id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,,1,0,,,,1,12,"36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975",0,,
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,81.69,1,0,,,,1,1,36126144,0,essential hypertension,0.2159614840844307
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
P07911,UMOD,Uromodulin,Tier 1,0.774,10,82.94,1,0,,,,1,4,"37533140,35446786",0,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,61.44,1,0,,,,1,2,"38928037,30312735",0,thrombocythemia 1,0.7027329039559379
Q9ULV1,FZD4,Frizzled-4,Tier 1,0.745,11,84.31,1,0,,,,1,1,18673242,0,Familial exudative vitreoretinopathy,0.8152111103672746
P21730,C5AR1,C5a anaphylatoxin chemotactic receptor 1,Tier 1,0.741,19,85.75,1,0,,,,1,5,"33495506,29981048,29327939,28288993,25901944",0,anti-neutrophil cytoplasmic antibody-associated vasculitis,0.5076734733894334
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
P20809,IL11,Interleukin-11,Tier 1,0.712,8,82.62,1,0,,,,1,8,"39408993,39263947,28791655,27878687,25696907,24629635",0,"osteoarthritis, hip",0.31754029889853136
P14207,FOLR2,Folate receptor beta,Tier 1,0.701,5,89.12,0,0,,,,1,2,28686804,0,neoplasm,0.11545394821329319
P15248,IL9,Interleukin-9,Tier 1,0.7,5,84.06,0,0,,,,1,1,40972397,0,neurodegenerative disease,0.40148548290272756
P01374,LTA,Lymphotoxin-alpha,Tier 1,0.7,3,83.44,0,0,,,,1,3,"41810142,30576605",0,,
P15309,ACP3,Prostatic acid phosphatase,Tier 1,0.695,17,92.25,1,0,,,,1,3,"41890985,25591398",0,prostate cancer,0.5521391557206573
Q95460,MR1,Major histocompatibility complex class I-related protein 1,Tier 1,0.693,79,87.5,0,0,,,,1,2,"41134135,20000526",0,Immunodeficiency,0.3336382138166145
Q9NPF0,CD320,CD320 antigen,Tier 1,0.69,6,63.81,0,0,,,,1,1,39493449,0,Methylmalonic aciduria due to transcobalamin receptor defect,0.49918945650121177
P48061,CXCL12,Stromal cell-derived factor 1,Tier 1,0.685,34,83.25,1,0,,,,1,36,"41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275",0,HIV-1 infection,0.3675509850165065
Q6NW40,RGMB,Repulsive guidance molecule B,Tier 1,0.683,11,79.44,1,0,,,,1,1,39263947,0,Abnormality of the skeletal system,0.42535629367019584
P39900,MMP12,Macrophage metalloelastase,Tier 1,0.68,86,86.94,0,0,,,,1,8,"41861669,38477735,38296402,37015819,35120890,34183667,27530235",0,atopic eczema,0.4795677061208266
Q9UEF7,KL,Klotho,Tier 1,0.676,6,89.06,1,0,,,,1,19,"41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411",0,type 2 diabetes mellitus,0.5587488336100863
Q86Z14,KLB,Beta-klotho,Tier 1,0.676,5,89.38,0,0,,,,1,1,40514411,0,congenital hypogonadotropic hypogonadism,0.462898767992589
P51681,CCR5,C-C chemokine receptor type 5,Tier 1,0.674,25,85.38,1,0,,,,1,23,"36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773",0,HIV infection,0.7442590579227027
P62576,nanA,Sialidase A,Tier 1,0.67,5,81.19,0,0,,,,1,4,"37350189,34976356,34341854,32034503",0,,
Q9GZX9,TWSG1,Twisted gastrulation protein homolog 1,Tier 1,0.67,6,80.38,0,0,,,,1,1,39299474,0,Abruptio Placentae,0.29495361755469174
P56704,WNT3A,Protein Wnt-3a,Tier 1,0.665,4,88.31,1,0,,,,1,1,37231925,0,neurodegenerative disease,0.5271953966006525
P05113,IL5,Interleukin-5,Tier 1,0.664,5,86.69,1,0,,,,1,12,"40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585",0,asthma,0.6399821251487101
O15169,AXIN1,Axin-1,Tier 1,0.664,22,61.09,0,0,,,,1,2,28129128,0,hepatocellular carcinoma,0.7864172882686208
P15941,MUC1,Mucin-1,Tier 1,0.66,23,47.41,0,0,,,,1,686,"42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896",0,"tubulointerstitial kidney disease, autosomal dominant, 2",0.7040398435219726
Q92876,KLK6,Kallikrein-6,Tier 1,0.659,21,91.75,0,0,,,,1,2,"30114962,22505517",0,neuroinflammatory disorder,0.1901077464611955
P22894,MMP8,Neutrophil collagenase,Tier 1,0.655,25,90.38,0,0,,,,1,4,"35821507,34183667,33534888,30197987",0,acne,0.603247809982021
Q12809,KCNH2,Voltage-gated inwardly rectifying potassium channel KCNH2,Tier 1,0.655,23,62.75,1,0,,,,1,1,22617876,0,Romano-Ward syndrome,0.8549238933917284
P45452,MMP13,Collagenase 3,Tier 1,0.65,49,88.62,0,0,,,,1,4,"41754778,40893365,38471488,38750696",0,"spondyloepimetaphyseal dysplasia, Missouri type",0.8032079813035149
P10747,CD28,T-cell-specific surface glycoprotein CD28,Tier 1,0.641,10,81.31,0,0,,,,1,12,"40702285,40479828,36979667,36126113,32584540,32280743,32024070,26999456,26992239,26320067,23756353,10435754",0,HIV infection,0.5105949023227331
Q13651,IL10RA,Interleukin-10 receptor subunit alpha,Tier 1,0.641,7,62.0,1,0,,,,1,2,"25870409,25558474",0,Autosomal recessive early-onset inflammatory bowel disease,0.8151052076044897
Q04609,FOLH1,Glutamate carboxypeptidase 2,Tier 1,0.64,88,93.81,0,0,,,,1,47,"41855944,41683470,41548790,41478044,41126016,40684732,39388218,39187748,38769597,34341883,33794195,33061374,33025277,32721116,32611993,32525981,32208602,29313393,28794625,28746182,27574424,27456457,27228412,27077564,26985893,26472453,26438155,25938427,25620467,25620167,25473281,24954476,24337602,24321253,23590171,21980237,21641946,21555850,21147500,20550178,20407731,19701187,19514954,19488725,18776550,15520166,12124337",0,prostate cancer,0.5500818985644047
O00206,TLR4,Toll-like receptor 4,Tier 1,0.621,15,89.19,1,0,,,,1,32,"41864915,41444487,40521190,39897575,38931862,38742374,38280803,37360693,36916435,36908619,35410404,35402075,35189346,34831332,32784904,29910175,29250957,25483705",0,major depressive disorder,0.5065500149392951
P78380,OLR1,Oxidized low-density lipoprotein receptor 1,Tier 1,0.62,13,87.44,0,0,,,,1,1,35821507,0,head and neck squamous cell carcinoma,0.10910332327226395
O14625,CXCL11,C-X-C motif chemokine 11,Tier 1,0.62,2,79.94,1,0,,,,1,4,"36649818,32784904,30578658,23935890",0,neoplasm,0.11537901464416651
Q9HBE5,IL21R,Interleukin-21 receptor,Tier 1,0.615,6,64.12,0,0,,,,1,2,"30800133,29244152",0,Cryptosporidiosis - chronic cholangitis - liver disease,0.7501392499286187
O60885,BRD4,Bromodomain-containing protein 4,Tier 1,0.615,100,55.31,0,0,,,,1,6,"41824501,41088826,40957137,35185589,22609015",0,Cornelia de Lange syndrome 6,0.6842985362822729
P01887,B2m,Beta-2-microglobulin,Tier 1,0.61,100,93.81,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",0,,
P12643,BMP2,Bone morphogenetic protein 2,Tier 1,0.61,21,79.56,0,0,,,,1,10,"41144653,38542880,37231465,35591468,35195734,34067593,33997500",0,"short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1",0.7361833785834584
P20062,TCN2,Transcobalamin-2,Tier 1,0.605,11,91.5,0,0,,,,1,3,"41935727,39493449",0,transcobalamin II deficiency,0.8116989428679681
P15018,LIF,Leukemia inhibitory factor,Tier 1,0.605,5,87.12,1,0,,,,1,38,"41611413,38359901,37549567,37175248,36838669,33640806,32253765,31791592,31357280,30771937,30037541,29289340,28963578,28763192,27855943,26877178,26764106,26695234,26344338,26113415,25335821,25311485,25035238,24716781,22648816,22471443,27335672,20673578,20151395,19803140,18646283,17315151,16331583,16053313,11791582,9823713,39571081,31461490",0,alcohol drinking,0.24197086949132446
P00797,REN,Renin,Tier 1,0.605,91,85.44,0,0,,,,1,456,"42025056,42000159,41992303,41979049,41942404,41934998,41909751,41904852,41851110,41849890,41794534,41780402,41770936,41718462,41711853,41698160,41671930,41659919,41629318,41545413,41538945,41529264,41519163,41454539,41443106,41386094,41330678,41327249,41249026,41234744,41207040,41205456,41175848,41172349,41171135,41164194,41161441,41148632,41118515,41089000,41067030,41024479,41002305,40994449,40968863,40963922,40893365,40891676,40870790,40801503,41906877,40832436,39923730,39263947,39129649,38811951,36190914,35983901,35907639,35187107,34619249,34248841,32981365,32838280,32527800,31988066,26746799,21147843",0,familial juvenile hyperuricemic nephropathy type 2,0.7657976389758877
P10636,MAPT,Microtubule-associated protein tau,Tier 1,0.605,100,49.22,1,0,,,,1,9,"40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187",0,Pick disease,0.7600399335134378
P46059,SLC15A1,Solute carrier family 15 member 1,Tier 1,0.603,3,87.0,1,0,,,,1,1,26811678,0,cleft palate,0.3279926002389253