id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12263,,,Tier 1,0.9,7,63.59,1,0,,,,0,0,,0,,
Q12879,GRIN2A,"Glutamate receptor ionotropic, NMDA 2A",Tier 1,0.88,37,60.84,1,0,,,,0,0,,0,Landau-Kleffner syndrome,0.8407159711916629
Q5T848,GPR158,Metabotropic glycine receptor,Tier 1,0.839,6,58.03,1,0,,,,0,0,,0,diverticular disease,0.4384404783771627
P0DSE2,TRB,M1-specific T cell receptor beta chain,Tier 1,0.83,5,90.12,1,0,,,,0,0,,0,,
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
Q9NS82,SLC7A10,Asc-type amino acid transporter 1,Tier 1,0.803,4,83.38,1,0,,,,0,0,,0,asthma,0.5295411410172121
O60895,RAMP2,Receptor activity-modifying protein 2,Tier 1,0.802,10,80.94,1,0,,,,0,0,,0,diabetes mellitus,0.4219370007650345
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P01909,HLA-DQA1,"HLA class II histocompatibility antigen, DQ alpha 1 chain",Tier 1,0.792,27,87.94,1,0,,,,0,0,,0,Pleural Mesothelioma,0.1228600330569846
Q13639,,,Tier 1,0.781,3,80.88,1,0,,,,0,0,,0,schizophrenia,0.6060830827022777
O15393,,,Tier 1,0.775,31,79.38,1,0,,,,0,0,,0,COVID-19,0.6157541390484623
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.769,20,91.12,1,0,,,,0,0,,0,psoriasis,0.7914863943708039
P98073,,,Tier 1,0.761,14,81.5,1,0,,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
O75762,TRPA1,Transient receptor potential cation channel subfamily A member 1,Tier 1,0.76,17,81.94,1,0,,,,0,0,,0,familial episodic pain syndrome with predominantly upper body involvement,0.6615353934604322
O43614,,,Tier 1,0.75,11,78.94,1,0,,,,0,0,,0,insomnia,0.5988748728311054
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
O43526,KCNQ2,Potassium voltage-gated channel subfamily KQT member 2,Tier 1,0.744,24,58.19,1,0,,,,0,0,,0,Benign familial neonatal seizures,0.8423358217314708
Q8N158,GPC2,Glypican-2,Tier 1,0.744,2,79.06,1,0,,,,0,0,,0,COVID-19,0.5409211817593593
O15245,SLC22A1,Solute carrier family 22 member 1,Tier 1,0.744,16,84.25,1,0,,,,0,0,,0,coronary artery disease,0.5384890077265535
P40879,SLC26A3,Chloride anion exchanger,Tier 1,0.742,13,85.06,1,0,,,,0,0,,0,congenital secretory chloride diarrhea 1,0.8189631913308207
P21730,C5AR1,C5a anaphylatoxin chemotactic receptor 1,Tier 1,0.741,19,85.75,1,0,,,,1,5,"33495506,29981048,29327939,28288993,25901944",0,anti-neutrophil cytoplasmic antibody-associated vasculitis,0.5076734733894334
D7RIG0,HLA-DRB1,,Tier 1,0.74,10,84.94,1,0,,,,0,0,,0,,
A0A1B0GX56,TRDV1,T cell receptor delta variable 1,Tier 1,0.737,7,90.69,1,0,,,,0,0,,0,colorectal carcinoma,0.07391597093694036
Q14028,CNGB1,Cyclic nucleotide-gated channel beta-1,Tier 1,0.734,11,57.66,1,0,,,,0,0,,0,retinitis pigmentosa,0.7931901344765326
P41145,OPRK1,Kappa-type opioid receptor,Tier 1,0.725,28,79.5,1,0,,,,0,0,,0,alcohol dependence,0.6106562988740131
P23416,GLRA2,Glycine receptor subunit alpha-2,Tier 1,0.723,13,83.81,1,0,,,,0,0,,0,"intellectual developmental disorder, X-linked, syndromic, Pilorge type",0.7805605973560554
B7Z8K6,TRDC,T cell receptor delta constant,Tier 1,0.72,12,81.38,1,0,,,,0,0,,0,,
P29033,GJB2,Gap junction beta-2 protein,Tier 1,0.72,24,86.19,1,0,,,,0,0,,0,palmoplantar keratoderma-deafness syndrome,0.8149616697051898
Q695T7,SLC6A19,Sodium-dependent neutral amino acid transporter B(0)AT1,Tier 1,0.715,19,90.0,1,0,,,,0,0,,0,Hartnup disease,0.8464240093600148
A0A0B4J271,TRAV12-3,T cell receptor alpha variable 12-3,Tier 1,0.715,12,92.56,1,0,,,,0,0,,0,ulcerative colitis,0.003139210371371825
P20809,IL11,Interleukin-11,Tier 1,0.712,8,82.62,1,0,,,,1,8,"39408993,39263947,28791655,27878687,25696907,24629635",0,"osteoarthritis, hip",0.31754029889853136
P49019,HCAR3,Hydroxycarboxylic acid receptor 3,Tier 1,0.709,11,79.19,1,0,,,,0,0,,0,Oral ulcer,0.3943093179045574
O15342,ATP6V0E1,V-type proton ATPase subunit e 1,Tier 1,0.708,9,92.88,1,0,,,,0,0,,0,multiple myeloma,0.18220286553988743
Q9BXJ8,TMEM120A,Transmembrane protein 120A,Tier 1,0.706,5,89.25,1,0,,,,0,0,,0,congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency,0.1609725589293368
P22888,LHCGR,Lutropin-choriogonadotropic hormone receptor,Tier 1,0.698,4,80.12,1,0,,,,0,0,,0,"Leydig cell hypoplasia, type 1",0.783461117057047
P30989,NTSR1,Neurotensin receptor type 1,Tier 1,0.695,24,79.62,1,0,,,,0,0,,0,Cough,0.31206841983343936
Q07699,SCN1B,Sodium channel regulatory subunit beta-1,Tier 1,0.695,36,87.06,1,0,,,,0,0,,0,Generalized epilepsy with febrile seizures-plus,0.7638796221342504
P15309,ACP3,Prostatic acid phosphatase,Tier 1,0.695,17,92.25,1,0,,,,1,3,"41890985,25591398",0,prostate cancer,0.5521391557206573
P48061,CXCL12,Stromal cell-derived factor 1,Tier 1,0.685,34,83.25,1,0,,,,1,36,"41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275",0,HIV-1 infection,0.3675509850165065
Q6NW40,RGMB,Repulsive guidance molecule B,Tier 1,0.683,11,79.44,1,0,,,,1,1,39263947,0,Abnormality of the skeletal system,0.42535629367019584
Q96RJ0,TAAR1,Trace amine-associated receptor 1,Tier 1,0.68,17,90.06,1,0,,,,0,0,,0,schizophrenia,0.41827765417829765
Q14973,SLC10A1,Hepatic sodium/bile acid cotransporter,Tier 1,0.679,11,83.5,1,0,,,,0,0,,0,"hypercholanemia, familial, 2",0.6937781800382379
Q9UEF7,KL,Klotho,Tier 1,0.676,6,89.06,1,0,,,,1,19,"41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411",0,type 2 diabetes mellitus,0.5587488336100863
O15399,GRIN2D,"Glutamate receptor ionotropic, NMDA 2D",Tier 1,0.675,13,63.22,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 46",0.7529662497608808
P51681,CCR5,C-C chemokine receptor type 5,Tier 1,0.674,25,85.38,1,0,,,,1,23,"36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773",0,HIV infection,0.7442590579227027
Q05586,GRIN1,"Glutamate receptor ionotropic, NMDA 1",Tier 1,0.67,84,82.88,1,0,,,,0,0,,0,"neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant",0.8446685494288694
Q99679,GPR21,Probable G-protein coupled receptor 21,Tier 1,0.67,5,83.12,1,0,,,,0,0,,0,type 2 diabetes mellitus,0.10141298237734184
Q8TDV5,GPR119,Glucose-dependent insulinotropic receptor,Tier 1,0.67,9,86.75,1,0,,,,0,0,,0,neurodegenerative disease,0.2992783744181862