id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P33897,ABCD1,ATP-binding cassette sub-family D member 1,Tier 1,0.96,1,A_surface,14,80.62,1,0,,,0,0,,1,adrenoleukodystrophy,0.8656366512509434
Q9NQ11,ATP13A2,Polyamine-transporting ATPase 13A2,Tier 1,0.953,1,A_surface,25,79.62,1,0,,,0,0,,1,Kufor-Rakeb syndrome,0.8439049037191295
P35499,SCN4A,Sodium channel protein type 4 subunit alpha,Tier 1,0.952,1,A_surface,3,72.44,1,0,,,0,0,,1,paramyotonia congenita of Von Eulenburg,0.8401628899371881
O00571,DDX3X,ATP-dependent RNA helicase DDX3X,Tier 1,0.951,1,A_surface,17,72.19,0,0,,,0,0,,1,X-linked non-syndromic intellectual disability,0.8362533125067105
P54760,EPHB4,Ephrin type-B receptor 4,Tier 1,0.95,1,A_surface,23,82.0,0,0,,,0,0,,1,Capillary malformation - arteriovenous malformation,0.8317426466005666
P07359,GP1BA,Platelet glycoprotein Ib alpha chain,Tier 1,0.95,1,A_surface,22,64.31,1,0,,,0,0,,1,Bernard-Soulier syndrome,0.8346884735388165
Q9NRA2,SLC17A5,Sialin,Tier 1,0.949,1,A_surface,7,84.12,1,0,,,0,0,,1,"free sialic acid storage disease, infantile form",0.8292382821211967
P63092,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Tier 1,0.948,1,A_surface,100,91.31,1,0,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
Q8WZA1,POMGNT1,"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1",Tier 1,0.948,1,A_surface,10,89.88,0,0,,,0,0,,1,"muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3",0.826104223872448
Q5JWF2,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas,Tier 1,0.948,1,A_surface,9,56.72,1,0,,,0,0,,1,pseudohypoparathyroidism type 1A,0.826829760867455
P16615,ATP2A2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,Tier 1,0.947,1,A_surface,15,85.44,1,0,,,0,0,,1,Darier disease,0.8223208039299769
Q13936,CACNA1C,Voltage-dependent L-type calcium channel subunit alpha-1C,Tier 1,0.947,1,A_surface,33,61.94,1,0,,,0,0,,1,Timothy syndrome,0.8227725490420764
P02730,SLC4A1,Band 3 anion transport protein,Tier 1,0.946,1,A_surface,54,82.12,1,0,,,0,0,,1,hereditary spherocytosis type 4,0.820137113225454
Q9H3H5,DPAGT1,UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase,Tier 1,0.943,1,A_surface,8,94.69,1,0,,,0,0,,1,DPAGT1-congenital disorder of glycosylation,0.8101246300555436
P49810,PSEN2,Presenilin-2,Tier 1,0.941,1,A_surface,2,71.81,1,0,,,0,0,,1,early-onset autosomal dominant Alzheimer disease,0.8047686386596943
O94766,B3GAT3,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3,Tier 1,0.94,1,A_surface,3,92.56,0,0,,,0,0,,1,"Larsen-like syndrome, B3GAT3 type",0.7995331164339264
Q9H2M9,RAB3GAP2,Rab3 GTPase-activating protein non-catalytic subunit,Tier 1,0.939,1,A_surface,1,79.62,1,0,,,0,0,,1,Cataract - intellectual disability - hypogonadism,0.7977527040203786
Q9Y5Y0,FLVCR1,Choline/ethanolamine transporter FLVCR1,Tier 1,0.938,1,A_surface,8,77.56,1,0,,,0,0,,1,Posterior column ataxia - retinitis pigmentosa,0.7932113640677738
Q14118,DAG1,Dystroglycan 1,Tier 1,0.938,1,A_surface,8,68.19,0,0,,,0,0,,1,autosomal recessive limb-girdle muscular dystrophy type 2P,0.7935290060634741
Q9UPN3,MACF1,"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5",Tier 1,0.938,1,A_surface,3,,0,0,,,0,0,,1,lissencephaly 9 with complex brainstem malformation,0.7945569032416216
P08473,MME,Neprilysin,Tier 1,0.937,1,A_surface,16,96.19,0,0,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
Q9NW15,ANO10,Anoctamin-10,Tier 1,0.937,1,A_surface,5,86.12,1,0,,,0,0,,1,autosomal recessive spinocerebellar ataxia 10,0.7915327777093032
P35916,FLT4,Vascular endothelial growth factor receptor 3,Tier 1,0.937,1,A_surface,2,72.44,0,0,,,0,0,,1,lymphatic malformation 1,0.7904355931811005
Q6PJF5,RHBDF2,Inactive rhomboid protein 2,Tier 1,0.936,1,A_surface,5,67.38,1,0,,,0,0,,1,palmoplantar keratoderma-esophageal carcinoma syndrome,0.7882817956366938
O75880,SCO1,Cytochrome c oxidase assembly factor SCO1,Tier 1,0.935,1,A_surface,10,77.75,0,0,,,0,0,,1,"mitochondrial complex IV deficiency, nuclear type 4",0.7827872588103603
Q9NP58,ABCB6,ATP-binding cassette sub-family B member 6,Tier 1,0.934,1,A_surface,16,83.06,1,0,,,0,0,,1,dyschromatosis universalis hereditaria 3,0.7783407126197405
Q8N766,EMC1,ER membrane protein complex subunit 1,Tier 1,0.931,1,A_surface,10,87.44,1,0,,,0,0,,1,"cerebellar atrophy, visual impairment, and psychomotor retardation;",0.7687056132401411
P78536,ADAM17,Disintegrin and metalloproteinase domain-containing protein 17,Tier 1,0.929,1,A_surface,33,72.69,1,0,,,0,0,,1,neonatal inflammatory skin and bowel disease,0.7624558659108367
Q9BVK8,TMEM147,BOS complex subunit TMEM147,Tier 1,0.928,1,A_surface,3,92.5,1,0,,,0,0,,1,"neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly",0.7615388401822349
O95714,HERC2,E3 ubiquitin-protein ligase HERC2,Tier 1,0.925,1,A_surface,15,,0,0,,,0,0,,1,developmental delay with autism spectrum disorder and gait instability,0.74952129063985
P20963,CD247,T-cell surface glycoprotein CD3 zeta chain,Tier 1,0.923,1,A_surface,38,62.41,1,0,,,0,0,,1,immunodeficiency 25,0.7436838111879828
P55011,SLC12A2,Solute carrier family 12 member 2,Tier 1,0.92,1,A_surface,14,73.12,1,0,,,0,0,,1,Delpire-McNeill syndrome,0.7337659829979022
P03891,MT-ND2,NADH-ubiquinone oxidoreductase chain 2,Tier 1,0.91,1,A_surface,7,95.12,1,0,,,0,0,,1,Leber hereditary optic neuropathy,0.6993991624020442
Q8N1F7,NUP93,Nuclear pore complex protein Nup93,Tier 1,0.909,1,A_surface,9,79.88,1,0,,,0,0,,1,"nephrotic syndrome, type 12",0.6970966479548709
O75787,ATP6AP2,Renin receptor,Tier 1,0.909,1,A_surface,10,79.19,1,0,,,0,0,,1,syndromic X-linked intellectual disability Hedera type,0.6955327890748848
P54289,CACNA2D1,Voltage-dependent calcium channel subunit alpha-2/delta-1,Tier 1,0.908,1,A_surface,30,86.56,1,0,,,0,0,,1,Seizure,0.6942469435259896
Q9NZ42,PSENEN,Gamma-secretase subunit PEN-2,Tier 1,0.905,1,A_surface,27,92.62,1,0,,,0,0,,1,hidradenitis suppurativa,0.6825090820129278
P19634,SLC9A1,Sodium/hydrogen exchanger 1,Tier 1,0.901,1,A_surface,20,67.56,1,0,,,0,0,,1,Lichtenstein-Knorr syndrome,0.6714801793153262
Q9Y6N7,ROBO1,Roundabout homolog 1,Tier 1,0.897,1,A_surface,12,60.0,0,0,,,0,0,,1,neurooculorenal syndrome,0.6567040910170603
P08172,CHRM2,Muscarinic acetylcholine receptor M2,Tier 1,0.889,1,A_surface,17,72.06,1,0,,,0,0,,1,asthma,0.6301982693270526
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.888,1,A_surface,22,80.12,1,0,,,0,0,,1,dicarboxylic aminoaciduria,0.6273449709512636
P01854,IGHE,Immunoglobulin heavy constant epsilon,Tier 1,0.888,1,A_surface,35,76.56,1,0,,,0,0,,1,asthma,0.6278691016373346
P31431,SDC4,Syndecan-4,Tier 1,0.885,1,A_surface,5,63.28,0,0,,,0,0,,1,non-small cell lung carcinoma,0.6168120240815278
P08913,ADRA2A,Alpha-2A adrenergic receptor,Tier 1,0.884,1,A_surface,19,70.19,1,0,,,0,0,,1,asthma,0.6126234478490361
P18577,RHCE,Blood group Rh(CE) polypeptide,Tier 1,0.883,1,A_surface,8,84.06,1,0,,,0,0,,1,Rh deficiency syndrome,0.6093164550623191
O95167,NDUFA3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,Tier 1,0.882,1,A_surface,7,96.75,1,0,,,0,0,,1,type 2 diabetes mellitus,0.6070846413772282
P22001,KCNA3,Potassium voltage-gated channel subfamily A member 3,Tier 1,0.879,1,A_surface,16,72.0,1,0,,,0,0,,1,multiple sclerosis,0.5972177355344198
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.878,1,A_surface,31,85.0,1,0,,,0,0,,1,Myasthenia gravis,0.5932721106551206
P20701,ITGAL,Integrin alpha-L,Tier 1,0.877,1,A_surface,41,82.62,0,0,,,0,0,,1,psoriasis,0.5899795223699872
P0DOY3,IGLC3,Immunoglobulin lambda constant 3,Tier 1,0.876,1,A_surface,4,96.06,0,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001