id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21359,NF1,Neurofibromin,Tier 1.5,0.965,1,A_surface,26,87.19,1,0,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
P36021,SLC16A2,Monocarboxylate transporter 8,Tier 1.5,0.956,1,A_surface,7,79.56,1,0,,,0,0,,1,Allan-Herndon-Dudley syndrome,0.8533069932022032
Q14524,SCN5A,Sodium channel protein type 5 subunit alpha,Tier 1.5,0.953,1,A_surface,16,67.25,1,0,,,0,0,,1,long QT syndrome 3,0.8448298602976083
Q969N2,PIGT,GPI-anchor transamidase component PIGT,Tier 1.5,0.953,1,A_surface,3,87.25,1,0,,,0,0,,1,multiple congenital anomalies-hypotonia-seizures syndrome 3,0.8439030764005646
P13637,ATP1A3,Sodium/potassium-transporting ATPase subunit alpha-3,Tier 1.5,0.953,1,A_surface,5,88.81,1,0,,,0,0,,1,alternating hemiplegia of childhood 2,0.842328126568451
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,Tier 1.5,0.952,1,A_surface,5,68.81,1,0,,,0,0,,1,"developmental and epileptic encephalopathy, 11",0.8388748085806758
Q9HAB3,SLC52A2,"Solute carrier family 52, riboflavin transporter, member 2",Tier 1.5,0.95,1,A_surface,1,84.12,1,0,,,0,0,,1,riboflavin transporter deficiency,0.8333271825486935
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.95,1,A_surface,1,77.88,1,0,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.947,1,A_surface,2,84.69,1,0,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,Tier 1.5,0.945,1,A_surface,14,72.69,1,0,,,1,4,"33334063,32127469,28010895,30594071",1,gastrointestinal stromal tumor,0.8167494524079806
P51798,CLCN7,H(+)/Cl(-) exchange transporter 7,Tier 1.5,0.942,1,A_surface,9,80.94,1,0,,,0,0,,1,Autosomal recessive malignant osteopetrosis,0.8065499095904218
Q96JI7,SPG11,Spatacsin,Tier 1.5,0.937,1,A_surface,3,66.75,1,0,,,0,0,,1,Autosomal recessive spastic paraplegia type 11,0.7886006646085494
Q8TD43,TRPM4,Transient receptor potential cation channel subfamily M member 4,Tier 1.5,0.936,1,A_surface,25,77.44,1,0,,,0,0,,1,Familial progressive cardiac conduction defect,0.7868180621357534
P05023,ATP1A1,Sodium/potassium-transporting ATPase subunit alpha-1,Tier 1.5,0.936,1,A_surface,10,88.69,1,0,,,0,0,,1,"Charcot-Marie-tooth disease, axonal, type 2DD",0.7868851290226483
P15529,CD46,Membrane cofactor protein,Tier 1.5,0.934,1,A_surface,7,82.12,1,0,,,1,9,"35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032",1,atypical hemolytic-uremic syndrome with MCP/CD46 anomaly,0.7798469882597787
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.929,1,A_surface,8,95.62,1,0,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
P00846,MT-ATP6,ATP synthase F(0) complex subunit a,Tier 1.5,0.928,1,A_surface,10,88.94,1,0,,,0,0,,1,NARP syndrome,0.760749518172638
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.921,1,A_surface,7,77.88,1,0,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
O15554,KCNN4,Intermediate conductance calcium-activated potassium channel protein 4,Tier 1.5,0.914,1,A_surface,17,84.19,1,0,,,0,0,,1,dehydrated hereditary stomatocytosis,0.7145864899974032
O75110,ATP9A,Probable phospholipid-transporting ATPase IIA,Tier 1.5,0.914,1,A_surface,4,84.19,1,0,,,0,0,,1,neurodevelopmental disorder with poor growth and behavioral abnormalities,0.7120328673255018
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.913,1,A_surface,5,56.41,1,0,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
P51797,CLCN6,H(+)/Cl(-) exchange transporter 6,Tier 1.5,0.897,1,A_surface,3,77.81,1,0,,,0,0,,1,"neurodegeneration, childhood-onset, with hypotonia, respiratory insufficiency, and brain imaging abnormalities",0.6554030932062199
P21731,TBXA2R,Thromboxane A2 receptor,Tier 1.5,0.892,1,A_surface,6,86.25,1,0,,,0,0,,1,bleeding diathesis due to thromboxane synthesis deficiency,0.639967145559869
P02786,TFRC,Transferrin receptor protein 1,Tier 1.5,0.887,1,A_surface,22,86.69,1,0,,,1,3,"39831311,29046922,32527800",1,TFRC-related combined immunodeficiency,0.623449899069336
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.88,1,A_surface,7,89.69,1,0,,,0,0,,1,congestive heart failure,0.5999952111132625
P01825,IGHV4-59,Immunoglobulin heavy variable 4-59,Tier 1.5,0.876,1,A_surface,3,91.56,1,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P15954,COX7C,"Cytochrome c oxidase subunit 7C, mitochondrial",Tier 1.5,0.868,1,A_surface,3,91.38,1,0,,,0,0,,1,neurodegenerative disease,0.5589133210585959
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.866,1,A_surface,19,72.06,1,0,,,0,0,,1,Knobloch syndrome,0.5526223217595396
Q8TEM1,NUP210,Nuclear pore membrane glycoprotein 210,Tier 1.5,0.862,1,A_surface,2,79.56,1,0,,,0,0,,1,HIV infection,0.5409211817593593
Q9Y6M7,SLC4A7,Sodium bicarbonate cotransporter 3,Tier 1.5,0.856,1,A_surface,1,67.5,1,0,,,0,0,,1,hypertension,0.5199335074832467
Q92536,SLC7A6,Y+L amino acid transporter 2,Tier 1.5,0.846,1,A_surface,2,83.19,1,0,,,0,0,,1,Abnormality of the skeletal system,0.48544421359843914
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.843,1,A_surface,16,83.62,1,0,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P14616,INSRR,Insulin receptor-related protein,Tier 1.5,0.838,1,A_surface,4,78.0,1,0,,,0,0,,1,neurodegenerative disease,0.4589515676875687
Q3MIR4,TMEM30B,Cell cycle control protein 50B,Tier 1.5,0.809,1,A_surface,1,92.19,1,0,,,0,0,,1,androgenetic alopecia,0.3618940606584721
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.806,1,A_surface,4,83.25,1,0,,,0,0,,0,progressive familial intrahepatic cholestasis type 3,0.851728159166962
P31785,IL2RG,Cytokine receptor common subunit gamma,Tier 1.5,0.804,1,A_surface,14,75.5,1,0,,,1,2,"30800133,33869115",0,gamma chain deficiency,0.8469997000418428
Q5ZPR3,CD276,CD276 antigen,Tier 1.5,0.804,1,A_surface,3,83.31,1,0,,,1,1,38866941,1,response to statin,0.3471917147958521
Q92982,NINJ1,Ninjurin-1,Tier 1.5,0.804,1,A_surface,5,63.56,1,0,,,0,0,,1,gout,0.3456637674136287
Q9UM01,SLC7A7,Y+L amino acid transporter 1,Tier 1.5,0.804,1,A_surface,5,83.81,1,0,,,0,0,,0,lysinuric protein intolerance,0.8450026270275782
P08100,RHO,Rhodopsin,Tier 1.5,0.804,1,A_surface,4,88.75,1,0,,,1,45,"41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760",0,retinitis pigmentosa,0.8481942240861982
P48029,SLC6A8,Sodium- and chloride-dependent creatine transporter 1,Tier 1.5,0.804,1,A_surface,6,84.62,1,0,,,0,0,,0,creatine transporter deficiency,0.847268393806457
Q9UQD0,SCN8A,Sodium channel protein type 8 subunit alpha,Tier 1.5,0.803,1,A_surface,4,68.38,1,0,,,0,0,,0,"developmental and epileptic encephalopathy, 13",0.8437707419548253
O95342,ABCB11,Bile salt export pump,Tier 1.5,0.801,1,A_surface,8,83.12,1,0,,,1,1,36313979,0,progressive familial intrahepatic cholestasis type 2,0.8372060401943777
P78508,KCNJ10,ATP-sensitive inward rectifier potassium channel 10,Tier 1.5,0.801,1,A_surface,4,82.44,1,0,,,0,0,,0,EAST syndrome,0.8357483559927158
Q16281,CNGA3,Cyclic nucleotide-gated channel alpha-3,Tier 1.5,0.799,1,A_surface,10,74.44,1,0,,,0,0,,0,achromatopsia,0.8315799021867489
Q9HD23,MRS2,"Magnesium transporter MRS2 homolog, mitochondrial",Tier 1.5,0.799,1,A_surface,9,71.06,1,0,,,0,0,,1,alcohol drinking,0.32910269130630654
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.797,1,A_surface,4,84.38,1,0,,,0,0,,0,glucose-galactose malabsorption,0.8220991027793896
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.797,1,A_surface,13,80.69,1,0,,,0,0,,0,Congenital myasthenic syndromes,0.8223287249629152
O60449,LY75,Lymphocyte antigen 75,Tier 1.5,0.796,1,A_surface,4,75.62,1,0,,,0,0,,1,Abruptio Placentae,0.31953367678705413
P23942,PRPH2,Peripherin-2,Tier 1.5,0.796,1,A_surface,1,87.0,1,0,,,0,0,,0,retinitis pigmentosa,0.8194208847382956