id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P01137,TGFB1,Transforming growth factor beta-1 proprotein,Tier 1,0.78,1,A2_pm_peripheral,20,79.56,1,0,,,1,4,"38132522,32370304,16775010,11856769",1,Camurati-Engelmann disease,0.7995305374459716
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.776,1,A2_pm_peripheral,6,79.56,1,0,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
Q92743,HTRA1,Serine protease HTRA1,Tier 1,0.768,1,A2_pm_peripheral,18,83.25,1,0,,,1,1,31988066,1,"cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2",0.7611877816680132
P35221,CTNNA1,Catenin alpha-1,Tier 1,0.765,1,A2_pm_peripheral,10,82.94,1,0,,,1,2,40265971,1,Butterfly-shaped pigment dystrophy,0.7487735496199569
P84077,ARF1,ADP-ribosylation factor 1,Tier 1,0.755,1,A2_pm_peripheral,36,85.94,1,0,,,1,3,"30965174,11320245",1,periventricular nodular heterotopia 8,0.7173626622431929
Q13546,RIPK1,Receptor-interacting serine/threonine-protein kinase 1,Tier 1,0.749,1,A2_pm_peripheral,39,69.75,1,0,,,1,2,"41290466,35919280",1,immunodeficiency 57,0.698121745966467
P50148,GNAQ,Guanine nucleotide-binding protein G(q) subunit alpha,Tier 1,0.748,1,A2_pm_peripheral,30,93.0,1,0,,,1,1,40015005,1,Sturge-Weber syndrome,0.6941111530708174
O95786,RIGI,Antiviral innate immune response receptor RIG-I,Tier 1,0.735,1,A2_pm_peripheral,44,85.19,1,0,,,1,6,"34487794,33253193,32946572,31600868,26018150,22127865",1,Singleton-Merten dysplasia,0.6485708110478319
P23921,RRM1,Ribonucleoside-diphosphate reductase large subunit,Tier 1,0.724,1,A2_pm_peripheral,12,92.25,1,0,,,1,1,21955496,1,non-small cell lung carcinoma,0.6122881671315019
P32121,ARRB2,Beta-arrestin-2,Tier 1.5,0.719,1,A2_pm_peripheral,1,83.81,1,0,,,1,4,"24736311,40652239,29054528",1,cancer,0.5962458729823639
P04406,GAPDH,Glyceraldehyde-3-phosphate dehydrogenase,Tier 1,0.706,1,A2_pm_peripheral,21,98.12,1,0,,,1,11,"39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199",1,neurodegenerative disease,0.55307368855439
P31948,STIP1,Stress-induced-phosphoprotein 1,Tier 1.5,0.689,1,A2_pm_peripheral,8,89.75,1,0,,,1,7,"41406518,38012811,34831332,32614006,27681499,24654750,24013070",1,neurodegenerative disease,0.4967711525222825
P21980,TGM2,Protein-glutamine gamma-glutamyltransferase 2,Tier 1.5,0.688,1,A2_pm_peripheral,17,92.88,1,0,,,1,1,35980938,1,neurodegenerative disease,0.49455272812698803
P49327,FASN,Fatty acid synthase,Tier 1,0.68,1,A2_pm_peripheral,34,85.44,1,0,,,1,1,41854184,1,dengue disease,0.46815584653391107
P63098,PPP3R1,Calcineurin subunit B type 1,Tier 1.5,0.673,1,A2_pm_peripheral,21,91.12,1,0,,,1,2,39263947,1,Abnormality of the skeletal system,0.44389060142742937
P08238,HSP90AB1,Heat shock protein HSP 90-beta,Tier 1,0.661,1,A2_pm_peripheral,32,84.31,1,0,,,1,1,35921069,1,multiple myeloma,0.40496963397728575
P06702,S100A9,Protein S100-A9,Tier 1,0.651,1,A2_pm_peripheral,13,94.31,1,0,,,1,9,"41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041",1,inborn error of immunity,0.36994943453938645
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.618,1,A2_pm_peripheral,100,49.22,1,0,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P41159,LEP,Leptin,Tier 1,0.606,1,A2_pm_peripheral,10,81.12,1,0,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
P43351,RAD52,DNA repair protein RAD52 homolog,Tier 1,0.528,1,A2_pm_peripheral,11,69.62,1,0,,,1,6,"37288783,32945515,31495919,26784987,24500205,23836560",0,Abnormality of the skeletal system,0.45994164258033876
O75182,SIN3B,Paired amphipathic helix protein Sin3b,Tier 1.5,0.501,1,A2_pm_peripheral,4,68.0,1,0,,,1,2,16914451,0,syndromic intellectual disability,0.37050380432141355
P55089,UCN,Urocortin,Tier 1.5,0.469,1,A2_pm_peripheral,6,68.25,1,0,,,1,3,"30221506,26488412,23248006",0,neurodegenerative disease,0.26311734927710556