id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,77.88,1,0,,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,95.62,1,0,,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,86.06,1,0,,,,0,0,,1,"cleft palate, proliferative retinopathy, and developmental delay",0.5770707112957068
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,89.31,1,0,,,,0,0,,1,neurodegenerative disease,0.5385822922582763
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,89.69,1,0,,,,0,0,,1,congestive heart failure,0.5999952111132625
P02748,C9,Complement component C9,Tier 1.5,0.796,9,78.75,1,0,,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,82.81,1,0,,,,1,1,41854184,1,,
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,83.62,1,0,,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,50.62,1,0,,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,91.38,1,0,,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.755,19,72.06,1,0,,,,0,0,,1,Knobloch syndrome,0.5526223217595396
P43007,SLC1A4,Neutral amino acid transporter A,Tier 1.5,0.75,1,80.56,1,0,,,,1,6,"36219068,31989939,27571928,26811678,19046328,16139842",1,spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome,0.8025684205131692
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.75,9,76.75,1,0,,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
P08648,ITGA5,Integrin alpha-5,Tier 1.5,0.748,14,85.25,1,0,,,,1,2,"32174798,38258032",1,skin disease,0.28465651599598124
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.743,1,77.88,1,0,,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
O60884,DNAJA2,DnaJ homolog subfamily A member 2,Tier 1.5,0.73,1,83.38,1,0,,,,1,2,"41935727,33879515",1,dengue disease,0.37068859424875583
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.72,3,76.69,1,0,,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.718,4,75.69,1,0,,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.711,5,56.41,1,0,,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.702,2,84.69,1,0,,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.7,3,82.94,1,0,,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P21359,NF1,Neurofibromin,Tier 1.5,0.695,26,87.19,1,0,,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
P01825,IGHV4-59,Immunoglobulin heavy variable 4-59,Tier 1.5,0.69,3,91.56,1,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q6NT16,SLC18B1,MFS-type transporter SLC18B1,Tier 1.5,0.688,4,84.62,1,0,,,,0,0,,1,Parkinson disease,0.276931649354752
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,Tier 1.5,0.685,5,68.81,1,0,,,,0,0,,1,"developmental and epileptic encephalopathy, 11",0.8388748085806758
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.682,10,90.25,1,0,,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
Q8TD43,TRPM4,Transient receptor potential cation channel subfamily M member 4,Tier 1.5,0.68,25,77.44,1,0,,,,0,0,,1,Familial progressive cardiac conduction defect,0.7868180621357534
O75935,DCTN3,Dynactin subunit 3,Tier 1.5,0.68,1,88.38,1,0,,,,0,0,,1,viral disease,0.03700998752471888
P05023,ATP1A1,Sodium/potassium-transporting ATPase subunit alpha-1,Tier 1.5,0.679,10,88.69,1,0,,,,0,0,,1,"Charcot-Marie-tooth disease, axonal, type 2DD",0.7868851290226483
Q92536,SLC7A6,Y+L amino acid transporter 2,Tier 1.5,0.678,2,83.19,1,0,,,,0,0,,1,Abnormality of the skeletal system,0.48544421359843914
P18564,ITGB6,Integrin beta-6,Tier 1.5,0.675,14,82.88,1,0,,,,0,0,,1,Hypoplastic amelogenesis imperfecta,0.6045342804405103
P36021,SLC16A2,Monocarboxylate transporter 8,Tier 1.5,0.675,7,79.56,1,0,,,,0,0,,1,Allan-Herndon-Dudley syndrome,0.8533069932022032
P32241,VIPR1,Vasoactive intestinal polypeptide receptor 1,Tier 1.5,0.667,17,76.0,1,0,,,,0,0,,1,diverticular disease,0.2747596866638145
O95563,MPC2,Mitochondrial pyruvate carrier 2,Tier 1.5,0.665,17,89.44,1,0,,,,0,0,,1,mitochondrial pyruvate carrier deficiency,0.18534429712437792
O15554,KCNN4,Intermediate conductance calcium-activated potassium channel protein 4,Tier 1.5,0.661,17,84.19,1,0,,,,0,0,,1,dehydrated hereditary stomatocytosis,0.7145864899974032
P98155,VLDLR,Very low-density lipoprotein receptor,Tier 1.5,0.66,27,75.69,1,0,,,,1,1,19188685,1,Dysequilibrium syndrome,0.790164037509625
P13637,ATP1A3,Sodium/potassium-transporting ATPase subunit alpha-3,Tier 1.5,0.654,5,88.81,1,0,,,,0,0,,1,alternating hemiplegia of childhood 2,0.842328126568451
Q14524,SCN5A,Sodium channel protein type 5 subunit alpha,Tier 1.5,0.654,16,67.25,1,0,,,,0,0,,1,long QT syndrome 3,0.8448298602976083
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,Tier 1.5,0.652,14,72.69,1,0,,,,1,4,"33334063,32127469,28010895,30594071",1,gastrointestinal stromal tumor,0.8167494524079806
O60449,LY75,Lymphocyte antigen 75,Tier 1.5,0.65,4,75.62,1,0,,,,0,0,,1,Abruptio Placentae,0.31953367678705413
O00468,AGRN,Agrin,Tier 1.5,0.649,1,68.81,1,0,,,,0,0,,1,congenital myasthenic syndrome 8,0.7912009864338403
Q15027,ACAP1,"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1",Tier 1.5,0.649,7,84.38,1,0,,,,0,0,,1,hypothyroidism,0.4891091360736571
O00478,BTN3A3,Butyrophilin subfamily 3 member A3,Tier 1.5,0.648,9,82.81,1,0,,,,0,0,,1,neoplasm,0.07870866954589865
P07237,P4HB,Protein disulfide-isomerase,Tier 1.5,0.644,14,88.5,1,0,,,,1,2,"31625090,28952381",1,Cole-Carpenter syndrome,0.7447295842045853
Q8TEM1,NUP210,Nuclear pore membrane glycoprotein 210,Tier 1.5,0.644,2,79.56,1,0,,,,0,0,,1,HIV infection,0.5409211817593593
Q9Y4R8,TELO2,Telomere length regulation protein TEL2 homolog,Tier 1.5,0.64,3,83.88,1,0,,,,0,0,,1,TELO2-related intellectual disability-neurodevelopmental disorder,0.7971337980726797
O60443,GSDME,Gasdermin-E,Tier 1.5,0.638,2,77.44,1,0,,,,0,0,,1,autosomal dominant nonsyndromic hearing loss,0.6288670542083885
P00846,MT-ATP6,ATP synthase F(0) complex subunit a,Tier 1.5,0.636,10,88.94,1,0,,,,0,0,,1,NARP syndrome,0.760749518172638
P21731,TBXA2R,Thromboxane A2 receptor,Tier 1.5,0.634,6,86.25,1,0,,,,0,0,,1,bleeding diathesis due to thromboxane synthesis deficiency,0.639967145559869
O75976,CPD,Carboxypeptidase D,Tier 1.5,0.625,3,82.5,1,0,,,,1,1,36457699,1,neurodegenerative disease,0.34777406871587735