id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P62873,GNB1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Tier 1,0.794,1,A2_pm_peripheral,100,97.06,1,0,,,0,0,,1,"intellectual disability, autosomal dominant 42",0.8462216225099116
P06737,PYGL,"Glycogen phosphorylase, liver form",Tier 1,0.787,1,A2_pm_peripheral,19,92.69,1,0,,,0,0,,1,glycogen storage disease VI,0.8220063508118274
P49770,EIF2B2,Translation initiation factor eIF2B subunit beta,Tier 1,0.787,1,A2_pm_peripheral,25,86.56,1,0,,,0,0,,1,CACH syndrome,0.824634396744653
P21333,FLNA,Filamin-A,Tier 1,0.786,1,A2_pm_peripheral,26,76.56,1,0,,,0,0,,1,Melnick-Needles syndrome,0.8200516896124751
Q01831,XPC,DNA repair protein complementing XP-C cells,Tier 1,0.782,1,A2_pm_peripheral,14,66.56,1,0,,,0,0,,1,Xeroderma pigmentosum complementation group C,0.8056391472748724
P01137,TGFB1,Transforming growth factor beta-1 proprotein,Tier 1,0.78,1,A2_pm_peripheral,20,79.56,1,0,,,1,4,"38132522,32370304,16775010,11856769",1,Camurati-Engelmann disease,0.7995305374459716
Q92743,HTRA1,Serine protease HTRA1,Tier 1,0.768,1,A2_pm_peripheral,18,83.25,1,0,,,1,1,31988066,1,"cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2",0.7611877816680132
Q9BYI3,HYCC1,Hyccin,Tier 1,0.766,1,A2_pm_peripheral,5,67.75,1,0,,,0,0,,1,Hypomyelination - congenital cataract,0.7528702184568328
P35221,CTNNA1,Catenin alpha-1,Tier 1,0.765,1,A2_pm_peripheral,10,82.94,1,0,,,1,2,40265971,1,Butterfly-shaped pigment dystrophy,0.7487735496199569
P13797,PLS3,Plastin-3,Tier 1,0.757,1,A2_pm_peripheral,6,88.75,1,0,,,0,0,,1,X-linked osteoporosis with fractures,0.721756781312783
P84077,ARF1,ADP-ribosylation factor 1,Tier 1,0.755,1,A2_pm_peripheral,36,85.94,1,0,,,1,3,"30965174,11320245",1,periventricular nodular heterotopia 8,0.7173626622431929
P07357,C8A,Complement component C8 alpha chain,Tier 1,0.75,1,A2_pm_peripheral,11,78.69,1,0,,,0,0,,1,Immunodeficiency due to a late component of complements deficiency,0.700643416115894
Q13546,RIPK1,Receptor-interacting serine/threonine-protein kinase 1,Tier 1,0.749,1,A2_pm_peripheral,39,69.75,1,0,,,1,2,"41290466,35919280",1,immunodeficiency 57,0.698121745966467
P50148,GNAQ,Guanine nucleotide-binding protein G(q) subunit alpha,Tier 1,0.748,1,A2_pm_peripheral,30,93.0,1,0,,,1,1,40015005,1,Sturge-Weber syndrome,0.6941111530708174
O95786,RIGI,Antiviral innate immune response receptor RIG-I,Tier 1,0.735,1,A2_pm_peripheral,44,85.19,1,0,,,1,6,"34487794,33253193,32946572,31600868,26018150,22127865",1,Singleton-Merten dysplasia,0.6485708110478319
P23921,RRM1,Ribonucleoside-diphosphate reductase large subunit,Tier 1,0.724,1,A2_pm_peripheral,12,92.25,1,0,,,1,1,21955496,1,non-small cell lung carcinoma,0.6122881671315019
P62987,UBA52,Ubiquitin-ribosomal protein eL40 fusion protein,Tier 1,0.712,1,A2_pm_peripheral,30,93.5,1,0,,,0,0,,1,HIV infection,0.5745684844613109
P04406,GAPDH,Glyceraldehyde-3-phosphate dehydrogenase,Tier 1,0.706,1,A2_pm_peripheral,21,98.12,1,0,,,1,11,"39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199",1,neurodegenerative disease,0.55307368855439
Q8NFH5,NUP35,Nucleoporin NUP35,Tier 1,0.702,1,A2_pm_peripheral,5,63.19,1,0,,,0,0,,1,influenza,0.5409211817593593
Q13033,STRN3,Striatin-3,Tier 1,0.701,1,A2_pm_peripheral,4,67.5,1,0,,,0,0,,1,neurodegenerative disease,0.5377902198332467
O75143,ATG13,Autophagy-related protein 13,Tier 1,0.701,1,A2_pm_peripheral,13,63.84,1,0,,,0,0,,1,neurodegenerative disease,0.5360512349298453
Q6IAA8,LAMTOR1,Ragulator complex protein LAMTOR1,Tier 1,0.7,1,A2_pm_peripheral,22,80.12,1,0,,,0,0,,1,neurodegenerative disease,0.5318107016634962
P49662,CASP4,Caspase-4,Tier 1,0.692,1,A2_pm_peripheral,9,78.38,1,0,,,0,0,,1,bacterial disease,0.5062783346658307
Q9UBL3,ASH2L,Set1/Ash2 histone methyltransferase complex subunit ASH2,Tier 1,0.691,1,A2_pm_peripheral,27,75.25,1,0,,,0,0,,1,neurodegenerative disease,0.5019091999413609
P49327,FASN,Fatty acid synthase,Tier 1,0.68,1,A2_pm_peripheral,34,85.44,1,0,,,1,1,41854184,1,dengue disease,0.46815584653391107
P83881,RPL36A,Large ribosomal subunit protein eL42,Tier 1,0.679,1,A2_pm_peripheral,30,94.31,1,0,,,0,0,,1,influenza,0.4619748183558772
Q5VZK9,CARMIL1,F-actin-uncapping protein LRRC16A,Tier 1,0.677,1,A2_pm_peripheral,3,67.38,1,0,,,0,0,,1,schizophrenia,0.45718735748281236
Q86TV6,TTC7B,Tetratricopeptide repeat protein 7B,Tier 1,0.673,1,A2_pm_peripheral,5,85.0,1,0,,,0,0,,1,neurodegenerative disease,0.4430588960838045
Q16763,UBE2S,Ubiquitin-conjugating enzyme E2 S,Tier 1,0.673,1,A2_pm_peripheral,9,80.69,1,0,,,0,0,,1,neurodegenerative disease,0.44489727765466
Q16555,DPYSL2,Dihydropyrimidinase-related protein 2,Tier 1,0.671,1,A2_pm_peripheral,15,90.25,1,0,,,0,0,,1,hypertension,0.4377422749119531
P61077,UBE2D3,Ubiquitin-conjugating enzyme E2 D3,Tier 1,0.667,1,A2_pm_peripheral,46,96.38,1,0,,,0,0,,1,hypertension,0.4222295115574527
P04899,GNAI2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Tier 1,0.665,1,A2_pm_peripheral,34,94.06,1,0,,,0,0,,1,ovarian granulosa cell tumor,0.4157773365202895
P08238,HSP90AB1,Heat shock protein HSP 90-beta,Tier 1,0.661,1,A2_pm_peripheral,32,84.31,1,0,,,1,1,35921069,1,multiple myeloma,0.40496963397728575
Q8N3R9,PALS1,Protein PALS1,Tier 1,0.652,1,A2_pm_peripheral,9,77.19,1,0,,,0,0,,1,COVID-19,0.3720065057444545
P06702,S100A9,Protein S100-A9,Tier 1,0.651,1,A2_pm_peripheral,13,94.31,1,0,,,1,9,"41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041",1,inborn error of immunity,0.36994943453938645
Q92797,SYMPK,Symplekin,Tier 1,0.651,1,A2_pm_peripheral,13,74.56,1,0,,,0,0,,1,dengue disease,0.3695798546847018
Q16658,FSCN1,Fascin,Tier 1,0.642,1,A2_pm_peripheral,28,94.19,1,0,,,0,0,,1,ankylosing spondylitis,0.3390409466148633
Q4FZB7,KMT5B,Histone-lysine N-methyltransferase KMT5B,Tier 1,0.628,1,A2_pm_peripheral,10,54.91,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 51",0.7943209483524042
Q5JVL4,EFHC1,EF-hand domain-containing protein 1,Tier 1,0.626,1,A2_pm_peripheral,2,83.88,1,0,,,0,0,,0,juvenile myoclonic epilepsy,0.7858434985198706
Q15019,SEPTIN2,Septin-2,Tier 1,0.621,1,A2_pm_peripheral,7,81.81,1,0,,,0,0,,1,"osteoarthritis, hip",0.2686294007302314
Q9NPP4,NLRC4,NLR family CARD domain-containing protein 4,Tier 1,0.619,1,A2_pm_peripheral,6,85.12,1,0,,,0,0,,0,periodic fever-infantile enterocolitis-autoinflammatory syndrome,0.7635956406357429
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.618,1,A2_pm_peripheral,100,49.22,1,0,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P35716,SOX11,Transcription factor SOX-11,Tier 1,0.614,1,A2_pm_peripheral,4,56.41,1,0,,,0,0,,0,intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism,0.7470288070793535
P41159,LEP,Leptin,Tier 1,0.606,1,A2_pm_peripheral,10,81.12,1,0,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
Q9Y5K8,ATP6V1D,V-type proton ATPase subunit D,Tier 1,0.552,1,A2_pm_peripheral,8,86.25,1,0,,,0,0,,1,Alzheimer disease,0.03916204989460526
Q9BVS4,RIOK2,Serine/threonine-protein kinase RIO2,Tier 1,0.552,1,A2_pm_peripheral,10,67.38,1,0,,,0,0,,0,neurodegenerative disease,0.539818754658029
Q9NXF7,DCAF16,DDB1- and CUL4-associated factor 16,Tier 1,0.548,1,A2_pm_peripheral,2,38.19,1,0,,,0,0,,0,neurodegenerative disease,0.5251061120759617
O43663,PRC1,Protein regulator of cytokinesis 1,Tier 1,0.544,1,A2_pm_peripheral,6,78.94,1,0,,,0,0,,0,neurodegenerative disease,0.5139662839321523
P43351,RAD52,DNA repair protein RAD52 homolog,Tier 1,0.528,1,A2_pm_peripheral,11,69.62,1,0,,,1,6,"37288783,32945515,31495919,26784987,24500205,23836560",0,Abnormality of the skeletal system,0.45994164258033876
Q9UK80,USP21,Ubiquitin carboxyl-terminal hydrolase 21,Tier 1,0.524,1,A2_pm_peripheral,4,69.75,1,0,,,0,0,,0,neurodegenerative disease,0.44616960950164986