id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P31040,SDHA,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",Tier 1.5,0.785,1,A2_pm_peripheral,4,93.94,1,0,,,0,0,,1,"mitochondrial complex II deficiency, nuclear type 1",0.815589203208636
Q12840,KIF5A,Kinesin heavy chain isoform 5A,Tier 1.5,0.781,1,A2_pm_peripheral,4,75.31,1,0,,,0,0,,1,hereditary spastic paraplegia 10,0.8029405627392309
O00330,PDHX,"Pyruvate dehydrogenase protein X component, mitochondrial",Tier 1.5,0.779,1,A2_pm_peripheral,5,77.31,1,0,,,0,0,,1,pyruvate dehydrogenase E3-binding protein deficiency,0.7957753555992844
Q9NQG7,HPS4,BLOC-3 complex member HPS4,Tier 1.5,0.779,1,A2_pm_peripheral,1,61.66,1,0,,,0,0,,1,Hermansky-Pudlak syndrome with pulmonary fibrosis,0.7967575753847002
O00468,AGRN,Agrin,Tier 1.5,0.777,1,A2_pm_peripheral,1,68.81,1,0,,,0,0,,1,congenital myasthenic syndrome 8,0.7912009864338403
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.776,1,A2_pm_peripheral,6,79.56,1,0,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
P32121,ARRB2,Beta-arrestin-2,Tier 1.5,0.719,1,A2_pm_peripheral,1,83.81,1,0,,,1,4,"24736311,40652239,29054528",1,cancer,0.5962458729823639
O15511,ARPC5,Actin-related protein 2/3 complex subunit 5,Tier 1.5,0.699,1,A2_pm_peripheral,2,92.19,1,0,,,0,0,,1,neurodegenerative disease,0.5305805352966168
P30154,PPP2R1B,Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform,Tier 1.5,0.699,1,A2_pm_peripheral,1,92.81,1,0,,,0,0,,1,cancer,0.5305484520119053
O00762,UBE2C,Ubiquitin-conjugating enzyme E2 C,Tier 1.5,0.689,1,A2_pm_peripheral,9,88.56,1,0,,,0,0,,1,neurodegenerative disease,0.49682303083942114
P31948,STIP1,Stress-induced-phosphoprotein 1,Tier 1.5,0.689,1,A2_pm_peripheral,8,89.75,1,0,,,1,7,"41406518,38012811,34831332,32614006,27681499,24654750,24013070",1,neurodegenerative disease,0.4967711525222825
P21980,TGM2,Protein-glutamine gamma-glutamyltransferase 2,Tier 1.5,0.688,1,A2_pm_peripheral,17,92.88,1,0,,,1,1,35980938,1,neurodegenerative disease,0.49455272812698803
P63098,PPP3R1,Calcineurin subunit B type 1,Tier 1.5,0.673,1,A2_pm_peripheral,21,91.12,1,0,,,1,2,39263947,1,Abnormality of the skeletal system,0.44389060142742937
Q9H0A8,COMMD4,COMM domain-containing protein 4,Tier 1.5,0.663,1,A2_pm_peripheral,4,80.75,1,0,,,0,0,,1,neurodegenerative disease,0.4109063598016124
Q00536,CDK16,Cyclin-dependent kinase 16,Tier 1.5,0.652,1,A2_pm_peripheral,3,71.94,1,0,,,0,0,,1,Intellectual disability,0.3718454818549898
O60551,NMT2,Glycylpeptide N-tetradecanoyltransferase 2,Tier 1.5,0.651,1,A2_pm_peripheral,3,80.88,1,0,,,0,0,,1,HIV infection,0.37004182950305764
P50748,KNTC1,Kinetochore-associated protein 1,Tier 1.5,0.64,1,A2_pm_peripheral,1,71.5,1,0,,,0,0,,1,"osteoarthritis, knee",0.3323628521281481
Q9UNZ2,NSFL1C,NSFL1 cofactor p47,Tier 1.5,0.638,1,A2_pm_peripheral,3,74.06,1,0,,,0,0,,1,neurodegenerative disease,0.3262410536701536
P49459,UBE2A,Ubiquitin-conjugating enzyme E2 A,Tier 1.5,0.626,1,A2_pm_peripheral,5,94.12,1,0,,,0,0,,0,syndromic X-linked intellectual disability Nascimento type,0.7867796040270276
A7E2V4,ZSWIM8,Zinc finger SWIM domain-containing protein 8,Tier 1.5,0.625,1,A2_pm_peripheral,1,61.94,1,0,,,0,0,,1,aortic stenosis,0.28253434569668473
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
P50552,VASP,Vasodilator-stimulated phosphoprotein,Tier 1.5,0.604,1,A2_pm_peripheral,11,69.75,1,0,,,0,0,,1,neurodegenerative disease,0.21494427179372053
Q8IUC6,TICAM1,TIR domain-containing adapter molecule 1,Tier 1.5,0.581,1,A2_pm_peripheral,8,62.78,1,0,,,0,0,,0,Herpetic encephalitis,0.6364986386236531
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.577,1,A2_pm_peripheral,9,76.75,1,0,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
P55010,EIF5,Eukaryotic translation initiation factor 5,Tier 1.5,0.577,1,A2_pm_peripheral,6,73.19,1,0,,,0,0,,1,Abnormality of the skeletal system,0.12225325872435809
P56597,NME5,Nucleoside diphosphate kinase 5,Tier 1.5,0.563,1,A2_pm_peripheral,1,90.06,1,0,,,0,0,,0,"ciliary dyskinesia, primary, 48, without situs inversus",0.5766985649142533
Q9GZN1,ACTR6,Actin-related protein 6,Tier 1.5,0.533,1,A2_pm_peripheral,9,94.31,1,0,,,0,0,,0,neurodegenerative disease,0.4758409073452339
Q5VTH2,CFAP126,Protein Flattop,Tier 1.5,0.51,1,A2_pm_peripheral,2,72.62,1,0,,,0,0,,0,hereditary pheochromocytoma-paraganglioma,0.4009925718465981
O75182,SIN3B,Paired amphipathic helix protein Sin3b,Tier 1.5,0.501,1,A2_pm_peripheral,4,68.0,1,0,,,1,2,16914451,0,syndromic intellectual disability,0.37050380432141355
P55089,UCN,Urocortin,Tier 1.5,0.469,1,A2_pm_peripheral,6,68.25,1,0,,,1,3,"30221506,26488412,23248006",0,neurodegenerative disease,0.26311734927710556
Q86UC2,RSPH3,Radial spoke head protein 3 homolog,Tier 1.5,0.39,1,A2_pm_peripheral,1,64.62,1,0,,,0,0,,0,,