id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q00604,NDP,Norrin,Tier 1.5,0.707,1,A_assoc,11,83.56,1,0,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P15884,TCF4,Transcription factor 4,Tier 1,0.705,1,A_assoc,5,51.12,0,0,,,1,4,"36252203,17909039,41851110,37805109",0,Pitt-Hopkins syndrome,0.8490531860867685
P20062,TCN2,Transcobalamin-2,Tier 1,0.694,1,A_assoc,11,91.5,0,0,,,1,3,"41935727,39493449",0,transcobalamin II deficiency,0.8116989428679681
P45452,MMP13,Collagenase 3,Tier 1,0.691,1,A_assoc,49,88.62,0,0,,,1,4,"41754778,40893365,38471488,38750696",0,"spondyloepimetaphyseal dysplasia, Missouri type",0.8032079813035149
Q13253,NOG,Noggin,Tier 1.5,0.685,1,A_assoc,2,86.06,0,0,,,1,2,38397086,0,proximal symphalangism 1A,0.7844136456463046
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.685,1,A_assoc,3,68.62,1,0,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
Q96S42,NODAL,Nodal homolog,Tier 1,0.684,1,A_assoc,1,75.44,0,0,,,1,3,"38155321,24146916,23918801",0,"heterotaxy, visceral, 5, autosomal",0.7788051667024423
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.684,1,A_assoc,8,73.25,0,0,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.682,1,A_assoc,5,87.06,0,0,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
P00797,REN,Renin,Tier 1,0.68,1,A_assoc,91,85.44,0,0,,,1,456,"42025056,42000159,41992303,41979049,41942404,41934998,41909751,41904852,41851110,41849890,41794534,41780402,41770936,41718462,41711853,41698160,41671930,41659919,41629318,41545413,41538945,41529264,41519163,41454539,41443106,41386094,41330678,41327249,41249026,41234744,41207040,41205456,41175848,41172349,41171135,41164194,41161441,41148632,41118515,41089000,41067030,41024479,41002305,40994449,40968863,40963922,40893365,40891676,40870790,40801503,41906877,40832436,39923730,39263947,39129649,38811951,36190914,35983901,35907639,35187107,34619249,34248841,32981365,32838280,32527800,31988066,26746799,21147843",0,familial juvenile hyperuricemic nephropathy type 2,0.7657976389758877
P05019,IGF1,Insulin-like growth factor 1,Tier 1,0.68,1,A_assoc,32,59.53,1,0,,,1,23,"38384162,35859339,35591468,33977395,33467925,32511241,31930684,26245346,24832383,23933187,23373648,16019422,41283885,39263947,38497478,33888746,15231297",0,growth delay due to insulin-like growth factor type 1 deficiency,0.7650418939376437
Q9GZV9,FGF23,Fibroblast growth factor 23,Tier 1,0.679,1,A_assoc,6,76.62,1,0,,,1,11,"39007037,38079395,35415885,32065590,30297602,30197987,41226313,36705086",0,autosomal dominant hypophosphatemic rickets,0.762326334964193
O15520,FGF10,Fibroblast growth factor 10,Tier 1.5,0.67,1,A_assoc,2,80.0,0,0,,,1,1,35415885,0,Lacrimoauriculodentodigital syndrome,0.7344198619465704
P35225,IL13,Interleukin-13,Tier 1,0.669,1,A_assoc,13,85.62,1,0,,,1,9,"41463156,35356877,33742062,32784904,27640094,29949702,21793788",0,atopic eczema,0.7297489019498119
Q9BQB4,SOST,Sclerostin,Tier 1,0.666,1,A_assoc,3,70.81,0,0,,,1,32,"42031715,41736700,41545413,41276911,41242313,40464222,40429697,34361085,33717084,33334063,21204783,42030934,41450662,41226313,39470582,39007037,38444701,38074899,37481136,35966595,35869074,35646527",0,sclerosteosis 1,0.7184345506579789
P05305,EDN1,Endothelin-1,Tier 1,0.666,1,A_assoc,17,65.19,1,0,,,1,2,"40438585,37198662",0,auriculocondylar syndrome,0.7193561828311311
O00300,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,Tier 1.5,0.666,1,A_assoc,1,86.5,0,0,,,1,1,15562003,0,juvenile Paget disease,0.7184894548525037
P01270,PTH,Parathyroid hormone,Tier 1,0.664,1,A_assoc,26,72.12,1,0,,,1,9,"40464222,40108760,39880691,38079395,25901535,41303575,41226313",0,"hypoparathyroidism, familial isolated 1",0.7147450451832739
P19835,CEL,Bile salt-activated lipase,Tier 1.5,0.658,1,A_assoc,7,82.56,0,0,,,1,2,"39653009,34940276",0,MODY,0.6940743944678538
O43323,DHH,Desert hedgehog protein,Tier 1,0.657,1,A_assoc,5,84.38,0,0,,,1,1,18698484,0,"46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome",0.6912706692651148
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.652,1,A_assoc,1,79.62,0,0,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
Q9Y5K2,KLK4,Kallikrein-4,Tier 1,0.65,1,A_assoc,18,90.12,0,0,,,1,2,"30114962,35323639",0,Hypomaturation amelogenesis imperfecta,0.6659029046455642
P05113,IL5,Interleukin-5,Tier 1,0.642,1,A_assoc,5,86.69,1,0,,,1,12,"40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585",0,asthma,0.6399821251487101
Q16552,IL17A,Interleukin-17A,Tier 1,0.641,1,A_assoc,44,84.31,1,0,,,1,30,"42017161,41754778,41482938,41477217,40410820,39376102,38091227,38031342,37879125,37238999,36517803,36375248,36326540,35724603,32784904,32387307,31316164,27827561,24056860,21524680,20967861,37563071,34531951",0,psoriasis,0.6367521314106471
O95390,GDF11,Growth/differentiation factor 11,Tier 1,0.636,1,A_assoc,5,73.12,0,0,,,1,7,"40664633,39909827,31638376,23663781,32408813",0,vertebral hypersegmentation and orofacial anomalies,0.6207007733160915
P05230,FGF1,Fibroblast growth factor 1,Tier 1,0.633,1,A_assoc,96,90.69,0,0,,,1,3,"35415885,33536494,27663888",0,cancer,0.6088477966360052
P22894,MMP8,Neutrophil collagenase,Tier 1,0.631,1,A_assoc,25,90.38,0,0,,,1,4,"35821507,34183667,33534888,30197987",0,acne,0.603247809982021
P09237,MMP7,Matrilysin,Tier 1,0.631,1,A_assoc,16,87.81,0,0,,,1,9,"41890985,37022120,36508319,33742062,31844116,30553167,28738067,27836219",0,acne,0.603247809982021
O76093,FGF18,Fibroblast growth factor 18,Tier 1.5,0.631,1,A_assoc,1,87.56,0,0,,,1,1,35415885,0,cancer,0.6028027301556572
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.631,1,A_assoc,1,81.5,0,0,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
P35247,SFTPD,Pulmonary surfactant-associated protein D,Tier 1,0.624,1,A_assoc,31,65.5,0,0,,,1,1,39884764,0,COVID-19,0.5808114412785164
P07492,GRP,Gastrin-releasing peptide,Tier 1,0.619,1,A_assoc,9,63.94,1,0,,,1,6,"38890976,38659329,37500079,29027923,41810845,23179274",0,type 2 diabetes mellitus,0.5648167305980163
Q9GZX6,IL22,Interleukin-22,Tier 1.5,0.619,1,A_assoc,6,88.12,0,0,,,1,7,"34208021,33869115,28942363,26792955,37041650",0,atopic eczema,0.5627493881195745
O95150,TNFSF15,Tumor necrosis factor ligand superfamily member 15,Tier 1,0.618,1,A_assoc,7,81.06,0,0,,,1,2,35026285,0,leprosy,0.5605330843692238
Q15726,KISS1,Metastasis-suppressor KiSS-1,Tier 1.5,0.618,1,A_assoc,2,59.41,1,0,,,1,1,35026192,0,hypogonadotropic hypogonadism,0.5608645918536114
Q9UNA0,ADAMTS5,A disintegrin and metalloproteinase with thrombospondin motifs 5,Tier 1,0.613,1,A_assoc,7,77.56,0,0,,,1,3,"35700850,26594036",0,Abnormality of the skeletal system,0.5442996355354548
Q9HCB6,SPON1,Spondin-1,Tier 1,0.613,1,A_assoc,4,77.25,0,0,,,1,2,"31640794,27640094",0,atrial fibrillation,0.5420224587351377
P22466,GAL,Galanin peptides,Tier 1.5,0.613,1,A_assoc,10,66.56,1,0,,,1,27,"40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673",0,temporal lobe epilepsy,0.5442263564708273
P56704,WNT3A,Protein Wnt-3a,Tier 1,0.608,1,A_assoc,4,88.31,1,0,,,1,1,37231925,0,neurodegenerative disease,0.5271953966006525
O00585,CCL21,C-C motif chemokine 21,Tier 1,0.608,1,A_assoc,5,72.69,1,0,,,1,2,"36314402,29733244",0,rheumatoid arthritis,0.5266345093424485
P56703,WNT3,Proto-oncogene Wnt-3,Tier 1.5,0.608,1,A_assoc,1,88.25,0,0,,,1,2,"40168709,18673242",0,neurodegenerative disease,0.5272184953415704
O14793,MSTN,Growth/differentiation factor 8,Tier 1,0.602,1,A_assoc,5,78.75,0,0,,,1,4,"41020397,40664633,40313273,33334063",0,myostatin-related muscle hypertrophy,0.5055829543398623
P78556,CCL20,C-C motif chemokine 20,Tier 1,0.6,1,A_assoc,6,88.69,1,0,,,1,1,36375248,0,inflammatory bowel disease,0.4987938599485985
P60568,IL2,Interleukin-2,Tier 1,0.6,1,A_assoc,37,84.12,1,0,,,1,45,"41754959,40972397,40761795,40447990,38081519,37805109,37141264,37110712,37074914,34511903,34386332,32784904,32574155,32280743,31383650,31270926,30800133,29556342,29055191,28129128,27959341,27878687,27819142,27529794,27179422,26048585,25919090,24682172,35756119,30883749,29244152,24968026,24418663,18319343,12900522",0,asthma,0.5009876866575907
O15496,PLA2G10,Group 10 secretory phospholipase A2,Tier 1,0.597,1,A_assoc,7,88.0,0,0,,,1,1,9526554,0,neurodegenerative disease,0.48857112988743956
P19801,AOC1,Diamine oxidase [copper-containing],Tier 1,0.596,1,A_assoc,5,95.0,0,0,,,1,1,29978265,0,Abnormality of the skeletal system,0.4879067570517193
Q9BW91,NUDT9,ADP-ribose pyrophosphatase,Tier 1,0.596,1,A_assoc,2,84.62,0,0,,,1,1,15303967,0,gout,0.48671248625701
P39900,MMP12,Macrophage metalloelastase,Tier 1,0.594,1,A_assoc,86,86.94,0,0,,,1,8,"41861669,38477735,38296402,37015819,35120890,34183667,27530235",0,atopic eczema,0.4795677061208266
P24855,DNASE1,Deoxyribonuclease-1,Tier 1.5,0.591,1,A_assoc,1,94.25,0,0,,,1,1,36838023,0,systemic lupus erythematosus,0.4692224712894944
P01236,PRL,Prolactin,Tier 1,0.589,1,A_assoc,12,85.56,0,0,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772