id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9Y4U1,MMACHC,Cyanocobalamin reductase / alkylcobalamin dealkylase,Tier 1.5,0.644,1,A2_pm_peripheral,7,85.62,0,0,,,0,0,,0,"Methylmalonic acidemia with homocystinuria, type cblC",0.8478185420804271
Q9Y215,COLQ,Acetylcholinesterase collagenic tail peptide,Tier 1.5,0.629,1,A2_pm_peripheral,1,54.47,0,0,,,0,0,,0,Congenital myasthenic syndromes,0.796199449860989
Q4FZB7,KMT5B,Histone-lysine N-methyltransferase KMT5B,Tier 1,0.628,1,A2_pm_peripheral,10,54.91,1,0,,,0,0,,0,"intellectual disability, autosomal dominant 51",0.7943209483524042
Q68CZ1,RPGRIP1L,Protein fantom,Tier 1.5,0.628,1,A2_pm_peripheral,1,70.06,0,0,,,0,0,,0,Joubert syndrome with hepatic defect,0.7930231953177929
Q5JVL4,EFHC1,EF-hand domain-containing protein 1,Tier 1,0.626,1,A2_pm_peripheral,2,83.88,1,0,,,0,0,,0,juvenile myoclonic epilepsy,0.7858434985198706
P49459,UBE2A,Ubiquitin-conjugating enzyme E2 A,Tier 1.5,0.626,1,A2_pm_peripheral,5,94.12,1,0,,,0,0,,0,syndromic X-linked intellectual disability Nascimento type,0.7867796040270276
O75800,ZMYND10,Zinc finger MYND domain-containing protein 10,Tier 1,0.625,1,A2_pm_peripheral,2,88.75,0,0,,,0,0,,0,primary ciliary dyskinesia,0.7822239837882315
Q86SQ9,DHDDS,Dehydrodolichyl diphosphate synthase complex subunit DHDDS,Tier 1,0.624,1,A2_pm_peripheral,9,94.75,0,0,,,0,0,,0,retinitis pigmentosa 59,0.7786578489187141
O43586,PSTPIP1,Proline-serine-threonine phosphatase-interacting protein 1,Tier 1,0.624,1,A2_pm_peripheral,4,85.75,0,0,,,0,0,,0,pyogenic arthritis-pyoderma gangrenosum-acne syndrome,0.7793785829807485
Q8NFD5,ARID1B,AT-rich interactive domain-containing protein 1B,Tier 1,0.624,1,A2_pm_peripheral,2,46.19,0,0,,,0,0,,0,Coffin-Siris syndrome 1,0.7813407475430133
Q9NPP4,NLRC4,NLR family CARD domain-containing protein 4,Tier 1,0.619,1,A2_pm_peripheral,6,85.12,1,0,,,0,0,,0,periodic fever-infantile enterocolitis-autoinflammatory syndrome,0.7635956406357429
Q15744,CEBPE,CCAAT/enhancer-binding protein epsilon,Tier 1.5,0.619,1,A2_pm_peripheral,1,63.19,0,0,,,0,0,,0,Recurrent infection due to specific granule deficiency,0.7619369036825959
Q96CW9,NTNG2,Netrin-G2,Tier 1.5,0.616,1,A2_pm_peripheral,3,84.5,0,0,,,0,0,,0,"neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia",0.7527757254195254
P35716,SOX11,Transcription factor SOX-11,Tier 1,0.614,1,A2_pm_peripheral,4,56.41,1,0,,,0,0,,0,intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism,0.7470288070793535
P48788,TNNI2,"Troponin I, fast skeletal muscle",Tier 1.5,0.613,1,A2_pm_peripheral,2,80.69,0,0,,,0,0,,0,distal arthrogryposis type 2B1,0.7424838485252128
O15350,TP73,Tumor protein p73,Tier 1,0.612,1,A2_pm_peripheral,28,65.19,0,0,,,0,0,,0,"ciliary dyskinesia, primary, 47, and lissencephaly",0.7409037542174439
Q6EMB2,TTLL5,Tubulin polyglutamylase TTLL5,Tier 1.5,0.607,1,A2_pm_peripheral,1,61.41,0,0,,,0,0,,0,Cone rod dystrophy,0.72210835127064
Q8N136,DAW1,Dynein assembly factor with WD repeat domains 1,Tier 1,0.596,1,A2_pm_peripheral,1,96.62,0,0,,,0,0,,0,"ciliary dyskinesia, primary, 52",0.6876653910907874
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.595,1,A2_pm_peripheral,1,74.94,0,0,,,0,0,,0,Seckel syndrome 9,0.683878095944948
Q4KMQ1,TPRN,Taperin,Tier 1.5,0.595,1,A2_pm_peripheral,1,54.44,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.6844134134291492
Q9H6P5,TASP1,Threonine aspartase 1,Tier 1,0.594,1,A2_pm_peripheral,10,86.81,0,0,,,0,0,,0,Suleiman-El-Hattab syndrome,0.6801464403674466
Q8IUC6,TICAM1,TIR domain-containing adapter molecule 1,Tier 1.5,0.581,1,A2_pm_peripheral,8,62.78,1,0,,,0,0,,0,Herpetic encephalitis,0.6364986386236531
P50607,TUB,Tubby protein homolog,Tier 1.5,0.579,1,A2_pm_peripheral,1,69.12,0,0,,,0,0,,0,retinitis pigmentosa,0.631297844631827
Q9UQC2,GAB2,GRB2-associated-binding protein 2,Tier 1,0.572,1,A2_pm_peripheral,10,51.91,0,0,,,0,0,,0,cancer,0.6072358553557748
Q8IWB6,TEX14,Inactive serine/threonine-protein kinase TEX14,Tier 1,0.571,1,A2_pm_peripheral,2,50.47,0,0,,,0,0,,0,spermatogenic failure 23,0.603775324929283
P56597,NME5,Nucleoside diphosphate kinase 5,Tier 1.5,0.563,1,A2_pm_peripheral,1,90.06,1,0,,,0,0,,0,"ciliary dyskinesia, primary, 48, without situs inversus",0.5766985649142533
Q13882,PTK6,Protein-tyrosine kinase 6,Tier 1,0.56,1,A2_pm_peripheral,9,88.81,0,0,,,0,0,,0,medullary thyroid gland carcinoma,0.5657289152364859
O76083,PDE9A,"High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A",Tier 1,0.553,1,A2_pm_peripheral,25,81.0,0,0,,,0,0,,0,coronary artery disease,0.5429744031742744
Q9BVS4,RIOK2,Serine/threonine-protein kinase RIO2,Tier 1,0.552,1,A2_pm_peripheral,10,67.38,1,0,,,0,0,,0,neurodegenerative disease,0.539818754658029
Q86T24,ZBTB33,Transcriptional regulator Kaiso,Tier 1,0.551,1,A2_pm_peripheral,19,54.78,0,0,,,0,0,,0,neurodegenerative disease,0.5355170277816887
Q9NXF7,DCAF16,DDB1- and CUL4-associated factor 16,Tier 1,0.548,1,A2_pm_peripheral,2,38.19,1,0,,,0,0,,0,neurodegenerative disease,0.5251061120759617
Q8WWN9,IPCEF1,Interactor protein for cytohesin exchange factors 1,Tier 1.5,0.547,1,A2_pm_peripheral,1,64.06,0,0,,,0,0,,0,response to tramadol,0.5225136314922196
Q14678,KANK1,KN motif and ankyrin repeat domain-containing protein 1,Tier 1,0.546,1,A2_pm_peripheral,5,53.97,0,0,,,0,0,,0,basal cell carcinoma,0.5204468359739138
Q8N8R7,ARL14EP,ARL14 effector protein,Tier 1.5,0.546,1,A2_pm_peripheral,1,80.69,0,0,,,0,0,,0,endometriosis,0.5215169504121038
O43663,PRC1,Protein regulator of cytokinesis 1,Tier 1,0.544,1,A2_pm_peripheral,6,78.94,1,0,,,0,0,,0,neurodegenerative disease,0.5139662839321523
P49789,FHIT,Bis(5'-adenosyl)-triphosphatase,Tier 1,0.542,1,A2_pm_peripheral,9,95.25,0,0,,,0,0,,0,Abnormality of the skeletal system,0.505651828927915
P48775,TDO2,"Tryptophan 2,3-dioxygenase",Tier 1,0.541,1,A2_pm_peripheral,22,90.06,0,0,,,0,0,,0,Hypertryptophanemia,0.5037265368575525
Q5UIP0,RIF1,Telomere-associated protein RIF1,Tier 1.5,0.541,1,A2_pm_peripheral,1,53.78,0,0,,,0,0,,0,neurodegenerative disease,0.5038900373620092
P11712,CYP2C9,Cytochrome P450 2C9,Tier 1,0.536,1,A2_pm_peripheral,15,92.94,0,0,,,0,0,,0,cholesterol embolism,0.4868290635834234
Q15788,NCOA1,Nuclear receptor coactivator 1,Tier 1,0.536,1,A2_pm_peripheral,100,46.72,0,0,,,0,0,,0,neurodegenerative disease,0.48697450901885614
Q9GZN1,ACTR6,Actin-related protein 6,Tier 1.5,0.533,1,A2_pm_peripheral,9,94.31,1,0,,,0,0,,0,neurodegenerative disease,0.4758409073452339
O14733,MAP2K7,Dual specificity mitogen-activated protein kinase kinase 7,Tier 1,0.529,1,A2_pm_peripheral,37,77.25,0,0,,,0,0,,0,neurodegenerative disease,0.4624505042962164
Q9BX66,SORBS1,Sorbin and SH3 domain-containing protein 1,Tier 1,0.527,1,A2_pm_peripheral,11,46.94,0,0,,,0,0,,0,neurodegenerative disease,0.45582260952481995
Q9UK80,USP21,Ubiquitin carboxyl-terminal hydrolase 21,Tier 1,0.524,1,A2_pm_peripheral,4,69.75,1,0,,,0,0,,0,neurodegenerative disease,0.44616960950164986
O00757,FBP2,"Fructose-1,6-bisphosphatase isozyme 2",Tier 1,0.523,1,A2_pm_peripheral,14,93.75,0,0,,,0,0,,0,"leukodystrophy, childhood-onset, remitting",0.44205857063120163
O15519,CFLAR,CASP8 and FADD-like apoptosis regulator,Tier 1,0.523,1,A2_pm_peripheral,17,78.31,1,0,,,0,0,,0,neurodegenerative disease,0.4419421569940659
Q9UKI9,POU2F3,"POU domain, class 2, transcription factor 3",Tier 1.5,0.523,1,A2_pm_peripheral,3,59.34,0,0,,,0,0,,0,erythematosquamous dermatosis,0.44361239146188985
O75747,PIK3C2G,Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma,Tier 1.5,0.523,1,A2_pm_peripheral,1,73.62,0,0,,,0,0,,0,mathematical ability,0.4448369190532247
Q9Y2I2,NTNG1,Netrin-G1,Tier 1.5,0.522,1,A2_pm_peripheral,1,83.62,0,0,,,0,0,,0,obesity,0.438954995963001
Q12923,PTPN13,Tyrosine-protein phosphatase non-receptor type 13,Tier 1,0.519,1,A2_pm_peripheral,12,60.03,0,0,,,0,0,,0,Abnormality of the skeletal system,0.43005634671382553