id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P04180,LCAT,Phosphatidylcholine-sterol acyltransferase,Tier 1.5,0.848,1,A_assoc,7,86.75,1,0,,,0,0,,1,Fish-eye disease,0.8273460309828392
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.847,1,A_assoc,10,90.25,1,0,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.847,1,A_assoc,3,82.94,1,0,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.84,1,A_assoc,3,76.69,1,0,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.836,1,A_assoc,9,50.62,1,0,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P35858,IGFALS,Insulin-like growth factor-binding protein complex acid labile subunit,Tier 1.5,0.833,1,A_assoc,1,90.56,1,0,,,0,0,,1,Reduced insulin like growth factor binding protein acid labile subunit concentration,0.7760522769257892
P02748,C9,Complement component C9,Tier 1.5,0.829,1,A_assoc,9,78.75,1,0,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
O15230,LAMA5,Laminin subunit alpha-5,Tier 1.5,0.828,1,A_assoc,2,79.12,1,0,,,0,0,,1,"nephrotic syndrome, IIa 26",0.7594872666460903
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.815,1,A_assoc,18,91.38,1,0,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.775,1,A_assoc,4,75.69,1,0,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
P10646,TFPI,Tissue factor pathway inhibitor,Tier 1.5,0.768,1,A_assoc,9,73.62,1,0,,,1,28,"32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161",1,hemophilia A,0.5591056672248635
P02771,AFP,Alpha-fetoprotein,Tier 1.5,0.765,1,A_assoc,5,88.94,1,0,,,1,195,"41849903,41732103,41688234,41327249,41051792,40839965,40750207,40684729,40578247,40383027,40381048,40347636,40262341,40216053,39982565,39942588,39890683,39771616,39479488,39383727,39305942,39167423,39140150,39082193,39067928,39007743,38904836,38852341,38356334,37836778,37709445,37606762,37366993,37303825,37295202,37284243,37228865,37104032,36989661,36979562,36842207,36693188,36512161,36389169,36290918,36240195,36130652,35969067,35793076,35747812,41637558,41575587,41123957,41103270,40349714,40286895,38899396,37325361",1,Congenital deficiency in alpha-fetoprotein,0.5500580170557311
P24593,IGFBP5,Insulin-like growth factor-binding protein 5,Tier 1.5,0.711,1,A_assoc,3,76.06,1,0,,,1,4,"39317671,31930684",1,hypothyroidism,0.3702458751451027
Q00604,NDP,Norrin,Tier 1.5,0.707,1,A_assoc,11,83.56,1,0,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
O43866,CD5L,CD5 antigen-like,Tier 1.5,0.706,1,A_assoc,4,85.88,1,0,,,1,3,"40215752,37100807",1,functional neutrophil defect,0.3529395470693119
P10145,CXCL8,Interleukin-8,Tier 1.5,0.706,1,A_assoc,21,88.06,1,0,,,1,15,"39564692,35821507,31985806,29268188,41866852,37732574,37016361,36037714,35197258,34884636,25998051,24129312",1,coronary artery disease,0.35357870191996843
P80162,CXCL6,C-X-C motif chemokine 6,Tier 1.5,0.699,1,A_assoc,2,81.0,1,0,,,1,3,"40008515,36649818,32628701",1,neurodegenerative disease,0.3309117033683961
O95970,LGI1,Leucine-rich glioma-inactivated protein 1,Tier 1.5,0.697,1,A_assoc,9,92.56,1,0,,,0,0,,0,autosomal dominant epilepsy with auditory features,0.8225657483127345
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.685,1,A_assoc,3,68.62,1,0,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P19876,CXCL3,C-X-C motif chemokine 3,Tier 1.5,0.679,1,A_assoc,2,81.88,1,0,,,0,0,,1,neurodegenerative disease,0.26311734927710556
P19875,CXCL2,C-X-C motif chemokine 2,Tier 1.5,0.674,1,A_assoc,4,81.62,1,0,,,0,0,,1,neurodegenerative disease,0.24624512698601778
O95631,NTN1,Netrin-1,Tier 1.5,0.648,1,A_assoc,5,88.5,1,0,,,0,0,,0,mirror movements 4,0.6611393488240481
Q9NWU2,GID8,Glucose-induced degradation protein 8 homolog,Tier 1.5,0.631,1,A_assoc,1,91.94,1,0,,,0,0,,1,Abnormality of the skeletal system,0.10187555420552867
Q6IBW4,NCAPH2,Condensin-2 complex subunit H2,Tier 1.5,0.62,1,A_assoc,1,62.41,1,0,,,0,0,,0,"cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1",0.5674645203025676
Q15726,KISS1,Metastasis-suppressor KiSS-1,Tier 1.5,0.618,1,A_assoc,2,59.41,1,0,,,1,1,35026192,0,hypogonadotropic hypogonadism,0.5608645918536114
P22466,GAL,Galanin peptides,Tier 1.5,0.613,1,A_assoc,10,66.56,1,0,,,1,27,"40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673",0,temporal lobe epilepsy,0.5442263564708273
Q63HQ2,EGFLAM,Pikachurin,Tier 1.5,0.574,1,A_assoc,3,80.56,1,0,,,0,0,,0,mathematical ability,0.41387833248094535
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.573,1,A_assoc,4,75.62,1,0,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
P01282,VIP,VIP peptides,Tier 1.5,0.55,1,A_assoc,5,67.62,1,0,,,1,24,"41292425,40957130,40403614,40056883,39952883,38763821,37527574,36669289,36129574,35879297,35436736,33990848,33688885,31689596,31403149,30167802,30069577,29708252,28441340,27542489,27334718,27088368,26802746,25782595",0,uterine fibroid,0.3332844575068197
O14960,LECT2,Leukocyte cell-derived chemotaxin-2,Tier 1.5,0.542,1,A_assoc,4,92.44,1,0,,,1,2,35045701,0,neurodegenerative disease,0.30565036648724025
Q06141,REG3A,Regenerating islet-derived protein 3-alpha,Tier 1.5,0.539,1,A_assoc,4,89.0,1,0,,,1,2,"39695715,24771595",0,alcohol drinking,0.29724052454892086
M5A8F1,ERVH48-1,Suppressyn,Tier 1.5,0.519,1,A_assoc,1,74.94,1,0,,,0,0,,0,hypertension,0.23115391486595976
P01178,OXT,Oxytocin-neurophysin 1,Tier 1.5,0.514,1,A_assoc,4,83.81,1,0,,,1,1,34649198,0,neurodegenerative disease,0.21368454441108417
Q5T4W7,ARTN,Artemin,Tier 1.5,0.512,1,A_assoc,5,75.0,1,0,,,0,0,,0,neurodegenerative disease,0.20507822956537197
P09683,SCT,Secretin,Tier 1.5,0.495,1,A_assoc,3,65.88,1,0,,,1,2,"17495522,7752141",0,idiopathic pulmonary fibrosis,0.14866387905285056
Q07325,CXCL9,C-X-C motif chemokine 9,Tier 1.5,0.486,1,A_assoc,1,87.44,1,0,,,1,7,"42046114,37395276,35204399,35018777,33742062,27959341,27819142",0,neoplasm,0.1199067650750674
Q8IZI9,IFNL3,Interferon lambda-3,Tier 1.5,0.484,1,A_assoc,3,84.81,1,0,,,0,0,,0,hepatocellular carcinoma,0.1145400757875244
O00230,CORT,Cortistatin,Tier 1.5,0.484,1,A_assoc,5,62.84,1,0,,,0,0,,0,neoplasm,0.11461560504839655
Q9Y5Q6,INSL5,Insulin-like peptide INSL5,Tier 1.5,0.477,1,A_assoc,3,64.06,1,0,,,0,0,,0,polycystic ovary syndrome,0.08868171274230166