id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12883,MYH7,Myosin-7,Tier 1,0.871,1,A_assoc,43,74.25,1,0,,,0,0,,1,hypertrophic cardiomyopathy,0.9029865147265421
P02462,COL4A1,Collagen alpha-1(IV) chain,Tier 1.5,0.854,1,A_assoc,4,48.47,0,0,,,0,0,,1,brain small vessel disease 1 with or without ocular anomalies,0.84655287380359
P03951,F11,Coagulation factor XI,Tier 1,0.853,1,A_assoc,100,86.88,0,0,,,0,0,,1,factor XI deficiency,0.841884208404384
P04180,LCAT,Phosphatidylcholine-sterol acyltransferase,Tier 1.5,0.848,1,A_assoc,7,86.75,1,0,,,0,0,,1,Fish-eye disease,0.8273460309828392
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,Tier 1.5,0.847,1,A_assoc,10,90.25,1,0,,,0,0,,1,lattice corneal dystrophy type I,0.8242841141270143
P07942,LAMB1,Laminin subunit beta-1,Tier 1.5,0.84,1,A_assoc,3,76.69,1,0,,,0,0,,1,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902
Q9BWP8,COLEC11,Collectin-11,Tier 1,0.839,1,A_assoc,3,78.31,0,0,,,0,0,,1,3MC syndrome 2,0.7977893521540559
P20908,COL5A1,Collagen alpha-1(V) chain,Tier 1,0.839,1,A_assoc,1,51.25,0,0,,,0,0,,1,"Ehlers-Danlos syndrome, classic type, 1",0.7979601586599098
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.838,1,A_assoc,40,60.34,0,0,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.838,1,A_assoc,15,90.88,1,0,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P22105,TNXB,Tenascin-X,Tier 1.5,0.837,1,A_assoc,3,87.81,0,0,,,0,0,,1,Ehlers-Danlos syndrome due to tenascin-X deficiency,0.7916412481554758
P13645,KRT10,"Keratin, type I cytoskeletal 10",Tier 1,0.836,1,A_assoc,6,64.31,0,0,,,0,0,,1,"epidermolytic hyperkeratosis 2A, autosomal dominant",0.7860749239386174
Q12904,AIMP1,Aminoacyl tRNA synthase complex-interacting multifunctional protein 1,Tier 1,0.834,1,A_assoc,6,81.12,0,0,,,0,0,,1,hypomyelinating leukodystrophy 3,0.7806847123659254
O43707,ACTN4,Alpha-actinin-4,Tier 1,0.833,1,A_assoc,5,84.12,0,0,,,0,0,,1,focal segmental glomerulosclerosis 1,0.7778533437264424
P35858,IGFALS,Insulin-like growth factor-binding protein complex acid labile subunit,Tier 1.5,0.833,1,A_assoc,1,90.56,1,0,,,0,0,,1,Reduced insulin like growth factor binding protein acid labile subunit concentration,0.7760522769257892
O15230,LAMA5,Laminin subunit alpha-5,Tier 1.5,0.828,1,A_assoc,2,79.12,1,0,,,0,0,,1,"nephrotic syndrome, IIa 26",0.7594872666460903
P08572,COL4A2,Collagen alpha-2(IV) chain,Tier 1.5,0.819,1,A_assoc,4,47.25,0,0,,,0,0,,1,porencephaly 2,0.7294975109351518
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.815,1,A_assoc,18,91.38,1,0,,,0,0,,1,"bone fragility with contractures, arterial rupture, and deafness",0.7159150369336311
P48200,IREB2,Iron-responsive element-binding protein 2,Tier 1,0.799,1,A_assoc,1,86.75,1,0,,,0,0,,1,"neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia",0.664403876125082
P02745,C1QA,Complement C1q subcomponent subunit A,Tier 1,0.79,1,A_assoc,11,82.62,1,0,,,0,0,,1,C1Q deficiency 1,0.6319053256658114
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.787,1,A_assoc,11,80.56,1,0,,,0,0,,1,C1Q deficiency,0.6233532074390745
Q9Y6C2,EMILIN1,EMILIN-1,Tier 1.5,0.786,1,A_assoc,2,62.91,0,0,,,0,0,,1,arterial tortuosity-bone fragility syndrome,0.6185329512431467
P49767,VEGFC,Vascular endothelial growth factor C,Tier 1.5,0.785,1,A_assoc,4,73.19,0,0,,,0,0,,1,Milroy disease,0.6170524106764851
P09486,SPARC,SPARC,Tier 1,0.784,1,A_assoc,4,84.31,0,0,,,0,0,,1,osteogenesis imperfecta,0.6138892200186172
P04746,AMY2A,Pancreatic alpha-amylase,Tier 1,0.78,1,A_assoc,51,96.75,0,0,,,0,0,,1,type 2 diabetes mellitus,0.5997984923419163
O00622,CCN1,CCN family member 1,Tier 1.5,0.765,1,A_assoc,2,73.12,0,0,,,0,0,,1,Abnormality of the skeletal system,0.5505331194769112
P02749,APOH,Beta-2-glycoprotein 1,Tier 1,0.764,1,A_assoc,14,93.12,0,0,,,0,0,,1,atrial fibrillation,0.5456247991985232
A8K2U0,A2ML1,Alpha-2-macroglobulin-like protein 1,Tier 1,0.764,1,A_assoc,5,80.5,1,0,,,0,0,,1,Otitis media,0.5479914512784171
P20061,TCN1,Transcobalamin-1,Tier 1,0.763,1,A_assoc,2,89.12,0,0,,,0,0,,1,vitamin B deficiency,0.5449702229454368
Q68CZ2,TNS3,Tensin-3,Tier 1.5,0.762,1,A_assoc,1,56.81,0,0,,,0,0,,1,neurodegenerative disease,0.539772721274482
Q14766,LTBP1,Latent-transforming growth factor beta-binding protein 1,Tier 1,0.754,1,A_assoc,1,58.88,0,0,,,0,0,,1,Abnormality of the skeletal system,0.5142669818409414
Q9Y3B8,REXO2,"Oligoribonuclease, mitochondrial",Tier 1.5,0.754,1,A_assoc,10,88.19,0,0,,,0,0,,1,neurodegenerative disease,0.5134178677464454
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.753,1,A_assoc,4,90.62,0,0,,,0,0,,1,age-related macular degeneration,0.5100732932209376
Q08043,ACTN3,Alpha-actinin-3,Tier 1,0.752,1,A_assoc,3,84.19,1,0,,,0,0,,1,Abnormality of the skeletal system,0.5080072819822437
Q9H792,PEAK1,Inactive tyrosine-protein kinase PEAK1,Tier 1,0.752,1,A_assoc,2,48.03,0,0,,,0,0,,1,type 2 diabetes mellitus,0.5080681892268507
Q04756,HGFAC,Hepatocyte growth factor activator serine protease,Tier 1,0.747,1,A_assoc,7,75.31,0,0,,,0,0,,1,metabolic disease,0.4900675680377984
Q9UM22,EPDR1,Mammalian ependymin-related protein 1,Tier 1,0.746,1,A_assoc,3,85.88,0,0,,,0,0,,1,Dupuytren Contracture,0.48568453021554975
Q07157,TJP1,Tight junction protein 1,Tier 1,0.741,1,A_assoc,19,54.62,0,0,,,0,0,,1,dengue disease,0.47083190223446686
P05161,ISG15,Ubiquitin-like protein ISG15,Tier 1,0.74,1,A_assoc,22,85.88,1,0,,,0,0,,1,COVID-19,0.4668295741563516
P0DUB6,AMY1A,Alpha-amylase 1A,Tier 1,0.738,1,A_assoc,13,96.69,0,0,,,0,0,,1,dentures,0.4597705945086364
Q9NR12,PDLIM7,PDZ and LIM domain protein 7,Tier 1,0.738,1,A_assoc,2,70.25,0,0,,,0,0,,1,neurodegenerative disease,0.4602637679250804
Q13177,PAK2,Serine/threonine-protein kinase PAK 2,Tier 1.5,0.736,1,A_assoc,5,74.62,0,0,,,0,0,,1,Knobloch syndrome,0.45371318009439854
Q13625,TP53BP2,Apoptosis-stimulating of p53 protein 2,Tier 1.5,0.735,1,A_assoc,6,58.97,0,0,,,0,0,,1,neurodegenerative disease,0.4484066399496438
Q9BVC4,MLST8,Target of rapamycin complex subunit LST8,Tier 1,0.733,1,A_assoc,45,91.62,1,0,,,0,0,,1,neurodegenerative disease,0.4440338170862142
P19827,ITIH1,Inter-alpha-trypsin inhibitor heavy chain H1,Tier 1,0.731,1,A_assoc,2,87.44,0,0,,,0,0,,1,"osteoarthritis, hip",0.4360348893142765
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.731,1,A_assoc,3,86.44,0,0,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q9UKU9,ANGPTL2,Angiopoietin-related protein 2,Tier 1.5,0.727,1,A_assoc,1,78.19,0,0,,,0,0,,1,Abnormality of the skeletal system,0.4235882639081519
Q96SL4,GPX7,Glutathione peroxidase 7,Tier 1.5,0.721,1,A_assoc,1,92.69,0,0,,,0,0,,1,Abnormality of the skeletal system,0.40349356855524837
Q14192,FHL2,Four and a half LIM domains protein 2,Tier 1,0.711,1,A_assoc,4,92.06,0,0,,,0,0,,1,familial isolated dilated cardiomyopathy,0.3714277539581253
Q16627,CCL14,C-C motif chemokine 14,Tier 1.5,0.711,1,A_assoc,2,85.38,0,0,,,0,0,,1,neurodegenerative disease,0.37013422446672883