id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9NZK5,ADA2,Adenosine deaminase 2,Tier 1,0.699,1,A_assoc,2,95.81,0,0,,,0,0,,0,deficiency of adenosine deaminase 2,0.8291292532404531
Q99972,MYOC,Myocilin,Tier 1,0.699,1,A_assoc,24,78.94,0,0,,,0,0,,0,"glaucoma 1, open angle, A",0.8294483747483756
O95970,LGI1,Leucine-rich glioma-inactivated protein 1,Tier 1.5,0.697,1,A_assoc,9,92.56,1,0,,,0,0,,0,autosomal dominant epilepsy with auditory features,0.8225657483127345
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,Tier 1,0.695,1,A_assoc,3,92.44,0,0,,,0,0,,0,"psoriasis 14, pustular",0.8155144873787125
Q96MK3,FAM20A,Pseudokinase FAM20A,Tier 1,0.693,1,A_assoc,4,85.25,0,0,,,0,0,,0,amelogenesis imperfecta type 1G,0.8106031517056754
P55000,SLURP1,Secreted Ly-6/uPAR-related protein 1,Tier 1,0.692,1,A_assoc,2,84.19,0,0,,,0,0,,0,mal de Meleda,0.8064330379723671
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.687,1,A_assoc,20,91.12,1,0,,,0,0,,0,psoriasis,0.7914863943708039
P29120,PCSK1,Neuroendocrine convertase 1,Tier 1.5,0.682,1,A_assoc,3,82.5,0,0,,,0,0,,0,obesity due to prohormone convertase I deficiency,0.773875795833803
P20849,COL9A1,Collagen alpha-1(IX) chain,Tier 1,0.678,1,A_assoc,5,61.5,0,0,,,0,0,,0,Stickler syndrome,0.7594904923903256
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.677,1,A_assoc,4,51.91,0,0,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
P55789,GFER,FAD-linked sulfhydryl oxidase ALR,Tier 1.5,0.677,1,A_assoc,7,76.88,0,0,,,0,0,,0,congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome,0.7556346526616893
Q12794,HYAL1,Hyaluronidase-1,Tier 1.5,0.672,1,A_assoc,1,94.0,0,0,,,0,0,,0,Hyaluronidase deficiency,0.7412407206736383
Q92752,TNR,Tenascin-R,Tier 1.5,0.672,1,A_assoc,2,78.5,0,0,,,0,0,,0,"neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus",0.7403484347367364
Q2MKA7,RSPO1,R-spondin-1,Tier 1,0.669,1,A_assoc,12,74.69,1,0,,,0,0,,0,palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome,0.7285342885472184
P12272,PTHLH,Parathyroid hormone-related protein,Tier 1,0.666,1,A_assoc,11,62.88,1,0,,,0,0,,0,brachydactyly type E,0.7203484375635054
Q99574,SERPINI1,Neuroserpin,Tier 1,0.665,1,A_assoc,3,88.12,0,0,,,0,0,,0,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303
P11686,SFTPC,Surfactant protein C,Tier 1.5,0.663,1,A_assoc,3,70.06,0,0,,,0,0,,0,Congenital pulmonary alveolar proteinosis,0.7110128683619542
O43897,TLL1,,Tier 1.5,0.662,1,A_assoc,1,80.31,0,0,,,0,0,,0,atrial heart septal defect,0.7050140477090344
P27352,CBLIF,Cobalamin binding intrinsic factor,Tier 1.5,0.655,1,A_assoc,2,90.5,0,0,,,0,0,,0,hereditary intrinsic factor deficiency,0.683930100359911
Q8N300,SVBP,Small vasohibin-binding protein,Tier 1,0.649,1,A_assoc,24,85.06,1,0,,,0,0,,0,"neurodevelopmental disorder with ataxia, hypotonia, and microcephaly",0.6640118055835142
O95631,NTN1,Netrin-1,Tier 1.5,0.648,1,A_assoc,5,88.5,1,0,,,0,0,,0,mirror movements 4,0.6611393488240481
Q9UHF0,TAC3,Tachykinin-3,Tier 1,0.63,1,A_assoc,2,64.88,1,0,,,0,0,,0,hypogonadotropic hypogonadism 10 with or without anosmia,0.5995324402695232
Q15818,NPTX1,Neuronal pentraxin-1,Tier 1.5,0.628,1,A_assoc,1,75.75,0,0,,,0,0,,0,spinocerebellar ataxia 50,0.5937598292127286
P07098,LIPF,Gastric triacylglycerol lipase,Tier 1.5,0.626,1,A_assoc,1,89.75,0,0,,,0,0,,0,obesity,0.5864662753480862
Q6IBW4,NCAPH2,Condensin-2 complex subunit H2,Tier 1.5,0.62,1,A_assoc,1,62.41,1,0,,,0,0,,0,"cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1",0.5674645203025676
Q8IU60,DCP2,m7GpppN-mRNA hydrolase,Tier 1,0.613,1,A_assoc,33,66.81,0,0,,,0,0,,0,neurodegenerative disease,0.5442061583114092
O00175,CCL24,C-C motif chemokine 24,Tier 1.5,0.613,1,A_assoc,2,82.12,0,0,,,0,0,,0,Iron deficiency anemia,0.5428194908352497
Q4VCS5,AMOT,Angiomotin,Tier 1,0.608,1,A_assoc,18,56.75,0,0,,,0,0,,0,neurodegenerative disease,0.5261379875719714
Q6IQ23,PLEKHA7,Pleckstrin homology domain-containing family A member 7,Tier 1,0.599,1,A_assoc,3,56.69,0,0,,,0,0,,0,open-angle glaucoma,0.49623877592982996
Q8NI35,PATJ,InaD-like protein,Tier 1,0.596,1,A_assoc,10,60.97,0,0,,,0,0,,0,Abnormality of the skeletal system,0.4853816860727928
P15085,CPA1,Carboxypeptidase A1,Tier 1,0.594,1,A_assoc,6,95.19,0,0,,,0,0,,0,type 2 diabetes mellitus,0.480064090634254
Q9ULL8,SHROOM4,Protein Shroom4,Tier 1.5,0.593,1,A_assoc,1,47.09,0,0,,,0,0,,0,"X-linked intellectual disability, Stocco dos Santos type",0.4759334640315342
Q9Y5W5,WIF1,Wnt inhibitory factor 1,Tier 1,0.585,1,A_assoc,5,79.62,0,0,,,0,0,,0,hair color,0.4484184681607677
P28039,AOAH,Acyloxyacyl hydrolase,Tier 1.5,0.585,1,A_assoc,2,90.38,0,0,,,0,0,,0,type 2 diabetes mellitus,0.4486206035972812
P11684,SCGB1A1,Uteroglobin,Tier 1.5,0.581,1,A_assoc,2,88.56,0,0,,,0,0,,0,chronic obstructive pulmonary disease,0.43588476688573263
Q9UJJ7,RPUSD1,RNA pseudouridylate synthase domain-containing protein 1,Tier 1,0.577,1,A_assoc,1,86.5,0,0,,,0,0,,0,neurodegenerative disease,0.4227872470118794
Q9Y2H5,PLEKHA6,Pleckstrin homology domain-containing family A member 6,Tier 1,0.576,1,A_assoc,2,56.44,0,0,,,0,0,,0,diverticular disease,0.42018657977785967
Q63HQ2,EGFLAM,Pikachurin,Tier 1.5,0.574,1,A_assoc,3,80.56,1,0,,,0,0,,0,mathematical ability,0.41387833248094535
Q86UU9,TAC4,Tachykinin-4,Tier 1,0.572,1,A_assoc,1,56.22,0,0,,,0,0,,0,COVID-19,0.40729589199586963
Q13007,IL24,Interleukin-24,Tier 1.5,0.572,1,A_assoc,2,83.38,0,0,,,0,0,,0,clear cell renal carcinoma,0.4074364261926763
Q96A83,COL26A1,Collagen alpha-1(XXVI) chain,Tier 1.5,0.568,1,A_assoc,6,59.66,0,0,,,0,0,,0,Inguinal hernia,0.39338285604421097
Q9UNH6,SNX7,Sorting nexin-7,Tier 1.5,0.567,1,A_assoc,1,85.81,0,0,,,0,0,,0,mathematical ability,0.3890274527063968
P20783,NTF3,Neurotrophin-3,Tier 1.5,0.565,1,A_assoc,5,73.75,0,0,,,0,0,,0,cancer,0.3844129381329447
P32881,IFNA8,Interferon alpha-8,Tier 1.5,0.563,1,A_assoc,1,84.62,0,0,,,0,0,,0,renal cell carcinoma,0.375708720608223
Q17R31,TATDN3,Deoxyribonuclease TATDN3,Tier 1,0.562,1,A_assoc,1,96.19,0,0,,,0,0,,0,neurodegenerative disease,0.373369201808849
P06850,CRH,Corticoliberin,Tier 1,0.562,1,A_assoc,5,61.97,1,0,,,0,0,,0,autosomal dominant nocturnal frontal lobe epilepsy,0.37224647599732263
Q9UM21,MGAT4A,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A",Tier 1.5,0.561,1,A_assoc,1,85.25,0,0,,,0,0,,0,COVID-19,0.37050380432141355
Q7L8A9,VASH1,Tubulinyl-Tyr carboxypeptidase 1,Tier 1,0.559,1,A_assoc,14,78.25,1,0,,,0,0,,0,Abnormality of the skeletal system,0.36366533692746233
P18509,ADCYAP1,Pituitary adenylate cyclase-activating polypeptide,Tier 1,0.559,1,A_assoc,12,62.56,1,0,,,0,0,,0,alcohol drinking,0.36407172744864225
Q8NBI3,DRAXIN,Draxin,Tier 1.5,0.558,1,A_assoc,1,58.47,0,0,,,0,0,,0,neurodegenerative disease,0.3590692945691625