id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P62873,GNB1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Tier 1,0.794,1,A2_pm_peripheral,100,97.06,1,0,,,0,0,,1,"intellectual disability, autosomal dominant 42",0.8462216225099116
P06737,PYGL,"Glycogen phosphorylase, liver form",Tier 1,0.787,1,A2_pm_peripheral,19,92.69,1,0,,,0,0,,1,glycogen storage disease VI,0.8220063508118274
P49770,EIF2B2,Translation initiation factor eIF2B subunit beta,Tier 1,0.787,1,A2_pm_peripheral,25,86.56,1,0,,,0,0,,1,CACH syndrome,0.824634396744653
P21333,FLNA,Filamin-A,Tier 1,0.786,1,A2_pm_peripheral,26,76.56,1,0,,,0,0,,1,Melnick-Needles syndrome,0.8200516896124751
P31040,SDHA,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",Tier 1.5,0.785,1,A2_pm_peripheral,4,93.94,1,0,,,0,0,,1,"mitochondrial complex II deficiency, nuclear type 1",0.815589203208636
Q01831,XPC,DNA repair protein complementing XP-C cells,Tier 1,0.782,1,A2_pm_peripheral,14,66.56,1,0,,,0,0,,1,Xeroderma pigmentosum complementation group C,0.8056391472748724
Q12840,KIF5A,Kinesin heavy chain isoform 5A,Tier 1.5,0.781,1,A2_pm_peripheral,4,75.31,1,0,,,0,0,,1,hereditary spastic paraplegia 10,0.8029405627392309
P01137,TGFB1,Transforming growth factor beta-1 proprotein,Tier 1,0.78,1,A2_pm_peripheral,20,79.56,1,0,,,1,4,"38132522,32370304,16775010,11856769",1,Camurati-Engelmann disease,0.7995305374459716
O00330,PDHX,"Pyruvate dehydrogenase protein X component, mitochondrial",Tier 1.5,0.779,1,A2_pm_peripheral,5,77.31,1,0,,,0,0,,1,pyruvate dehydrogenase E3-binding protein deficiency,0.7957753555992844
Q9NQG7,HPS4,BLOC-3 complex member HPS4,Tier 1.5,0.779,1,A2_pm_peripheral,1,61.66,1,0,,,0,0,,1,Hermansky-Pudlak syndrome with pulmonary fibrosis,0.7967575753847002
O00468,AGRN,Agrin,Tier 1.5,0.777,1,A2_pm_peripheral,1,68.81,1,0,,,0,0,,1,congenital myasthenic syndrome 8,0.7912009864338403
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.776,1,A2_pm_peripheral,6,79.56,1,0,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
Q92743,HTRA1,Serine protease HTRA1,Tier 1,0.768,1,A2_pm_peripheral,18,83.25,1,0,,,1,1,31988066,1,"cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2",0.7611877816680132
Q9BYI3,HYCC1,Hyccin,Tier 1,0.766,1,A2_pm_peripheral,5,67.75,1,0,,,0,0,,1,Hypomyelination - congenital cataract,0.7528702184568328
P35221,CTNNA1,Catenin alpha-1,Tier 1,0.765,1,A2_pm_peripheral,10,82.94,1,0,,,1,2,40265971,1,Butterfly-shaped pigment dystrophy,0.7487735496199569
P13797,PLS3,Plastin-3,Tier 1,0.757,1,A2_pm_peripheral,6,88.75,1,0,,,0,0,,1,X-linked osteoporosis with fractures,0.721756781312783
P84077,ARF1,ADP-ribosylation factor 1,Tier 1,0.755,1,A2_pm_peripheral,36,85.94,1,0,,,1,3,"30965174,11320245",1,periventricular nodular heterotopia 8,0.7173626622431929
P07357,C8A,Complement component C8 alpha chain,Tier 1,0.75,1,A2_pm_peripheral,11,78.69,1,0,,,0,0,,1,Immunodeficiency due to a late component of complements deficiency,0.700643416115894
Q13546,RIPK1,Receptor-interacting serine/threonine-protein kinase 1,Tier 1,0.749,1,A2_pm_peripheral,39,69.75,1,0,,,1,2,"41290466,35919280",1,immunodeficiency 57,0.698121745966467
P50148,GNAQ,Guanine nucleotide-binding protein G(q) subunit alpha,Tier 1,0.748,1,A2_pm_peripheral,30,93.0,1,0,,,1,1,40015005,1,Sturge-Weber syndrome,0.6941111530708174
O95786,RIGI,Antiviral innate immune response receptor RIG-I,Tier 1,0.735,1,A2_pm_peripheral,44,85.19,1,0,,,1,6,"34487794,33253193,32946572,31600868,26018150,22127865",1,Singleton-Merten dysplasia,0.6485708110478319
P23921,RRM1,Ribonucleoside-diphosphate reductase large subunit,Tier 1,0.724,1,A2_pm_peripheral,12,92.25,1,0,,,1,1,21955496,1,non-small cell lung carcinoma,0.6122881671315019
P32121,ARRB2,Beta-arrestin-2,Tier 1.5,0.719,1,A2_pm_peripheral,1,83.81,1,0,,,1,4,"24736311,40652239,29054528",1,cancer,0.5962458729823639
P62987,UBA52,Ubiquitin-ribosomal protein eL40 fusion protein,Tier 1,0.712,1,A2_pm_peripheral,30,93.5,1,0,,,0,0,,1,HIV infection,0.5745684844613109
P04406,GAPDH,Glyceraldehyde-3-phosphate dehydrogenase,Tier 1,0.706,1,A2_pm_peripheral,21,98.12,1,0,,,1,11,"39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199",1,neurodegenerative disease,0.55307368855439
Q8NFH5,NUP35,Nucleoporin NUP35,Tier 1,0.702,1,A2_pm_peripheral,5,63.19,1,0,,,0,0,,1,influenza,0.5409211817593593
Q13033,STRN3,Striatin-3,Tier 1,0.701,1,A2_pm_peripheral,4,67.5,1,0,,,0,0,,1,neurodegenerative disease,0.5377902198332467
O75143,ATG13,Autophagy-related protein 13,Tier 1,0.701,1,A2_pm_peripheral,13,63.84,1,0,,,0,0,,1,neurodegenerative disease,0.5360512349298453
Q6IAA8,LAMTOR1,Ragulator complex protein LAMTOR1,Tier 1,0.7,1,A2_pm_peripheral,22,80.12,1,0,,,0,0,,1,neurodegenerative disease,0.5318107016634962
O15511,ARPC5,Actin-related protein 2/3 complex subunit 5,Tier 1.5,0.699,1,A2_pm_peripheral,2,92.19,1,0,,,0,0,,1,neurodegenerative disease,0.5305805352966168
P30154,PPP2R1B,Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform,Tier 1.5,0.699,1,A2_pm_peripheral,1,92.81,1,0,,,0,0,,1,cancer,0.5305484520119053
P49662,CASP4,Caspase-4,Tier 1,0.692,1,A2_pm_peripheral,9,78.38,1,0,,,0,0,,1,bacterial disease,0.5062783346658307
Q9UBL3,ASH2L,Set1/Ash2 histone methyltransferase complex subunit ASH2,Tier 1,0.691,1,A2_pm_peripheral,27,75.25,1,0,,,0,0,,1,neurodegenerative disease,0.5019091999413609
O00762,UBE2C,Ubiquitin-conjugating enzyme E2 C,Tier 1.5,0.689,1,A2_pm_peripheral,9,88.56,1,0,,,0,0,,1,neurodegenerative disease,0.49682303083942114
P31948,STIP1,Stress-induced-phosphoprotein 1,Tier 1.5,0.689,1,A2_pm_peripheral,8,89.75,1,0,,,1,7,"41406518,38012811,34831332,32614006,27681499,24654750,24013070",1,neurodegenerative disease,0.4967711525222825
P21980,TGM2,Protein-glutamine gamma-glutamyltransferase 2,Tier 1.5,0.688,1,A2_pm_peripheral,17,92.88,1,0,,,1,1,35980938,1,neurodegenerative disease,0.49455272812698803
P49327,FASN,Fatty acid synthase,Tier 1,0.68,1,A2_pm_peripheral,34,85.44,1,0,,,1,1,41854184,1,dengue disease,0.46815584653391107
P83881,RPL36A,Large ribosomal subunit protein eL42,Tier 1,0.679,1,A2_pm_peripheral,30,94.31,1,0,,,0,0,,1,influenza,0.4619748183558772
Q5VZK9,CARMIL1,F-actin-uncapping protein LRRC16A,Tier 1,0.677,1,A2_pm_peripheral,3,67.38,1,0,,,0,0,,1,schizophrenia,0.45718735748281236
Q86TV6,TTC7B,Tetratricopeptide repeat protein 7B,Tier 1,0.673,1,A2_pm_peripheral,5,85.0,1,0,,,0,0,,1,neurodegenerative disease,0.4430588960838045
Q16763,UBE2S,Ubiquitin-conjugating enzyme E2 S,Tier 1,0.673,1,A2_pm_peripheral,9,80.69,1,0,,,0,0,,1,neurodegenerative disease,0.44489727765466
P63098,PPP3R1,Calcineurin subunit B type 1,Tier 1.5,0.673,1,A2_pm_peripheral,21,91.12,1,0,,,1,2,39263947,1,Abnormality of the skeletal system,0.44389060142742937
Q16555,DPYSL2,Dihydropyrimidinase-related protein 2,Tier 1,0.671,1,A2_pm_peripheral,15,90.25,1,0,,,0,0,,1,hypertension,0.4377422749119531
P61077,UBE2D3,Ubiquitin-conjugating enzyme E2 D3,Tier 1,0.667,1,A2_pm_peripheral,46,96.38,1,0,,,0,0,,1,hypertension,0.4222295115574527
P04899,GNAI2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Tier 1,0.665,1,A2_pm_peripheral,34,94.06,1,0,,,0,0,,1,ovarian granulosa cell tumor,0.4157773365202895
Q9H0A8,COMMD4,COMM domain-containing protein 4,Tier 1.5,0.663,1,A2_pm_peripheral,4,80.75,1,0,,,0,0,,1,neurodegenerative disease,0.4109063598016124
P08238,HSP90AB1,Heat shock protein HSP 90-beta,Tier 1,0.661,1,A2_pm_peripheral,32,84.31,1,0,,,1,1,35921069,1,multiple myeloma,0.40496963397728575
Q8N3R9,PALS1,Protein PALS1,Tier 1,0.652,1,A2_pm_peripheral,9,77.19,1,0,,,0,0,,1,COVID-19,0.3720065057444545
Q00536,CDK16,Cyclin-dependent kinase 16,Tier 1.5,0.652,1,A2_pm_peripheral,3,71.94,1,0,,,0,0,,1,Intellectual disability,0.3718454818549898
P06702,S100A9,Protein S100-A9,Tier 1,0.651,1,A2_pm_peripheral,13,94.31,1,0,,,1,9,"41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041",1,inborn error of immunity,0.36994943453938645