id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P13569,CFTR,Cystic fibrosis transmembrane conductance regulator,Tier 1,0.824,1,A_surface,58,75.62,1,0,,,1,10,"41148207,31029337,30595527,22483890,15657417",0,cystic fibrosis,0.9133535862571094
P07949,RET,Proto-oncogene tyrosine-protein kinase receptor Ret,Tier 1,0.809,1,A_surface,34,78.81,1,0,,,1,83,"41962371,41744190,41636718,41526122,41406741,41171123,41082837,41060784,41027166,40932619,40815127,40711581,40633058,40602121,40410423,40285964,40252505,40222299,39344894,39288589,39190775,38953438,38876068,38852325,38718747,38604287,38354543,38282384,38237282,37851382,37774402,37757695,37437453,37245460,36952259,36315022,35550937,35420408,34342436,34132907,34016094,33513536,33462661,33119785,33011620,32760976,32527800,32212604,32138930,31897454",0,medullary thyroid gland carcinoma,0.8617460262224842
Q12809,KCNH2,Voltage-gated inwardly rectifying potassium channel KCNH2,Tier 1,0.806,1,A_surface,23,62.75,1,0,,,1,1,22617876,0,Romano-Ward syndrome,0.8549238933917284
P31785,IL2RG,Cytokine receptor common subunit gamma,Tier 1.5,0.804,1,A_surface,14,75.5,1,0,,,1,2,"30800133,33869115",0,gamma chain deficiency,0.8469997000418428
P08100,RHO,Rhodopsin,Tier 1.5,0.804,1,A_surface,4,88.75,1,0,,,1,45,"41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760",0,retinitis pigmentosa,0.8481942240861982
P07911,UMOD,Uromodulin,Tier 1,0.803,1,A_surface,10,82.94,1,0,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P07333,CSF1R,Macrophage colony-stimulating factor 1 receptor,Tier 1,0.802,1,A_surface,26,77.81,0,0,,,1,1,29277631,0,"leukoencephalopathy, diffuse hereditary, with spheroids 1",0.8391971566583056
O95342,ABCB11,Bile salt export pump,Tier 1.5,0.801,1,A_surface,8,83.12,1,0,,,1,1,36313979,0,progressive familial intrahepatic cholestasis type 2,0.8372060401943777
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.8,1,A_surface,16,84.94,0,0,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
P16473,TSHR,Thyrotropin receptor,Tier 1,0.8,1,A_surface,9,74.0,1,0,,,1,6,"41054857,40997970,40588369,38650837",0,hypothyroidism due to TSH receptor mutations,0.8327127196409464
Q92736,RYR2,Ryanodine receptor 2,Tier 1,0.8,1,A_surface,26,,1,0,,,1,1,24130701,0,catecholaminergic polymorphic ventricular tachycardia 1,0.8338648743498255
P10912,GHR,Growth hormone receptor,Tier 1.5,0.799,1,A_surface,9,58.69,0,0,,,1,5,"38811951,38477735,31603904",0,Laron syndrome,0.8304020079647765
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.795,1,A_surface,11,84.31,1,0,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
Q13651,IL10RA,Interleukin-10 receptor subunit alpha,Tier 1,0.795,1,A_surface,7,62.0,1,0,,,1,2,"25870409,25558474",0,Autosomal recessive early-onset inflammatory bowel disease,0.8151052076044897
Q01974,ROR2,Tyrosine-protein kinase transmembrane receptor ROR2,Tier 1,0.794,1,A_surface,6,68.31,0,0,,,1,2,"41782379,18673242",0,autosomal recessive Robinow syndrome,0.8145559265435566
Q9UM73,ALK,ALK tyrosine kinase receptor,Tier 1,0.791,1,A_surface,79,68.19,0,0,,,1,6,"40347134,38604287,32218299,29205808,24116381,21281497",0,neuroblastoma,0.8016889264946979
Q4KMG0,CDON,Cell adhesion molecule-related/down-regulated by oncogenes,Tier 1,0.79,1,A_surface,3,62.03,0,0,,,1,3,"36333824,24629635,18698484",0,holoprosencephaly,0.800378039564866
P16410,CTLA4,Cytotoxic T-lymphocyte protein 4,Tier 1.5,0.787,1,A_surface,22,80.12,0,0,,,1,26,"41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549",0,autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency,0.7906408646569979
P22223,CDH3,Cadherin-3,Tier 1,0.786,1,A_surface,19,76.75,0,0,,,1,1,41304780,0,EEM syndrome,0.7851776755128059
Q96MS0,ROBO3,Roundabout homolog 3,Tier 1.5,0.784,1,A_surface,3,63.69,0,0,,,1,2,32369590,0,horizontal gaze palsy with progressive scoliosis,0.7813306356858872
P43220,GLP1R,Glucagon-like peptide 1 receptor,Tier 1,0.78,1,A_surface,70,81.5,1,0,,,1,2,"40691365,30957581",0,type 2 diabetes mellitus,0.7667004144705459
P51654,GPC3,Glypican-3,Tier 1.5,0.779,1,A_surface,4,75.06,1,0,,,1,65,"42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753",0,Simpson-Golabi-Behmel syndrome type 1,0.762708583613362
P20023,CR2,Complement receptor type 2,Tier 1.5,0.776,1,A_surface,9,74.94,1,0,,,1,1,33235290,0,"immunodeficiency, common variable, 7",0.7543125403898414
P26678,PLN,Phospholamban,Tier 1,0.775,1,A_surface,7,81.88,0,0,,,1,9,"39536855,32382487,30777430,25240642,21848510,19158349",0,hypertrophic cardiomyopathy,0.750557685745381
Q9HBE5,IL21R,Interleukin-21 receptor,Tier 1,0.775,1,A_surface,6,64.12,0,0,,,1,2,"30800133,29244152",0,Cryptosporidiosis - chronic cholangitis - liver disease,0.7501392499286187
Q9Y6Q6,TNFRSF11A,Tumor necrosis factor receptor superfamily member 11A,Tier 1,0.775,1,A_surface,1,58.91,0,0,,,1,1,15562003,0,Osteopetrosis - hypogammaglobulinemia,0.7487328542164448
P04035,HMGCR,3-hydroxy-3-methylglutaryl-coenzyme A reductase,Tier 1,0.774,1,A_surface,24,75.31,1,0,,,1,1,36470581,0,Hypercholesterolemia,0.7460937406970991
P40126,DCT,L-dopachrome tautomerase,Tier 1.5,0.774,1,A_surface,1,89.12,0,0,,,1,1,27245069,0,oculocutaneous albinism type 8,0.7468868816172217
P51681,CCR5,C-C chemokine receptor type 5,Tier 1,0.773,1,A_surface,25,85.38,1,0,,,1,23,"36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773",0,HIV infection,0.7442590579227027
Q9NR97,TLR8,Toll-like receptor 8,Tier 1,0.771,1,A_surface,39,86.12,0,0,,,1,4,"40085160,39956743",0,"immunodeficiency 98 with autoinflammation, X-linked",0.7360623201088097
P21860,ERBB3,Receptor tyrosine-protein kinase erbB-3,Tier 1,0.77,1,A_surface,23,72.44,1,0,,,1,9,"40851486,33770580,33039492,31846731,31626948,29440899,23990977,22733765,18942860",0,"visceral neuropathy, familial, 1, autosomal recessive",0.7335342096528644
P08887,IL6R,Interleukin-6 receptor subunit alpha,Tier 1.5,0.768,1,A_surface,10,77.88,1,0,,,1,18,"40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809",0,rheumatoid arthritis,0.7269057706798291
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.767,1,A_surface,7,59.91,1,0,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P47871,GCGR,Glucagon receptor,Tier 1,0.766,1,A_surface,27,81.88,1,0,,,1,5,"28775305,23770039,23744070",0,GCGR-related hyperglucagonemia,0.7213152740071143
P26842,CD27,CD27 antigen,Tier 1,0.763,1,A_surface,5,71.69,0,0,,,1,3,"39841045,30609550,26320067",0,lymphoproliferative syndrome 2,0.7084378623696481
P40225,THPO,Thrombopoietin,Tier 1,0.761,1,A_surface,3,61.44,1,0,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
P15941,MUC1,Mucin-1,Tier 1,0.761,1,A_surface,23,47.41,0,0,,,1,686,"42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896",0,"tubulointerstitial kidney disease, autosomal dominant, 2",0.7040398435219726
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.76,1,A_surface,3,80.19,0,0,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.759,1,A_surface,2,79.19,0,0,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
Q9BYF1,ACE2,Angiotensin-converting enzyme 2,Tier 1,0.758,1,A_surface,100,90.69,1,0,,,1,91,"41716474,41541792,41274248,40642289,40333723,40321580,40227272,39964138,39923730,39281706,38973558,38553521,37932762,37808754,37692001,37666993,37385465,37375202,36950312,36822303,36714461,36683236,36581924,36073793,35972202,35910791,35907639,35542182,34876524,34855379,34847324,34798263,34696413,34619249,34458322,34282416,34248841,34230708,34230707,34166652,34123223,33684258,33683787,33629859,33561300,33389440,32981365,32838280,32551560,36288301,36170362,35748608,34953639",0,COVID-19,0.6925739512122528
P15391,CD19,B-lymphocyte antigen CD19,Tier 1.5,0.755,1,A_surface,4,62.22,1,0,,,1,13,"41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492",0,"immunodeficiency, common variable, 3",0.6821072538733047
P32970,CD70,CD70 antigen,Tier 1.5,0.75,1,A_surface,1,83.19,0,0,,,1,1,30609550,0,severe combined immunodeficiency due to CD70 deficiency,0.6651491980619259
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.748,1,A_surface,8,63.03,1,0,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.744,1,A_surface,6,67.38,0,0,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
P48551,IFNAR2,Interferon alpha/beta receptor 2,Tier 1,0.743,1,A_surface,9,64.44,0,0,,,1,1,35212764,0,COVID-19,0.6417504201511338
P21554,CNR1,Cannabinoid receptor 1,Tier 1,0.741,1,A_surface,32,71.69,1,0,,,1,1,19231809,0,obesity,0.6357831368051927
Q15116,PDCD1,Programmed cell death protein 1,Tier 1,0.738,1,A_surface,37,74.12,0,0,,,1,27,"41479885,40811947,40758411,39562585,37424077,34156677,33904236,33896107,33319876,33155587,32574155,32429721,31727249,31434881,28912094,28288993,41907643,41125194,38158454,37944524,36484532,36015348,34861397,34386332",0,melanoma,0.6260691959208758
Q8NER1,TRPV1,Transient receptor potential cation channel subfamily V member 1,Tier 1.5,0.738,1,A_surface,8,71.94,1,0,,,1,2,"40855286,28604222",0,migraine disorder,0.6269329225883602
P04233,CD74,HLA class II histocompatibility antigen gamma chain,Tier 1,0.737,1,A_surface,24,69.94,1,0,,,1,1,30899255,0,non-small cell lung carcinoma,0.6217636836935354
P42658,DPP6,A-type potassium channel modulatory protein DPP6,Tier 1.5,0.737,1,A_surface,8,86.69,1,0,,,1,1,41313574,0,Autosomal dominant microcephaly,0.6225938492787458