id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P35555,FBN1,Fibrillin-1,Tier 1,0.809,1,A2_pm_peripheral,11,,0,0,,,0,0,,1,Marfan syndrome,0.8969300970597663
P51531,SMARCA2,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2,Tier 1,0.797,1,A2_pm_peripheral,31,65.06,0,0,,,0,0,,1,intellectual disability-sparse hair-brachydactyly syndrome,0.85547142397368
P62873,GNB1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,Tier 1,0.794,1,A2_pm_peripheral,100,97.06,1,0,,,0,0,,1,"intellectual disability, autosomal dominant 42",0.8462216225099116
P52333,JAK3,Tyrosine-protein kinase JAK3,Tier 1,0.794,1,A2_pm_peripheral,42,85.69,0,0,,,0,0,,1,T-B+ severe combined immunodeficiency due to JAK3 deficiency,0.8450717197794638
O75369,FLNB,Filamin-B,Tier 1,0.788,1,A2_pm_peripheral,23,76.25,0,0,,,0,0,,1,Larsen syndrome,0.826975893141549
P06737,PYGL,"Glycogen phosphorylase, liver form",Tier 1,0.787,1,A2_pm_peripheral,19,92.69,1,0,,,0,0,,1,glycogen storage disease VI,0.8220063508118274
P49770,EIF2B2,Translation initiation factor eIF2B subunit beta,Tier 1,0.787,1,A2_pm_peripheral,25,86.56,1,0,,,0,0,,1,CACH syndrome,0.824634396744653
P21333,FLNA,Filamin-A,Tier 1,0.786,1,A2_pm_peripheral,26,76.56,1,0,,,0,0,,1,Melnick-Needles syndrome,0.8200516896124751
O43175,PHGDH,D-3-phosphoglycerate dehydrogenase,Tier 1,0.784,1,A2_pm_peripheral,21,92.94,0,0,,,0,0,,1,PHGDH deficiency,0.8128323162948055
Q9Y3Z3,SAMHD1,Deoxynucleoside triphosphate triphosphohydrolase SAMHD1,Tier 1,0.783,1,A2_pm_peripheral,76,88.19,0,0,,,0,0,,1,Aicardi-Goutières syndrome,0.8101030032946703
Q8TD16,BICD2,Protein bicaudal D homolog 2,Tier 1,0.782,1,A2_pm_peripheral,2,78.0,0,0,,,0,0,,1,autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures,0.8072433385790271
Q08499,PDE4D,"3',5'-cyclic-AMP phosphodiesterase 4D",Tier 1,0.782,1,A2_pm_peripheral,100,67.44,0,0,,,0,0,,1,acrodysostosis 2 with or without hormone resistance,0.8053064772512085
Q01831,XPC,DNA repair protein complementing XP-C cells,Tier 1,0.782,1,A2_pm_peripheral,14,66.56,1,0,,,0,0,,1,Xeroderma pigmentosum complementation group C,0.8056391472748724
Q96BN8,OTULIN,Ubiquitin thioesterase otulin,Tier 1,0.781,1,A2_pm_peripheral,12,83.81,0,0,,,0,0,,1,"autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive",0.804614072482804
P49773,HINT1,Adenosine 5'-monophosphoramidase HINT1,Tier 1,0.777,1,A2_pm_peripheral,59,96.19,0,0,,,0,0,,1,Autosomal recessive axonal neuropathy with neuromyotonia,0.7895184274923306
Q9Y263,PLAA,Phospholipase A-2-activating protein,Tier 1,0.77,1,A2_pm_peripheral,5,84.0,0,0,,,0,0,,1,"neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies",0.7656265019633831
Q9NWZ3,IRAK4,Interleukin-1 receptor-associated kinase 4,Tier 1,0.768,1,A2_pm_peripheral,96,83.94,0,0,,,0,0,,1,immunodeficiency 67,0.7593923638641371
Q9BYI3,HYCC1,Hyccin,Tier 1,0.766,1,A2_pm_peripheral,5,67.75,1,0,,,0,0,,1,Hypomyelination - congenital cataract,0.7528702184568328
Q01484,ANK2,Ankyrin-2,Tier 1,0.762,1,A2_pm_peripheral,11,61.78,0,0,,,0,0,,1,Romano-Ward syndrome,0.7390647393986454
P13797,PLS3,Plastin-3,Tier 1,0.757,1,A2_pm_peripheral,6,88.75,1,0,,,0,0,,1,X-linked osteoporosis with fractures,0.721756781312783
P07948,LYN,Tyrosine-protein kinase Lyn,Tier 1,0.754,1,A2_pm_peripheral,6,83.12,0,0,,,0,0,,1,"autoinflammatory disease, systemic, with vasculitis",0.7119500711989845
O15117,FYB1,FYN-binding protein 1,Tier 1,0.752,1,A2_pm_peripheral,3,56.59,0,0,,,0,0,,1,thrombocytopenia 3,0.7067701415491194
P07357,C8A,Complement component C8 alpha chain,Tier 1,0.75,1,A2_pm_peripheral,11,78.69,1,0,,,0,0,,1,Immunodeficiency due to a late component of complements deficiency,0.700643416115894
Q9Y5K6,CD2AP,CD2-associated protein,Tier 1,0.749,1,A2_pm_peripheral,12,62.22,0,0,,,0,0,,1,focal segmental glomerulosclerosis,0.6952333377860125
Q8IZQ1,WDFY3,WD repeat and FYVE domain-containing protein 3,Tier 1,0.748,1,A2_pm_peripheral,2,,0,0,,,0,0,,1,Autosomal dominant microcephaly,0.6934322596452817
Q96CW1,AP2M1,AP-2 complex subunit mu,Tier 1,0.741,1,A2_pm_peripheral,4,89.19,0,0,,,0,0,,1,intellectual developmental disorder 60 with seizures,0.6712897942723018
P48730,CSNK1D,Casein kinase I isoform delta,Tier 1,0.732,1,A2_pm_peripheral,46,81.0,0,0,,,0,0,,1,Familial advanced sleep-phase syndrome,0.6394614732145313
P27815,PDE4A,"3',5'-cyclic-AMP phosphodiesterase 4A",Tier 1,0.732,1,A2_pm_peripheral,5,64.5,0,0,,,0,0,,1,psoriasis,0.6394621747004946
Q5VST9,OBSCN,Obscurin,Tier 1,0.73,1,A2_pm_peripheral,25,,0,0,,,0,0,,1,Abnormality of the skeletal system,0.6328288822708418
P11233,RALA,Ras-related protein Ral-A,Tier 1,0.723,1,A2_pm_peripheral,16,89.31,0,0,,,0,0,,1,Hiatt-Neu-Cooper neurodevelopmental syndrome,0.6092132376035464
Q16186,ADRM1,Proteasomal ubiquitin receptor ADRM1,Tier 1,0.722,1,A2_pm_peripheral,21,62.28,0,0,,,0,0,,1,multiple myeloma,0.6073517074927846
Q96RT1,ERBIN,Erbin,Tier 1,0.719,1,A2_pm_peripheral,11,55.66,0,0,,,0,0,,1,cancer,0.5976773185991211
Q32MZ4,LRRFIP1,Leucine-rich repeat flightless-interacting protein 1,Tier 1,0.719,1,A2_pm_peripheral,1,55.0,0,0,,,0,0,,1,cancer,0.5961939963929208
P08631,HCK,Tyrosine-protein kinase HCK,Tier 1,0.717,1,A2_pm_peripheral,40,83.12,0,0,,,0,0,,1,chronic myelogenous leukemia,0.5900239698979759
P48736,PIK3CG,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform",Tier 1,0.713,1,A2_pm_peripheral,100,87.81,0,0,,,0,0,,1,chronic lymphocytic leukemia,0.5769181159547517
P62987,UBA52,Ubiquitin-ribosomal protein eL40 fusion protein,Tier 1,0.712,1,A2_pm_peripheral,30,93.5,1,0,,,0,0,,1,HIV infection,0.5745684844613109
Q14160,SCRIB,Protein scribble homolog,Tier 1,0.708,1,A2_pm_peripheral,36,62.53,0,0,,,0,0,,1,spina bifida,0.5598219103770152
Q9NZ08,ERAP1,Endoplasmic reticulum aminopeptidase 1,Tier 1,0.706,1,A2_pm_peripheral,23,92.38,0,0,,,0,0,,1,psoriasis,0.5539585583227815
P56945,BCAR1,Breast cancer anti-estrogen resistance protein 1,Tier 1,0.706,1,A2_pm_peripheral,5,61.69,0,0,,,0,0,,1,neurodegenerative disease,0.5525303421948999
Q9NZN5,ARHGEF12,Rho guanine nucleotide exchange factor 12,Tier 1,0.703,1,A2_pm_peripheral,4,60.22,0,0,,,0,0,,1,glaucoma,0.5425904569436921
P24723,PRKCH,Protein kinase C eta type,Tier 1,0.702,1,A2_pm_peripheral,4,81.62,0,0,,,0,0,,1,acute myeloid leukemia,0.5407196990475681
Q8NFH5,NUP35,Nucleoporin NUP35,Tier 1,0.702,1,A2_pm_peripheral,5,63.19,1,0,,,0,0,,1,influenza,0.5409211817593593
Q07866,KLC1,Kinesin light chain 1,Tier 1,0.701,1,A2_pm_peripheral,4,75.0,0,0,,,0,0,,1,"mitochondrial complex IV deficiency, nuclear type 17",0.5354714606179074
O94806,PRKD3,Serine/threonine-protein kinase D3,Tier 1,0.701,1,A2_pm_peripheral,1,68.56,0,0,,,0,0,,1,acute myeloid leukemia,0.5352221987091332
Q13033,STRN3,Striatin-3,Tier 1,0.701,1,A2_pm_peripheral,4,67.5,1,0,,,0,0,,1,neurodegenerative disease,0.5377902198332467
O75143,ATG13,Autophagy-related protein 13,Tier 1,0.701,1,A2_pm_peripheral,13,63.84,1,0,,,0,0,,1,neurodegenerative disease,0.5360512349298453
Q6IAA8,LAMTOR1,Ragulator complex protein LAMTOR1,Tier 1,0.7,1,A2_pm_peripheral,22,80.12,1,0,,,0,0,,1,neurodegenerative disease,0.5318107016634962
P53582,METAP1,Methionine aminopeptidase 1,Tier 1,0.698,1,A2_pm_peripheral,41,94.38,0,0,,,0,0,,1,neurodegenerative disease,0.5276150237273258
O60911,CTSV,Cathepsin L2,Tier 1,0.698,1,A2_pm_peripheral,25,92.94,0,0,,,0,0,,1,neurodegenerative disease,0.525380406990464
Q99816,TSG101,Tumor susceptibility gene 101 protein,Tier 1,0.698,1,A2_pm_peripheral,21,82.94,0,0,,,0,0,,1,HIV infection,0.5281860759333491