id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,77.88,1,0,,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P02748,C9,Complement component C9,Tier 1.5,0.796,9,78.75,1,0,,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,82.81,1,0,,,,1,1,41854184,1,,
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,83.62,1,0,,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,50.62,1,0,,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P43007,SLC1A4,Neutral amino acid transporter A,Tier 1.5,0.75,1,80.56,1,0,,,,1,6,"36219068,31989939,27571928,26811678,19046328,16139842",1,spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome,0.8025684205131692
P08648,ITGA5,Integrin alpha-5,Tier 1.5,0.748,14,85.25,1,0,,,,1,2,"32174798,38258032",1,skin disease,0.28465651599598124
O60884,DNAJA2,DnaJ homolog subfamily A member 2,Tier 1.5,0.73,1,83.38,1,0,,,,1,2,"41935727,33879515",1,dengue disease,0.37068859424875583
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.718,4,75.69,1,0,,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P46094,XCR1,Chemokine XC receptor 1,Tier 1.5,0.715,1,84.94,1,0,,,,1,1,35212764,0,COVID-19,0.459103766220463
P32239,CCKBR,Gastrin/cholecystokinin type B receptor,Tier 1.5,0.713,5,75.75,1,0,,,,1,2,"33776434,27754762",0,gastroesophageal reflux disease,0.4256110167566802
P25106,ACKR3,Atypical chemokine receptor 3,Tier 1.5,0.71,14,82.44,1,0,,,,1,2,"40401615,28670693",0,oculomotor-abducens synkinesis,0.49893280382434735
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.7,3,82.94,1,0,,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P21359,NF1,Neurofibromin,Tier 1.5,0.695,26,87.19,1,0,,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.681,8,63.03,1,0,,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
P98155,VLDLR,Very low-density lipoprotein receptor,Tier 1.5,0.66,27,75.69,1,0,,,,1,1,19188685,1,Dysequilibrium syndrome,0.790164037509625
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,Tier 1.5,0.652,14,72.69,1,0,,,,1,4,"33334063,32127469,28010895,30594071",1,gastrointestinal stromal tumor,0.8167494524079806
P08100,RHO,Rhodopsin,Tier 1.5,0.645,4,88.75,1,0,,,,1,45,"41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760",0,retinitis pigmentosa,0.8481942240861982
P07237,P4HB,Protein disulfide-isomerase,Tier 1.5,0.644,14,88.5,1,0,,,,1,2,"31625090,28952381",1,Cole-Carpenter syndrome,0.7447295842045853
P15391,CD19,B-lymphocyte antigen CD19,Tier 1.5,0.642,4,62.22,1,0,,,,1,13,"41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492",0,"immunodeficiency, common variable, 3",0.6821072538733047
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.641,4,75.62,1,0,,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
P45844,ABCG1,ATP-binding cassette sub-family G member 1,Tier 1.5,0.639,5,81.12,1,0,,,,1,1,41854184,0,neurodegenerative disease,0.3915225348167794
P51654,GPC3,Glypican-3,Tier 1.5,0.636,4,75.06,1,0,,,,1,65,"42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753",0,Simpson-Golabi-Behmel syndrome type 1,0.762708583613362
P31785,IL2RG,Cytokine receptor common subunit gamma,Tier 1.5,0.635,14,75.5,1,0,,,,1,2,"30800133,33869115",0,gamma chain deficiency,0.8469997000418428
O75976,CPD,Carboxypeptidase D,Tier 1.5,0.625,3,82.5,1,0,,,,1,1,36457699,1,neurodegenerative disease,0.34777406871587735
O95342,ABCB11,Bile salt export pump,Tier 1.5,0.624,8,83.12,1,0,,,,1,1,36313979,0,progressive familial intrahepatic cholestasis type 2,0.8372060401943777
P49238,CX3CR1,CX3C chemokine receptor 1,Tier 1.5,0.62,2,80.5,1,0,,,,1,2,28727998,0,age-related macular degeneration,0.4006854573775187
Q06141,REG3A,Regenerating islet-derived protein 3-alpha,Tier 1.5,0.62,4,89.0,1,0,,,,1,2,"39695715,24771595",0,alcohol drinking,0.29724052454892086
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.619,6,79.56,1,0,,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
Q07325,CXCL9,C-X-C motif chemokine 9,Tier 1.5,0.617,1,87.44,1,0,,,,1,7,"42046114,37395276,35204399,35018777,33742062,27959341,27819142",0,neoplasm,0.1199067650750674
P01876,IGHA1,Immunoglobulin heavy constant alpha 1,Tier 1.5,0.612,14,81.88,1,0,,,,1,2,37325361,1,IGA glomerulonephritis,0.12053726815801102
O43866,CD5L,CD5 antigen-like,Tier 1.5,0.61,4,85.88,1,0,,,,1,3,"40215752,37100807",1,functional neutrophil defect,0.3529395470693119
P41146,OPRL1,Nociceptin receptor,Tier 1.5,0.61,4,82.31,1,0,,,,1,1,14970396,0,neurodegenerative disease,0.4039002828932129
P23368,ME2,"NAD-dependent malic enzyme, mitochondrial",Tier 1.5,0.61,18,94.38,1,0,,,,1,2,"39602246,29779113",1,diabetes mellitus,0.277416610655893
P15529,CD46,Membrane cofactor protein,Tier 1.5,0.608,7,82.12,1,0,,,,1,9,"35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032",1,atypical hemolytic-uremic syndrome with MCP/CD46 anomaly,0.7798469882597787
P55157,MTTP,Microsomal triglyceride transfer protein large subunit,Tier 1.5,0.608,2,86.56,1,0,,,,1,1,23770039,1,abetalipoproteinemia,0.8281089516017405
P04201,MAS1,Proto-oncogene Mas,Tier 1.5,0.605,3,83.5,1,0,,,,1,10,"40518278,34016094,30415442,27936442,23618401",0,Abnormality of the skeletal system,0.40450059258174326
P10646,TFPI,Tissue factor pathway inhibitor,Tier 1.5,0.605,9,73.62,1,0,,,,1,28,"32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161",1,hemophilia A,0.5591056672248635
P41231,P2RY2,P2Y purinoceptor 2,Tier 1.5,0.605,3,78.88,1,0,,,,1,1,33911033,0,nontoxic goiter,0.43556889579550895
Q8NER1,TRPV1,Transient receptor potential cation channel subfamily V member 1,Tier 1.5,0.6,8,71.94,1,0,,,,1,2,"40855286,28604222",0,migraine disorder,0.6269329225883602
P0DSE1,TRA,M1-specific T cell receptor alpha chain,Tier 1.5,0.6,3,88.81,1,0,,,,1,7,"41693575,41636061,39837202,37015819,28860472,25844955,19457263",0,,
P02786,TFRC,Transferrin receptor protein 1,Tier 1.5,0.587,22,86.69,1,0,,,,1,3,"39831311,29046922,32527800",1,TFRC-related combined immunodeficiency,0.623449899069336
P31948,STIP1,Stress-induced-phosphoprotein 1,Tier 1.5,0.585,8,89.75,1,0,,,,1,7,"41406518,38012811,34831332,32614006,27681499,24654750,24013070",1,neurodegenerative disease,0.4967711525222825
Q15813,TBCE,Tubulin-specific chaperone E,Tier 1.5,0.582,6,89.19,1,0,,,,1,1,34448574,1,hypoparathyroidism-retardation-dysmorphism syndrome,0.7744447925917005
P55259,GP2,Pancreatic secretory granule membrane major glycoprotein GP2,Tier 1.5,0.577,4,78.62,1,0,,,,1,3,"36902059,25483705,24334484",0,type 2 diabetes mellitus,0.5235291484788168
P08887,IL6R,Interleukin-6 receptor subunit alpha,Tier 1.5,0.575,10,77.88,1,0,,,,1,18,"40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809",0,rheumatoid arthritis,0.7269057706798291