id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.865,27,79.19,1,0,,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.804,7,80.75,1,0,,,,1,3,"41518674,39071952,29103909",1,mycosis fungoides,0.5404546856597274
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P13671,C6,Complement component C6,Tier 1,0.795,11,79.62,1,0,,,,1,31,"41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710",1,Immunodeficiency due to a late component of complements deficiency,0.75437296887129
P04156,PRNP,Major prion protein,Tier 1,0.785,70,64.19,1,0,,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
P14210,HGF,Hepatocyte growth factor,Tier 1,0.78,36,83.5,1,0,,,,1,64,"41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087",1,"hearing loss, autosomal recessive",0.5910507391848663
P04839,CYBB,NADPH oxidase 2,Tier 1,0.776,6,90.25,1,0,,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
P01189,POMC,Pro-opiomelanocortin,Tier 1,0.76,13,57.66,1,0,,,,1,1,30161145,1,obesity due to pro-opiomelanocortin deficiency,0.6958797353500403
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
P21730,C5AR1,C5a anaphylatoxin chemotactic receptor 1,Tier 1,0.741,19,85.75,1,0,,,,1,5,"33495506,29981048,29327939,28288993,25901944",0,anti-neutrophil cytoplasmic antibody-associated vasculitis,0.5076734733894334
P15144,ANPEP,Aminopeptidase N,Tier 1,0.74,15,93.06,1,0,,,,1,1,33554306,1,cholelithiasis,0.5030146927270738
P0C0L4,C4A,Complement C4-A,Tier 1,0.74,12,83.44,1,0,,,,1,4,"37566081,36619572,34739903,31019918",1,,
Q03405,PLAUR,Urokinase plasminogen activator surface receptor,Tier 1,0.738,13,81.44,1,0,,,,1,2,37533140,1,Abdominal Aortic Aneurysm,0.4819526979346149
P20809,IL11,Interleukin-11,Tier 1,0.712,8,82.62,1,0,,,,1,8,"39408993,39263947,28791655,27878687,25696907,24629635",0,"osteoarthritis, hip",0.31754029889853136
P13987,CD59,CD59 glycoprotein,Tier 1,0.705,17,79.31,1,0,,,,1,1,19915929,1,primary CD59 deficiency,0.7738276843579196
Q12884,FAP,Prolyl endopeptidase FAP,Tier 1,0.7,4,95.62,1,0,,,,1,7,"40046817,39710916,39026723,37192373,36838669,36494579,35879297",1,psoriasis,0.40173767366839236
P15309,ACP3,Prostatic acid phosphatase,Tier 1,0.695,17,92.25,1,0,,,,1,3,"41890985,25591398",0,prostate cancer,0.5521391557206573
P00738,HP,Haptoglobin,Tier 1,0.695,15,84.81,1,0,,,,1,76,"41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903",1,Hypercholesterolemia,0.5684135700226365
O95858,TSPAN15,Tetraspanin-15,Tier 1,0.692,3,87.56,1,0,,,,1,1,37047289,1,venous thromboembolism,0.5182425801223098
P00451,F8,Coagulation factor VIII,Tier 1,0.691,25,60.75,1,0,,,,1,13,"40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313",1,hemophilia A,0.9108044347811838
P50148,GNAQ,Guanine nucleotide-binding protein G(q) subunit alpha,Tier 1,0.685,30,93.0,1,0,,,,1,1,40015005,1,Sturge-Weber syndrome,0.6941111530708174
P48061,CXCL12,Stromal cell-derived factor 1,Tier 1,0.685,34,83.25,1,0,,,,1,36,"41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275",0,HIV-1 infection,0.3675509850165065
Q6NW40,RGMB,Repulsive guidance molecule B,Tier 1,0.683,11,79.44,1,0,,,,1,1,39263947,0,Abnormality of the skeletal system,0.42535629367019584
P13501,CCL5,C-C motif chemokine 5,Tier 1,0.68,23,88.44,1,0,,,,1,6,"41371773,39422353,32784904,30578658,29111236,27392463",1,neoplasm,0.12028522937584413
P61073,CXCR4,C-X-C chemokine receptor type 4,Tier 1,0.68,33,82.25,1,0,,,,1,17,"40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187",1,WHIM syndrome,0.8009225456235435
P12259,F5,Coagulation factor V,Tier 1,0.68,17,61.91,1,0,,,,1,4,"32696338,15496523,24629635,17878169",1,thrombophilia due to activated protein C resistance,0.7962069693286362
Q9UEF7,KL,Klotho,Tier 1,0.676,6,89.06,1,0,,,,1,19,"41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411",0,type 2 diabetes mellitus,0.5587488336100863
P49913,CAMP,Cathelicidin antimicrobial peptide,Tier 1,0.675,20,80.0,1,0,,,,1,30,"41316897,40997974,40501769,39429683,39045230,38471488,37947789,35479481,34957366,33832411,31940088,31099939,26843427,26358810,25659966,25437358,25390494,25048161,25044725,24814025,24325980,23748105,23744070,21673794,18165929,12569622,10913311,10780486,37400771",1,prostate carcinoma,0.11970033909944687
P51681,CCR5,C-C chemokine receptor type 5,Tier 1,0.674,25,85.38,1,0,,,,1,23,"36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773",0,HIV infection,0.7442590579227027
P56704,WNT3A,Protein Wnt-3a,Tier 1,0.665,4,88.31,1,0,,,,1,1,37231925,0,neurodegenerative disease,0.5271953966006525
P01137,TGFB1,Transforming growth factor beta-1 proprotein,Tier 1,0.665,20,79.56,1,0,,,,1,4,"38132522,32370304,16775010,11856769",1,Camurati-Engelmann disease,0.7995305374459716
P05113,IL5,Interleukin-5,Tier 1,0.664,5,86.69,1,0,,,,1,12,"40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585",0,asthma,0.6399821251487101
P15151,PVR,Poliovirus receptor,Tier 1,0.66,13,84.88,1,0,,,,1,3,"37958909,36598052,16419035",1,Alzheimer disease,0.3596586826147091
P03952,KLKB1,Plasma kallikrein,Tier 1,0.656,22,87.88,1,0,,,,1,6,"40008515,36859809,33674695,28959386,28632925,23692437",1,inherited prekallikrein deficiency,0.7077440022291496
Q12809,KCNH2,Voltage-gated inwardly rectifying potassium channel KCNH2,Tier 1,0.655,23,62.75,1,0,,,,1,1,22617876,0,Romano-Ward syndrome,0.8549238933917284
P37173,TGFBR2,TGF-beta receptor type-2,Tier 1,0.654,22,81.0,1,0,,,,1,8,"32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769",1,Loeys-Dietz syndrome,0.8390072008866913
P02724,GYPA,Glycophorin-A,Tier 1,0.653,16,59.41,1,0,,,,1,1,40599565,1,malaria,0.37656968762740295
P60033,CD81,CD81 antigen,Tier 1,0.652,16,87.38,1,0,,,,1,5,"34505435,32730952,28959386,23877701,19997645",1,"immunodeficiency, common variable, 6",0.6168240011812034
P46531,NOTCH1,Neurogenic locus notch homolog protein 1,Tier 1,0.652,29,59.59,1,0,,,,1,4,"38559166,34431568,33614227,28685750",1,Adams-Oliver syndrome,0.8199672000988557
P01344,IGF2,Insulin-like growth factor 2,Tier 1,0.643,16,59.03,1,0,,,,1,13,"38059276,33977395,33467925,31570709,28281528,23373648,19391177,40554308,39225423,32040773",1,Silver-Russell syndrome,0.7290427440273365
Q13651,IL10RA,Interleukin-10 receptor subunit alpha,Tier 1,0.641,7,62.0,1,0,,,,1,2,"25870409,25558474",0,Autosomal recessive early-onset inflammatory bowel disease,0.8151052076044897
P06702,S100A9,Protein S100-A9,Tier 1,0.637,13,94.31,1,0,,,,1,9,"41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041",1,inborn error of immunity,0.36994943453938645
P05109,S100A8,Protein S100-A8,Tier 1,0.635,13,93.06,1,0,,,,1,5,"41654945,41111484,32964813,32478041,22353892",1,inborn error of immunity,0.37050380432141355
P02647,APOA1,Apolipoprotein A-I,Tier 1,0.63,32,73.56,1,0,,,,1,10,"41773457,38397086,36756582,36340071,31493779,35517584,24008390,41925578,30834248",1,"hypoalphalipoproteinemia, primary, 2",0.7727382344191134
P02788,LTF,Lactotransferrin,Tier 1,0.625,34,94.94,1,0,,,,1,3,"33534888,33398328,30340834",1,tuberculosis,0.5046393442671729
P21796,VDAC1,Non-selective voltage-gated ion channel VDAC1,Tier 1,0.621,11,93.06,1,0,,,,1,1,39984095,1,neurodegenerative disease,0.511588013122545
O00206,TLR4,Toll-like receptor 4,Tier 1,0.621,15,89.19,1,0,,,,1,32,"41864915,41444487,40521190,39897575,38931862,38742374,38280803,37360693,36916435,36908619,35410404,35402075,35189346,34831332,32784904,29910175,29250957,25483705",0,major depressive disorder,0.5065500149392951