id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25054,APC,Adenomatous polyposis coli protein,Tier 1,0.644,1,A2_pm_peripheral,31,,0,0,,,1,39,"41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673",0,familial adenomatous polyposis 1,0.8462165290909345
P15104,GLUL,Glutamine synthetase,Tier 1.5,0.622,1,A2_pm_peripheral,12,97.5,1,0,,,1,4,"39533430,30085248,21282981",0,congenital brain dysgenesis due to glutamine synthetase deficiency,0.7733687702812198
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.618,1,A2_pm_peripheral,100,49.22,1,0,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P12643,BMP2,Bone morphogenetic protein 2,Tier 1,0.611,1,A2_pm_peripheral,21,79.56,0,0,,,1,10,"41144653,38542880,37231465,35591468,35195734,34067593,33997500",0,"short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1",0.7361833785834584
O14640,DVL1,Segment polarity protein dishevelled homolog DVL-1,Tier 1.5,0.611,1,A2_pm_peripheral,3,59.84,0,0,,,1,1,37231925,0,autosomal dominant Robinow syndrome,0.7359277384599506
P41159,LEP,Leptin,Tier 1,0.606,1,A2_pm_peripheral,10,81.12,1,0,,,1,14,"40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164",0,obesity due to congenital leptin deficiency,0.7197450249224271
Q2Q1W2,TRIM71,E3 ubiquitin-protein ligase TRIM71,Tier 1.5,0.578,1,A2_pm_peripheral,2,79.12,0,0,,,1,2,31732746,0,"hydrocephalus, congenital communicating, 1",0.6276048232841862
P51813,BMX,Cytoplasmic tyrosine-protein kinase BMX,Tier 1,0.555,1,A2_pm_peripheral,6,75.75,0,0,,,1,1,34962102,0,alopecia areata,0.5491699656070116
Q96RU8,TRIB1,Tribbles homolog 1,Tier 1,0.552,1,A2_pm_peripheral,5,76.56,0,0,,,1,1,36579647,0,neurodegenerative disease,0.5397808385585621
Q5TC82,RC3H1,Roquin-1,Tier 1,0.545,1,A2_pm_peripheral,6,61.12,0,0,,,1,2,27010430,0,"hemophagocytic lymphohistiocytosis, familial, 6",0.5161798637096334
Q96AT9,RPE,Ribulose-phosphate 3-epimerase,Tier 1,0.54,1,A2_pm_peripheral,4,96.56,0,0,,,1,19,"37958909,31080896,26923800,25270019,23539459,22913867,22710369,22281826,21701525,21546514,21448811,21137477,20623466,19197318,18628724,18441313,17891009,17369776,16815269",0,neurodegenerative disease,0.4992627094132485
Q96MU7,YTHDC1,YTH domain-containing protein 1,Tier 1,0.533,1,A2_pm_peripheral,100,60.34,0,0,,,1,1,41430607,0,neurodegenerative disease,0.47698771849556626
P43351,RAD52,DNA repair protein RAD52 homolog,Tier 1,0.528,1,A2_pm_peripheral,11,69.62,1,0,,,1,6,"37288783,32945515,31495919,26784987,24500205,23836560",0,Abnormality of the skeletal system,0.45994164258033876
Q9Y2K6,USP20,Ubiquitin carboxyl-terminal hydrolase 20,Tier 1.5,0.509,1,A2_pm_peripheral,1,72.31,0,0,,,1,1,30863411,0,connective tissue neoplasm,0.3981371748391643
O75182,SIN3B,Paired amphipathic helix protein Sin3b,Tier 1.5,0.501,1,A2_pm_peripheral,4,68.0,1,0,,,1,2,16914451,0,syndromic intellectual disability,0.37050380432141355
P32298,GRK4,G protein-coupled receptor kinase 4,Tier 1.5,0.49,1,A2_pm_peripheral,1,88.69,0,0,,,1,2,31555351,0,Nausea and vomiting,0.33267400228074584
Q13569,TDG,G/T mismatch-specific thymine DNA glycosylase,Tier 1,0.472,1,A2_pm_peripheral,21,70.19,0,0,,,1,5,"34906054,33568907,33015024,32649855,32280216",0,venous thromboembolism,0.2744822808753576
P55089,UCN,Urocortin,Tier 1.5,0.469,1,A2_pm_peripheral,6,68.25,1,0,,,1,3,"30221506,26488412,23248006",0,neurodegenerative disease,0.26311734927710556
Q9NYZ3,GTSE1,G2 and S phase-expressed protein 1,Tier 1,0.462,1,A2_pm_peripheral,2,50.94,0,0,,,1,1,41902775,0,Paroxysmal supraventricular tachycardia,0.240265138515043
P19957,PI3,Elafin,Tier 1.5,0.446,1,A2_pm_peripheral,3,72.25,0,0,,,1,3,"37351609,36517803,30087279",0,Abruptio Placentae,0.18626794135552627
P01887,B2m,Beta-2-microglobulin,Tier 1,0.39,1,A2_pm_peripheral,100,93.81,0,0,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",0,,
P16213,B2M,Beta-2-microglobulin,Tier 1,0.39,1,A2_pm_peripheral,9,94.19,0,0,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",0,,
K7N5M4,B2M,,Tier 1,0.39,1,A2_pm_peripheral,24,90.94,0,0,,,1,3,"41850110,40373155,38904251",0,,
K7N5M3,B2M,,Tier 1,0.39,1,A2_pm_peripheral,22,87.81,0,0,,,1,3,"41850110,40373155,38904251",0,,
P16110,Lgals3,Galectin-3,Tier 1,0.39,1,A2_pm_peripheral,5,72.44,0,0,,,1,4,"39681229,31418072",0,,
A0A2K6KCS5,YTHDC1,YTH domain-containing family protein,Tier 1,0.39,1,A2_pm_peripheral,2,53.59,0,0,,,1,1,41430607,0,,
Q9H4F8,SMOC1,SPARC-related modular calcium-binding protein 1,Tier 1.5,0.388,0,A2_pm_peripheral,0,73.31,0,0,,,1,1,36333824,0,microphthalmia with limb anomalies,0.8103774498041117
Q9UHK6,AMACR,Alpha-methylacyl-CoA racemase,Tier 1.5,0.374,0,A2_pm_peripheral,0,95.81,0,0,,,1,10,"40271962,35780537,35539643,26547498,24994506",0,Alpha-methylacyl-CoA racemase deficiency,0.762086344446303
O14543,SOCS3,Suppressor of cytokine signaling 3,Tier 1.5,0.287,0,A2_pm_peripheral,0,71.88,0,0,,,1,2,39571081,0,neurodegenerative disease,0.47223972419523075
Q9P2M7,CGN,Cingulin,Tier 1.5,0.251,0,A2_pm_peripheral,0,69.56,0,0,,,1,3,"35297595,33476120,21342520",0,Abnormality of the skeletal system,0.3547927821140923
Q8WW22,DNAJA4,DnaJ homolog subfamily A member 4,Tier 1.5,0.241,0,A2_pm_peripheral,0,84.44,0,0,,,1,2,"41935727,33879515",0,coronary atherosclerosis,0.3210951574534216
Q9Y5Z7,HCFC2,Host cell factor 2,Tier 1.5,0.235,0,A2_pm_peripheral,0,72.88,0,0,,,1,24,"41651417,41187655,40586934,40410820,40371468,38829419,38471488,36836536,36517803,36480517,34132569,32981365,32884147,32157871,32101978,31985806,31077760,25534780,23770039,20967861,20445260,19195013,15629041,12177446",0,neurodegenerative disease,0.29928415571034084
Q6XZB0,LIPI,Lipase member I,Tier 1.5,0.215,0,A2_pm_peripheral,0,89.44,0,0,,,1,2,"32981012,27715478",0,metabolic disease,0.23399905961107478
Q8N143,BCL6B,B-cell CLL/lymphoma 6 member B protein,Tier 1.5,0.199,0,A2_pm_peripheral,0,54.31,0,0,,,1,1,41169059,0,tympanic membrane perforation,0.18130132303178323
Q16206,ENOX2,Ecto-NOX disulfide-thiol exchanger 2,Tier 1.5,0.167,0,A2_pm_peripheral,0,77.06,0,0,,,1,2,37504074,0,chronic myelogenous leukemia,0.0726224414455439
O77932,DXO,Decapping and exoribonuclease protein,Tier 1.5,0.161,0,A2_pm_peripheral,0,92.69,0,0,,,1,2,27432610,0,breast cancer,0.05174117965585824