id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
P21730,C5AR1,C5a anaphylatoxin chemotactic receptor 1,Tier 1,0.741,19,85.75,1,0,,,,1,5,"33495506,29981048,29327939,28288993,25901944",0,anti-neutrophil cytoplasmic antibody-associated vasculitis,0.5076734733894334
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
P46094,XCR1,Chemokine XC receptor 1,Tier 1.5,0.715,1,84.94,1,0,,,,1,1,35212764,0,COVID-19,0.459103766220463
P32239,CCKBR,Gastrin/cholecystokinin type B receptor,Tier 1.5,0.713,5,75.75,1,0,,,,1,2,"33776434,27754762",0,gastroesophageal reflux disease,0.4256110167566802
P20809,IL11,Interleukin-11,Tier 1,0.712,8,82.62,1,0,,,,1,8,"39408993,39263947,28791655,27878687,25696907,24629635",0,"osteoarthritis, hip",0.31754029889853136
P25106,ACKR3,Atypical chemokine receptor 3,Tier 1.5,0.71,14,82.44,1,0,,,,1,2,"40401615,28670693",0,oculomotor-abducens synkinesis,0.49893280382434735
P14207,FOLR2,Folate receptor beta,Tier 1,0.701,5,89.12,0,0,,,,1,2,28686804,0,neoplasm,0.11545394821329319
P15248,IL9,Interleukin-9,Tier 1,0.7,5,84.06,0,0,,,,1,1,40972397,0,neurodegenerative disease,0.40148548290272756
P01374,LTA,Lymphotoxin-alpha,Tier 1,0.7,3,83.44,0,0,,,,1,3,"41810142,30576605",0,,
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.7,0,72.06,0,0,,,,1,1,35311942,0,,
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.7,1,81.5,0,0,,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
P15309,ACP3,Prostatic acid phosphatase,Tier 1,0.695,17,92.25,1,0,,,,1,3,"41890985,25591398",0,prostate cancer,0.5521391557206573
P21781,FGF7,Fibroblast growth factor 7,Tier 1.5,0.695,0,82.44,0,0,,,,1,5,"35415885,15719578,7547864,16462265",0,cancer,0.5963369026823151
Q95460,MR1,Major histocompatibility complex class I-related protein 1,Tier 1,0.693,79,87.5,0,0,,,,1,2,"41134135,20000526",0,Immunodeficiency,0.3336382138166145
Q9NPF0,CD320,CD320 antigen,Tier 1,0.69,6,63.81,0,0,,,,1,1,39493449,0,Methylmalonic aciduria due to transcobalamin receptor defect,0.49918945650121177
P48061,CXCL12,Stromal cell-derived factor 1,Tier 1,0.685,34,83.25,1,0,,,,1,36,"41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275",0,HIV-1 infection,0.3675509850165065
Q6NW40,RGMB,Repulsive guidance molecule B,Tier 1,0.683,11,79.44,1,0,,,,1,1,39263947,0,Abnormality of the skeletal system,0.42535629367019584
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.681,8,63.03,1,0,,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
P39900,MMP12,Macrophage metalloelastase,Tier 1,0.68,86,86.94,0,0,,,,1,8,"41861669,38477735,38296402,37015819,35120890,34183667,27530235",0,atopic eczema,0.4795677061208266
P26718,KLRK1,NKG2-D type II integral membrane protein,Tier 1.5,0.679,22,79.19,0,0,,,,1,1,24629635,0,Behcet's syndrome,0.18614538678991077
Q9UEF7,KL,Klotho,Tier 1,0.676,6,89.06,1,0,,,,1,19,"41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411",0,type 2 diabetes mellitus,0.5587488336100863
Q86Z14,KLB,Beta-klotho,Tier 1,0.676,5,89.38,0,0,,,,1,1,40514411,0,congenital hypogonadotropic hypogonadism,0.462898767992589
P51681,CCR5,C-C chemokine receptor type 5,Tier 1,0.674,25,85.38,1,0,,,,1,23,"36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773",0,HIV infection,0.7442590579227027
P62576,nanA,Sialidase A,Tier 1,0.67,5,81.19,0,0,,,,1,4,"37350189,34976356,34341854,32034503",0,,
Q9GZX9,TWSG1,Twisted gastrulation protein homolog 1,Tier 1,0.67,6,80.38,0,0,,,,1,1,39299474,0,Abruptio Placentae,0.29495361755469174
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.668,4,79.81,0,0,,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
O00744,WNT10B,Protein Wnt-10b,Tier 1.5,0.668,0,80.06,0,0,,,,1,2,"32810272,18673242",0,Split hand-split foot malformation,0.7755225395358214
P56704,WNT3A,Protein Wnt-3a,Tier 1,0.665,4,88.31,1,0,,,,1,1,37231925,0,neurodegenerative disease,0.5271953966006525
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.665,6,67.38,0,0,,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
P05113,IL5,Interleukin-5,Tier 1,0.664,5,86.69,1,0,,,,1,12,"40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585",0,asthma,0.6399821251487101
O15169,AXIN1,Axin-1,Tier 1,0.664,22,61.09,0,0,,,,1,2,28129128,0,hepatocellular carcinoma,0.7864172882686208
Q6PCB0,VWA1,von Willebrand factor A domain-containing protein 1,Tier 1.5,0.664,0,78.38,0,0,,,,1,4,"41906877,41693575,38904251,38299345",0,"neuronopathy, distal hereditary motor, autosomal recessive 7",0.7420531156755253