id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P12883,MYH7,Myosin-7,Tier 1,0.871,1,A_assoc,43,74.25,1,0,,,0,0,,1,hypertrophic cardiomyopathy,0.9029865147265421
P03951,F11,Coagulation factor XI,Tier 1,0.853,1,A_assoc,100,86.88,0,0,,,0,0,,1,factor XI deficiency,0.841884208404384
Q9BWP8,COLEC11,Collectin-11,Tier 1,0.839,1,A_assoc,3,78.31,0,0,,,0,0,,1,3MC syndrome 2,0.7977893521540559
P20908,COL5A1,Collagen alpha-1(V) chain,Tier 1,0.839,1,A_assoc,1,51.25,0,0,,,0,0,,1,"Ehlers-Danlos syndrome, classic type, 1",0.7979601586599098
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.838,1,A_assoc,40,60.34,0,0,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.838,1,A_assoc,15,90.88,1,0,,,0,0,,1,Factor XIII subunit A deficiency,0.7939842013132387
P13645,KRT10,"Keratin, type I cytoskeletal 10",Tier 1,0.836,1,A_assoc,6,64.31,0,0,,,0,0,,1,"epidermolytic hyperkeratosis 2A, autosomal dominant",0.7860749239386174
Q12904,AIMP1,Aminoacyl tRNA synthase complex-interacting multifunctional protein 1,Tier 1,0.834,1,A_assoc,6,81.12,0,0,,,0,0,,1,hypomyelinating leukodystrophy 3,0.7806847123659254
O43707,ACTN4,Alpha-actinin-4,Tier 1,0.833,1,A_assoc,5,84.12,0,0,,,0,0,,1,focal segmental glomerulosclerosis 1,0.7778533437264424
P48200,IREB2,Iron-responsive element-binding protein 2,Tier 1,0.799,1,A_assoc,1,86.75,1,0,,,0,0,,1,"neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia",0.664403876125082
P02745,C1QA,Complement C1q subcomponent subunit A,Tier 1,0.79,1,A_assoc,11,82.62,1,0,,,0,0,,1,C1Q deficiency 1,0.6319053256658114
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.787,1,A_assoc,11,80.56,1,0,,,0,0,,1,C1Q deficiency,0.6233532074390745
P09486,SPARC,SPARC,Tier 1,0.784,1,A_assoc,4,84.31,0,0,,,0,0,,1,osteogenesis imperfecta,0.6138892200186172
P04746,AMY2A,Pancreatic alpha-amylase,Tier 1,0.78,1,A_assoc,51,96.75,0,0,,,0,0,,1,type 2 diabetes mellitus,0.5997984923419163
P02749,APOH,Beta-2-glycoprotein 1,Tier 1,0.764,1,A_assoc,14,93.12,0,0,,,0,0,,1,atrial fibrillation,0.5456247991985232
A8K2U0,A2ML1,Alpha-2-macroglobulin-like protein 1,Tier 1,0.764,1,A_assoc,5,80.5,1,0,,,0,0,,1,Otitis media,0.5479914512784171
P20061,TCN1,Transcobalamin-1,Tier 1,0.763,1,A_assoc,2,89.12,0,0,,,0,0,,1,vitamin B deficiency,0.5449702229454368
Q14766,LTBP1,Latent-transforming growth factor beta-binding protein 1,Tier 1,0.754,1,A_assoc,1,58.88,0,0,,,0,0,,1,Abnormality of the skeletal system,0.5142669818409414
Q08043,ACTN3,Alpha-actinin-3,Tier 1,0.752,1,A_assoc,3,84.19,1,0,,,0,0,,1,Abnormality of the skeletal system,0.5080072819822437
Q9H792,PEAK1,Inactive tyrosine-protein kinase PEAK1,Tier 1,0.752,1,A_assoc,2,48.03,0,0,,,0,0,,1,type 2 diabetes mellitus,0.5080681892268507
Q04756,HGFAC,Hepatocyte growth factor activator serine protease,Tier 1,0.747,1,A_assoc,7,75.31,0,0,,,0,0,,1,metabolic disease,0.4900675680377984
Q9UM22,EPDR1,Mammalian ependymin-related protein 1,Tier 1,0.746,1,A_assoc,3,85.88,0,0,,,0,0,,1,Dupuytren Contracture,0.48568453021554975
Q07157,TJP1,Tight junction protein 1,Tier 1,0.741,1,A_assoc,19,54.62,0,0,,,0,0,,1,dengue disease,0.47083190223446686
P05161,ISG15,Ubiquitin-like protein ISG15,Tier 1,0.74,1,A_assoc,22,85.88,1,0,,,0,0,,1,COVID-19,0.4668295741563516
P0DUB6,AMY1A,Alpha-amylase 1A,Tier 1,0.738,1,A_assoc,13,96.69,0,0,,,0,0,,1,dentures,0.4597705945086364
Q9NR12,PDLIM7,PDZ and LIM domain protein 7,Tier 1,0.738,1,A_assoc,2,70.25,0,0,,,0,0,,1,neurodegenerative disease,0.4602637679250804
Q9BVC4,MLST8,Target of rapamycin complex subunit LST8,Tier 1,0.733,1,A_assoc,45,91.62,1,0,,,0,0,,1,neurodegenerative disease,0.4440338170862142
P19827,ITIH1,Inter-alpha-trypsin inhibitor heavy chain H1,Tier 1,0.731,1,A_assoc,2,87.44,0,0,,,0,0,,1,"osteoarthritis, hip",0.4360348893142765
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.731,1,A_assoc,3,86.44,0,0,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q14192,FHL2,Four and a half LIM domains protein 2,Tier 1,0.711,1,A_assoc,4,92.06,0,0,,,0,0,,1,familial isolated dilated cardiomyopathy,0.3714277539581253
P26447,S100A4,Protein S100-A4,Tier 1,0.709,1,A_assoc,17,86.44,0,0,,,0,0,,1,Alzheimer disease,0.36416197951415524
O95399,UTS2,Urotensin-2,Tier 1,0.706,1,A_assoc,2,58.44,0,0,,,0,0,,1,hair color,0.35316475479030335
O00602,FCN1,Ficolin-1,Tier 1,0.705,1,A_assoc,7,84.94,0,0,,,0,0,,1,neurodegenerative disease,0.351581018821974
P41222,PTGDS,Prostaglandin-H2 D-isomerase,Tier 1,0.703,1,A_assoc,17,87.81,0,0,,,0,0,,1,keratoconus,0.3422478065390684
Q9NZK5,ADA2,Adenosine deaminase 2,Tier 1,0.699,1,A_assoc,2,95.81,0,0,,,0,0,,0,deficiency of adenosine deaminase 2,0.8291292532404531
Q99972,MYOC,Myocilin,Tier 1,0.699,1,A_assoc,24,78.94,0,0,,,0,0,,0,"glaucoma 1, open angle, A",0.8294483747483756
P48059,LIMS1,LIM and senescent cell antigen-like-containing domain protein 1,Tier 1,0.697,1,A_assoc,14,88.06,0,0,,,0,0,,1,Abruptio Placentae,0.3236383460637068
O75629,CREG1,Protein CREG1,Tier 1,0.697,1,A_assoc,1,87.38,0,0,,,0,0,,1,acquired neutropenia,0.3238393577317927
Q9UK55,SERPINA10,Protein Z-dependent protease inhibitor,Tier 1,0.697,1,A_assoc,4,86.75,0,0,,,0,0,,1,macular degeneration,0.3247169581531489
O60711,LPXN,Leupaxin,Tier 1,0.697,1,A_assoc,4,76.38,0,0,,,0,0,,1,myopathy,0.32321299435969897
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,Tier 1,0.695,1,A_assoc,3,92.44,0,0,,,0,0,,0,"psoriasis 14, pustular",0.8155144873787125
P19652,ORM2,Alpha-1-acid glycoprotein 2,Tier 1,0.695,1,A_assoc,5,91.19,0,0,,,0,0,,1,complication,0.3155973286233708
Q96MK3,FAM20A,Pseudokinase FAM20A,Tier 1,0.693,1,A_assoc,4,85.25,0,0,,,0,0,,0,amelogenesis imperfecta type 1G,0.8106031517056754
P55000,SLURP1,Secreted Ly-6/uPAR-related protein 1,Tier 1,0.692,1,A_assoc,2,84.19,0,0,,,0,0,,0,mal de Meleda,0.8064330379723671
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.687,1,A_assoc,20,91.12,1,0,,,0,0,,0,psoriasis,0.7914863943708039
P20849,COL9A1,Collagen alpha-1(IX) chain,Tier 1,0.678,1,A_assoc,5,61.5,0,0,,,0,0,,0,Stickler syndrome,0.7594904923903256
Q2MKA7,RSPO1,R-spondin-1,Tier 1,0.669,1,A_assoc,12,74.69,1,0,,,0,0,,0,palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome,0.7285342885472184
P12272,PTHLH,Parathyroid hormone-related protein,Tier 1,0.666,1,A_assoc,11,62.88,1,0,,,0,0,,0,brachydactyly type E,0.7203484375635054
Q99574,SERPINI1,Neuroserpin,Tier 1,0.665,1,A_assoc,3,88.12,0,0,,,0,0,,0,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303
Q8N300,SVBP,Small vasohibin-binding protein,Tier 1,0.649,1,A_assoc,24,85.06,1,0,,,0,0,,0,"neurodevelopmental disorder with ataxia, hypotonia, and microcephaly",0.6640118055835142