id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q4FZB7,KMT5B,Histone-lysine N-methyltransferase KMT5B,Tier 1,0.628,1,A2_pm_peripheral,10,54.91,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 51",0.7943209483524042
Q5JVL4,EFHC1,EF-hand domain-containing protein 1,Tier 1,0.626,1,A2_pm_peripheral,2,83.88,1,0,,,0,0,,0,juvenile myoclonic epilepsy,0.7858434985198706
P49459,UBE2A,Ubiquitin-conjugating enzyme E2 A,Tier 1.5,0.626,1,A2_pm_peripheral,5,94.12,1,0,,,0,0,,0,syndromic X-linked intellectual disability Nascimento type,0.7867796040270276
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
Q9NPP4,NLRC4,NLR family CARD domain-containing protein 4,Tier 1,0.619,1,A2_pm_peripheral,6,85.12,1,0,,,0,0,,0,periodic fever-infantile enterocolitis-autoinflammatory syndrome,0.7635956406357429
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.618,1,A2_pm_peripheral,100,49.22,1,0,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P35716,SOX11,Transcription factor SOX-11,Tier 1,0.614,1,A2_pm_peripheral,4,56.41,1,0,,,0,0,,0,intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism,0.7470288070793535
P41159,LEP,Leptin,Tier 1,0.606,1,A2_pm_peripheral,10,81.12,1,0,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
Q8IUC6,TICAM1,TIR domain-containing adapter molecule 1,Tier 1.5,0.581,1,A2_pm_peripheral,8,62.78,1,0,,,0,0,,0,Herpetic encephalitis,0.6364986386236531
P56597,NME5,Nucleoside diphosphate kinase 5,Tier 1.5,0.563,1,A2_pm_peripheral,1,90.06,1,0,,,0,0,,0,"ciliary dyskinesia, primary, 48, without situs inversus",0.5766985649142533
Q9BVS4,RIOK2,Serine/threonine-protein kinase RIO2,Tier 1,0.552,1,A2_pm_peripheral,10,67.38,1,0,,,0,0,,0,neurodegenerative disease,0.539818754658029
Q9NXF7,DCAF16,DDB1- and CUL4-associated factor 16,Tier 1,0.548,1,A2_pm_peripheral,2,38.19,1,0,,,0,0,,0,neurodegenerative disease,0.5251061120759617
O43663,PRC1,Protein regulator of cytokinesis 1,Tier 1,0.544,1,A2_pm_peripheral,6,78.94,1,0,,,0,0,,0,neurodegenerative disease,0.5139662839321523
Q9GZN1,ACTR6,Actin-related protein 6,Tier 1.5,0.533,1,A2_pm_peripheral,9,94.31,1,0,,,0,0,,0,neurodegenerative disease,0.4758409073452339
P43351,RAD52,DNA repair protein RAD52 homolog,Tier 1,0.528,1,A2_pm_peripheral,11,69.62,1,0,,,1,6,"37288783,32945515,31495919,26784987,24500205,23836560",0,Abnormality of the skeletal system,0.45994164258033876
Q9UK80,USP21,Ubiquitin carboxyl-terminal hydrolase 21,Tier 1,0.524,1,A2_pm_peripheral,4,69.75,1,0,,,0,0,,0,neurodegenerative disease,0.44616960950164986
O15519,CFLAR,CASP8 and FADD-like apoptosis regulator,Tier 1,0.523,1,A2_pm_peripheral,17,78.31,1,0,,,0,0,,0,neurodegenerative disease,0.4419421569940659
Q5VTH2,CFAP126,Protein Flattop,Tier 1.5,0.51,1,A2_pm_peripheral,2,72.62,1,0,,,0,0,,0,hereditary pheochromocytoma-paraganglioma,0.4009925718465981
O75182,SIN3B,Paired amphipathic helix protein Sin3b,Tier 1.5,0.501,1,A2_pm_peripheral,4,68.0,1,0,,,1,2,16914451,0,syndromic intellectual disability,0.37050380432141355
O00451,GFRA2,GDNF family receptor alpha-2,Tier 1,0.487,1,A2_pm_peripheral,5,75.0,1,0,,,0,0,,0,poisoning,0.32401333746089783
P59768,GNG2,Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Tier 1,0.485,1,A2_pm_peripheral,100,89.56,1,0,,,0,0,,0,multiple sclerosis,0.3157760490336847
P55089,UCN,Urocortin,Tier 1.5,0.469,1,A2_pm_peripheral,6,68.25,1,0,,,1,3,"30221506,26488412,23248006",0,neurodegenerative disease,0.26311734927710556
Q86UC2,RSPH3,Radial spoke head protein 3 homolog,Tier 1.5,0.39,1,A2_pm_peripheral,1,64.62,1,0,,,0,0,,0,,