id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P15056,BRAF,Serine/threonine-protein kinase B-raf,Tier 1,0.803,1,A2_pm_peripheral,100,66.38,0,0,,,1,6,"39624124,34874026,33497198,31726389,24486214,11856330",1,cardiofaciocutaneous syndrome,0.8764542776642054
P04049,RAF1,RAF proto-oncogene serine/threonine-protein kinase,Tier 1,0.799,1,A2_pm_peripheral,75,67.5,0,0,,,1,4,"15112994,12173045,11856330,9883908",1,Noonan syndrome,0.8625147809861142
Q06187,BTK,Tyrosine-protein kinase BTK,Tier 1,0.794,1,A2_pm_peripheral,100,84.44,0,0,,,1,1,41951939,1,X-linked agammaglobulinemia,0.8454716106068291
O60315,ZEB2,Zinc finger E-box-binding homeobox 2,Tier 1.5,0.789,1,A2_pm_peripheral,1,48.16,0,0,,,1,3,"27719642,24146916,18698484",1,Mowat-Wilson syndrome,0.8313744323041312
Q02750,MAP2K1,Dual specificity mitogen-activated protein kinase kinase 1,Tier 1,0.788,1,A2_pm_peripheral,94,83.25,0,0,,,1,1,29580944,1,cardiofaciocutaneous syndrome,0.825549979325162
P11274,BCR,Breakpoint cluster region protein,Tier 1.5,0.785,1,A2_pm_peripheral,5,64.81,0,0,,,1,20,"41951939,41535871,40882628,37937247,37103734,32929022,32507237,31825964,31650445,31295447,29299123,28686804,25809097,23836560,22411871,21810089,21653319,21030439,16990253,11713794",1,chronic myelogenous leukemia,0.8183048540102864
P01111,NRAS,GTPase NRas,Tier 1,0.783,1,A2_pm_peripheral,35,92.06,0,0,,,1,2,"39952900,39371477",1,Noonan syndrome 6,0.8087775198380727
O60674,JAK2,Tyrosine-protein kinase JAK2,Tier 1,0.78,1,A2_pm_peripheral,100,86.88,0,0,,,1,8,"41455398,34121564,32985358,31279934,30415442,25809097,22411871,20711698",1,polycythemia vera,0.8000866241942614
P01137,TGFB1,Transforming growth factor beta-1 proprotein,Tier 1,0.78,1,A2_pm_peripheral,20,79.56,1,0,,,1,4,"38132522,32370304,16775010,11856769",1,Camurati-Engelmann disease,0.7995305374459716
P98170,XIAP,E3 ubiquitin-protein ligase XIAP,Tier 1,0.78,1,A2_pm_peripheral,74,74.25,0,0,,,1,4,"35383192,29864441,27514505,26318819",1,X-linked lymphoproliferative disease,0.8013347966323413
Q9UHD9,UBQLN2,Ubiquilin-2,Tier 1,0.778,1,A2_pm_peripheral,4,61.03,0,0,,,1,2,23541532,1,amyotrophic lateral sclerosis type 15,0.7942015735994536
Q9ULC3,RAB23,Ras-related protein Rab-23,Tier 1.5,0.776,1,A2_pm_peripheral,6,79.56,1,0,,,1,1,23618401,1,RAB23-related Carpenter syndrome,0.7879955689930709
O15294,OGT,UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit,Tier 1,0.77,1,A2_pm_peripheral,44,93.06,0,0,,,1,2,"36868188,36626902",1,"intellectual disability, X-linked 106",0.7660009745204424
P55263,ADK,Adenosine kinase,Tier 1.5,0.769,1,A2_pm_peripheral,4,93.31,0,0,,,1,2,26051465,1,adenosine kinase deficiency,0.7617058236708037
Q92743,HTRA1,Serine protease HTRA1,Tier 1,0.768,1,A2_pm_peripheral,18,83.25,1,0,,,1,1,31988066,1,"cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2",0.7611877816680132
P35221,CTNNA1,Catenin alpha-1,Tier 1,0.765,1,A2_pm_peripheral,10,82.94,1,0,,,1,2,40265971,1,Butterfly-shaped pigment dystrophy,0.7487735496199569
P26038,MSN,Moesin,Tier 1,0.755,1,A2_pm_peripheral,10,86.38,0,0,,,1,65,"41813080,41784619,41611946,40904334,40886652,40258621,40222299,39454415,39053429,38856817,38759442,38687941,38561432,38446130,38349197,38295649,38266273,37869770,37806507,37423650,37353120,37062561,37058944,36982925,36843953,36700559,36562728,36179642,35026109,34893239,34538325,33960345,33727809,33528465,33149582,32882423,32291531,32170403,31872318,31792209,31213813,31072481,30985076,30865739,32254866,29955964,29568450,29136862,28917759,28832225",1,combined immunodeficiency due to moesin deficiency,0.7157135146765757
P84077,ARF1,ADP-ribosylation factor 1,Tier 1,0.755,1,A2_pm_peripheral,36,85.94,1,0,,,1,3,"30965174,11320245",1,periventricular nodular heterotopia 8,0.7173626622431929
Q13153,PAK1,Serine/threonine-protein kinase PAK 1,Tier 1,0.753,1,A2_pm_peripheral,41,73.69,0,0,,,1,2,"32636813,20564698",1,"intellectual developmental disorder with macrocephaly, seizures, and speech delay",0.7110292416229067
Q13546,RIPK1,Receptor-interacting serine/threonine-protein kinase 1,Tier 1,0.749,1,A2_pm_peripheral,39,69.75,1,0,,,1,2,"41290466,35919280",1,immunodeficiency 57,0.698121745966467
P35241,RDX,Radixin,Tier 1.5,0.749,1,A2_pm_peripheral,2,86.56,0,0,,,1,2,"33253235,30700648",1,"hearing loss, autosomal recessive",0.6973070672344621
P50148,GNAQ,Guanine nucleotide-binding protein G(q) subunit alpha,Tier 1,0.748,1,A2_pm_peripheral,30,93.0,1,0,,,1,1,40015005,1,Sturge-Weber syndrome,0.6941111530708174
P61586,RHOA,Transforming protein RhoA,Tier 1,0.744,1,A2_pm_peripheral,100,93.56,0,0,,,1,4,"25645980,19389625,12927206,12123800",1,"ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies",0.6804889074382072
Q00535,CDK5,Cyclin-dependent kinase 5,Tier 1,0.744,1,A2_pm_peripheral,10,91.56,0,0,,,1,4,"33291667,33200349",1,Alzheimer disease,0.6800338890220147
O95786,RIGI,Antiviral innate immune response receptor RIG-I,Tier 1,0.735,1,A2_pm_peripheral,44,85.19,1,0,,,1,6,"34487794,33253193,32946572,31600868,26018150,22127865",1,Singleton-Merten dysplasia,0.6485708110478319
P26196,DDX6,Probable ATP-dependent RNA helicase DDX6,Tier 1,0.734,1,A2_pm_peripheral,9,84.06,0,0,,,1,2,34132569,1,intellectual developmental disorder with impaired language and dysmorphic facies,0.6482686715821397
P12931,SRC,Proto-oncogene tyrosine-protein kinase Src,Tier 1,0.73,1,A2_pm_peripheral,78,83.44,0,1,1Y57,2SRC,1,19,"40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895",1,cancer,0.6343904000453656
P61769,B2M,Beta-2-microglobulin,Tier 1,0.725,1,A2_pm_peripheral,100,94.06,0,0,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P23921,RRM1,Ribonucleoside-diphosphate reductase large subunit,Tier 1,0.724,1,A2_pm_peripheral,12,92.25,1,0,,,1,1,21955496,1,non-small cell lung carcinoma,0.6122881671315019
P43405,SYK,Tyrosine-protein kinase SYK,Tier 1,0.723,1,A2_pm_peripheral,93,84.0,0,0,,,1,2,"35782912,31825964",1,immunodeficiency 82 with systemic inflammation,0.608506293550361
P06241,FYN,Tyrosine-protein kinase Fyn,Tier 1,0.721,1,A2_pm_peripheral,53,80.81,0,0,,,1,5,"38559166,37149826,34757788,32668060,29754498",1,chronic myelogenous leukemia,0.6018224074412558
P32121,ARRB2,Beta-arrestin-2,Tier 1.5,0.719,1,A2_pm_peripheral,1,83.81,1,0,,,1,4,"24736311,40652239,29054528",1,cancer,0.5962458729823639
P07947,YES1,Tyrosine-protein kinase Yes,Tier 1,0.716,1,A2_pm_peripheral,1,81.88,0,0,,,1,1,34757788,1,chronic myelogenous leukemia,0.5851678597856559
P09769,FGR,Tyrosine-protein kinase Fgr,Tier 1.5,0.716,1,A2_pm_peripheral,3,82.19,0,0,,,1,1,39564692,1,chronic myelogenous leukemia,0.5869168331059803
P45984,MAPK9,Mitogen-activated protein kinase 9,Tier 1,0.707,1,A2_pm_peripheral,5,81.44,0,0,,,1,1,41505229,1,cancer,0.5569349147269519
P04406,GAPDH,Glyceraldehyde-3-phosphate dehydrogenase,Tier 1,0.706,1,A2_pm_peripheral,21,98.12,1,0,,,1,11,"39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199",1,neurodegenerative disease,0.55307368855439
P42680,TEC,Tyrosine-protein kinase Tec,Tier 1.5,0.705,1,A2_pm_peripheral,1,85.0,0,0,,,1,13,"39352470,39329798,36414190,36105684,35624657,35462326,35006795,30578658,30398689,27548775,26843427,25016253,24875764",1,alopecia areata,0.5491699656070116
O75534,CSDE1,Cold shock domain-containing protein E1,Tier 1,0.704,1,A2_pm_peripheral,5,79.56,0,0,,,1,1,10101203,1,neurodegenerative disease,0.5472997885061864
P17252,PRKCA,Protein kinase C alpha type,Tier 1.5,0.704,1,A2_pm_peripheral,6,86.38,0,0,,,1,1,41505229,1,acute myeloid leukemia,0.547429504944985
P67809,YBX1,Y-box-binding protein 1,Tier 1,0.703,1,A2_pm_peripheral,11,61.84,0,0,,,1,9,"31989173,31160337,22730292,21245151,16093451",1,dengue disease,0.5435698373845997
P34947,GRK5,G protein-coupled receptor kinase 5,Tier 1,0.702,1,A2_pm_peripheral,23,90.38,0,0,,,1,1,18230760,1,venous thromboembolism,0.5394311062516939
Q92888,ARHGEF1,Rho guanine nucleotide exchange factor 1,Tier 1,0.695,1,A2_pm_peripheral,7,73.19,0,0,,,1,6,"25645980,23757206,25033804,22689339,19389625,12123800",1,immunodeficiency 62,0.5170912094162261
Q96PY5,FMNL2,Formin-like protein 2,Tier 1.5,0.695,1,A2_pm_peripheral,1,76.44,0,0,,,1,1,41149482,1,open-angle glaucoma,0.5157968177633478
P09543,CNP,"2',3'-cyclic-nucleotide 3'-phosphodiesterase",Tier 1.5,0.689,1,A2_pm_peripheral,1,87.25,0,0,,,1,9,"40034273,38569854,37704353,35528922,31171207,30089209,27192549,19021295",1,"myopia 2, autosomal dominant",0.49606855995054094
P31948,STIP1,Stress-induced-phosphoprotein 1,Tier 1.5,0.689,1,A2_pm_peripheral,8,89.75,1,0,,,1,7,"41406518,38012811,34831332,32614006,27681499,24654750,24013070",1,neurodegenerative disease,0.4967711525222825
P21980,TGM2,Protein-glutamine gamma-glutamyltransferase 2,Tier 1.5,0.688,1,A2_pm_peripheral,17,92.88,1,0,,,1,1,35980938,1,neurodegenerative disease,0.49455272812698803
P49327,FASN,Fatty acid synthase,Tier 1,0.68,1,A2_pm_peripheral,34,85.44,1,0,,,1,1,41854184,1,dengue disease,0.46815584653391107
Q07812,BAX,Apoptosis regulator BAX,Tier 1,0.679,1,A2_pm_peripheral,37,85.94,0,0,,,1,21,"41323565,41237573,40761795,40148451,39946362,39318128,37301952,36907299,36843953,36309655,32987067,32486412,31747745,30005287,27843907,26325285,24481451,23582862,23528042,21563784,21362508",1,T-cell acute lymphoblastic leukemia,0.4626258720529755
P09104,ENO2,Gamma-enolase,Tier 1,0.676,1,A2_pm_peripheral,16,97.06,0,0,,,1,1,36384120,1,neurodegenerative disease,0.4533558777394424
P07355,ANXA2,Annexin A2,Tier 1,0.673,1,A2_pm_peripheral,41,94.25,0,0,,,1,12,"40685636,31029658,29906496,24489826,35211356,29982617,27890659,27777972,26061649",1,neurodegenerative disease,0.4424399692174707