id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q05086,,,Tier 1,0.753,1,unknown,27,80.75,1,0,,,0,0,,1,Angelman syndrome,0.8429347259838658
Q15858,,,Tier 1,0.747,1,unknown,43,69.06,1,0,,,0,0,,1,primary erythermalgia,0.8237835765987434
Q92608,,,Tier 1,0.734,1,unknown,6,79.81,1,0,,,0,0,,1,DOCK2 deficiency,0.7814025939223274
Q5T5Y3,,,Tier 1,0.694,1,unknown,4,54.34,1,0,,,0,0,,1,"cortical dysplasia, complex, with other brain malformations 12",0.6471266259726068
Q08945,SSRP1,FACT complex subunit SSRP1,Tier 1,0.675,1,unknown,11,74.19,1,0,,,1,1,39653795,1,HIV infection,0.5844684701481319
P43487,,,Tier 1,0.651,1,unknown,4,83.38,1,0,,,0,0,,1,HIV infection,0.5030392466541774
Q14213,,,Tier 1,0.628,1,unknown,4,87.62,1,0,,,0,0,,1,neurodegenerative disease,0.42776938116451996
F8WCM5,,,Tier 1,0.624,1,unknown,4,48.81,1,0,,,0,0,,1,neurodegenerative disease,0.4145162522265602
Q13131,,,Tier 1,0.614,1,unknown,12,79.56,1,0,,,0,0,,1,cardiovascular disease,0.37913864498012223
P07360,,,Tier 1,0.611,1,unknown,15,89.75,1,0,,,0,0,,1,complement deficiency,0.3695798546847018
P20339,,,Tier 1,0.611,1,unknown,14,84.88,1,0,,,0,0,,1,tuberculosis,0.3708733841760982
P08034,,,Tier 1,0.604,1,unknown,15,80.25,1,0,,,0,0,,0,Charcot-Marie-Tooth disease X-linked dominant 1,0.8483281160610058
Q96HW7,,,Tier 1,0.599,1,unknown,11,83.19,1,0,,,0,0,,1,systemic lupus erythematosus,0.3316421846062003
Q8NBJ9,,,Tier 1,0.598,1,unknown,7,80.25,1,0,,,0,0,,1,hypothyroidism,0.32686531914177924
P23415,,,Tier 1,0.597,1,unknown,9,84.0,1,0,,,0,0,,0,hereditary hyperekplexia,0.822516157871453
Q96Q15,,,Tier 1,0.593,1,unknown,10,76.88,1,0,,,0,0,,1,contracture,0.30952829622581673
Q15061,,,Tier 1,0.593,1,unknown,3,69.62,1,0,,,0,0,,1,triple-negative breast cancer,0.31136131887350776
Q13422,,,Tier 1,0.591,1,unknown,10,47.75,1,0,,,0,0,,0,pancytopenia due to IKZF1 mutations,0.8043234687306351
P48067,SLC6A9,Sodium- and chloride-dependent glycine transporter 1,Tier 1,0.582,1,unknown,9,81.12,1,0,,,0,0,,0,atypical glycine encephalopathy,0.7733051820377859
P29973,,,Tier 1,0.566,1,unknown,19,76.25,1,0,,,0,0,,0,retinitis pigmentosa,0.7206608041231198
P98073,,,Tier 1,0.563,1,unknown,14,81.5,1,0,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
Q8N9N8,,,Tier 1,0.554,1,unknown,4,75.69,1,0,,,0,0,,1,Nestor-Guillermo progeria syndrome,0.17918659722662342
O15393,,,Tier 1,0.535,1,unknown,31,79.38,1,0,,,0,0,,0,COVID-19,0.6157541390484623
Q13639,,,Tier 1,0.532,1,unknown,3,80.88,1,0,,,0,0,,0,schizophrenia,0.6060830827022777
O43614,,,Tier 1,0.53,1,unknown,11,78.94,1,0,,,0,0,,0,insomnia,0.5988748728311054
O75616,ERAL1,"GTPase Era, mitochondrial",Tier 1,0.504,1,unknown,2,77.94,1,0,,,0,0,,0,neurodegenerative disease,0.5128349940245936
Q15291,,,Tier 1,0.5,1,unknown,27,77.75,1,0,,,0,0,,0,neurodegenerative disease,0.500512770014237
P25025,,,Tier 1,0.499,1,unknown,18,79.56,1,0,,,0,0,,0,WHIM syndrome 2,0.4956521666475962
P06307,,,Tier 1,0.487,1,unknown,9,65.12,1,0,,,0,0,,0,Abnormality of the skeletal system,0.45523854320041374
Q9UNN5,,,Tier 1,0.475,1,unknown,16,77.0,1,0,,,0,0,,0,atrial fibrillation,0.41761152415302133
Q9NVH2,,,Tier 1,0.465,1,unknown,8,88.06,1,0,,,0,0,,0,neurodegenerative disease,0.38183943401611947
Q86X95,CIRSR,Corepressor of RBPJ and splicing regulator,Tier 1,0.463,1,unknown,2,59.72,1,0,,,0,0,,0,major depressive disorder,0.3767349972483621
Q14416,,,Tier 1,0.461,1,unknown,31,85.69,1,0,,,0,0,,0,schizophrenia,0.36850365898315596
P13725,,,Tier 1,0.446,1,unknown,3,78.75,1,0,,,0,0,,0,coronary artery disease,0.3209548186332283
P32248,,,Tier 1,0.445,1,unknown,7,78.38,1,0,,,0,0,,0,neurodegenerative disease,0.31793347108990094
Q03188,,,Tier 1,0.437,1,unknown,14,48.03,1,0,,,0,0,,0,pernicious anemia,0.28985906769534225
P02778,,,Tier 1,0.387,1,unknown,6,89.56,1,0,,,0,0,,0,rheumatoid arthritis,0.1225158134105281
A8MTA8,CIMIP2B,Ciliary microtubule inner protein 2B,Tier 1,0.383,1,unknown,2,68.75,1,0,,,0,0,,0,Meckel syndrome,0.11087395640541053
A0A5C2GQT9,,,Tier 1,0.35,1,unknown,5,96.38,1,0,,,0,0,,0,,
P0DOX7,,Immunoglobulin kappa light chain,Tier 1,0.35,1,unknown,14,96.19,1,0,,,0,0,,0,,
P23724,PRE7,Proteasome subunit beta type-6,Tier 1,0.35,1,unknown,30,94.62,1,0,,,0,0,,0,,
P25043,PUP1,Proteasome subunit beta type-2,Tier 1,0.35,1,unknown,30,93.62,1,0,,,0,0,,0,,
Q6GMX0,,Ig-like domain-containing protein,Tier 1,0.35,1,unknown,11,92.31,1,0,,,0,0,,0,,
Q7Z3Y4,,Ig-like domain-containing protein,Tier 1,0.35,1,unknown,23,92.38,1,0,,,0,0,,0,,
P0DOX5,,Immunoglobulin gamma-1 heavy chain,Tier 1,0.35,1,unknown,100,91.62,1,0,,,0,0,,0,,
Q8TCD0,,Ig-like domain-containing protein,Tier 1,0.35,1,unknown,38,91.5,1,0,,,0,0,,0,,
B9EE38,NADH3,NADH-ubiquinone oxidoreductase chain 3,Tier 1,0.35,1,unknown,2,90.25,1,0,,,0,0,,0,,
A0A6J0Y1Z7,,,Tier 1,0.35,1,unknown,1,89.25,1,0,,,0,0,,0,,
P16218,celH,Endoglucanase H,Tier 1,0.35,1,unknown,23,88.94,1,0,,,0,0,,0,,
Q6N089,DKFZp686P15220,Ig-like domain-containing protein,Tier 1,0.35,1,unknown,17,87.69,1,0,,,0,0,,0,,