id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,95.62,1,0,,,,0,0,,1,Rh deficiency syndrome,0.764209214915708
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,86.06,1,0,,,,0,0,,1,"cleft palate, proliferative retinopathy, and developmental delay",0.5770707112957068
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,89.31,1,0,,,,0,0,,1,neurodegenerative disease,0.5385822922582763
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,89.69,1,0,,,,0,0,,1,congestive heart failure,0.5999952111132625
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,91.38,1,0,,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.755,19,72.06,1,0,,,,0,0,,1,Knobloch syndrome,0.5526223217595396
P26022,PTX3,Pentraxin-related protein PTX3,Tier 1.5,0.75,9,76.75,1,0,,,,0,0,,1,polycystic ovary syndrome,0.12287624125782433
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,Tier 1.5,0.743,1,77.88,1,0,,,,0,0,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178
P16389,KCNA2,Potassium voltage-gated channel subfamily A member 2,Tier 1.5,0.735,0,77.38,0,0,,,,0,0,,1,genetic developmental and epileptic encephalopathy,0.7513374591580034
P98196,ATP11A,Phospholipid-transporting ATPase IH,Tier 1.5,0.735,0,82.94,0,0,,,,0,0,,1,"hearing loss, autosomal dominant 84",0.5506821963658654
P20702,ITGAX,Integrin alpha-X,Tier 1.5,0.732,9,88.0,0,0,,,,0,0,,1,neurodegenerative disease,0.41708750879240836
P09603,,,Tier 1.5,0.729,8,57.41,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
P22732,SLC2A5,"Solute carrier family 2, facilitated glucose transporter member 5",Tier 1.5,0.728,0,90.56,0,0,,,,0,0,,1,Prolonged QT interval,0.3326218692162316
Q9P2B2,PTGFRN,Prostaglandin F2 receptor negative regulator,Tier 1.5,0.728,0,84.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48052208463481294
Q92636,NSMAF,Protein FAN,Tier 1.5,0.725,0,88.31,0,0,,,,0,0,,1,placental retention,0.36802220150078147
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.72,3,76.69,1,0,,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
Q9NR82,KCNQ5,Potassium voltage-gated channel subfamily KQT member 5,Tier 1.5,0.711,5,56.41,1,0,,,,0,0,,1,"intellectual disability, autosomal dominant 46",0.7086662845211597
O95562,SFT2D2,Vesicle transport protein SFT2B,Tier 1.5,0.71,0,78.5,0,0,,,,0,0,,1,neurodegenerative disease,0.38598268164814226
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.71,2,88.38,0,0,,,,0,0,,1,,
P03905,MT-ND4,NADH-ubiquinone oxidoreductase chain 4,Tier 1.5,0.705,0,93.94,0,0,,,,0,0,,1,Leber hereditary optic neuropathy,0.7517935125709835
P14770,GP9,Platelet glycoprotein IX,Tier 1.5,0.702,2,84.69,1,0,,,,0,0,,1,Bernard-Soulier syndrome,0.8233582238860002
P01615,IGKV2D-28,Immunoglobulin kappa variable 2D-28,Tier 1.5,0.695,0,91.0,0,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q30154,HLA-DRB5,"HLA class II histocompatibility antigen, DR beta 5 chain",Tier 1.5,0.694,4,86.75,0,0,,,,0,0,,1,seasonal allergic rhinitis,0.19424611770933498
Q9Y678,COPG1,Coatomer subunit gamma-1,Tier 1.5,0.692,1,87.88,0,0,,,,0,0,,1,neurodegenerative disease,0.4905625531390244
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.691,4,90.62,0,0,,,,0,0,,1,age-related macular degeneration,0.5100732932209376
P01825,IGHV4-59,Immunoglobulin heavy variable 4-59,Tier 1.5,0.69,3,91.56,1,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q8IUH8,SPPL2C,Signal peptide peptidase-like 2C,Tier 1.5,0.69,0,67.06,0,0,,,,0,0,,1,"osteoarthritis, hip",0.35379836590273994
Q6NT16,SLC18B1,MFS-type transporter SLC18B1,Tier 1.5,0.688,4,84.62,1,0,,,,0,0,,1,Parkinson disease,0.276931649354752
Q14520,HABP2,Factor VII-activating protease,Tier 1.5,0.686,0,77.62,0,0,,,,0,0,,1,follicular thyroid carcinoma,0.46213907606907034
Q96MP8,KCTD7,BTB/POZ domain-containing protein KCTD7,Tier 1.5,0.685,0,81.12,0,0,,,,0,0,,1,progressive myoclonic epilepsy type 3,0.8021556079083692
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,Tier 1.5,0.685,5,68.81,1,0,,,,0,0,,1,"developmental and epileptic encephalopathy, 11",0.8388748085806758
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.682,10,90.25,1,0,,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
O75935,DCTN3,Dynactin subunit 3,Tier 1.5,0.68,1,88.38,1,0,,,,0,0,,1,viral disease,0.03700998752471888
Q8TD43,TRPM4,Transient receptor potential cation channel subfamily M member 4,Tier 1.5,0.68,25,77.44,1,0,,,,0,0,,1,Familial progressive cardiac conduction defect,0.7868180621357534
O94842,TOX4,TOX high mobility group box family member 4,Tier 1.5,0.68,1,54.72,0,0,,,,0,0,,1,neurodegenerative disease,0.43085410155338943
P05023,ATP1A1,Sodium/potassium-transporting ATPase subunit alpha-1,Tier 1.5,0.679,10,88.69,1,0,,,,0,0,,1,"Charcot-Marie-tooth disease, axonal, type 2DD",0.7868851290226483
Q92536,SLC7A6,Y+L amino acid transporter 2,Tier 1.5,0.678,2,83.19,1,0,,,,0,0,,1,Abnormality of the skeletal system,0.48544421359843914
Q96DA2,RAB39B,Ras-related protein Rab-39B,Tier 1.5,0.678,1,88.38,0,0,,,,0,0,,1,early-onset parkinsonism-intellectual disability syndrome,0.7782306319395635
P36021,SLC16A2,Monocarboxylate transporter 8,Tier 1.5,0.675,7,79.56,1,0,,,,0,0,,1,Allan-Herndon-Dudley syndrome,0.8533069932022032
P18564,ITGB6,Integrin beta-6,Tier 1.5,0.675,14,82.88,1,0,,,,0,0,,1,Hypoplastic amelogenesis imperfecta,0.6045342804405103
Q9UI42,CPA4,Carboxypeptidase A4,Tier 1.5,0.674,5,93.69,0,0,,,,0,0,,1,rheumatoid arthritis,0.19026118958920038
P08572,COL4A2,Collagen alpha-2(IV) chain,Tier 1.5,0.673,4,47.25,0,0,,,,0,0,,1,porencephaly 2,0.7294975109351518
P78357,CNTNAP1,Contactin-associated protein 1,Tier 1.5,0.673,0,81.12,0,0,,,,0,0,,1,Hypomyelination neuropathy - arthrogryposis,0.8286745612673082
Q14C86,GAPVD1,GTPase-activating protein and VPS9 domain-containing protein 1,Tier 1.5,0.67,0,62.19,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.46694942126454214