id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9Y2C5,SLC17A4,Probable small intestine urate exporter,Tier 1.5,0.878,0,83.69,0,0,,,,0,0,,0,inflammatory bowel disease,0.09896486250497885
P35346,SSTR5,Somatostatin receptor type 5,Tier 1.5,0.841,7,81.25,1,0,,,,0,0,,0,acromegaly,0.6094707180356006
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.835,4,83.25,1,0,,,,0,0,,0,progressive familial intrahepatic cholestasis type 3,0.851728159166962
O75899,GABBR2,Gamma-aminobutyric acid type B receptor subunit 2,Tier 1.5,0.824,26,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 59",0.7356789732167734
P0DPK4,NOTCH2NLC,Notch homolog 2 N-terminal-like protein C,Tier 1.5,0.805,0,80.81,0,0,,,,0,0,,0,neuronal intranuclear inclusion disease,0.4999829066911242
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.802,13,80.69,1,0,,,,0,0,,0,Congenital myasthenic syndromes,0.8223287249629152
P29275,ADORA2B,Adenosine receptor A2b,Tier 1.5,0.801,4,88.12,1,0,,,,0,0,,0,migraine disorder,0.6060142180667235
Q9H2X9,SLC12A5,Solute carrier family 12 member 5,Tier 1.5,0.8,2,78.44,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6993945840545625
Q13705,ACVR2B,Activin receptor type-2B,Tier 1.5,0.791,9,83.31,1,0,,,,0,0,,0,Heterotaxia,0.7109733260300651
Q14031,COL4A6,Collagen alpha-6(IV) chain,Tier 1.5,0.79,0,47.41,0,0,,,,0,0,,0,Dupuytren Contracture,0.5880367459451578
Q96CS2,HAUS1,HAUS augmin-like complex subunit 1,Tier 1.5,0.79,1,88.62,1,0,,,,0,0,,0,device complication,0.27547205131467467
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,Tier 1.5,0.782,6,73.88,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 14",0.8165232785825526
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.779,7,82.0,0,0,,,,0,0,,0,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.777,4,84.38,1,0,,,,0,0,,0,glucose-galactose malabsorption,0.8220991027793896
P30542,ADORA1,Adenosine receptor A1,Tier 1.5,0.777,5,92.44,1,0,,,,0,0,,0,asthma,0.7232344154541454
P01568,IFNA21,Interferon alpha-21,Tier 1.5,0.777,0,85.0,0,0,,,,0,0,,0,renal cell carcinoma,0.3695798546847018
P29017,CD1C,T-cell surface glycoprotein CD1c,Tier 1.5,0.77,10,88.56,0,0,,,,0,0,,0,neoplasm,0.1106047389635713
Q9BVX2,TMEM106C,Transmembrane protein 106C,Tier 1.5,0.77,0,80.81,0,0,,,,0,0,,0,prostate carcinoma,0.21737104399686757
P43004,SLC1A2,Excitatory amino acid transporter 2,Tier 1.5,0.768,7,77.75,1,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 41",0.7772658651722512
A0A1B0GTW7,CIROP,Ciliated left-right organizer metallopeptidase,Tier 1.5,0.764,0,73.44,0,0,,,,0,0,,0,"heterotaxy, visceral, 12, autosomal",0.6929422132808513
O60931,CTNS,Cystinosin,Tier 1.5,0.764,6,89.44,1,0,,,,0,0,,0,nephropathic cystinosis,0.841818398377195
Q9Y5Y9,SCN10A,Sodium channel protein type 10 subunit alpha,Tier 1.5,0.761,8,67.31,1,0,,,,0,0,,0,atrial fibrillation,0.7126293968222049
O15370,SOX12,Transcription factor SOX-12,Tier 1.5,0.76,0,63.0,0,0,,,,0,0,,0,type 2 diabetes mellitus,0.3277369133971199
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.76,1,74.94,0,0,,,,0,0,,0,Seckel syndrome 9,0.683878095944948
Q9BZR8,BCL2L14,Apoptosis facilitator Bcl-2-like protein 14,Tier 1.5,0.76,0,62.38,0,0,,,,0,0,,0,hypothyroidism,0.33117514363294837
O15552,FFAR2,Free fatty acid receptor 2,Tier 1.5,0.759,11,88.06,1,0,,,,0,0,,0,type 1 diabetes mellitus,0.09182737097469269
A6NI61,MYMK,Protein myomaker,Tier 1.5,0.758,0,90.44,0,0,,,,0,0,,0,Carey-Fineman-Ziter  syndrome,0.7790386256350393
P35462,DRD3,D(3) dopamine receptor,Tier 1.5,0.757,6,75.38,1,0,,,,0,0,,0,schizophrenia,0.6687268941647396
O00591,GABRP,Gamma-aminobutyric acid receptor subunit pi,Tier 1.5,0.752,2,79.12,1,0,,,,0,0,,0,migraine disorder,0.6191855696357259
P0DMS8,ADORA3,Adenosine receptor A3,Tier 1.5,0.751,5,91.31,1,0,,,,0,0,,0,migraine disorder,0.6052134617149065
Q16585,SGCB,Beta-sarcoglycan,Tier 1.5,0.75,0,76.44,0,0,,,,0,0,,0,autosomal recessive limb-girdle muscular dystrophy type 2E,0.8154766151472349
P46089,GPR3,G-protein coupled receptor 3,Tier 1.5,0.748,8,81.81,1,0,,,,0,0,,0,hypertension,0.18488148594282316
P56730,PRSS12,Neurotrypsin,Tier 1.5,0.746,0,77.31,0,0,,,,0,0,,0,"intellectual disability, autosomal recessive 1",0.6621935416695687
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.74,4,51.91,0,0,,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
Q14246,ADGRE1,Adhesion G protein-coupled receptor E1,Tier 1.5,0.74,0,76.69,0,0,,,,0,0,,0,diabetic ketoacidosis,0.20424823130055986
Q8N6D2,RNF182,E3 ubiquitin-protein ligase RNF182,Tier 1.5,0.74,0,70.25,0,0,,,,0,0,,0,periapical tissue disease,0.304701328693288
Q86YT5,SLC13A5,Na(+)/citrate cotransporter,Tier 1.5,0.739,4,86.06,1,0,,,,0,0,,0,genetic developmental and epileptic encephalopathy,0.6853612674939716
Q00LT1,PRCD,Photoreceptor disk component PRCD,Tier 1.5,0.737,0,63.97,0,0,,,,0,0,,0,retinitis pigmentosa,0.7650522818524582
Q9Y4U1,MMACHC,Cyanocobalamin reductase / alkylcobalamin dealkylase,Tier 1.5,0.735,7,85.62,0,0,,,,0,0,,0,"Methylmalonic acidemia with homocystinuria, type cblC",0.8478185420804271
Q9ULX7,CA14,Carbonic anhydrase 14,Tier 1.5,0.734,2,90.69,0,0,,,,0,0,,0,epilepsy,0.4397024990575866
Q99593,TBX5,T-box transcription factor TBX5,Tier 1.5,0.733,4,62.66,0,0,,,,0,0,,0,Holt-Oram syndrome,0.827317913681364
P53539,FOSB,Protein FosB,Tier 1.5,0.73,12,59.12,0,0,,,,0,0,,0,neurodegenerative disease,0.22246010664492422
O43914,TYROBP,TYRO protein tyrosine kinase-binding protein,Tier 1.5,0.728,5,64.62,0,0,,,,0,0,,0,Nasu-Hakola disease,0.7323368313860329
Q9H741,SPRING1,SREBP regulating gene protein,Tier 1.5,0.725,2,81.31,1,0,,,,0,0,,0,Anxiety,0.35244791107935663
P48764,SLC9A3,Sodium/hydrogen exchanger 3,Tier 1.5,0.725,1,65.94,1,0,,,,0,0,,0,congenital sodium diarrhea,0.6503153836708786
P41968,MC3R,Melanocortin receptor 3,Tier 1.5,0.723,6,83.88,1,0,,,,0,0,,0,alcohol drinking,0.3298167673588826
Q9NWH7,SPATA6,Spermatogenesis-associated protein 6,Tier 1.5,0.72,0,65.19,0,0,,,,0,0,,0,hypothyroidism,0.4205896274474635
Q15399,TLR1,Toll-like receptor 1,Tier 1.5,0.72,6,87.19,0,0,,,,0,0,,0,asthma,0.5956884825296496
Q6MZM0,HEPHL1,Ferroxidase HEPHL1,Tier 1.5,0.72,0,89.44,0,0,,,,0,0,,0,pili torti-developmental delay-neurological abnormalities syndrome,0.40268634456935765
Q9NZD1,GPRC5D,G-protein coupled receptor family C group 5 member D,Tier 1.5,0.716,2,76.06,1,0,,,,0,0,,0,multiple myeloma,0.5555243624684951