id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,77.88,1,0,,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.865,27,79.19,1,0,,,,1,5,"42031715,37175248,18673242",1,"tooth agenesis, selective, 7",0.7022725510765017
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.804,7,80.75,1,0,,,,1,3,"41518674,39071952,29103909",1,mycosis fungoides,0.5404546856597274
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P02748,C9,Complement component C9,Tier 1.5,0.796,9,78.75,1,0,,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
P13671,C6,Complement component C6,Tier 1,0.795,11,79.62,1,0,,,,1,31,"41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710",1,Immunodeficiency due to a late component of complements deficiency,0.75437296887129
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,82.81,1,0,,,,1,1,41854184,1,,
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P04156,PRNP,Major prion protein,Tier 1,0.785,70,64.19,1,0,,,,1,2,"39556313,34067472",1,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,83.62,1,0,,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P14210,HGF,Hepatocyte growth factor,Tier 1,0.78,36,83.5,1,0,,,,1,64,"41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087",1,"hearing loss, autosomal recessive",0.5910507391848663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P04839,CYBB,NADPH oxidase 2,Tier 1,0.776,6,90.25,1,0,,,,1,2,24635113,1,chronic granulomatous disease,0.8633132852459866
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,50.62,1,0,,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
P01189,POMC,Pro-opiomelanocortin,Tier 1,0.76,13,57.66,1,0,,,,1,1,30161145,1,obesity due to pro-opiomelanocortin deficiency,0.6958797353500403
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P43007,SLC1A4,Neutral amino acid transporter A,Tier 1.5,0.75,1,80.56,1,0,,,,1,6,"36219068,31989939,27571928,26811678,19046328,16139842",1,spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome,0.8025684205131692
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
P08648,ITGA5,Integrin alpha-5,Tier 1.5,0.748,14,85.25,1,0,,,,1,2,"32174798,38258032",1,skin disease,0.28465651599598124
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
P21730,C5AR1,C5a anaphylatoxin chemotactic receptor 1,Tier 1,0.741,19,85.75,1,0,,,,1,5,"33495506,29981048,29327939,28288993,25901944",0,anti-neutrophil cytoplasmic antibody-associated vasculitis,0.5076734733894334
P15144,ANPEP,Aminopeptidase N,Tier 1,0.74,15,93.06,1,0,,,,1,1,33554306,1,cholelithiasis,0.5030146927270738
P0C0L4,C4A,Complement C4-A,Tier 1,0.74,12,83.44,1,0,,,,1,4,"37566081,36619572,34739903,31019918",1,,
Q03405,PLAUR,Urokinase plasminogen activator surface receptor,Tier 1,0.738,13,81.44,1,0,,,,1,2,37533140,1,Abdominal Aortic Aneurysm,0.4819526979346149
O60884,DNAJA2,DnaJ homolog subfamily A member 2,Tier 1.5,0.73,1,83.38,1,0,,,,1,2,"41935727,33879515",1,dengue disease,0.37068859424875583
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
P05187,ALPP,"Alkaline phosphatase, placental type",Tier 1,0.72,8,93.44,0,0,,,,1,7,"41329468,38238732,37425696,37047289,31687420,25919296,23467613",1,male reproductive organ cancer,0.16284411775950106
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
P29622,SERPINA4,Kallistatin,Tier 1,0.719,3,86.69,0,0,,,,1,4,"38904251,30297859,37351609,28794177",1,optic atrophy,0.28896631154492924
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.718,4,75.69,1,0,,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138