id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P46094,XCR1,Chemokine XC receptor 1,Tier 1.5,0.715,1,84.94,1,0,,,,1,1,35212764,0,COVID-19,0.459103766220463
P32239,CCKBR,Gastrin/cholecystokinin type B receptor,Tier 1.5,0.713,5,75.75,1,0,,,,1,2,"33776434,27754762",0,gastroesophageal reflux disease,0.4256110167566802
P25106,ACKR3,Atypical chemokine receptor 3,Tier 1.5,0.71,14,82.44,1,0,,,,1,2,"40401615,28670693",0,oculomotor-abducens synkinesis,0.49893280382434735
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.7,0,72.06,0,0,,,,1,1,35311942,0,,
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.7,1,81.5,0,0,,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
P21781,FGF7,Fibroblast growth factor 7,Tier 1.5,0.695,0,82.44,0,0,,,,1,5,"35415885,15719578,7547864,16462265",0,cancer,0.5963369026823151
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.681,8,63.03,1,0,,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
P26718,KLRK1,NKG2-D type II integral membrane protein,Tier 1.5,0.679,22,79.19,0,0,,,,1,1,24629635,0,Behcet's syndrome,0.18614538678991077
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.668,4,79.81,0,0,,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
O00744,WNT10B,Protein Wnt-10b,Tier 1.5,0.668,0,80.06,0,0,,,,1,2,"32810272,18673242",0,Split hand-split foot malformation,0.7755225395358214
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.665,6,67.38,0,0,,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
Q6PCB0,VWA1,von Willebrand factor A domain-containing protein 1,Tier 1.5,0.664,0,78.38,0,0,,,,1,4,"41906877,41693575,38904251,38299345",0,"neuronopathy, distal hereditary motor, autosomal recessive 7",0.7420531156755253
A2RU14,TMEM218,Transmembrane protein 218,Tier 1.5,0.663,0,87.62,0,0,,,,1,6,"41360349,34861273,31349094,29277631,26580576,26248137",0,Joubert syndrome 39,0.7308441626389979
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.66,5,87.06,0,0,,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
Q86YL7,PDPN,Podoplanin,Tier 1.5,0.66,6,57.97,0,0,,,,1,4,"41304780,41292412,39451677",0,Microscopic hematuria,0.41183796492083136
O15389,SIGLEC5,Sialic acid-binding Ig-like lectin 5,Tier 1.5,0.656,3,77.75,0,0,,,,1,3,"33584010,27678199,24405684",0,dentures,0.15815607474115415
O15263,DEFB4A,Defensin beta 4A,Tier 1.5,0.65,6,78.0,0,0,,,,1,2,"40362575,32067984",0,ulcerative colitis,0.09865892368546408
P84996,GNAS,Protein ALEX,Tier 1.5,0.65,0,43.59,0,0,,,,1,9,"39154820,37963924,36037714,34488577,31129134,30979095,30682825,29146902,28626560",0,,
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.648,8,73.25,0,0,,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
Q2I0M5,RSPO4,R-spondin-4,Tier 1.5,0.646,0,78.56,0,0,,,,1,3,"38238732,37425696",0,nonsyndromic congenital nail disorder 4,0.7604902779349189
Q9BQ51,PDCD1LG2,Programmed cell death 1 ligand 2,Tier 1.5,0.645,2,86.38,0,0,,,,1,1,38928037,0,melanoma,0.42716921377769757
P08100,RHO,Rhodopsin,Tier 1.5,0.645,4,88.75,1,0,,,,1,45,"41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760",0,retinitis pigmentosa,0.8481942240861982
Q9UKP5,ADAMTS6,A disintegrin and metalloproteinase with thrombospondin motifs 6,Tier 1.5,0.644,0,77.5,0,0,,,,1,1,35700850,0,Abnormality of the skeletal system,0.5444162515485208
P15391,CD19,B-lymphocyte antigen CD19,Tier 1.5,0.642,4,62.22,1,0,,,,1,13,"41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492",0,"immunodeficiency, common variable, 3",0.6821072538733047
Q8NEV9,IL27,Interleukin-27 subunit alpha,Tier 1.5,0.641,4,75.62,1,0,,,,1,2,"35859339,32784904",0,Crohn's disease,0.40963715551754365
P07202,TPO,Thyroid peroxidase,Tier 1.5,0.64,0,83.44,0,0,,,,1,1,29881374,0,familial thyroid dyshormonogenesis,0.6710562308468054
P45844,ABCG1,ATP-binding cassette sub-family G member 1,Tier 1.5,0.639,5,81.12,1,0,,,,1,1,41854184,0,neurodegenerative disease,0.3915225348167794
P31994,FCGR2B,Low affinity immunoglobulin gamma Fc region receptor II-b,Tier 1.5,0.636,5,78.44,0,0,,,,1,1,38928037,0,systemic lupus erythematosus,0.460465747544726
P51654,GPC3,Glypican-3,Tier 1.5,0.636,4,75.06,1,0,,,,1,65,"42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753",0,Simpson-Golabi-Behmel syndrome type 1,0.762708583613362
Q16674,MIA,Melanoma-derived growth regulatory protein,Tier 1.5,0.636,4,86.38,0,0,,,,1,15,"41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019",0,neurodegenerative disease,0.36367051545295126
P31785,IL2RG,Cytokine receptor common subunit gamma,Tier 1.5,0.635,14,75.5,1,0,,,,1,2,"30800133,33869115",0,gamma chain deficiency,0.8469997000418428
Q92563,SPOCK2,Testican-2,Tier 1.5,0.627,0,66.94,0,0,,,,1,8,"39695715,35474272,32958645,28794177,38656806,36288905",0,Back pain,0.3687304175767662
P34810,CD68,Macrosialin,Tier 1.5,0.627,0,73.19,0,0,,,,1,4,"37422510,33321636,28315675,27940247",0,neurodegenerative disease,0.3710186480081222
O95342,ABCB11,Bile salt export pump,Tier 1.5,0.624,8,83.12,1,0,,,,1,1,36313979,0,progressive familial intrahepatic cholestasis type 2,0.8372060401943777
Q96NZ8,WFIKKN1,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1",Tier 1.5,0.621,2,78.06,0,0,,,,1,1,33591955,0,neurodegenerative disease,0.3060887002952384
P49238,CX3CR1,CX3C chemokine receptor 1,Tier 1.5,0.62,2,80.5,1,0,,,,1,2,28727998,0,age-related macular degeneration,0.4006854573775187
Q06141,REG3A,Regenerating islet-derived protein 3-alpha,Tier 1.5,0.62,4,89.0,1,0,,,,1,2,"39695715,24771595",0,alcohol drinking,0.29724052454892086
Q13508,ART3,Ecto-ADP-ribosyltransferase 3,Tier 1.5,0.62,0,74.0,0,0,,,,1,5,"41503480,41083485,41020397,40313273,41325160",0,type 2 diabetes mellitus,0.3004670185438895
O43435,TBX1,T-box transcription factor TBX1,Tier 1.5,0.619,1,68.19,0,0,,,,1,1,24797903,0,22q11.2 deletion syndrome,0.8406035626999856
Q96MS0,ROBO3,Roundabout homolog 3,Tier 1.5,0.618,3,63.69,0,0,,,,1,2,32369590,0,horizontal gaze palsy with progressive scoliosis,0.7813306356858872
Q07325,CXCL9,C-X-C motif chemokine 9,Tier 1.5,0.617,1,87.44,1,0,,,,1,7,"42046114,37395276,35204399,35018777,33742062,27959341,27819142",0,neoplasm,0.1199067650750674
O60938,KERA,Keratocan,Tier 1.5,0.612,0,87.56,0,0,,,,1,3,"37696275,41280530,38079395",0,cornea plana 2,0.7200491760465073