id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q05086,,,Tier 1,0.753,1,unknown,27,80.75,1,0,,,0,0,,1,Angelman syndrome,0.8429347259838658
P04275,,,Tier 1.5,0.749,1,unknown,48,75.5,1,0,,,0,0,,1,Von Willebrand disease,0.8296081124598669
Q15858,,,Tier 1,0.747,1,unknown,43,69.06,1,0,,,0,0,,1,primary erythermalgia,0.8237835765987434
Q92608,,,Tier 1,0.734,1,unknown,6,79.81,1,0,,,0,0,,1,DOCK2 deficiency,0.7814025939223274
Q5T5Y3,,,Tier 1,0.694,1,unknown,4,54.34,1,0,,,0,0,,1,"cortical dysplasia, complex, with other brain malformations 12",0.6471266259726068
Q08945,SSRP1,FACT complex subunit SSRP1,Tier 1,0.675,1,unknown,11,74.19,1,0,,,1,1,39653795,1,HIV infection,0.5844684701481319
P43487,,,Tier 1,0.651,1,unknown,4,83.38,1,0,,,0,0,,1,HIV infection,0.5030392466541774
Q14213,,,Tier 1,0.628,1,unknown,4,87.62,1,0,,,0,0,,1,neurodegenerative disease,0.42776938116451996
F8WCM5,,,Tier 1,0.624,1,unknown,4,48.81,1,0,,,0,0,,1,neurodegenerative disease,0.4145162522265602
Q13131,,,Tier 1,0.614,1,unknown,12,79.56,1,0,,,0,0,,1,cardiovascular disease,0.37913864498012223
P07360,,,Tier 1,0.611,1,unknown,15,89.75,1,0,,,0,0,,1,complement deficiency,0.3695798546847018
P20339,,,Tier 1,0.611,1,unknown,14,84.88,1,0,,,0,0,,1,tuberculosis,0.3708733841760982
Q96HW7,,,Tier 1,0.599,1,unknown,11,83.19,1,0,,,0,0,,1,systemic lupus erythematosus,0.3316421846062003
Q8NBJ9,,,Tier 1,0.598,1,unknown,7,80.25,1,0,,,0,0,,1,hypothyroidism,0.32686531914177924
Q96Q15,,,Tier 1,0.593,1,unknown,10,76.88,1,0,,,0,0,,1,contracture,0.30952829622581673
Q15061,,,Tier 1,0.593,1,unknown,3,69.62,1,0,,,0,0,,1,triple-negative breast cancer,0.31136131887350776
P07305,,,Tier 1.5,0.562,1,unknown,16,68.75,1,0,,,0,0,,1,open-angle glaucoma,0.2081722206162343
Q8N9N8,,,Tier 1,0.554,1,unknown,4,75.69,1,0,,,0,0,,1,Nestor-Guillermo progeria syndrome,0.17918659722662342