id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q00604,NDP,Norrin,Tier 1.5,0.707,1,A_assoc,11,83.56,1,0,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
O95970,LGI1,Leucine-rich glioma-inactivated protein 1,Tier 1.5,0.697,1,A_assoc,9,92.56,1,0,,,0,0,,0,autosomal dominant epilepsy with auditory features,0.8225657483127345
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.687,1,A_assoc,20,91.12,1,0,,,0,0,,0,psoriasis,0.7914863943708039
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.685,1,A_assoc,3,68.62,1,0,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P05019,IGF1,Insulin-like growth factor 1,Tier 1,0.68,1,A_assoc,32,59.53,1,0,,,1,23,"38384162,35859339,35591468,33977395,33467925,32511241,31930684,26245346,24832383,23933187,23373648,16019422,41283885,39263947,38497478,33888746,15231297",0,growth delay due to insulin-like growth factor type 1 deficiency,0.7650418939376437
Q9GZV9,FGF23,Fibroblast growth factor 23,Tier 1,0.679,1,A_assoc,6,76.62,1,0,,,1,11,"39007037,38079395,35415885,32065590,30297602,30197987,41226313,36705086",0,autosomal dominant hypophosphatemic rickets,0.762326334964193
P35225,IL13,Interleukin-13,Tier 1,0.669,1,A_assoc,13,85.62,1,0,,,1,9,"41463156,35356877,33742062,32784904,27640094,29949702,21793788",0,atopic eczema,0.7297489019498119
Q2MKA7,RSPO1,R-spondin-1,Tier 1,0.669,1,A_assoc,12,74.69,1,0,,,0,0,,0,palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome,0.7285342885472184
P05305,EDN1,Endothelin-1,Tier 1,0.666,1,A_assoc,17,65.19,1,0,,,1,2,"40438585,37198662",0,auriculocondylar syndrome,0.7193561828311311
P12272,PTHLH,Parathyroid hormone-related protein,Tier 1,0.666,1,A_assoc,11,62.88,1,0,,,0,0,,0,brachydactyly type E,0.7203484375635054
P01270,PTH,Parathyroid hormone,Tier 1,0.664,1,A_assoc,26,72.12,1,0,,,1,9,"40464222,40108760,39880691,38079395,25901535,41303575,41226313",0,"hypoparathyroidism, familial isolated 1",0.7147450451832739
Q8N300,SVBP,Small vasohibin-binding protein,Tier 1,0.649,1,A_assoc,24,85.06,1,0,,,0,0,,0,"neurodevelopmental disorder with ataxia, hypotonia, and microcephaly",0.6640118055835142
O95631,NTN1,Netrin-1,Tier 1.5,0.648,1,A_assoc,5,88.5,1,0,,,0,0,,0,mirror movements 4,0.6611393488240481
P05113,IL5,Interleukin-5,Tier 1,0.642,1,A_assoc,5,86.69,1,0,,,1,12,"40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585",0,asthma,0.6399821251487101
Q16552,IL17A,Interleukin-17A,Tier 1,0.641,1,A_assoc,44,84.31,1,0,,,1,30,"42017161,41754778,41482938,41477217,40410820,39376102,38091227,38031342,37879125,37238999,36517803,36375248,36326540,35724603,32784904,32387307,31316164,27827561,24056860,21524680,20967861,37563071,34531951",0,psoriasis,0.6367521314106471
Q9UHF0,TAC3,Tachykinin-3,Tier 1,0.63,1,A_assoc,2,64.88,1,0,,,0,0,,0,hypogonadotropic hypogonadism 10 with or without anosmia,0.5995324402695232
Q6IBW4,NCAPH2,Condensin-2 complex subunit H2,Tier 1.5,0.62,1,A_assoc,1,62.41,1,0,,,0,0,,0,"cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1",0.5674645203025676
P07492,GRP,Gastrin-releasing peptide,Tier 1,0.619,1,A_assoc,9,63.94,1,0,,,1,6,"38890976,38659329,37500079,29027923,41810845,23179274",0,type 2 diabetes mellitus,0.5648167305980163
Q15726,KISS1,Metastasis-suppressor KiSS-1,Tier 1.5,0.618,1,A_assoc,2,59.41,1,0,,,1,1,35026192,0,hypogonadotropic hypogonadism,0.5608645918536114
P22466,GAL,Galanin peptides,Tier 1.5,0.613,1,A_assoc,10,66.56,1,0,,,1,27,"40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673",0,temporal lobe epilepsy,0.5442263564708273
P56704,WNT3A,Protein Wnt-3a,Tier 1,0.608,1,A_assoc,4,88.31,1,0,,,1,1,37231925,0,neurodegenerative disease,0.5271953966006525
O00585,CCL21,C-C motif chemokine 21,Tier 1,0.608,1,A_assoc,5,72.69,1,0,,,1,2,"36314402,29733244",0,rheumatoid arthritis,0.5266345093424485
P78556,CCL20,C-C motif chemokine 20,Tier 1,0.6,1,A_assoc,6,88.69,1,0,,,1,1,36375248,0,inflammatory bowel disease,0.4987938599485985
P60568,IL2,Interleukin-2,Tier 1,0.6,1,A_assoc,37,84.12,1,0,,,1,45,"41754959,40972397,40761795,40447990,38081519,37805109,37141264,37110712,37074914,34511903,34386332,32784904,32574155,32280743,31383650,31270926,30800133,29556342,29055191,28129128,27959341,27878687,27819142,27529794,27179422,26048585,25919090,24682172,35756119,30883749,29244152,24968026,24418663,18319343,12900522",0,asthma,0.5009876866575907
P10997,IAPP,Islet amyloid polypeptide,Tier 1,0.589,1,A_assoc,76,78.31,1,0,,,1,9,"40602090,26881276,25659966,18090326,16462265",0,AL amyloidosis,0.4629911629562602
P13500,CCL2,C-C motif chemokine 2,Tier 1,0.584,1,A_assoc,14,86.94,1,0,,,1,34,"42007960,41360349,41207524,39422353,39317671,38016488,34440571,32784904,31267721,31039360,30056058,29111236,28385802,28315675,28186566,27878687,27392463,26868748,25970072,25901662,25457849,25457848,25236655,24694577,24561613,24481979,21813474,21147843,19156777,18997060,18776253,18258851,11591377,36508319",0,Crohn's disease,0.44619484388731423
Q63HQ2,EGFLAM,Pikachurin,Tier 1.5,0.574,1,A_assoc,3,80.56,1,0,,,0,0,,0,mathematical ability,0.41387833248094535
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.573,1,A_assoc,4,75.62,1,0,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
P01275,GCG,Pro-glucagon,Tier 1,0.562,1,A_assoc,42,68.94,1,0,,,1,4,"40563394,37298475,22915350,22658959",0,psoriasis,0.37425807740488537
P06850,CRH,Corticoliberin,Tier 1,0.562,1,A_assoc,5,61.97,1,0,,,0,0,,0,autosomal dominant nocturnal frontal lobe epilepsy,0.37224647599732263
P48061,CXCL12,Stromal cell-derived factor 1,Tier 1,0.56,1,A_assoc,34,83.25,1,0,,,1,36,"41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275",0,HIV-1 infection,0.3675509850165065
Q7L8A9,VASH1,Tubulinyl-Tyr carboxypeptidase 1,Tier 1,0.559,1,A_assoc,14,78.25,1,0,,,0,0,,0,Abnormality of the skeletal system,0.36366533692746233
P18509,ADCYAP1,Pituitary adenylate cyclase-activating polypeptide,Tier 1,0.559,1,A_assoc,12,62.56,1,0,,,0,0,,0,alcohol drinking,0.36407172744864225
P01282,VIP,VIP peptides,Tier 1.5,0.55,1,A_assoc,5,67.62,1,0,,,1,24,"41292425,40957130,40403614,40056883,39952883,38763821,37527574,36669289,36129574,35879297,35436736,33990848,33688885,31689596,31403149,30167802,30069577,29708252,28441340,27542489,27334718,27088368,26802746,25782595",0,uterine fibroid,0.3332844575068197
P61278,SST,Somatostatin,Tier 1,0.549,1,A_assoc,10,65.81,1,0,,,1,14,"41851736,41043050,40363817,39451684,37992929,31793775,19755178,38709872,37198662,30644734,28542563,20388107,17585951,21625282",0,Abruptio Placentae,0.32971414126477894
P01303,NPY,Pro-neuropeptide Y,Tier 1,0.548,1,A_assoc,10,75.62,1,0,,,1,8,"40040002,38709872,38654828,38033269,33297678,29923734,15984861,11756401",0,Nephropathy,0.3251645152074003
P20809,IL11,Interleukin-11,Tier 1,0.545,1,A_assoc,8,82.62,1,0,,,1,8,"39408993,39263947,28791655,27878687,25696907,24629635",0,"osteoarthritis, hip",0.31754029889853136
O15240,VGF,Neurosecretory protein VGF,Tier 1,0.545,1,A_assoc,5,60.44,1,0,,,0,0,,0,Abnormality of the skeletal system,0.3156209584671744
P0DMC3,APELA,Apelin receptor early endogenous ligand,Tier 1,0.544,1,A_assoc,3,72.56,1,0,,,0,0,,0,attention deficit hyperactivity disorder,0.3148526492327248
O14960,LECT2,Leukocyte cell-derived chemotaxin-2,Tier 1.5,0.542,1,A_assoc,4,92.44,1,0,,,1,2,35045701,0,neurodegenerative disease,0.30565036648724025
P48645,NMU,Neuromedin-U,Tier 1,0.541,1,A_assoc,3,62.72,1,0,,,1,2,"32339148,30826654",0,hypertension,0.30207473951583863
Q06141,REG3A,Regenerating islet-derived protein 3-alpha,Tier 1.5,0.539,1,A_assoc,4,89.0,1,0,,,1,2,"39695715,24771595",0,alcohol drinking,0.29724052454892086
P30990,NTS,Neurotensin/neuromedin N,Tier 1,0.53,1,A_assoc,11,61.34,1,0,,,1,38,"41846533,41572478,41548876,41047530,40992279,40326235,39631853,39413601,38897014,38131768,36907299,36735817,36228172,36222059,36084454,36067715,35926421,35279502,34971987,34215054,33412470,33404751,32558232,31919610,31187249,31163397,30771936,30724076,30339976,26916821,26382019,32260691,20597503,19740763,18082623,17150545,12054450,9425088",0,Alzheimer disease,0.26512620584304225
P15018,LIF,Leukemia inhibitory factor,Tier 1,0.523,1,A_assoc,5,87.12,1,0,,,1,38,"41611413,38359901,37549567,37175248,36838669,33640806,32253765,31791592,31357280,30771937,30037541,29289340,28963578,28763192,27855943,26877178,26764106,26695234,26344338,26113415,25335821,25311485,25035238,24716781,22648816,22471443,27335672,20673578,20151395,19803140,18646283,17315151,16331583,16053313,11791582,9823713,39571081,31461490",0,alcohol drinking,0.24197086949132446
P01350,GAST,Gastrin,Tier 1,0.523,1,A_assoc,4,64.88,1,0,,,1,2,"41810845,23179274",0,neurodegenerative disease,0.24399028152288016
M5A8F1,ERVH48-1,Suppressyn,Tier 1.5,0.519,1,A_assoc,1,74.94,1,0,,,0,0,,0,hypertension,0.23115391486595976
P01178,OXT,Oxytocin-neurophysin 1,Tier 1.5,0.514,1,A_assoc,4,83.81,1,0,,,1,1,34649198,0,neurodegenerative disease,0.21368454441108417
Q5T4W7,ARTN,Artemin,Tier 1.5,0.512,1,A_assoc,5,75.0,1,0,,,0,0,,0,neurodegenerative disease,0.20507822956537197
P01286,GHRH,Somatoliberin,Tier 1,0.51,1,A_assoc,3,77.75,1,0,,,1,1,35061691,0,urinary tract obstruction,0.2012239584361017
P09683,SCT,Secretin,Tier 1.5,0.495,1,A_assoc,3,65.88,1,0,,,1,2,"17495522,7752141",0,idiopathic pulmonary fibrosis,0.14866387905285056