id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21359,NF1,Neurofibromin,Tier 1.5,0.965,1,A_surface,26,87.19,1,0,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
P04839,CYBB,NADPH oxidase 2,Tier 1,0.959,1,A_surface,6,90.25,1,0,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
P29965,CD40LG,CD40 ligand,Tier 1,0.954,1,A_surface,8,82.62,1,0,,,1,6,"37331977,36203210,26504624",1,hyper-IgM syndrome type 1,0.8451678829647167
P37173,TGFBR2,TGF-beta receptor type-2,Tier 1,0.952,1,A_surface,22,81.0,1,0,,,1,8,"32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769",1,Loeys-Dietz syndrome,0.8390072008866913
P19438,TNFRSF1A,Tumor necrosis factor receptor superfamily member 1A,Tier 1,0.951,1,A_surface,13,71.38,1,0,,,1,1,35197258,1,TNF receptor 1-associated periodic fever syndrome,0.8352778213184682
P06744,GPI,Glucose-6-phosphate isomerase,Tier 1,0.949,1,A_surface,13,97.94,1,0,,,1,19,"41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815",1,hemolytic anemia due to glucophosphate isomerase deficiency,0.8306909118751346
P36897,TGFBR1,TGF-beta receptor type-1,Tier 1,0.948,1,A_surface,44,84.19,1,0,,,1,1,41089000,1,Loeys-Dietz syndrome 1,0.8275292516338373
P22607,FGFR3,Fibroblast growth factor receptor 3,Tier 1,0.948,1,A_surface,13,74.19,1,0,,,1,6,"38569854,37704353,34864168,33952673,31357131",1,achondroplasia,0.8270702096931246
P04156,PRNP,Major prion protein,Tier 1,0.947,1,A_surface,70,64.19,1,0,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
P05106,ITGB3,Integrin beta-3,Positive Control,0.946,1,A_surface,123,87.0,1,1,8T2U,8T2V,1,2,"22133781,23544955",1,Glanzmann thrombasthenia 1,0.8208115968652424
P08069,IGF1R,Insulin-like growth factor 1 receptor,Tier 1,0.945,1,A_surface,46,78.0,1,0,,,1,10,"40997970,39263947,33410883,30041514,23373648,16019422,15231297",1,growth delay due to insulin-like growth factor I resistance,0.8166352227841136
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,Tier 1.5,0.945,1,A_surface,14,72.69,1,0,,,1,4,"33334063,32127469,28010895,30594071",1,gastrointestinal stromal tumor,0.8167494524079806
Q13563,PKD2,Polycystin-2,Tier 1,0.943,1,A_surface,31,70.12,1,0,,,1,3,"41315228,36126144",1,polycystic kidney disease 2,0.810960823768978
P58335,ANTXR2,Anthrax toxin receptor 2,Tier 1,0.941,1,A_surface,14,71.81,1,0,,,1,4,"41503480,41083485,41020397,40313273",1,hyaline fibromatosis syndrome,0.8028849863986661
P61073,CXCR4,C-X-C chemokine receptor type 4,Tier 1,0.94,1,A_surface,33,82.25,1,0,,,1,17,"40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187",1,WHIM syndrome,0.8009225456235435
P15529,CD46,Membrane cofactor protein,Tier 1.5,0.934,1,A_surface,7,82.12,1,0,,,1,9,"35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032",1,atypical hemolytic-uremic syndrome with MCP/CD46 anomaly,0.7798469882597787
P13987,CD59,CD59 glycoprotein,Tier 1,0.932,1,A_surface,17,79.31,1,0,,,1,1,19915929,1,primary CD59 deficiency,0.7738276843579196
P02511,CRYAB,Alpha-crystallin B chain,Tier 1,0.925,1,A_surface,21,75.75,1,0,,,1,2,"28720498,23530262",1,myofibrillar myopathy 2,0.7505030087389963
Q14432,PDE3A,"cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A",Tier 1,0.924,1,A_surface,9,60.25,1,0,,,1,1,34456709,1,Brachydactyly - arterial hypertension,0.7468849549430213
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.921,1,A_surface,7,77.88,1,0,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
P07204,THBD,Thrombomodulin,Tier 1,0.92,1,A_surface,13,78.62,1,0,,,1,5,"41988704,34708097,28549218,21526769,7622501",1,thrombomodulin-related bleeding disorder,0.7323266135403641
Q9H244,P2RY12,P2Y purinoceptor 12,Tier 1,0.919,1,A_surface,5,84.44,1,0,,,1,2,"32679592,19509485",1,platelet-type bleeding disorder 8,0.7304079345653686
P08575,PTPRC,Receptor-type tyrosine-protein phosphatase C,Tier 1,0.916,1,A_surface,6,76.06,1,0,,,1,1,25251012,1,immunodeficiency 104,0.7200430416648742
Q9UNQ0,ABCG2,Broad substrate specificity ATP-binding cassette transporter ABCG2,Tier 1,0.915,1,A_surface,29,85.25,1,0,,,1,8,"40873307,36807620,35544739,33833512,31180052,31085078,26176230,24319544",1,gout,0.7158028003520317
P13612,ITGA4,Integrin alpha-4,Tier 1,0.914,1,A_surface,7,84.44,1,0,,,1,3,"30065768,28670693,26504766",1,Crohn's disease,0.7134551179424343
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.911,1,A_surface,27,79.19,1,0,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
P40189,IL6ST,Interleukin-6 receptor subunit beta,Tier 1,0.911,1,A_surface,20,74.62,1,0,,,1,2,"39571081,22258147",1,Autosomal recessive hyper-IgE syndrome,0.7027634038262931
Q15303,ERBB4,Receptor tyrosine-protein kinase erbB-4,Tier 1,0.903,1,A_surface,14,73.12,1,0,,,1,3,"32592467,30697465,23990977",1,non-small cell lung carcinoma,0.6754899662390331
O15455,TLR3,Toll-like receptor 3,Tier 1,0.899,1,A_surface,20,90.62,1,0,,,1,7,"26018150,25528762,17150912,17150911",1,Herpetic encephalitis,0.6617401048830444
P07550,ADRB2,Beta-2 adrenergic receptor,Tier 1,0.89,1,A_surface,100,79.12,1,0,,,1,2,"41637639,32376022",1,asthma,0.634300392456126
P11836,MS4A1,B-lymphocyte antigen CD20,Tier 1,0.888,1,A_surface,10,70.5,1,0,,,1,2,"39865939,29561802",1,chronic lymphocytic leukemia,0.6275806230802832
P02786,TFRC,Transferrin receptor protein 1,Tier 1.5,0.887,1,A_surface,22,86.69,1,0,,,1,3,"39831311,29046922,32527800",1,TFRC-related combined immunodeficiency,0.623449899069336
P01133,EGF,Pro-epidermal growth factor,Tier 1,0.886,1,A_surface,13,70.31,1,0,,,1,34,"41906877,41873087,41693575,39408993,38904251,38837175,37423441,35213974,34893239,32511241,32200913,31990606,31004648,30809312,36132464,28842588,28029038,27301192,26504624,25450403,25261371,24777583,23531534,23104156,21999227,21687663,21576228,19420593,19063705,20641927,15037656,13680379,12842895,12173045",1,cancer,0.6205045573389423
P60033,CD81,CD81 antigen,Tier 1,0.885,1,A_surface,16,87.38,1,0,,,1,5,"34505435,32730952,28959386,23877701,19997645",1,"immunodeficiency, common variable, 6",0.6168240011812034
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.862,1,A_surface,7,80.75,1,0,,,1,3,"41518674,39071952,29103909",1,mycosis fungoides,0.5404546856597274
P05362,ICAM1,Intercellular adhesion molecule 1,Tier 1,0.859,1,A_surface,14,88.44,1,0,,,1,43,"41699153,40650261,40539828,40329889,39154820,37052638,36508319,35312740,35212764,34038704,32884147,32784904,30697465,30617526,28631505,27132231,25582325,25368913,21147843,20665479,12714656,11320245,10097084,9740353,9200462,8932275",1,neurodegenerative disease,0.5292405353144124
Q9NNX6,CD209,CD209 antigen,Tier 1,0.858,1,A_surface,14,71.44,1,0,,,1,1,37017594,1,dengue disease,0.5252368050139995
O95858,TSPAN15,Tetraspanin-15,Tier 1,0.855,1,A_surface,3,87.56,1,0,,,1,1,37047289,1,venous thromboembolism,0.5182425801223098
P11717,IGF2R,Cation-independent mannose-6-phosphate receptor,Tier 1,0.853,1,A_surface,24,73.12,1,0,,,1,5,"40554308,39225423,38059276,36126144,32040773",1,coronary artery disease,0.511249370339317
P15144,ANPEP,Aminopeptidase N,Tier 1,0.851,1,A_surface,15,93.06,1,0,,,1,1,33554306,1,cholelithiasis,0.5030146927270738
Q03405,PLAUR,Urokinase plasminogen activator surface receptor,Tier 1,0.845,1,A_surface,13,81.44,1,0,,,1,2,37533140,1,Abdominal Aortic Aneurysm,0.4819526979346149
Q07108,CD69,Early activation antigen CD69,Tier 1,0.844,1,A_surface,6,82.12,1,0,,,1,5,"40448637,39048513,37110712,32401486,16331266",1,hypothyroidism,0.48068618377072814
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.843,1,A_surface,16,83.62,1,0,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P08174,CD55,Complement decay-accelerating factor,Tier 1,0.84,1,A_surface,33,78.25,1,0,,,1,3,"33398182,19915929,37566081",1,Protein-losing enteropathy,0.46728275901717004
P01871,IGHM,Immunoglobulin heavy constant mu,Tier 1,0.839,1,A_surface,30,85.44,1,0,,,1,3,"33981223,16825284",1,agammaglobulinemia,0.4624778576025314
O75084,FZD7,Frizzled-7,Tier 1,0.837,1,A_surface,13,83.19,1,0,,,1,2,"18673242,22363130",1,Abnormality of the skeletal system,0.45589181219776254
P01833,PIGR,Polymeric immunoglobulin receptor,Tier 1,0.833,1,A_surface,16,76.69,1,0,,,1,2,"31640794,29277631",1,clear cell renal carcinoma,0.44260204134234277
O60462,NRP2,Neuropilin-2,Tier 1,0.825,1,A_surface,16,78.62,1,0,,,1,2,41915779,1,esophageal disease,0.41662112843122434
P13569,CFTR,Cystic fibrosis transmembrane conductance regulator,Tier 1,0.824,1,A_surface,58,75.62,1,0,,,1,10,"41148207,31029337,30595527,22483890,15657417",0,cystic fibrosis,0.9133535862571094
P02724,GYPA,Glycophorin-A,Tier 1,0.813,1,A_surface,16,59.41,1,0,,,1,1,40599565,1,malaria,0.37656968762740295