id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,95.62,1,0,,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,86.06,1,0,,,,0,0,,1,"cleft palate, proliferative retinopathy, and developmental delay",0.5770707112957068
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,89.31,1,0,,,,0,0,,1,neurodegenerative disease,0.5385822922582763
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,89.69,1,0,,,,0,0,,1,congestive heart failure,0.5999952111132625
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,80.12,1,0,,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,90.88,1,0,,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,87.12,1,0,,,,0,0,,1,neurodegenerative disease,0.45156128674958135
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,80.56,1,0,,,,0,0,,1,C1Q deficiency,0.6233532074390745
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,91.38,1,0,,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,,1,0,,,,0,0,,1,,
P07360,,,Tier 1,0.755,15,89.75,1,0,,,,0,0,,1,complement deficiency,0.3695798546847018
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.755,19,72.06,1,0,,,,0,0,,1,Knobloch syndrome,0.5526223217595396
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,85.0,1,0,,,,0,0,,1,Myasthenia gravis,0.5932721106551206
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.75,9,76.75,1,0,,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.743,1,77.88,1,0,,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
P16389,KCNA2,Potassium voltage-gated channel subfamily A member 2,Tier 1.5,0.735,0,77.38,0,0,,,,0,0,,1,genetic developmental and epileptic encephalopathy,0.7513374591580034
P98196,ATP11A,Phospholipid-transporting ATPase IH,Tier 1.5,0.735,0,82.94,0,0,,,,0,0,,1,"hearing loss, autosomal dominant 84",0.5506821963658654
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
P20702,ITGAX,Integrin alpha-X,Tier 1.5,0.732,9,88.0,0,0,,,,0,0,,1,neurodegenerative disease,0.41708750879240836
P09603,,,Tier 1.5,0.729,8,57.41,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
P22732,SLC2A5,"Solute carrier family 2, facilitated glucose transporter member 5",Tier 1.5,0.728,0,90.56,0,0,,,,0,0,,1,Prolonged QT interval,0.3326218692162316
Q9P2B2,PTGFRN,Prostaglandin F2 receptor negative regulator,Tier 1.5,0.728,0,84.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48052208463481294
Q92636,NSMAF,Protein FAN,Tier 1.5,0.725,0,88.31,0,0,,,,0,0,,1,placental retention,0.36802220150078147
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
P11215,ITGAM,Integrin alpha-M,Tier 1,0.72,30,86.25,1,0,,,,0,0,,1,systemic lupus erythematosus,0.30502849242596436
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.72,3,76.69,1,0,,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.711,5,56.41,1,0,,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
Q9NV96,TMEM30A,Cell cycle control protein 50A,Tier 1,0.71,33,89.5,1,0,,,,0,0,,1,atrial fibrillation,0.31177132249681394
O95562,SFT2D2,Vesicle transport protein SFT2B,Tier 1.5,0.71,0,78.5,0,0,,,,0,0,,1,neurodegenerative disease,0.38598268164814226
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.71,2,88.38,0,0,,,,0,0,,1,,
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
P03905,MT-ND4,NADH-ubiquinone oxidoreductase chain 4,Tier 1.5,0.705,0,93.94,0,0,,,,0,0,,1,Leber hereditary optic neuropathy,0.7517935125709835
O60486,PLXNC1,Plexin-C1,Tier 1,0.703,4,79.06,1,0,,,,0,0,,1,asthma,0.532656225351722
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.702,2,84.69,1,0,,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
P01615,IGKV2D-28,Immunoglobulin kappa variable 2D-28,Tier 1.5,0.695,0,91.0,0,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q30154,HLA-DRB5,"HLA class II histocompatibility antigen, DR beta 5 chain",Tier 1.5,0.694,4,86.75,0,0,,,,0,0,,1,seasonal allergic rhinitis,0.19424611770933498
Q9Y678,COPG1,Coatomer subunit gamma-1,Tier 1.5,0.692,1,87.88,0,0,,,,0,0,,1,neurodegenerative disease,0.4905625531390244
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.691,4,90.62,0,0,,,,0,0,,1,age-related macular degeneration,0.5100732932209376
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385