id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
P35346,SSTR5,Somatostatin receptor type 5,Tier 1.5,0.841,7,81.25,1,0,,,,0,0,,0,acromegaly,0.6094707180356006
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.835,4,83.25,1,0,,,,0,0,,0,progressive familial intrahepatic cholestasis type 3,0.851728159166962
O75899,GABBR2,Gamma-aminobutyric acid type B receptor subunit 2,Tier 1.5,0.824,26,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 59",0.7356789732167734
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.802,13,80.69,1,0,,,,0,0,,0,Congenital myasthenic syndromes,0.8223287249629152
P29275,ADORA2B,Adenosine receptor A2b,Tier 1.5,0.801,4,88.12,1,0,,,,0,0,,0,migraine disorder,0.6060142180667235
Q9H2X9,SLC12A5,Solute carrier family 12 member 5,Tier 1.5,0.8,2,78.44,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6993945840545625
Q13705,ACVR2B,Activin receptor type-2B,Tier 1.5,0.791,9,83.31,1,0,,,,0,0,,0,Heterotaxia,0.7109733260300651
Q96CS2,HAUS1,HAUS augmin-like complex subunit 1,Tier 1.5,0.79,1,88.62,1,0,,,,0,0,,0,device complication,0.27547205131467467
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,Tier 1.5,0.782,6,73.88,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 14",0.8165232785825526
P30542,ADORA1,Adenosine receptor A1,Tier 1.5,0.777,5,92.44,1,0,,,,0,0,,0,asthma,0.7232344154541454
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.777,4,84.38,1,0,,,,0,0,,0,glucose-galactose malabsorption,0.8220991027793896
P43004,SLC1A2,Excitatory amino acid transporter 2,Tier 1.5,0.768,7,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 41",0.7772658651722512
O60931,CTNS,Cystinosin,Tier 1.5,0.764,6,89.44,1,0,,,,0,0,,0,nephropathic cystinosis,0.841818398377195
Q9Y5Y9,SCN10A,Sodium channel protein type 10 subunit alpha,Tier 1.5,0.761,8,67.31,1,0,,,,0,0,,0,atrial fibrillation,0.7126293968222049
O15552,FFAR2,Free fatty acid receptor 2,Tier 1.5,0.759,11,88.06,1,0,,,,0,0,,0,type 1 diabetes mellitus,0.09182737097469269
P35462,DRD3,D(3) dopamine receptor,Tier 1.5,0.757,6,75.38,1,0,,,,0,0,,0,schizophrenia,0.6687268941647396
O00591,GABRP,Gamma-aminobutyric acid receptor subunit pi,Tier 1.5,0.752,2,79.12,1,0,,,,0,0,,0,migraine disorder,0.6191855696357259
P0DMS8,ADORA3,Adenosine receptor A3,Tier 1.5,0.751,5,91.31,1,0,,,,0,0,,0,migraine disorder,0.6052134617149065
P46089,GPR3,G-protein coupled receptor 3,Tier 1.5,0.748,8,81.81,1,0,,,,0,0,,0,hypertension,0.18488148594282316
Q86YT5,SLC13A5,Na(+)/citrate cotransporter,Tier 1.5,0.739,4,86.06,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6853612674939716
P48764,SLC9A3,Sodium/hydrogen exchanger 3,Tier 1.5,0.725,1,65.94,1,0,,,,0,0,,0,congenital sodium diarrhea,0.6503153836708786
Q9H741,SPRING1,SREBP regulating gene protein,Tier 1.5,0.725,2,81.31,1,0,,,,0,0,,0,Anxiety,0.35244791107935663
P41968,MC3R,Melanocortin receptor 3,Tier 1.5,0.723,6,83.88,1,0,,,,0,0,,0,alcohol drinking,0.3298167673588826
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
Q9NZD1,GPRC5D,G-protein coupled receptor family C group 5 member D,Tier 1.5,0.716,2,76.06,1,0,,,,0,0,,0,multiple myeloma,0.5555243624684951
P46094,XCR1,Chemokine XC receptor 1,Tier 1.5,0.715,1,84.94,1,0,,,,1,1,35212764,0,COVID-19,0.459103766220463
P32239,CCKBR,Gastrin/cholecystokinin type B receptor,Tier 1.5,0.713,5,75.75,1,0,,,,1,2,"33776434,27754762",0,gastroesophageal reflux disease,0.4256110167566802
Q9BZV2,SLC19A3,Thiamine transporter 2,Tier 1.5,0.712,19,81.56,1,0,,,,0,0,,0,biotin-responsive basal ganglia disease,0.8189646480334981
Q401N2,ZACN,Ligand-gated cation channel ZACN,Tier 1.5,0.711,9,77.56,1,0,,,,0,0,,0,atrial heart septal defect,0.20510272364083965
Q2M385,MPEG1,Macrophage-expressed gene 1 protein,Tier 1.5,0.71,5,82.75,1,0,,,,0,0,,0,immunodeficiency 77,0.7043238859467001
P25106,ACKR3,Atypical chemokine receptor 3,Tier 1.5,0.71,14,82.44,1,0,,,,1,2,"40401615,28670693",0,oculomotor-abducens synkinesis,0.49893280382434735
Q8N6U8,GPR161,G-protein coupled receptor 161,Tier 1.5,0.708,2,68.62,1,0,,,,0,0,,0,medulloblastoma,0.583267884969527
P34995,PTGER1,Prostaglandin E2 receptor EP1 subtype,Tier 1.5,0.707,1,74.81,1,0,,,,0,0,,0,erectile dysfunction,0.5684936888228123
Q1HG43,DUOXA1,Dual oxidase maturation factor 1,Tier 1.5,0.703,2,82.44,1,0,,,,0,0,,0,familial thyroid dyshormonogenesis,0.33299144907091627
Q8TDU6,GPBAR1,G-protein coupled bile acid receptor 1,Tier 1.5,0.703,5,80.44,1,0,,,,0,0,,0,cholelithiasis,0.13532265841527905
Q99705,MCHR1,Melanin-concentrating hormone receptor 1,Tier 1.5,0.702,10,84.44,1,0,,,,0,0,,0,carpal tunnel syndrome,0.3206604001931773
P33032,MC5R,Melanocortin receptor 5,Tier 1.5,0.693,3,82.62,1,0,,,,0,0,,0,color vision disorder,0.32934412559476917
P25929,NPY1R,Neuropeptide Y receptor type 1,Tier 1.5,0.69,6,79.88,1,0,,,,0,0,,0,mathematical ability,0.4585181664868048
Q16280,CNGA2,Cyclic nucleotide-gated channel alpha-2,Tier 1.5,0.689,2,77.75,1,0,,,,0,0,,0,neurodegenerative disease,0.3406621245682051
Q9UM01,SLC7A7,Y+L amino acid transporter 1,Tier 1.5,0.685,5,83.81,1,0,,,,0,0,,0,lysinuric protein intolerance,0.8450026270275782
P78508,KCNJ10,ATP-sensitive inward rectifier potassium channel 10,Tier 1.5,0.684,4,82.44,1,0,,,,0,0,,0,EAST syndrome,0.8357483559927158
P49683,PRLHR,Prolactin-releasing peptide receptor,Tier 1.5,0.683,5,80.56,1,0,,,,0,0,,0,"Diarrhea, Infantile",0.32874115667653925
M5A8F1,ERVH48-1,Suppressyn,Tier 1.5,0.683,1,74.94,1,0,,,,0,0,,0,hypertension,0.23115391486595976
P23942,PRPH2,Peripherin-2,Tier 1.5,0.682,1,87.0,1,0,,,,0,0,,0,retinitis pigmentosa,0.8194208847382956
P30550,GRPR,Gastrin-releasing peptide receptor,Tier 1.5,0.681,4,78.5,1,0,,,,0,0,,0,neoplasm,0.11047703208351528
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.681,8,63.03,1,0,,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
P47872,SCTR,Secretin receptor,Tier 1.5,0.68,3,76.56,1,0,,,,0,0,,0,type 2 diabetes mellitus,0.5001973915505248