id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,80.12,1,0,,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,90.88,1,0,,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,87.12,1,0,,,,0,0,,1,neurodegenerative disease,0.45156128674958135
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,80.56,1,0,,,,0,0,,1,C1Q deficiency,0.6233532074390745
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,,1,0,,,,0,0,,1,,
P07360,,,Tier 1,0.755,15,89.75,1,0,,,,0,0,,1,complement deficiency,0.3695798546847018
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,85.0,1,0,,,,0,0,,1,Myasthenia gravis,0.5932721106551206
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
P11215,ITGAM,Integrin alpha-M,Tier 1,0.72,30,86.25,1,0,,,,0,0,,1,systemic lupus erythematosus,0.30502849242596436
Q9NV96,TMEM30A,Cell cycle control protein 50A,Tier 1,0.71,33,89.5,1,0,,,,0,0,,1,atrial fibrillation,0.31177132249681394
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
O60486,PLXNC1,Plexin-C1,Tier 1,0.703,4,79.06,1,0,,,,0,0,,1,asthma,0.532656225351722
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q8NBJ9,,,Tier 1,0.688,7,80.25,1,0,,,,0,0,,1,hypothyroidism,0.32686531914177924
O95399,UTS2,Urotensin-2,Tier 1,0.685,2,58.44,0,0,,,,0,0,,1,hair color,0.35316475479030335
P63092,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Tier 1,0.683,100,91.31,1,0,,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
Q14213,,,Tier 1,0.683,4,87.62,1,0,,,,0,0,,1,neurodegenerative disease,0.42776938116451996
Q99584,S100A13,Protein S100-A13,Tier 1,0.681,12,80.81,0,0,,,,0,0,,1,neurodegenerative disease,0.41302685279153983
Q9UNN8,PROCR,Endothelial protein C receptor,Tier 1,0.68,13,86.44,1,0,,,,0,0,,1,venous thromboembolism,0.5497662282245215
Q9HBI1,PARVB,Beta-parvin,Tier 1,0.68,3,81.75,0,0,,,,0,0,,1,thyroiditis,0.28021156500366357
O00602,FCN1,Ficolin-1,Tier 1,0.675,7,84.94,0,0,,,,0,0,,1,neurodegenerative disease,0.351581018821974
Q9UK55,SERPINA10,Protein Z-dependent protease inhibitor,Tier 1,0.672,4,86.75,0,0,,,,0,0,,1,macular degeneration,0.3247169581531489
P02749,APOH,Beta-2-glycoprotein 1,Tier 1,0.67,14,93.12,0,0,,,,0,0,,1,atrial fibrillation,0.5456247991985232
P06703,S100A6,Protein S100-A6,Tier 1,0.67,6,87.19,0,0,,,,0,0,,1,neoplasm,0.10449825238323361
P78552,IL13RA1,Interleukin-13 receptor subunit alpha-1,Tier 1,0.67,4,81.56,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48627783096767857
P54762,EPHB1,Ephrin type-B receptor 1,Tier 1,0.665,8,83.62,0,0,,,,0,0,,1,medullary thyroid gland carcinoma,0.5204553830376101
Q14344,GNA13,Guanine nucleotide-binding protein subunit alpha-13,Tier 1,0.66,17,91.44,1,0,,,,0,0,,1,lymphoma,0.37253457492562664
Q7L2H7,EIF3M,Eukaryotic translation initiation factor 3 subunit M,Tier 1,0.66,0,55.28,0,0,,,,0,0,,1,Hernia,0.2963310523049043
P05543,SERPINA7,Thyroxine-binding globulin,Tier 1,0.655,9,87.06,0,0,,,,0,0,,1,neoplasm,0.09631257418600654
P20701,ITGAL,Integrin alpha-L,Tier 1,0.655,41,82.62,0,0,,,,0,0,,1,psoriasis,0.5899795223699872
Q5JWF2,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas,Tier 1,0.653,9,56.72,1,0,,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
P54764,,,Tier 1,0.652,17,83.5,0,0,,,,0,0,,1,medullary thyroid gland carcinoma,0.5195314334008982
P04746,AMY2A,Pancreatic alpha-amylase,Tier 1,0.65,51,96.75,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.5997984923419163
Q13936,CACNA1C,Voltage-dependent L-type calcium channel subunit alpha-1C,Tier 1,0.65,33,61.94,1,0,,,,0,0,,1,Timothy syndrome,0.8227725490420764
P62491,RAB11A,Ras-related protein Rab-11A,Tier 1,0.64,30,87.19,0,0,,,,0,0,,1,Intellectual disability,0.4852051194358318
P26447,S100A4,Protein S100-A4,Tier 1,0.636,17,86.44,0,0,,,,0,0,,1,Alzheimer disease,0.36416197951415524
P54289,CACNA2D1,Voltage-dependent calcium channel subunit alpha-2/delta-1,Tier 1,0.635,30,86.56,1,0,,,,0,0,,1,Seizure,0.6942469435259896
P20963,CD247,T-cell surface glycoprotein CD3 zeta chain,Tier 1,0.635,38,62.41,1,0,,,,0,0,,1,immunodeficiency 25,0.7436838111879828
Q96A54,ADIPOR1,Adiponectin receptor protein 1,Tier 1,0.632,3,83.25,0,0,,,,0,0,,1,Retinal dystrophy,0.17324768030468937
Q16555,DPYSL2,Dihydropyrimidinase-related protein 2,Tier 1,0.63,15,90.25,1,0,,,,0,0,,1,hypertension,0.4377422749119531
O14939,PLD2,Phospholipase D2,Tier 1,0.63,6,88.94,0,0,,,,0,0,,1,systemic lupus erythematosus,0.22499036596471594
Q15113,PCOLCE,Procollagen C-endopeptidase enhancer 1,Tier 1,0.63,4,79.56,0,0,,,,0,0,,1,hair color,0.09954732229482598
P49790,NUP153,Nuclear pore complex protein Nup153,Tier 1,0.63,12,43.59,1,0,,,,0,0,,1,HIV infection,0.5431773609684529
O75970,MPDZ,Multiple PDZ domain protein,Tier 1,0.628,9,63.72,0,0,,,,0,0,,1,Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies,0.7761660121864681