id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P29400,COL4A5,Collagen alpha-5(IV) chain,Tier 1.5,0.794,1,A2_pm_peripheral,2,48.12,0,0,,,0,0,,1,X-linked Alport syndrome,0.8472963899466404
Q14315,FLNC,Filamin-C,Tier 1.5,0.791,1,A2_pm_peripheral,14,75.06,0,0,,,0,0,,1,hypertrophic cardiomyopathy 26,0.8363192336142512
P31040,SDHA,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",Tier 1.5,0.785,1,A2_pm_peripheral,4,93.94,1,0,,,0,0,,1,"mitochondrial complex II deficiency, nuclear type 1",0.815589203208636
O95630,STAMBP,STAM-binding protein,Tier 1.5,0.782,1,A2_pm_peripheral,5,84.0,0,0,,,0,0,,1,microcephaly-capillary malformation syndrome,0.8060251236043802
Q12840,KIF5A,Kinesin heavy chain isoform 5A,Tier 1.5,0.781,1,A2_pm_peripheral,4,75.31,1,0,,,0,0,,1,hereditary spastic paraplegia 10,0.8029405627392309
O00330,PDHX,"Pyruvate dehydrogenase protein X component, mitochondrial",Tier 1.5,0.779,1,A2_pm_peripheral,5,77.31,1,0,,,0,0,,1,pyruvate dehydrogenase E3-binding protein deficiency,0.7957753555992844
Q9NQG7,HPS4,BLOC-3 complex member HPS4,Tier 1.5,0.779,1,A2_pm_peripheral,1,61.66,1,0,,,0,0,,1,Hermansky-Pudlak syndrome with pulmonary fibrosis,0.7967575753847002
P12814,ACTN1,Alpha-actinin-1,Tier 1.5,0.777,1,A2_pm_peripheral,4,85.25,0,0,,,0,0,,1,platelet-type bleeding disorder 15,0.7887662502912471
O00468,AGRN,Agrin,Tier 1.5,0.777,1,A2_pm_peripheral,1,68.81,1,0,,,0,0,,1,congenital myasthenic syndrome 8,0.7912009864338403
Q9NZ09,UBAP1,Ubiquitin-associated protein 1,Tier 1.5,0.764,1,A2_pm_peripheral,3,62.5,0,0,,,0,0,,1,"spastic paraplegia 80, autosomal dominant",0.7464670113492812
Q6NZI2,CAVIN1,Caveolae-associated protein 1,Tier 1.5,0.76,1,A2_pm_peripheral,3,67.38,0,0,,,0,0,,1,congenital generalized lipodystrophy type 4,0.7317728549444928
Q92997,DVL3,Segment polarity protein dishevelled homolog DVL-3,Tier 1.5,0.759,1,A2_pm_peripheral,9,58.91,0,0,,,0,0,,1,autosomal dominant Robinow syndrome,0.7284158836126389
P22735,TGM1,Protein-glutamine gamma-glutamyltransferase K,Tier 1.5,0.754,1,A2_pm_peripheral,1,84.12,0,0,,,0,0,,1,autosomal recessive congenital ichthyosis,0.714755023666953
P31939,ATIC,Bifunctional purine biosynthesis protein ATIC,Tier 1.5,0.754,1,A2_pm_peripheral,5,97.38,0,0,,,0,0,,1,AICA-ribosiduria,0.7137167364484167
Q8IXK2,GALNT12,Polypeptide N-acetylgalactosaminyltransferase 12,Tier 1.5,0.748,1,A2_pm_peripheral,1,93.5,0,0,,,0,0,,1,"colorectal cancer, susceptibility to, 1",0.6932727729787528
O43516,WIPF1,WAS/WASL-interacting protein family member 1,Tier 1.5,0.737,1,A2_pm_peripheral,4,58.5,0,0,,,0,0,,1,Wiskott-Aldrich syndrome,0.6561328889736038
Q12929,EPS8,Epidermal growth factor receptor kinase substrate 8,Tier 1.5,0.731,1,A2_pm_peripheral,2,70.31,0,0,,,0,0,,1,autosomal recessive nonsyndromic hearing loss 102,0.6354471967036509
Q9NZ56,FMN2,Formin-2,Tier 1.5,0.729,1,A2_pm_peripheral,2,49.97,0,0,,,0,0,,1,autosomal recessive non-syndromic intellectual disability,0.6298956049368037
O95425,SVIL,Supervillin,Tier 1.5,0.718,1,A2_pm_peripheral,2,53.44,0,0,,,0,0,,1,myofibrillar myopathy 10,0.5924877747412329
P10398,ARAF,Serine/threonine-protein kinase A-Raf,Tier 1.5,0.709,1,A2_pm_peripheral,6,70.06,0,0,,,0,0,,1,cancer,0.5616780822043126
Q01581,HMGCS1,"Hydroxymethylglutaryl-CoA synthase, cytoplasmic",Tier 1.5,0.707,1,A2_pm_peripheral,1,91.31,0,0,,,0,0,,1,neurodegenerative disease,0.55518193177393
Q9NT62,ATG3,Ubiquitin-like-conjugating enzyme ATG3,Tier 1.5,0.707,1,A2_pm_peripheral,4,73.38,0,0,,,0,0,,1,neurodegenerative disease,0.5571514462681344
Q02156,PRKCE,Protein kinase C epsilon type,Tier 1.5,0.706,1,A2_pm_peripheral,2,79.94,0,0,,,0,0,,1,acute myeloid leukemia,0.5549599198877609
P00326,ADH1C,Alcohol dehydrogenase 1C,Tier 1.5,0.704,1,A2_pm_peripheral,2,98.12,0,0,,,0,0,,1,alcohol drinking,0.5465864505308649
Q99828,CIB1,Calcium and integrin-binding protein 1,Tier 1.5,0.701,1,A2_pm_peripheral,9,75.75,0,0,,,0,0,,1,epidermodysplasia verruciformis,0.5381616248572979
O15511,ARPC5,Actin-related protein 2/3 complex subunit 5,Tier 1.5,0.699,1,A2_pm_peripheral,2,92.19,1,0,,,0,0,,1,neurodegenerative disease,0.5305805352966168
P30154,PPP2R1B,Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform,Tier 1.5,0.699,1,A2_pm_peripheral,1,92.81,1,0,,,0,0,,1,cancer,0.5305484520119053
Q16774,GUK1,Guanylate kinase,Tier 1.5,0.698,1,A2_pm_peripheral,14,93.94,0,0,,,0,0,,1,neurodegenerative disease,0.526507567426656
O60861,GAS7,Growth arrest-specific protein 7,Tier 1.5,0.694,1,A2_pm_peripheral,2,83.75,0,0,,,0,0,,1,open-angle glaucoma,0.5145811266752988
Q53QZ3,ARHGAP15,Rho GTPase-activating protein 15,Tier 1.5,0.691,1,A2_pm_peripheral,1,76.06,0,0,,,0,0,,1,diverticular disease,0.5042377909782373
O00762,UBE2C,Ubiquitin-conjugating enzyme E2 C,Tier 1.5,0.689,1,A2_pm_peripheral,9,88.56,1,0,,,0,0,,1,neurodegenerative disease,0.49682303083942114
Q86SR1,GALNT10,Polypeptide N-acetylgalactosaminyltransferase 10,Tier 1.5,0.688,1,A2_pm_peripheral,2,90.75,0,0,,,0,0,,1,obesity,0.49376752835968046
O75815,BCAR3,Breast cancer anti-estrogen resistance protein 3,Tier 1.5,0.687,1,A2_pm_peripheral,1,65.69,0,0,,,0,0,,1,neurodegenerative disease,0.4887088231206927
Q96FQ6,S100A16,Protein S100-A16,Tier 1.5,0.687,1,A2_pm_peripheral,3,81.12,0,0,,,0,0,,1,neurodegenerative disease,0.4899214982350221
Q8TBX8,PIP4K2C,Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma,Tier 1.5,0.684,1,A2_pm_peripheral,5,80.31,0,0,,,0,0,,1,neurodegenerative disease,0.47990990136472794
O00194,RAB27B,Ras-related protein Rab-27B,Tier 1.5,0.684,1,A2_pm_peripheral,1,84.56,0,0,,,0,0,,1,major depressive disorder,0.4805047942947544
O15247,CLIC2,Chloride intracellular channel protein 2,Tier 1.5,0.682,1,A2_pm_peripheral,3,92.94,0,0,,,0,0,,1,neurodegenerative disease,0.47298055353356755
P55290,CDH13,Cadherin-13,Tier 1.5,0.681,1,A2_pm_peripheral,1,85.06,0,0,,,0,0,,1,obesity,0.46894210628323796
P29966,MARCKS,Myristoylated alanine-rich C-kinase substrate,Tier 1.5,0.68,1,A2_pm_peripheral,1,49.56,0,0,,,0,0,,1,neurodegenerative disease,0.46643540997688115
Q2M2I8,AAK1,AP2-associated protein kinase 1,Tier 1.5,0.68,1,A2_pm_peripheral,8,58.38,0,0,,,0,0,,1,gout,0.46827769429345545
Q9Y6G9,DYNC1LI1,Cytoplasmic dynein 1 light intermediate chain 1,Tier 1.5,0.679,1,A2_pm_peripheral,3,59.34,0,0,,,0,0,,1,viral disease,0.4619748183558772
P50479,PDLIM4,PDZ and LIM domain protein 4,Tier 1.5,0.674,1,A2_pm_peripheral,3,70.19,0,0,,,0,0,,1,neurodegenerative disease,0.44613257652494276
Q15052,ARHGEF6,Rho guanine nucleotide exchange factor 6,Tier 1.5,0.664,1,A2_pm_peripheral,2,71.12,0,0,,,0,0,,1,X-linked non-syndromic intellectual disability,0.4120399602397905
Q9H0A8,COMMD4,COMM domain-containing protein 4,Tier 1.5,0.663,1,A2_pm_peripheral,4,80.75,1,0,,,0,0,,1,neurodegenerative disease,0.4109063598016124
Q9UDT6,CLIP2,CAP-Gly domain-containing linker protein 2,Tier 1.5,0.662,1,A2_pm_peripheral,2,73.81,0,0,,,0,0,,1,neurodegenerative disease,0.4062409434374931
P30838,ALDH3A1,"Aldehyde dehydrogenase, dimeric NADP-preferring",Tier 1.5,0.661,1,A2_pm_peripheral,7,97.94,0,0,,,0,0,,1,keratoconus,0.4038959168376703
P55196,AFDN,Afadin,Tier 1.5,0.66,1,A2_pm_peripheral,6,63.22,0,0,,,0,0,,1,colorectal adenocarcinoma,0.40056821502974077
O00159,MYO1C,Unconventional myosin-Ic,Tier 1.5,0.654,1,A2_pm_peripheral,1,84.31,0,0,,,0,0,,1,neurodegenerative disease,0.38105114285659336
Q00536,CDK16,Cyclin-dependent kinase 16,Tier 1.5,0.652,1,A2_pm_peripheral,3,71.94,1,0,,,0,0,,1,Intellectual disability,0.3718454818549898
P09496,CLTA,Clathrin light chain A,Tier 1.5,0.651,1,A2_pm_peripheral,1,70.12,0,0,,,0,0,,1,influenza,0.3695798546847018