,78.88,1,0,,,,1,1,33911033,0,nontoxic goiter,0.43556889579550895
P46059,SLC15A1,Solute carrier family 15 member 1,Tier 1,0.603,3,87.0,1,0,,,,1,1,26811678,0,cleft palate,0.3279926002389253
P13500,CCL2,C-C motif chemokine 2,Tier 1,0.6,14,86.94,1,0,,,,1,34,"42007960,41360349,41207524,39422353,39317671,38016488,34440571,32784904,31267721,31039360,30056058,29111236,28385802,28315675,28186566,27878687,27392463,26868748,25970072,25901662,25457849,25457848,25236655,24694577,24561613,24481979,21813474,21147843,19156777,18997060,18776253,18258851,11591377,36508319",0,Crohn's disease,0.44619484388731423
Q8NER1,TRPV1,Transient receptor potential cation channel subfamily V member 1,Tier 1.5,0.6,8,71.94,1,0,,,,1,2,"40855286,28604222",0,migraine disorder,0.6269329225883602
P0DSE1,TRA,M1-specific T cell receptor alpha chain,Tier 1.5,0.6,3,88.81,1,0,,,,1,7,"41693575,41636061,39837202,37015819,28860472,25844955,19457263",0,,
P49682,CXCR3,C-X-C chemokine receptor type 3,Tier 1,0.595,12,80.56,1,0,,,,1,2,"27959341,15938634",0,neoplasm,0.11982670035221332
Q9NP91,SLC6A20,Sodium- and chloride-dependent transporter XTRP3,Tier 1,0.594,10,93.12,1,0,,,,1,1,35212764,0,COVID-19,0.5415298766216101
P41159,LEP,Leptin,Tier 1,0.582,10,81.12,1,0,,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
Q9BYF1,ACE2,Angiotensin-converting enzyme 2,Tier 1,0.58,100,90.69,1,0,,,,1,91,"41716474,41541792,41274248,40642289,40333723,40321580,40227272,39964138,39923730,39281706,38973558,38553521,37932762,37808754,37692001,37666993,37385465,37375202,36950312,36822303,36714461,36683236,36581924,36073793,35972202,35910791,35907639,35542182,34876524,34855379,34847324,34798263,34696413,34619249,34458322,34282416,34248841,34230708,34230707,34166652,34123223,33684258,33683787,33629859,33561300,33389440,32981365,32838280,32551560,36288301,36170362,35748608,34953639",0,COVID-19,0.6925739512122528
P55259,GP2,Pancreatic secretory granule membrane major glycoprotein GP2,Tier 1.5,0.577,4,78.62,1,0,,,,1,3,"36902059,25483705,24334484",0,type 2 diabetes mellitus,0.5235291484788168